Web Access Research Portal

Researcher: Taberlay, PC (Associate Professor Phillippa Taberlay)

Fields of Research

Epigenetics (incl. genome methylation and epigenomics)
Neurology and neuromuscular diseases
Cancer cell biology
Biochemistry and cell biology
Cancer genetics
Genome structure and regulation
Neurogenetics
Molecular targets
Bioinformatic methods development
Neurosciences
Cellular nervous system
Biological mathematics
Radiation therapy
Genomics
Anthropological genetics
Cell development, proliferation and death
Developmental genetics (incl. sex determination)
Cellular interactions (incl. adhesion, matrix, cell wall)
Gene expression (incl. microarray and other genome-wide approaches)
Predictive and prognostic markers
Autonomic nervous system
Cell metabolism
Animal physiology - cell
Cell neurochemistry
Chiropractic
Biostatistics

Research Objectives

Clinical health
Expanding knowledge in the biological sciences
Expanding knowledge in the health sciences
Expanding knowledge in the biomedical and clinical sciences
Treatment of human diseases and conditions
Expanding knowledge in the mathematical sciences
Expanding knowledge in the environmental sciences
Efficacy of medications
Ageing and older people

Career Best Publications

DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival; Cancer Cell
Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups; Epigenetics and Chromatin
Mining cancer methylomes: prospects and challenges
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes; Proceedings of the National Academy of Sciences
Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming; Cell
Reconfiguration of Nucleosome Depleted Regions at Distal Regulatory Elements Accompanies DNA Methylation of Enhancers and Insulators in Cancer; Genome Research
Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations; Genome Research

Research Publications

A genome-wide CRISPR/CAS9 screen to identify novel therapeutic targents for uveal melanoma; The Royal Australian and New Zealand College of Ophthalmologists 50th Annual Scientific Congress
Age, but not amyloidosis, induced changes in global levels of histone modifications in susceptible and disease-resistant neurons in Alzheimer's disease model mice; Frontiers in Aging Neuroscience
Alterations in three-dimensional organization of the cancer genome and epigenome; Cold Spring Harbor Symposia on Quantitative Biology
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer; Clinical Epigenetics
Cancer Epigenetics; Drug Discovery in Cancer Epigenetics
Chromatin remodeler mutations in human cancers: epigenetic implications
Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains; Nature Communications
Determinants of a transcriptionally competent environment at the GM-CSF promoter; Nucleic Acids Research
Distinct mechanisms of regulation of the ITGA6 and ITGB4 genes by RUNX1 in myeloid cells; Journal of Cellular Physiology
DNA methylation and cancer; Progress in drug research
DNA methylation changes following DNA damage in prostate cancer cells; Epigenetics
DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival; Cancer Cell
Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines; Genomics Data
id #12216 - Dysregulation of the neuronal epigenome occurs prior to pathology-onset and alters with progressive amyloidosis; Australasian Neuroscience Society (ANS) 2019 Conference
Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups; Epigenetics and Chromatin
Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia; Frontiers in Immunology
Mining cancer methylomes: prospects and challenges
Mutations in Chromatin Remodeling Factors; Encyclopedia of Cancer 3rd Edition
Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease; Neurobiology of Aging
Neurofilament-labelled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease; Epigenetics 2015 - Australian Scientific Conference
No difference in DNA methylation and hydroxymethylation marks in cortical pyramidal neurons, interneurons and microglia in control, early- and late-stage sporadic AD cases; 9th Alzheimerís + Parkinsonís Disease (A+PD) Symposium
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes; Proceedings of the National Academy of Sciences
Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming; Cell
Poster 299 - Epigenetic dysregulation of critical gene regulatory elements in AD mice; Australasian Neuroscience Society Annual Scientific Meeting 2016
Poster 341 - Simultaneous alterations in nucleosome positions and DNA methylation predict epigenome-wide changes in Alzheimer's disease; Australasian Neuroscience Society Annual Scientific Meeting 2016
Recapitulation of juvenile-like histone landscape in aged neurons; Australian Dementia Forum 2019
Reconfiguration of Nucleosome Depleted Regions at Distal Regulatory Elements Accompanies DNA Methylation of Enhancers and Insulators in Cancer; Genome Research
Regulation of gene expression by the RUNX-1 transcription factor; The Genome Conference
Role of 5-Hydroxymethylation and TET enzymes in remodelling the epigenome; Experimental Medicine
Targeting Epigentic Modifiers in Cancer; Current Medicinal Chemistry
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition; Molecular Cell
The DNA methylation landscape in cancer; Essays in Biochemistry
The leukemia inhibitory factor receptor gene is a direct target of RUNX1; Journal of Cellular Biochemistry
The Role of Nucleosomes in Epigenetic Gene Regulation; Clinical Epigenetics
Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations; Genome Research
Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1; Leukemia Research

Research Projects

A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania; Royal Hobart Hospital Research Foundation (RHHRF)
Ageing matters: Chromatin remodelling in healthy ageing and disease; National Health & Medical Research Council (NHMRC)
Charting epigenetic reprogramming in Alzheimer's disease mice; The Mason Foundation (ANZCT-Mason Fdn)
Chromatin Dynamics as a Driver of Disease Initiation and Development; National Health & Medical Research Council (NHMRC)
Deciphering the molecular basis of three-dimensional BRG1-driven chromatin remodelling in cancer cells; National Health & Medical Research Council (NHMRC)
Delineating the epigenetic evolution of neurons in human sporadic Alzheimer's disease; National Health & Medical Research Council (NHMRC)
Determining the functional importance of global, BRG1-driven interactions in cancer cells; Cancer Australia (CANCA)
Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies; University of Tasmania Foundation Inc (UTF)
EMBO Conference on Chromatin and Epigenetics attendance ; Cancer Council of Tasmania (CCT)
Examining DNA hydroxymethylation as a radiosensitisation target in medulloblastoma; Cancer Council of Tasmania (CCT)
Gaining new insights into metastatic bone tumours; Royal Hobart Hospital Research Foundation (RHHRF)
Identifying critical neuronal signatures of epigenetic modifier complexes of Alzheimer's disease initiation and progression; Brain Foundation (BrainF)
Mapping epigenomic information in a three-dimensional prostate cancer cell environment; Cancer Council of Tasmania (CCT)
Molecular profiling of the post radiotherapy chromatin landscape in prostate cancer cells; Cancer Council of Tasmania (CCT)
New geNOMeC maps of neuronal epigenetic changes in Alzheimer's disease; Rebecca L Cooper Medical Research Foundation (RLCMRF)
Philippa Oakford: Epigenetics 2007 Australian Scientific Conference; David Collins Leukaemia Foundation (DCLF)
Single-cell DNA Methylome Sequencing to detect epigenetic heterogeneity in aged pyramidal neurons; University of Tasmania (UTAS)
The impact of repeated DNA damage on the molecular profile of prostate cancer cells; Royal Hobart Hospital Research Foundation (RHHRF)
Turning back the clock on brain cell aging; Australian Research Council (ARC)
Assessing the role of DNA loops in cancer cells
Beyond Traditional Gene Boundaries: Understanding the importance of enhancer epigenetic reprogramming and atypical long-range interactions in cancer cells.
BRG1-driven interactions in cancer cells.
De-looping DNA loops using epigenetic cancer therapies.
Determining the functional importance of global, BRG1-driven interactions in cancer cells.

Research Candidate Supervision