Web Access Research Portal

Researcher: King, AE (Associate Professor Anna King)

Research Fields

Cellular Nervous System
Central Nervous System
Neurology and Neuromuscular Diseases
Neurosciences
Cell Development, Proliferation and Death
Autonomic Nervous System
Chemical Sciences
Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
Aged Health Care
Cell Metabolism
Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Instrumental Methods (excl. Immunological and Bioassay Methods)
Analytical Chemistry
Ophthalmology
Separation Science
Basic Pharmacology
Plant Physiology
Microtechnology
Residential Client Care
Health Promotion
Pharmaceutical Sciences
Biomechanical Engineering
Microbial Ecology
Flexible Manufacturing Systems
Biomedical Engineering
Aboriginal and Torres Strait Islander Health
Neurogenetics

Research Impact

Nervous System and Disorders
Neurodegenerative Disorders Related to Ageing
Public Health (excl. Specific Population Health)
Expanding Knowledge in the Chemical Sciences
Expanding Knowledge in the Biological Sciences
Inherited Diseases (incl. Gene Therapy)
Expanding Knowledge in the Medical and Health Sciences
Nutrition
Preventive Medicine
Fabricated Metal Products
Hearing, Vision, Speech and Their Disorders
Skeletal System and Disorders (incl. Arthritis)
Food Safety
Expanding Knowledge in Technology
Scientific Instruments
Human Pharmaceutical Products
Nursing
Health Education and Promotion
Human Pharmaceutical Treatments (e.g. Antibiotics)
Coastal and Estuarine Water Management
Energy Storage (excl. Hydrogen)
Diabetes
Cancer and Related Disorders
Evaluation of Health Outcomes

