Web Access Research Portal

Researcher: Brettingham-Moore, KH (Dr Kate Brettingham-Moore)

Fields of Research

Biochemistry and cell biology
Cancer genetics
Epigenetics (incl. genome methylation and epigenomics)
Cancer cell biology
Molecular targets
Gene expression (incl. microarray and other genome-wide approaches)
Radiation therapy
Genome structure and regulation
Cellular immunology
Medical biochemistry - nucleic acids
Medical bacteriology
Oncology and carcinogenesis
Cellular interactions (incl. adhesion, matrix, cell wall)
Bioinformatic methods development
Solid tumours
Predictive and prognostic markers
Medical biochemistry and metabolomics
Cell development, proliferation and death

Research Objectives

Clinical health
Expanding knowledge in the environmental sciences
Expanding knowledge in the health sciences
Expanding knowledge in the biological sciences
Treatment of human diseases and conditions
Efficacy of medications
Expanding knowledge in the biomedical and clinical sciences
Diagnosis of human diseases and conditions

Career Best Publications

Research Publications

A role for the BAF remodelling complex in GM-CSF gene regulation; ComBio 2005
A role for the NF-KB family member, Crel, in chromatin remodelling events at the GM-CSF promotor; Combined ASBMB, ANZSCDB and ASPS Annual Meeting
Cancer Epigenetics; Drug Discovery in Cancer Epigenetics
Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere; Genome Research
Chromatin remodelling: Distinct molecular events during differentiation and activation of T cells; Current Immunology Reviews
Defining the molecular events required for GM-CSF gene activation in T cells; ComBio 2003 Conference
Depletion of c-Rel from cytokine gene promoters is required for chromatin reassembly and termination of gene responses to T cell activation; PLoS One
Determinants of a transcriptionally competent environment at the GM-CSF promoter; Nucleic Acids Research
Disecting the molecular events involved in activation of GM-CSF gene expression in T cells; The Genome Conference
Distinct mechanisms of regulation of the ITGA6 and ITGB4 genes by RUNX1 in myeloid cells; Journal of Cellular Physiology
Distinct signals and factors are required for GM-CSF promotor chromatin remodelling and gene transcription; Combined ASBMB, ANZSCDB and ASPS Annual Meeting
DNA methylation changes following DNA damage in prostate cancer cells; Epigenetics
GM-CSF gene activation; providing an insight into the role of BRG1 in gene regulation; Mechanisms of Eukaryotic Transcription
GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements; Nucleic Acids Research
GM-CSF promotor remodeling and gene transcription in response to T cell activation are distinct events; 25th Annual Conference of the Organisation and Expression of the Genome
Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia; Frontiers in Immunology
LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin; PLoS Genetics
Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer; Journal of Surgical Oncology
MRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury; HPB
Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma; Clinical Cancer Research
RNA-seq profiling of a radiation resistant and radiation sensitive prostate cancer cell line highlights opposing regulation of DNA repair and targets for radiosensitization; BMC Cancer
Selective remodelling of a single nucleosome precedes GM-CSF transcription in T cells; ComBio 2002
The leukemia inhibitory factor receptor gene is a direct target of RUNX1; Journal of Cellular Biochemistry
Toll-like receptor signaling is functional in immune cells of the endangered Tasmanian devil; Developmental and Comparative Immunology
Transcription factors and chromatin remodelers involved in activating the GM-CSF gene; The Genome Conference
Using gene expression profiling to predict response and prognosis in gastrointestinal cancers-the promise and the perils; Annals of Surgical Oncology

Research Projects

Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies; University of Tasmania Foundation Inc (UTF)
Epigenetic regulation of inegrin beta 4 as a predictor of prostate cancer progression; Cancer Council of Tasmania (CCT)
Examining DNA hydroxymethylation as a radiosensitisation target in medulloblastoma; Cancer Council of Tasmania (CCT)
Gaining new insights into metastatic bone tumours; Royal Hobart Hospital Research Foundation (RHHRF)
Identifying shared mechanisms in response to radiotherapy; Cancer Council of Tasmania (CCT)
Investigating molecular determinants of radiation response in prostate cancer cells; University of Tasmania (UTAS)
Mapping epigenomic information in a three-dimensional prostate cancer cell environment; Cancer Council of Tasmania (CCT)
Molecular profiling of the post radiotherapy chromatin landscape in prostate cancer cells; Cancer Council of Tasmania (CCT)
Regulation of integrins by RUNX1 in leukaemia; David Collins Leukaemia Foundation (DCLF)
Role of NF-kB in radiosensitivity and resistance in prostate cancer; Cancer Council of Tasmania (CCT)
The impact of repeated DNA damage on the molecular profile of prostate cancer cells; Royal Hobart Hospital Research Foundation (RHHRF)
Transcriptome analysis for predicting response to radiotherapy in prostate cancer patients; Royal Hobart Hospital Research Foundation (RHHRF)
David Collins Leukaemia Foundation Elite Research Scholarship - Epigenetic and Transcriptional regulation of leukaemia

Research Candidate Supervision