Web Access Research Portal

Researcher: Chuah, MI (Dr Inn Chuah)

Fields of Research

Cellular Nervous System
Central Nervous System
Animal Neurobiology
Cell Neurochemistry
Sensory Systems
Neurology and Neuromuscular Diseases
Cellular Immunology
Neurosciences
Medical Biochemistry and Metabolomics
Clinical Chemistry (diagnostics)
Innate Immunity
Epidemiology
Cell Metabolism
Peripheral Nervous System
Neurogenetics
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Biological Sciences
Respiratory Diseases
Animal Developmental and Reproductive Biology
Medical Physiology
Systems Biology
Clinical Nursing: Secondary (Acute Care)
Autonomic Nervous System
Biochemistry and Cell Biology
Medical and Health Sciences
Medical Biotechnology
Animal Structure and Function
Cardiology (incl. Cardiovascular Diseases)
Otorhinolaryngology
Molecular Evolution

Research Objectives

Nervous System and Disorders
Expanding Knowledge in the Environmental Sciences
Neurodegenerative Disorders Related to Ageing
Diabetes
Health
Immune System and Allergy
Health Related to Ageing
Expanding Knowledge in the Biological Sciences
Expanding Knowledge in the Medical and Health Sciences
Disease Distribution and Transmission (incl. Surveillance and Response)
Clinical Health (Organs, Diseases and Abnormal Conditions)
Respiratory System and Diseases (incl. Asthma)
Preventive Medicine
Injury Control
Infectious Diseases
Cardiovascular System and Diseases

Career Best Publications

Cellular and Molecular Biology of Ensheathing Cells; Microscopy Research and Technique
Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors; Molecular Brain Research
Developmental Anatomy of the Olfactory System; Handbook of Olfaction and Gustation
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes; Glia
Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury; Journal of Neuroscience
Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1; Glia
Neurotrophic factors in the primary olfactory pathway; Progress in Neurobiology

