Web Access Research Portal

Researcher: Small, DH (Professor David Small)

Research Fields

Neurosciences
Cellular Nervous System
Cell Neurochemistry
Neurology and Neuromuscular Diseases
Central Nervous System
Biochemistry and Cell Biology
Pharmaceutical Sciences
Autonomic Nervous System
Basic Pharmacology
Cell Physiology
Biologically Active Molecules
Clinical Pharmacology and Therapeutics
Peripheral Nervous System
Clinical Chemistry (diagnostics)
Animal Cell and Molecular Biology
Plant Cell and Molecular Biology
Animal Physiology - Systems
Cell Development, Proliferation and Death

Research Impact

Neurodegenerative Disorders Related to Ageing
Nervous System and Disorders
Expanding Knowledge in the Medical and Health Sciences
Expanding Knowledge in the Biological Sciences
Health Related to Ageing
Health
Human Pharmaceutical Treatments (e.g. Antibiotics)
Urogenital System and Disorders
Human Biological Preventatives (e.g. Vaccines)
Cancer and Related Disorders
Coastal and Estuarine Flora, Fauna and Biodiversity
Preventive Medicine
Mental Health
Aquaculture Fin Fish (excl. Tuna)
Expanding Knowledge in the Environmental Sciences
Health and Support Services

Career Best Publications

A Heparin-binding Domain in the Amyloid Protein Precursor of Alzheimer's Disease Is Involved in the Regulation of Neurite Outgrowth; Journal of Neuroscience
Alzheimer's disease and Aβ toxicity: from top to bottom; Nature Reviews Neuroscience
Association and Release of the Amyloid Protein Precursor of Alzheimer's Disease from Chick Brain Extracellular Matrix; Journal of Neuroscience
Cholinergic Regulation of Neurite Outgrowth from Isolated Chick Sympathetic Neurons in Culture; Journal of Neuroscience
Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?; Trends in Neurosciences
Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer's disease; The Lancet
High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly; Journal of Structural Biology
Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?
Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth; Journal of Biological Chemistry
The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor; Journal of Neurochemistry
The Amyloid Protein Precursor of Alzheimer's Disease Is a Mediator of the Effects of Nerve Growth Factor on Neurite Outgrowth; Neuron
The beta-amyloid protein of Alzheimers disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism; Brain

