Web Access Research Portal

Researcher: Woodhouse, A (Dr Adele Woodhouse)

Fields of Research

Neurology and Neuromuscular Diseases
Cellular Nervous System
Central Nervous System
Animal Physiology - Biophysics
Epigenetics (incl. Genome Methylation and Epigenomics)
Animal Physiology - Cell
Cell Development, Proliferation and Death
Biological Sciences
Medical Microbiology
Anthropological Genetics
Autonomic Nervous System
Biological Mathematics
Sensory Systems
Cell Neurochemistry

Research Objectives

Nervous System and Disorders
Expanding Knowledge in the Biological Sciences
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Medical and Health Sciences
Behaviour and Health
Expanding Knowledge in the Mathematical Sciences
Inherited Diseases (incl. Gene Therapy)
Human Pharmaceutical Treatments (e.g. Antibiotics)
Ageing and Older People

Career Best Publications

Research Publications

In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury; 4th Congress of Federation of Asian-Oceanain Neuroscience Societies
Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice; Journal of Neurotrauma
Age, but not amyloidosis, induced changes in global levels of histone modifications in susceptible and disease-resistant neurons in Alzheimer's disease model mice; Frontiers in Aging Neuroscience
Anaesthetic exposure and dementia: What can we learn from studies in transgenic mice?; Australian Society of Anaesthetists
Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system ; Brain Research Bulletin
Biophysical properties of substantia nigra dopaminergic neurons in organotypic cultures; Society for Neuroscience
Ca2+/cAMP-sensitive covariation of IA and IH voltage dependences tunes rebound firing in dopaminergic neurons; Journal of Neuroscience
Co-regulation of IA and IH voltage dependences flexibly tunes dopaminergic neuron rebound firing; Ion Channel Meeting
Co-variation of IA and IH voltage dependences tunes rebound firing in dopaminergic neurons; Society for Neurosciences
Co-variation of voltage-dependence of A-type and H-type currents maximizes the dynamic range of rebound firing in dopaminergic neurons; Meeting of the Société des Neurosciences
Cytoplasmic cytochrome c immunolabelling in dystrophic neurites in Alzheimer's disease; Acta Neuropathologica
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease; Acta Neuropathologica
Defining the earliest pathological changes of Alzheimer's disease; Current Alzheimer research
Does Beta-Amyloid Plaque Formation Cause Structural Injury to Neuronal Processes?; Neurotoxicity Research
Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging; Neurobiology of Aging
Excitotoxicity in ALS: Overstimulation, or overreaction?; Experimental Neurology
Murine spinal neurons in vitro develop proximal axonal transport abnormalities and swellings that are similar to early axonal changes in amyotrophic lateral sclerosis; Society for Neuroscience
Mutant human APP transgenic mice demonstrate dystrophic neurite pathology identical to preclinical Alzheimer's disease; Congress of the Federation of the Asian-Oceanian Neuroscience Societies
Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease; Neurobiology of Aging
Neurofilament-labeled pyramidal neurons and astrocytes are deficient in DNA methylation marks in Alzheimer's disease; Neurobiology of Aging
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology; Neurobiology of Aging: Experimental and Clinical Research
Neuron-glia interactions underlying axonal health in an in vitro spinal culture model of relevance to ALS; 19th Symposium on ALS/MND
No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases; Neurobiology of Disease
Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons; eLife
Olfactory ensheathing cells exhibit different rates of proliferation and apoptosis in the presence of uninjured and injured spinal cord tissue; The International Neurotrauma Symposium
Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors; Cellular and Molecular Life Sciences
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; Society for Neuroscience Annual Meeting
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; 21st Annual National Neurotrauma Society Symposium
Pathological links between traumatic brain injury and dementia: Australian pre-clinical research; Journal of Neurotrauma
Plaque-induced axonal pathology in transgenic mice expressing human mutant amyloid precursor protein genes replicates the dystrophic neurites characteristic of preclinical AD; Society for Neuroscience
Presenilin-1 familial Alzheimer's disease cases exhibit altered pathology in comparison to sporadic AD; Australian Neuroscience Society Annual Conference 2008
Proliferation, apoptosis and migration of ensheathing cells in response to spinal cord tissue; The Australian Neuroscience Society
Proteins and genes related to apoptosis are not elevated in pathological brain aging or Alzheimer's disease; Society for Neuroscience
Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice; BMC Anesthesiology
Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development; Journal of Neuroscience Research
Spinal cord tissue affects ensheathing cell proliferation and apoptosis; NeuroReport
The dystrophic neurite pathology exhibited by TgCRND8 and Tg2576 transgenic mice models preclinical Alzheimer's disease; IBRO World Congress of Neuroscience
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease; Experimental Neurology
The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons; P L o S One
The role of anesthesia in exacerbation of ad pathology in a transgenic mouse model of amyloid plaque deposition; Australian Neuroscience Society Conference
Vaccination strategies for Alzheimer's disease: a new hope?; Drugs and Aging

Research Projects

Assessing the alterations in cortical neuron activity in the vicinity of AB plaques in Alzheimer's disease model mice; University of Tasmania (UTAS)
Charting epigenetic reprogramming in Alzheimer's disease mice; The Mason Foundation (ANZCT-Mason Fdn)
Charting epigenetic reprogramming in Alzheimer's disease mice; Dementia Australia Research Foundation Ltd (DARF)
Delineating the epigenetic evolution of neurons in human sporadic Alzheimer's disease; National Health & Medical Research Council (NHMRC)
Identifying critical neuronal signatures of epigenetic modifier complexes of Alzheimer's disease initiation and progression; Brain Foundation (BrainF)
New geNOMeC maps of neuronal epigenetic changes in Alzheimer's disease; Rebecca L Cooper Medical Research Foundation (RLCMRF)
Regulation of dendritic ion channels and its role in intrinsic neuronal excitability in health and disease; National Health & Medical Research Council (NHMRC)
Selectively vulnerable neurons in Alzheimer's disease: functional and morphological changes in healthy ageing and early Alzheimer's disease; Dementia Australia Research Foundation Ltd (DARF)
Selectively vulnerable neurons in Alzheimers disease: functional and morphological changes; The Yulgilbar Foundation (Yulgilbar)
Single-cell DNA Methylome Sequencing to detect epigenetic heterogeneity in aged pyramidal neurons; University of Tasmania (UTAS)
TDP-43 Misprocessing drives synaptic deficits that leads to ALS; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Turning back the clock on brain cell aging; Australian Research Council (ARC)
Identifying critical neuronal signatures of epigenetic modifier complexes alteration in human Alzheimer's disease

Research Candidate Supervision

Traumatic Brain Injury- Characterisation of Healing, Reactive and Plasticity Response