Research Publications

α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury; Neurobiology of Disease
In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury; 4th Congress of Federation of Asian-Oceanain Neuroscience Societies
A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system; International Society of Neuroimmunology
A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system; The International Neurotrauma Symposium
A rat spinal lesion model to investigate olfactory ensheathing cell transplantation in CNS injury; Combio, 2000
Alpha-internexin in Alzheimer's disease pathology demonstrates hierarchy of neuronal degeneration and neuropathic role of plaque formation
ALS-like axonal pathology in cultured spinal motor neurons; 18th Symposium on ALS/MND
ALS-like pathology in cultured spinal motor neurons following excitoxicity; IBRO International Conference
An extracellular role for metallothionein in recovery from brain injury; Symposium on Neural Regeneration
An extracellular role for metallothoinein in recovery from brain injury; 23rd Annual Meeting of the Australian Neuroscience Society
Axonopathy, excitotoxicity and neuronal degeneration in ALS 2008; Australian Neuroscience Society Conference
Bacteria and PAMPs activate nuclear factor κB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells; Glia
Basic fibroblast growth factor in the primary olfactory pathway: mitogenic effect on ensheathing cells; Neuroscience
Cellular and Molecular Biology of Ensheathing Cells; Microscopy Research and Technique
Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer’s disease; Alzheimer's & Dementia: Translational Research & Clinical Interventions
Connectivity of pathology: the olfactory system as a model for network-driven mechanisms of Alzheimer’s disease pathogenesis; Frontiers in Aging Neuroscience
Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors; Molecular Brain Research
Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway; Journal of Neuroinflammation
Denervation of the olfactory bulb leads to decreased Aβ plaque load in a transgenic mouse model of Alzheimer's disease; Current Alzheimer Research
Developmental anatomy of the olfactory system; Handbook of Olfaction and Gustation
Developmental Anatomy of the Olfactory System; Handbook of Olfaction and Gustation
Developmental anatomy of the olfactory system in the opossum Monodelphis domestica; International Symposium on Olfaction and Taste XII and AChemS XIX
Developmental anatomy of the primary olfactory pathway in the opossum Monodelphis domestica
Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments; Frontiers in Cellular Neuroscience
Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice; Histology and histopathology
Do olfactory ensheathing cells play a role in the defense of the brain against infection?; Neuroembryology and Aging
Early "e; spinal repair following a neonatal transection in the opossum, Monodelphis domestica; Society for Neuroscience
Effect of glial growth factor II on ensheathing cell culture; 15th Australian Conference for Electron Microscopy
Effect of olfactory ensheathing cells on reactive astrocytes in vitro; Cellular and Molecular Life Sciences
Effects of astrocyte implantation into the hemisected adult rat spinal cord; Neuroscience
Effects of olfactory ensheathing cells on astrogliosis; Australian Neuroscience Society
Encapsulated olfactory ensheathing cells in spinal cord repair; International Society for Developmental Neuroscience
Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons; European Journal of Neuroscience
Extracellular, neuroactive properties of metallothioneins; Society for Neuroscience
Gene expression profile of rat olfactory ensheathing cells; The International Neurotrauma Symposium
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes; Glia
Glial Growth Factor 2 induces proliferation and structural changes in ensheathing cells; Brain Research
Glial modulation of the innate immune response olfactory enseathing cells join the melee?; New Research On Innate Immunity
Glycoconjugates within the oviduct and their functional significance with special reference to marsupials; Histology and Histopathology
Immune responses in the compromised olfactory pathway of CX3CR1+/GFP and CX3CR1GFP/GFP mice; European Macrophage and Dendritic Society 24th annual Meeting
Immune responses to bacterial challenge in olfactory tissues of CX3CR1+/GFP and CX3CR1GFP/GFP mice; 10th annual meeting of the Asia-Pacific Society for Neuroscience
Inducible nitric oxide synthase expression in the primary olfactory pathway of wild type CX3CR1+/GFP and CX3CR1GFP/GFP mice following damage and bacterial challenge; Australian Neuroscience Society
Inducible nitric oxide synthase in response to bacterial challenge in nasal tissues of wild type, CX3CR1+/GFP and CX3 CR1GFP/GFP mice; TLROZ 2009: Pattern recognition receptors in health and disease
Inducible production of nitric oxide by olfactory ensheathing cells in response to bacteria; Australian Neuroscience Society
Inducible production of nitric oxide by olfactory ensheathing cells in response to bacteria; Infectious diseases of the nervous system: pathogenesis and worldwide impact, Institut Pasteur
Injury to neurons induces metallothionein expression in adjacent astrocytes: role of soluble factors; 21st Annual National Neurotrauma Society Symposium
Interaction of olfactory ensheathing cells with other cell types in vitro and after transplantation: Glial scars and inflammation ; Experimental Neurology: A Journal of Neuroscience Research
Localisation of α-, β- and γ- synuclein in neuron and oligodendrocyte cultures; Society for Neuroscience
Metallothionein based neuronal therapeutic and therapeutic methods
Metallothionein biology in the ageing and neurodegenerative brain; Neurotoxicity Research
Metallothionein expression by NG2 glial cells following CNS injury; Cellular and Molecular Life Sciences
Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice; NeuroReport
Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways ; Experimental Neurology: A Journal of Neuroscience Research
Metallothionein induction following neuronal injury reveals neuron - astrocyte interactions; Society for Neuroscience Annual Meeting
Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy; Cellular and Molecular Life Sciences
Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury; Journal of Neuroscience
Metallothionein-III Inhibits Initial Neurite Formation in Developing Neurons as Well as Postinjury, Regenerative Neurite Sprouting; Experimental Neurology
Metallothioneins 1 and 2 are expressed in the olfactory mucosa of mice in untreated animals and during the regeneration of the epithelial layer; Biochemical and Biophysical Research Communications
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Changes in arginase1 and inducible nitric oxide synthase; Journal of Neuroinflammation
Morphological and functional plasticity of olfactory ensheathing cells; Journal of Neurocytology
Morphological plasticity of olfactory ensheathing cells; Australian Neuroscience Society
Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1; Glia
Morphological plasticity of olfactory ensheathing cells is regulated by cyclic AMP and endothelin-1; Symposium on Neural Regeneration
Mucin expression in olfactory mucosa of wild type, CX3CR1+/GFP and CX3CR1GFP/GFP mice in response to bacterial challenge; 6th Annual Scientific Meeting of the Australian and New Zealand Association of Clinical Anatomists
Nerve growth factor promotes olfactory axonal elongation; Neuroreport
Neuorn-glia communication: metallothionein expression is rapidly increased by astrocytes in response to neuronal injury; Symposium on Neural Regeneration
Neuregulin and nogo expression in olfactory ensheathing cells after transplantation into the injured spinal cord; Symposium on Neural Regeneration
Neuron-astrocyte interactions following neuronal injury activate a novel, metallothionein based neuroprotective mechanism; The International Neurotrauma Symposium
Neuron-astrocyte signalling regulates astrocytic expression of neuroprotective metallothionein protein following neuronal injury; Asia-Pacific Society for Neurochmistry
Neuron-glia communication: metallothionein expression is rapidly increased by astrocytes in response to neuronal injury; First Joint Symposium of the National and International Neurotrauma Societies
Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury; Journal of Neurochemistry
Neuron-glia interaction and metallothionein expression in a culture model of axonal injury; The Australian Neuroscience Society
Neuronally released factors induce metallothionein in neighbouring astrocytes following injury; Combio 2003
Neurotrophic factors in the primary olfactory pathway; Progress in Neurobiology
Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord; Cellular and Molecular Life Sciences
Olfactory ensheathing cells are attracted to, and are capable of phagocytosing bacteria; The 28th Annual Meeting of the Australian Neuroscience Society
Olfactory ensheathing cells are attracted to, and can endocytose, bacteria; Cellular and Molecular Life Sciences
Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system; The Journal of Comparative Neurology
Olfactory ensheathing cells display antimicrobial activity in culture and may contribute to the innate immune defense of the olfactory system; Australian Neuroscience Society
Olfactory ensheathing cells exhibit different rates of proliferation and apoptosis in the presence of uninjured and injured spinal cord tissue; The International Neurotrauma Symposium
Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes ; Molecular and Cellular Neuroscience
Olfactory Ensheathing Cells Produce BDNF and GDNF; 19th Annual Meeting of the Australian Neuroscience Society
Olfactory ensheathing cells produce NGF, BDNF, GDNF and neuregulins in culture; International Congress on Differentiation and Cell Biology
Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord; Experimental Neurology
Olfactory ensheathing cells promote collateral axonal branching in the lesioned adult rat spinal cord; Symposium on Neural Regeneration
Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors; Cellular and Molecular Life Sciences
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; 21st Annual National Neurotrauma Society Symposium
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; Society for Neuroscience Annual Meeting
Olfactory ensheathing cells, innate immunity and nitric oxide; Institute of Neurology, University College
Olfactory Ensheathing Cells: Nitric Oxide Production and Innate Immunity; Glia
Pathogens induce nitric oxide production by olfactory ensheathing cells; 7th IBRO World Congress of Neuroscience
Production of neuro-active metallothionein-III isoforms and assay of their action in a rat model of cortical damage; Combio, 2000
Proliferation, apoptosis and migration of ensheathing cells in response to spinal cord tissue; The Australian Neuroscience Society
Protective role of metallothioneins in the injured mammalian brain; Reviews in the Neurosciences
Recent insights into the neuroprotective role of metallothionein in the injured brain; The Australian Neuroscience Society
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury; Journal of Biological Chemistry
Response of ensheathing cells (olfactory Schwann cells) to zinc sulfate-induced degeneration of olfactory nerves; 15th Annual Meeting of the Australian Neuroscience Society
Response of neurons to injury in coculture with olfactory ensheathing cells; International Society for Developmental Neuroscience
Response of olfactory Schwann cells to intranasal zinc sulfate irrigation; Journal of Neuroscience Research
Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III; Biochemical Journal
Soluble factors from the olfactory bulb attract olfactory Schwann cells; Journal of Neuroscience
Spinal cord tissue affects ensheathing cell proliferation and apoptosis; NeuroReport
TGF-beta receptor type II and fetuin in the developing neocortex; Society for Neuroscience
The brain response to injury involves mobilization of nestin progenitors and axonal sprouting
The global gene expression of olfactory ensheathing cells and comparisons to astrocytes and Schwann cells; The Australian Neuroscience Society
The link between cellular changes associated with axonal injury and Alzheimer's Disease; The International Neurotrauma Symposium
The role of extracellular metallothionein in cortical wound healing; 23rd Annual Meeting of the Australian Neuroscience Society
Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro; Journal of Cellular and Molecular Medicine
Ultrastructural study of ensheathing cells in early development of olfactory axons; Developmental Brain Research
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; Society for Neuroscience Annual Meeting
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; 21st Annual National Neurotrauma Society Symposium
Whole bacteria, but not specific ligands for Toll-like receptors 2 or 4, activate NF kB and cytokine production in olfactory ensheathing cells in vitro; Society for Neuroscience