Research Publications

α7-nicotinic acetylcholine receptors mediate an Aβ1-42-induced increase in the level of acetylcholinesterase in primary cortical neurons; Journal of Neurochemistry
β Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH; The FEBS Journal
β-amyloid fibril formation is promoted by step edges of highly oriented pyrolytic graphite; Biopolymers: Original Research on Biological Molecules and Assemblies
β-Amyloid precursor protein: function in stem cell development and Alzheimer's disease brain; Neurodegenerative Diseases
A Brief Introduction to the History of the β-Amyloid Protein of Alzheimer's Disease; Abeta Peptide and Alzheimer's Disease
A direct interaction of Aβ with anionic cellular lipids mediates binding to neurons (Poster); 12th International Conference on Alzheimerís and Parkinsonís Diseases
A function for butyrylcholinesterase; Journal of Neurochemistry
A Heparin-binding Domain in the Amyloid Protein Precursor of Alzheimer's Disease Is Involved in the Regulation of Neurite Outgrowth; Journal of Neuroscience
A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments; Biochemistry
A novel zinc(II) binding site modulates the function of the beta-A4 amyloid protein precursor of Alzheimer's disease; Journal of Biological Chemistry
A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease; Biochemistry
Acetycholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides; Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain Sciences
Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer's disease; Journal of Alzheimer's Disease
Acetylcholinesterase inhibitors for the treatment of dementia in Alzheimer's disease: do we need new inhibitors?; Expert Opinion on Emerging Drugs
Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease; Journal of Neurochemistry
Activation of cathepsin D by glycosaminoglycans; The F E B S Journal
Affinity Purification of Proteoglycans that bind to the Amyloid Protein Precursor of Alzheimers Disease; Journal of Neurochemistry
Alois Alzheimer and Alzheimer's disease: a centennial perspective; Journal of Neurochemistry
Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice; Neurobiology of Aging: Experimental and Clinical Research
Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition; Journal of Neurochemistry
Altered glycosylation of acetylcholinesterase in lumbar cerebrospinal fluid of patients with Alzheimer's disease; Journal of Neurology, Neurosurgery and Psychiatry
Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease; Brain Research
Alzheimer's disease and Aβ toxicity: from top to bottom; Nature Reviews Neuroscience
Alzheimer's disease therapeutics: new approaches to an ageing problem; I U B M B Life: (International Union of Biochemistry and Molecular Biology)
Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer's Disease; Abeta Peptide and Alzheimer's Disease - Celebrating a Century of Research
Amyloid-beta Decreases Cell-Surface AMPA Receptors by Increasing Intracellular Calcium and Phosphorylation of GluR2; Journal of Alzheimer's Disease
An abnormality of plasma amyloid protein precursor in Alzheimer's disease; Annals of Neurology
An amyloid peptide beta-A4 25-35, mimics the function of substance P on modulation of nicotine-evoked secretion and desensitization in cultured bovine adrenal chromaffin cells; Journal of Neurochemistry
An unusually glycosylated form of acetylcholinesterase is a CSF biomarker for Alzheimer's disease; Acta Neurologica Scandinavica. Supplementum
Analysis of Aβ cell interactions and uptake in hippocampal culture; 32nd Annual Meeting of the Australian Neuroscience Society
Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner; Neuroscience: An International Journal
App
APP regulates neural stem or progenitor cell differentiation through neurogenin 2 expresssion; Federation of European Neuroscience Societies
APP stimulates neural stem/progenitor cell proliferation by increasing cystatin C secretion. (Poster); 33rd Annual Meeting Australian Neuroscience Society
Association and Release of the Amyloid Protein Precursor of Alzheimer's Disease from Chick Brain Extracellular Matrix; Journal of Neuroscience
Association of serotonin, dopamine, or noradrenaline with an actin-like component in pheochromocytoma (PC12) cells; Journal of Neurochemistry
Astrocytes in Alzheimer's Disease: Emerging Roles in Calcium Dysregulation and Synaptic Plasticity; Journal of Alzheimer's Disease
Binding of Amyloidogenic Transthyretin to the Plasma Membrane Alters Membrane Fluidity and Induces Neurotoxicity; Biochemistry
Binding of [H-3] serotonin to skeletal muscle actin; Journal of Neurochemistry
Biochemical, Cellular and Behavioural Aspects of Neurodegeneration: the View from Down Under; Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration
Candidate Gamma-Secretases in the Generation of the Carboxyl-Terminus of the Alzheimers-Disease Beta-A4 Amyloid - Possible Involvement Of Cathepsin-D; Biochemistry
Characterization of a dipeptidyl aminopeptidase from bovine adrenal medulla; Journal of Neurochemistry
Characterization of early stage intermediates in the nucleation phase of Aβ aggregation; Biochemistry
Cholesterol and anionic phospholipids increase the binding of amyloidogenic transthyretin to lipid membranes; Biochimica et Biophysica Acta
Cholesterol is necessary both for the toxic effect of Aβ peptides on vascular smooth muscle cells and for Aβ binding to vascular smooth muscle cell membranes; Journal of Neurochemistry
Cholinergic Regulation of Neurite Outgrowth from Isolated Chick Sympathetic Neurons in Culture; Journal of Neuroscience
Cystatin C regulates neural stem or progenitor cell proliferation (Poster); 34th Annual Meeting Australasian Neuroscience Society
Cytoplasmic Domain of the â-Amyloid Protein Precursor of Alzheimer's Disease: Function, Regulation of Proteolysis, and Implications for Drug Development; Journal of Neuroscience Research
Disruption of protein trafficking in Alzheimer's Disease: APP, Aβ and AMPA receptors; Australian Neuroscience Society 31st Annual Meeting
Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease?; Trends in Neurosciences
Do microglia default on network maintenance in Alzheimer's disease?; Journal of Alzheimer's Disease
Dysregulation of Ca2+ homeostasis in Alzheimer's disease: role in acetylcholinesterase production and AMPA receptor internalization; Neurodegenerative Diseases
Dysregulation of Calcium Homeostasis in Alzheimer's Disease; Neurochemical Research
Effect of Heparin on APP Metabolism and Aβ Production in Cortical Neurons; Neurodegenerative Diseases
Effects of glycosaminoglycans on the level of β- and α-secretase and APP processing in Tg2576 primary cortical cells; Australian Neuroscience Society Annual Meeting
Effects of glycosaminoglycans on the level of β- and α-secretase and APP processing in Tg2576 primary cortical cells; APSN 2012
Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice; PLoS One
Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice; Australian Neuroscience Society 31st Annual Meeting
Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor-related protein on neurite outgrowth from sympathetic neurons in culture; F E B S Letters: (Federation of European Biochemical Societies)
Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease; F E B S Letters: (Federation of European Biochemical Societies)
Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease; F E B S Letters: (Federation of European Biochemical Societies)
Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease; Journal of Neurochemistry
Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease; Journal of Neuroscience Research
Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer's disease; The Lancet
