Web Access Research Portal

Researcher: Howells, DW (Professor David Howells)

Fields of Research

Central nervous system
Neurology and neuromuscular diseases
Cardiology (incl. cardiovascular diseases)
Systems physiology
Clinical sciences
Health services and systems
Cell neurochemistry
Medical biotechnology diagnostics (incl. biosensors)
Basic pharmacology
Cell development, proliferation and death
Signal transduction
Autonomic nervous system
Structural biology (incl. macromolecular modelling)
Cellular nervous system
Inorganic materials (incl. nanomaterials)
Other health sciences
Other biological sciences
Toxicology (incl. clinical toxicology)
Sensory systems
Medical physics
Cancer cell biology
Cellular interactions (incl. adhesion, matrix, cell wall)
Proteomics and intermolecular interactions (excl. medical proteomics)
Radiology and organ imaging
Cellular immunology

Research Objectives

Clinical health
Expanding knowledge in the health sciences
Expanding knowledge in the biomedical and clinical sciences
Diagnosis of human diseases and conditions
Expanding knowledge in the biological sciences
Treatment of human diseases and conditions
Efficacy of medications
Expanding knowledge in the chemical sciences

Career Best Publications

Research Publications

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation; Scientific Reports
A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y12 receptor in platelets; Thrombosis Research
A concerted appeal for international cooperation in preclinical stroke research; Stroke: A Journal of Cerebral Circulation
A pathway proteomic profile of ischemic stroke survivors reveals innate immune dysfunction in association with mild symptoms of depression - a pilot study; Frontiers in Neurology
Acute routine leukocyte and neutrophil counts are predictive of poststroke recovery at 3 and 12 months poststroke: an exploratory study; Neurorehabilitation and Neural Repair
Acute stroke biomarkers: Are we there yet?; Frontiers in Neurology
An automated approach to improve the quantification of pericytes and microglia in whole mouse brain sections; eNeuro
Applications of Nanotechnology in the Diagnosis and Therapy of Stroke; Seminars in Thrombosis and Hemostasis
Automated quantification of multiple cell types in fluorescently labeled whole mouse brain sections using QuPath; Bio-protocol
Bringing rigour to translational medicine; Nature reviews. Neurology
Circadian biology and stroke; Stroke
Combined meta-analysis of preclinical cell therapy studies shows overlapping effect modifiers for multiple diseases; BMJ Open Science
Correlated resting-state functional MRI activity of frontostriatal, thalamic, temporal, and cerebellar brain regions differentiates stroke survivors with high compared to low depressive symptom scores; Neural Plasticity
Corticospinal tract sprouting in the injured rat spinal cord stimulated by Schwann cell preconditioning of the motor cortex; Neurological Research: A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods; Journal of Neuroscience Methods
Detection of activated platelets in a mouse model of carotid artery thrombosis with 18F-labeled single-chain antibodies; Nuclear Medicine and Biology
Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models; Physiology and Behavior
Differential susceptibility of human neural progenitors and neurons to ischaemic injury; Brain Research Bulletin
Discovery and longitudinal evaluation of candidate biomarkers for ischaemic stroke by mass spectrometry-based proteomics; Biomarker Insights
Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis; JAMA Neurology
Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis; Stroke: A Journal of Cerebral Circulation
Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases; Public Library of Science Biology
Evidence-based Translational Medicine; Stroke: A Journal of Cerebral Circulation
Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: selecting the optimal outcomes and statistical power for multi-centre preclinical trials; PLoS ONE
Exercise reduces infarct volume and facilitates neurobehavioral recovery: results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia; Neurorehabilitation and neural repair
Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment; Frontiers in Neurology
Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat; Neuropsychiatric Disease and Treatment
How to increase value and reduce waste when research priorities are set; The Lancet
Human In Vitro Models of Ischaemic Stroke: A Test Bed for Translation; Translational Stroke Research
Human ischaemic cascade studies using SH-SY5Y cells: a systematic review and meta-analysis; Translational Stroke Research
Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature; PLOS One
Hypertension and experimental stroke therapies; Journal of Cerebral Blood Flow and Metabolism
Hypothermia protects human neurons; International Journal of Stroke
Hypothermia revisited: Impact of ischaemic duration and between experiment variability; Journal of Cerebral Blood Flow and Metabolism
Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE; Epilepsia
Improving the efficiency of the development of drugs for stroke; International Journal of Stroke
Improving the stroke drug 'bottleneck'
Longitudinal stroke recovery associated with dysregulation of complement system - A proteomics pathway analysis; Frontiers in Neurology
Meta-analysis of data from animal studies: a practical guide; Journal of neuroscience methods
NXY-059, a failed stroke neuroprotectant, offers no protection to stem cell-derived human neurons; Journal of Stroke and Cerebrovascular Diseases
Olfactory ensheathing cell transplantation in experimental spinal cord injury: effect size and reporting bias of 62 experimental treatments: a systematic review and meta-analysis; PLoS Biology
Optimisation of iron oxide nanoparticles for agglomeration and blockage in aqueous flow systems; Australian Journal of Chemistry
Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis; Neurology
Pericytes and Neurovascular Function in the Healthy and Diseased Brain; Frontiers in cellular neuroscience
Pharmacological PDGFRβ inhibitors imatinib and sunitinib cause human brain pericyte death in vitro; Toxicology and Applied Pharmacology
Poly I:C and LPS induce blood brain barrier disruption and a fatigue behavioural phenotype in rodents in vivo; Society for Neuroscience Conference 2019
Protocol for a retrospective, controlled cohort study of the impact of a change in Nature journals' editorial policy for life sciences research on the completeness of reporting study design and execution; Scientometrics
Recruitment to trials of late thrombolysis: lessons from the EXTEND study; Journal of Clinical Neuroscience
Reduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot study; PLoS ONE
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement; Public Library of Science Biology
Risk of bias reporting in the recent animal focal cerebral ischaemia literature; Clinical Science
Separating surgery from stroke: the effects of surgical severity on photothrombotic animal models of cerebral ischaemia
Standardized mean differences cause funnel plot distortion in publication bias assessments; eLife
Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies; PLoS biology
STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol; International journal of stroke : official journal of the International Stroke Society
Systematic Review and Meta-Analysis of Therapeutic Hypothermia in Animal Models of Spinal Cord Injury; PL o S One
Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke; Neuroprotective Therapy for Stroke and Ischemic Disease
Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically; Journal of Cerebral Blood Flow and Metabolism
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research; PLoS Biology
The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine; International Journal of Stroke
The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies; International journal of stroke
The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals; International journal of stroke
The Right Rodent for the Job: Infarct Variability Between Strains and Its Impact on Logistics of Experimental Animal Studies; Neuroprotective Therapy for Stroke and Ischemic Disease
Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke; Journal of Cerebral Blood Flow and Metabolism
Untangling the effects of surgery and anaesthesia on a vasoconstrictive model of cerebral ischaemia
Vascular perfusion differs in two distinct PDGFRβ-positive zones within the ischemic core of male mice 2 weeks following photothrombotic stroke; Journal of neuroscience research
What has preclinical systematic review ever done for us?; BMJ Open Science

