Web Access Research Portal

Researcher: Howells, DW (Professor David Howells)

Research Fields

Central Nervous System
Neurology and Neuromuscular Diseases
Neurosciences
Clinical Sciences
Medical and Health Sciences
Orthopaedics
Medical Biotechnology Diagnostics (incl. Biosensors)
Public Health and Health Services
Medical Physics
Signal Transduction
Radiology and Organ Imaging

Research Impact

Nervous System and Disorders
Expanding Knowledge in the Medical and Health Sciences
Cardiovascular System and Diseases
Expanding Knowledge in the Biological Sciences
Diagnostic Methods
Cancer and Related Disorders
Surgical Methods and Procedures

Career Best Publications

Research Publications

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation; Scientific Reports
A concerted appeal for international cooperation in preclinical stroke research; Stroke: A Journal of Cerebral Circulation
A pathway proteomic profile of ischemic stroke survivors reveals innate immune dysfunction in association with mild symptoms of depression - a pilot study; Frontiers in Neurology
Bringing rigour to translational medicine; Nature reviews. Neurology
Corticospinal tract sprouting in the injured rat spinal cord stimulated by Schwann cell preconditioning of the motor cortex; Neurological Research: A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies; Nuclear Medicine and Biology
Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis; JAMA Neurology
Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis; Stroke: A Journal of Cerebral Circulation
Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases; Public Library of Science Biology
Evidence-based Translational Medicine; Stroke: A Journal of Cerebral Circulation
Exercise reduces infarct volume and facilitates neurobehavioral recovery: results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia; Neurorehabilitation and neural repair
Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment; Frontiers in Neurology
Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat; Neuropsychiatric Disease and Treatment
How to increase value and reduce waste when research priorities are set; The Lancet
Human In Vitro Models of Ischaemic Stroke: A Test Bed for Translation; Translational Stroke Research
Human In Vitro Models of Ischaemic Stroke: A Test Bed for Translation; Translational Stroke Research
Hypertension and experimental stroke therapies; Journal of Cerebral Blood Flow and Metabolism
Hypothermia protects human neurons; International Journal of Stroke
Improving the efficiency of the development of drugs for stroke; International Journal of Stroke
Meta-analysis of data from animal studies: a practical guide; Journal of neuroscience methods
Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis; PLoS biology
Recruitment to trials of late thrombolysis: lessons from the EXTEND study; Journal of Clinical Neuroscience
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement; Public Library of Science Biology
Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies; PLoS biology
STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol; International journal of stroke : official journal of the International Stroke Society
Systematic Review and Meta-Analysis of Therapeutic Hypothermia in Animal Models of Spinal Cord Injury; PL o S One
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically; Journal of Cerebral Blood Flow and Metabolism
The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine; International Journal of Stroke
The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals; International journal of stroke

Research Projects

Biomarkers for assessing the effectiveness of hypothermia as a therapy in ischemic stroke patients; National Health & Medical Research Council (NHMRC)
Blood-brain barrier energy dysfunction: the unifying cause of fatigue; The Mason Foundation (ANZCT-Mason Fdn)
Improving Stroke Outcome: Attenuating Progression and Recurrence; National Health & Medical Research Council (NHMRC)
Paving the way for future stroke drug development: creating a reproducible, humanised model of stroke; Royal Hobart Hospital Research Foundation (RHHRF)
Understanding the human ischemic cascade: Improving the process of drug development for cerebral ischemia ; Royal Hobart Hospital Research Foundation (RHHRF)

Research Candidate Supervision