Career Best Publications

Research Publications

α-Synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway; Neurotoxicity Research
In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury; 4th Congress of Federation of Asian-Oceanain Neuroscience Societies
A Novel In Vitro Primary Culture Model of the Lower Motor Neuron–Neuromuscular Junction Circuit; Microfluidic and Compartmentalized Platforms for Neurobiological Research
AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo; Investigative Ophthalmology & Visual Science (Online)
Acute neocortical injury induces axonal sprouting and dendritic remodelling
Alpha-synuclein is a potential neuroprotectant in both wild-type cortical and dopaminergic neurons, but not A53T mutant neurons; 9th International Conference AD/PD
Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection; Experimental Neurology
Alpha-synuclein upregulation is a neuroprotective response of dopaminergic and cortical neurons; Australian Society for Medical Research
ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1; Cell Death Discovery
ALS-like axonal pathology in cultured spinal motor neurons; 18th Symposium on ALS/MND
ALS-like pathology in cultured spinal motor neurons following excitoxicity; IBRO International Conference
Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease; Brain research bulletin
Alzheimer's Disease and NQO1: Is there a Link?; Current Alzheimer research
Amyloid β accumulation and inner retinal degenerative changes in Alzheimer's disease transgenic mouse; Neuroscience Letters: An International Multidisciplinary Journal Devoted to The Rapid Publication of Basic Research in Neurosciences
An in vitro investigation of the role of interneurons in the development of ALS; 22nd Symposium on ALS/MND
Anaesthetic exposure and dementia: What can we learn from studies in transgenic mice?; Australian Society of Anaesthetists
Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis; Journal of Chemical Neuroanatomy
Axonal shearing in mature cortical neurons induces attempted regeneration and the reestablishment of neurite polarity; Brain Research: International Multidisciplinary Journal Devoted to Fundamental Research in The Brain Sciences
Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system ; Brain Research Bulletin
Axonopathy, excitotoxicity and neuronal degeneration in ALS 2008; Australian Neuroscience Society Conference
C9ORF72 expression and cellular localization over mouse development; Acta neuropathologica communications
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking; Human Molecular Genetics
Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1G93A mouse model of ALS; Scientific Reports
Changes in TDP-43 expression in development, ageing and in the neurofilament light protein knockout mouse; Neurobiology of Aging: Experimental and Clinical Research
Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model; ASN Neuro
Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer’s disease; Alzheimer's & Dementia: Translational Research & Clinical Interventions
Connectivity of pathology: the olfactory system as a model for network-driven mechanisms of Alzheimer’s disease pathogenesis; Frontiers in Aging Neuroscience
Cortical murine neurons lacking the neurofilament light chain protein have an attenuated response to injury in vitro; Journal of Neurotrauma
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease; Acta Neuropathologica
Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice; The Journal of Comparative Neurology
Defining the earliest pathological changes of Alzheimer’s disease; Current Alzheimer research
Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and alpha internexin immunoreactivity; Brain Research
Delayed morphological alterations in a subpopulation of interneurons in the peri-wound region following focal damage to the adult rat neocortex; The 38th Annual Meeting of the Society of Neuroscience
Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments; Frontiers in Cellular Neuroscience
Does metallothionein attenuate mutant SOD1 aggregation in MND; 22nd Symposium on ALS/MND
Excitotoxicity and Axon Degeneration; Handbook of Neurotoxicity
Excitotoxicity in ALS: Overstimulation, or overreaction?; Experimental Neurology
Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons; European Journal of Neuroscience
Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol; Acta Neuropathologica Communications
Focal Damage to the Adult Rat Neocortex Induces Wound Healing Accompanied by Axonal Sprouting and Dendritic Structural Plasticity ; Cerebral Cortex
Focal damage to the neocortex induces dendritic structural plasticity; Dementia, Ageing and Neurodegenerative Diseases Group Conference
Focal damage to the neocortex induces dendritic structural plasticity; Australian Neuroscience Society/Australian Physiological Society
Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro; Experimental Neurology
Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity; Disease Models & Mechanisms
Investigating the cause and consequence of axonal pathology in amyotrophic lateral sclerosis; DANDIS Conference, Australian Neuroscience Society
Investigating the role of inhibition in neurological disease; 32nd Annual Meeting Australian Neuroscience Society
Investigating the role of interneurons in neurological disease; DANDIS
Lab on a chip for studying neuronal degeneration; 3rd Australia & New Zealand Micro/Nanofluidics and Bionano Symposium
Lab-on-a-chip: A novel in vitro model for studying traumatic brain injury; 11th Asia Pacific International Symposium on Microscale Separations and Analysis
Localisation of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity; Journal of Comparative Neurology
Microfludic maze for studying the role of neuron-glia signalling in neuronal networks; MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Microfluidic culture platform for studying neuronal response to axonal stretch injury; 28th International Symposium on Microscale Bioseparations and Analyse
Microfluidic culture platform for studying neuronal response to axonal stretch injury; 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Microfluidic culture platform for studying neuronal response to mild to very mild axonal stretch injury; Biomicrofluidics
Microfluidic investigation of excitotoxin induced ALS-like axonal degeneration; 20th Symposium on ALS/MND
Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit; Journal of Neuroscience Methods
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Changes in arginase1 and inducible nitric oxide synthase; Journal of Neuroinflammation
Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing; Journal of Comparative Neurology
Modelling ALS pathology in vitro; 22nd Symposium on ALS/MND
Modelling site specific excitotixicity in vitro; University of Tasmania Sharing Excellence in Research meeting
Modelling site-specific excitotoxicity in vivo; 22nd International Symposium on ALS/MND
Murine spinal neurons in vitro develop proximal axonal transport abnormalities and swellings that are similar to early axonal changes in amyotrophic lateral sclerosis; Society for Neuroscience
Neurodegeneration in ALS and AD: which comes first the axon or the soma?; Australian Neuroscience Society Conference
Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease; Neurobiology of Aging
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology; Neurobiology of Aging: Experimental and Clinical Research
Neuron-glia interactions underlying axonal health in an in vitro spinal culture model of relevance to ALS; 19th Symposium on ALS/MND
Neuroprotective upregulation of endogenous alpha-synuclein precedes ubiquitination in cultured dopaminergic neurons ; Neurotoxicity Research
Novel alpha-internexin pathological alterations in both the spinal cord and brain of the G93A SOD1 model of amytrophic lateral sclerosis; Society for Neuroscience
Novel alpha-internexin pathological alterations in both the spinal cord and forebrain of the G93A SOD1 model of Amyotrophic Lateral Sclerosis; Australian Society for Medical Research
Peripheral treatment with enoxaparin exacerbates amyloid plaque pathology in Tg2576 mice; Journal of Neuroscience Research
Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS; Acta Neuropathologica
Relationship between the developmental localisation of glutamate receptor subunits in vitro and susceptibility to excitotoxicity; Australian Neuroscience Society Conference
Retinal ganglion cell axons regenerate in the presence of intact sensory fibres; Neuroreport
Site specific excitotoxicity: a model of amyotrophic lateral sclerosis; 32nd Annual Meeting Australian Neuroscience Society
Site-specific excitotoxin exposure in vivo leads to neuronal excitotoxicity and axonal dysfunction; 32nd Annual Meeting Australian Neuroscience Society
Stainless steel pinholes for fast fabrication of high-performance microchip electrophoresis devices by CO2 laser ablation; Analytical Chemistry
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease; Experimental Neurology
The experience of food insecurity amongst elderly Tasmanians; Food Futures Conference 2011
The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain; Metabolomics
The role of anesthesia in exacerbation of ad pathology in a transgenic mouse model of amyloid plaque deposition; Australian Neuroscience Society Conference