Heparan sulfates mediate the binding of basic fibroblast growth factor to a specific receptor on neural precursor cells; Journal of Biological Chemistry
Heparin Activates β-Secretase (BACE1) of Alzheimer's Disease and Increases Autocatalysis of the Enzyme; Biochemistry
High resolution scanning tunnelling microscopy of the β-amyloid protein (Aβ1-40) of Alzheimer's disease suggests a novel mechanism of oligomer assembly; Journal of Structural Biology
Human brain beta-A4 amyloid protein precursor of Alzheimer's disease: purification and partial characterization. ; Journal of Neurochemistry
Identification of a trypsin-like site associated with acetylcholinesterase by affinity labelling with [H-3] diisopropyl fluorophosphate; Journal of Neurochemistry
Identification of heparin-binding domains in the amyloid precursor protein of Alzheimer's disease by deletion mutagenesis and peptide mapping; Journal of Neurochemistry
In Vivo Methylation of an Arginine in Chicken Myelin Basic Protein; Journal of Neurochemistry
Inhibition of Aβ aggregation and neurotoxicity by the 39-kDa receptor-associated protein; Journal of Neurochemistry
Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease; Journal of Neurochemistry
Interaction of the receptor-associated protein (RAP) with APP and Aβ; Australian Neuroscience Society 31st Annual Meeting
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions; Biological Chemistry: Official Journal of The German Society for Biochemistry and Molecular Biology
Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury; Journal of Neuropathology and Experimental Neurology
LIF treatment reduces Nogo-A deposits in spinal cord injury modulating Rho GTPase activity and CRMP-2 phosphorylation; Journal of Neurodegeneration and Regeneration
Mechanisms of synaptic homeostasis in Alzheimer's disease; Current Alzheimer Research
Mechanisms of Transthyretin Aggregation and Toxicity; Protein Aggregation and Fibrillogenesis in Cerebral and Systematic Amyloid Disease, Subcellular Biochemistry 65
Memory loss caused by Ŗ-amyloid protein is rescued by aŖ3-adrenoceptor agonist; Neurobiology of Aging
Metallothionein I/II and metallothionein III induce growth cone chemotaxis via disparate mechanisms; Australian Neuroscience Society 31st Annual Meeting
Molecular isoform distribution and glycosylation of acetylcholinesterase are altered in brain and cerebrospinal fluid of patients with Alzheimer's disease; Journal of Neurochemistry
Myelopathy associated with vitamin B12 deficiency - new approaches to an old problem
N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin; Scientific Reports
Network dysfunction in Alzheimer's disease: does synaptic scaling drive disease progression?
Neural Network Dysfunction in Alzheimer's Disease: A Drug Development Perspective; Drug News and Perspectives: The International Drug Newsmagazine
Neurodegeneration in Familal Amyloidotic Polyneuropathy; Clinical and Experimental Pharmacology and Physiology
Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis; Journal of Biological Chemistry
Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice; Journal of Neuroscience Research
Presenilins and the gamma-secretase: still a complex problem; Molecular Brain
Proteases and proteolytic processing in the nervous system: key targets for drug development; Journal of Neuroscience Research
Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease β-amyloid protein precursor: effect of C-terminal truncation on the production of β-amyloid protein; Journal of Neuroscience Research
Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease; IUBMB Life
Proteolytic Processing of Alzheimers-Disease Beta-A4 Amyloid Precursor Protein in Human Platelets; Journal of Biological Chemistry
Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth; F E B S Letters: (Federation of European Biochemical Societies)
Regulation of proBACE1 by glycosaminoglycans
Regulation of the cell adhesion molecule, L1CAM by the Aβ peptide of Alzheimer's Disease; Australian Neuroscience Society 31st Annual Meeting
Relative increase in Alzheimer's disease of soluble forms of cerebral A beta amyloid protein precursor containing the Kunitz protease inhibitory domain; Journal of Biological Chemistry
Revisiting the role of acetylcholinesterase in Alzheimer's disease: cross-talk with P-tau and β-amyloid; Frontiers in Molecular Neuroscience
Role of cystatin C in amyloid precursor protein-induced proliferation of neural stem/progenitor cells; Journal of Biological Chemistry
Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth; Journal of Biological Chemistry
Serotonin binds specifically and saturably to an actin-like protein isolated from rat brain synaptosomes; National Academy of Sciences of The United States of America. Proceedings
Single-Molecule Imaging of Amyloid-β Protein (Aβ) of Alzheimerís Disease: From Single-Molecule Structures to Aggregation Mechanisms and Membrane Interactions; Bio-nanoimaging: Protein Misfolding & Aggregation
Size and sulfation are critical for the effect of heparin on APP processing and A beta production; Journal of Neurochemistry
STIM1 is necessary for regulation of growth cone motility; Australian Neuroscience Society 31st Annual Meeting
STIM1 is necessary for store-operated calcium entry in turning growth cones; Journal of Neurochemistry
Substrate-bound beta-amyloid peptides inhibit cell adhesion and neurite outgrowth in primary neuronal cultures; Journal of Neurochemistry
Surface Plasmon Resonance for the Analysis of β-Amyloid Interactions and Fibril Formation in Alzheimer's Disease Research; Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration
Surface Plasmon Resonance Spectroscopy in Determination of the Interactions Between Amyloid β Proteins (Aβ) and Lipid Membranes ; Methods in Molecular Biology: Surface Plasmon Resonance
Surface Plasmon Resonance Spectroscopy: A New Lead in Studying the Membrane Binding of Amyloidogenic Transthyretin; Methods in Molecular Biology
Targeting pre-mRNA splicing: a BACE-ic strategy for AD drug development?; Journal of Neurochemistry
The β-amyloid peptide of Alzheimer's disease decreases adhesion of vascular smooth muscle cells to the basement membrane; Journal of Neurochemistry
The β-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the α7 nicotinic acetylcholine receptor; Journal of Neurochemistry
The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells; Journal of Neurochemistry
The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons; European Journal of Biochemistry: The Febs Journal
The Amyloid Protein Precursor of Alzheimer's Disease Is a Mediator of the Effects of Nerve Growth Factor on Neurite Outgrowth; Neuron
The beta-amyloid protein of Alzheimers disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism; Brain
The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from gamma-secretase; European Journal of Biochemistry: The Febs Journal
The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons; Journal of Neuroscience Research
The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease; Journal of Alzheimer's Disease
The role of Neurogenin2 in APP-stimulated neural stem or progenitor cell differentiation; 34th Annual Meeting Australasian Neuroscience Society
Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine; European Journal of Biochemistry: The Febs Journal
Transthyretin and familial amyloidotic polyneuropathy: Recent progress in understanding the molecular mechanism of neurodegeneration; The F E B S Journal
Transthyretin oligomers induce calcium influx via voltage-gated calcium channels; Journal of Neurochemistry
TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons; Molecular Neurodegeneration
Wheat germ agglutinin-binding glycoproteins are decreased in Alzheimer's disease cerebrospinal fluid; Journal of Neurochemistry