Research Projects

Acquisition of a VS200 Research Slide Scanner for the College of Health and Medicine; Ian Potter Foundation (IPF)
Biomarkers for assessing the effectiveness of hypothermia as a therapy in ischemic stroke patients; National Health & Medical Research Council (NHMRC)
Blood-brain barrier energy dysfunction: the unifying cause of fatigue; The Mason Foundation (ANZCT-Mason Fdn)
Can anti-diabetic agents improve blood flow and outcome following stroke in type 2 diabetes?; Royal Hobart Hospital Research Foundation (RHHRF)
Can idebenone be used to reduce severity of stroke?; Royal Hobart Hospital Research Foundation (RHHRF)
Can metformin and exenatide improve brain vascular function in type 2 diabetes to reduce stroke severity? ; Diabetes Australia Research Program (DARP)
Detecting microvascular injury after stroke using a blood test; Royal Hobart Hospital Research Foundation (RHHRF)
Harnessing the dual roles of pericytes to improve stroke outcomes; National Health & Medical Research Council (NHMRC)
Improving Stroke Outcome: Attenuating Progression and Recurrence; National Health & Medical Research Council (NHMRC)
Paving the way for future stroke drug development: creating a new gold-standard model of stroke; Royal Hobart Hospital Research Foundation (RHHRF)
Special delivery to the brain: Using cutting-edge ultrasound to increase drug delivery to reduce brain damage after a stroke; Royal Hobart Hospital Research Foundation (RHHRF)
Toward targeted drug delivery to the brain using ultrasound; Royal Hobart Hospital Research Foundation (RHHRF)
Understanding the human ischemic cascade: Improving the process of drug development for cerebral ischemia ; Royal Hobart Hospital Research Foundation (RHHRF)

Research Candidate Supervision