Research Projects

2013: 24th Symposium on ALC/MND - Italy, 6-8 December 2013; University of Tasmania (UTAS)
Axon degeneration and axon protection in CNS disease and injury; National Health & Medical Research Council (NHMRC)
Axon protection in Alzheimer's disease; Equity Trustees Limited (EQT)
Axonal protection in ALS; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Determining the mechanism underlying post-operative cognitive decline; Royal Hobart Hospital Research Foundation (RHHRF)
Does plasticity drive Alzheimers disease and can sleep help; The Mason Foundation (ANZCT-Mason Fdn)
How do microglia-synapse dynamics change with AD; Alzheimer's Australia Dementia Research Foundation (AADRF)
Identifying the role of oligodendrocytes in disease onset and the progression in Amyotrophic Lateral Sclerosis ; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
INHIBITORY REGULATION OF MOTOR NEURONS: A NEW TARGET MECHANISM FOR ALS ?; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Interneuron dysfunction in Amyotrophic Lateral Sclerosis: A new target for potential therapeutics?; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Investigating Batten disease-causing CLN3 mutations in patient-specific stem cells and neurons; Royal Hobart Hospital Research Foundation (RHHRF)
Investigating the causes and consequences of axonal pathology in amyotrophic lateral sclerosis; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Investigating the role of oligodendrocytes in frontotemporal lobar dementia (FTLD); Alzheimer's Australia Dementia Research Foundation (AADRF)
Microfluidic technology to help understand physical damage to brain cells; Australian Research Council (ARC)
Myelin loss in Alzheimer's disease; Alzheimer's Australia Dementia Research Foundation (AADRF)
Neurofilaments as a mechanism for the effect of mild iodine deficiency on brain development; Brain Foundation (BrainF)
Nina Buscombe Award Travel Grant; Motor Neurone Disease Victoria (MNDVIC)
Staying connected: determining targets to protect neuronal circuitry in ALS; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
The role of ALS/FTLD proteins in axon function and degeneration in disease ; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
The role of distal axonal degeneration in ALS; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
The Role of Distal Axonal Degeneration in Amyotrophic Lateral Sclerosis (Motor Neuron Disease); University of Tasmania (UTAS)
The role of excitotoxicity in mediating distal axonal degeneration in ALS; National Health & Medical Research Council (NHMRC)
The role of FTLD proteins in neurite health, function and dysfunction; Alzheimer's Australia Dementia Research Foundation (AADRF)
The role of muscle-neuron Signaling in Neuromuscular Disease; University of Tasmania (UTAS)
The Tasmanian Healthy Brain Project: a longitudinal intervention study to reduce the risk of ageing-related cognitive decline and dementia; National Health & Medical Research Council (NHMRC)
Travel to attend ALS/MND International Symposium in Birmingham 2008; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Unravelling the cellular pathology underlying neuronal degeneration in motor neuron disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Bioplatforms Australia (BPA) - collaborative research
PhD top-up - Kelsey Hanson

Research Candidate Supervision

Alpha-synuclein in the Neurodegenerative Mechanisms of Parkinson's Disease and Dementia with Lewy Bodies
Axonal and Synaptic Pathology in Alzheimer's Disease
Distal Axon and Neuromuscular Junction Degeneration in Amyotrophic Lateral Sclerosis
Do Growth Factors Predict Responders and Non-Responders to Enrichment in Humans and in Mice?
Effect of Agmatine in a Mouse Model of Mitochondrial Optic Neuropathy.
Effects of General Anaesthesia on the Potentiation and Capacity to Resist Alzheimer's Disease pathology
Investigating the Potential Theraputic Value of Metallothionein-Like Derivatives in Neurodegenrative Disorders
Role of Neurofilaments in Ageing and Neurodegenerative Disease
The Microfluidic Device- A Novel In-Vitro Model of Traumatic Brain Injury
The Response of the Mature Central Nervous System to Traumatic Brain Injury
The Role of FTLD Proteins in Neurite Health, Function and Dysfunction
The Role of Interneurons in Amyotrophic Lateral Sclerosis
Traumatic Brain Injury- Characterisation of Healing, Reactive and Plasticity Response