Web Access Research Portal

Researcher: Taberlay, PC (Dr Phillippa Taberlay)

Fields of Research

Epigenetics (incl. Genome Methylation and Epigenomics)
Neurology and Neuromuscular Diseases
Biochemistry and Cell Biology
Neurogenetics
Bioinformatics
Genome Structure and Regulation
Cancer Cell Biology
Neurosciences
Cancer Genetics
Biological Mathematics
Anthropological Genetics
Developmental Genetics (incl. Sex Determination)
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Cell Development, Proliferation and Death
Autonomic Nervous System
Radiation Therapy
Animal Physiology - Cell
Cell Neurochemistry
Chiropractic

Research Objectives

Cancer and Related Disorders
Expanding Knowledge in the Biological Sciences
Nervous System and Disorders
Expanding Knowledge in the Medical and Health Sciences
Immune System and Allergy
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Environmental Sciences
Expanding Knowledge in the Mathematical Sciences
Ageing and Older People
Urogenital System and Disorders

Career Best Publications

DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival; Cancer Cell
Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines; Genomics Data
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes; National Academy of Sciences of The United States of America. Proceedings
Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming; Cell
Reconfiguration of Nucleosome Depleted Regions at Distal Regulatory Elements Accompanies DNA Methylation of Enhancers and Insulators in Cancer; Genome Research
Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations; Genome Research

Research Publications

Alterations in Three-Dimensional Organization of the Cancer Genome and Epigenome; Cold Spring Harbor Laboratory. Symposia on Quantitative Biology
Cancer Epigenetics; Drug Discovery in Cancer Epigenetics
Chromatin remodeler mutations in human cancers: epigenetic implications
Determinants of a transcriptionally competent environment at the GM-CSF promoter; Nucleic Acids Research
DNA Methylation Screening Identifies Driver Epigenetic Events of Cancer Cell Survival; Cancer Cell
Genome-wide nucleosome occupancy and DNA methylation profiling of four human cell lines; Genomics Data
Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia; Frontiers in Immunology
Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia; Frontiers in Immunology
Mining cancer methylomes: prospects and challenges
Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease; Neurobiology of Aging
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes; National Academy of Sciences of The United States of America. Proceedings
Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming; Cell
Reconfiguration of Nucleosome Depleted Regions at Distal Regulatory Elements Accompanies DNA Methylation of Enhancers and Insulators in Cancer; Genome Research
Regulation of gene expression by the RUNX-1 transcription factor; The Genome Conference
Role of 5-Hydroxymethylation and TET enzymes in remodelling the epigenome; Experimental Medicine
Targeting Epigentic Modifiers in Cancer; Current Medicinal Chemistry
The leukemia inhibitory factor receptor gene is a direct target of RUNX1; Journal of Cellular Biochemistry
Three-dimensional disorganisation of the cancer genome occurs coincident with long range genetic and epigenetic alterations; Genome Research
Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1; Leukemia Research

Research Projects

Charting epigenetic reprogramming in Alzheimer's disease mice; The Mason Foundation (ANZCT-Mason Fdn)
Chromatin Dynamics as a Driver of Disease Initiation and Development; National Health & Medical Research Council (NHMRC)
Determining the functional importance of global, BRG1-driven interactions in cancer cells; Cancer Australia (CANCA)
EMBO Conference on Chromatin and Epigenetics attendance ; Cancer Council of Tasmania (CCT)
Identifying critical neuronal signatures of epigenetic modifier complexes of Alzheimer's disease initiation and progression; Brain Foundation (BrainF)
Mapping epigenomic information in a three-dimensional prostate cancer cell environment; Cancer Council of Tasmania (CCT)
Molecular profiling of the post radiotherapy chromatin landscape in prostate cancer cells; Cancer Council of Tasmania (CCT)
New geNOMeC maps of neuronal epigenetic changes in Alzheimer's disease; Rebecca L Cooper Medical Research Foundation (RLCMRF)
Philippa Oakford: Epigenetics 2007 Australian Scientific Conference; David Collins Leukaemia Foundation (DCLF)
Single-cell DNA Methylome Sequencing to detect epigenetic heterogeneity in aged pyramidal neurons; University of Tasmania (UTAS)
Assessing the role of DNA loops in cancer cells
Beyond Traditional Gene Boundaries: Understanding the importance of enhancer epigenetic reprogramming and atypical long-range interactions in cancer cells.
BRG1-driven interactions in cancer cells.
De-looping DNA loops using epigenetic cancer therapies.
Determining the functional importance of global, BRG1-driven interactions in cancer cells.

Research Candidate Supervision