Research Projects

Are microglia the villains of AB toxicity in Alzheimer's disease; Alzheimer's Australia Dementia Research Foundation (AADRF)
Biochemical studies on amyloid diseases; National Health & Medical Research Council (NHMRC)
David Small Research Fellowship - SRF B; National Health & Medical Research Council (NHMRC)
Establishing a state-of-the-art 'Live Cell Recording and Imaging Facility' at Menzies Research Institute Tasmania; Rebecca L Cooper Medical Research Foundation (RLCMRF)
Establishment of a Confocal/multiphoton Microscope for Imaging of Living Systems; Australian Research Council (ARC)
Establishment of a digital transmission electron microscopy facility; Australian Research Council (ARC)
How amyloid causes neurodegeneration: the role of transthyretin in familial amyloidotic polyneuropathy; National Health & Medical Research Council (NHMRC)
Multidimensional analysis of biomarkers for the early detection of Alzheimer's disease using in vivo MRS; The Mason Foundation (ANZCT-Mason Fdn)
Oligodendrocyte Progenitor Cells - A new target for Alzheimer's Disease Treatment; Bupa Foundation/Alzheimer's Society (BUPA/ALZSOC)
Regulation of the beta-secretase (BACE1) by glycosaminoglycans; National Health & Medical Research Council (NHMRC)
The receptor-associated protein (RAP) as a molecular chaperone for the amyloid protein (Abeta) of Alzheimer's disease; National Health & Medical Research Council (NHMRC)
The role of store-operated calcium entry in neuronal development; National Health & Medical Research Council (NHMRC)
Transient receptor potential channels, calcium and Alzheimer's disease; National Health & Medical Research Council (NHMRC)
Understanding the cause of Alzheimer's disease; National Health & Medical Research Council (NHMRC)

Research Candidate Supervision

Role of Phosphoinositides in the Biology of the Amyloid Precursor Protein
Role of the 39-kDa Receptor-Associated Protein (RAP) in Alzheimer's Disease
STIM1 Mediates Multiple Signalling Pathways in Neuronal Growth Cones
Studies on the Use of Glycosaminoglycans for the Treatment of Alzheimer's Disease
Understanding the Mechanisms that Cause Alzheimer's Disease