Research Projects

2012: 34th International Symposium of the Research Group on the Central Nervous System - The Neurobiology of Ageing and Alzheimer's disease, Canada; University of Tasmania (UTAS)
Assessing the Ability of Metallothionein to Promote Functional Recovery in an Animal Model of Traumatic Spinal Cord Injury; Royal Hobart Hospital Research Foundation (RHHRF)
Cellular interaction in the development of the primary olfactory pathways; National Health & Medical Research Council (NHMRC)
Developing metallothioneine as a therapeutic agent for the treatment of traumatic brain injury; MAIB Injury Prevention & Management Foundation (MAIB)
Effect of Cytokines on Olfactory Ensheating Cell Survival and Growth Factor Production; University of Tasmania (UTAS)
Effect of metallothionein and exercise on progression of motor neurone disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Ensheathing cells and neurotrophic factors; Australian Research Council (ARC)
Establishment of a Fluorescent Stereo-microscope Facility to Determine the Ability of Mature Neurons to Recover from Trauma; National Health & Medical Research Council (NHMRC)
Extrinsic influence on nerve growth.; Australian Research Council (ARC)
Genetic Analysis of Olfactory Ensheathing Cell Action During the Implantation into Lesioned Spinal Cords; International Institute for Research in Paraplegia (IRIP)
How do Olfactory Ensheathing Cells Repair Injured Nerve Cells; National Health & Medical Research Council (NHMRC)
Identifying the Specific Structural Features of Metallothionein that Regulate its Ability to Modulate Astrogliosis; Australian Research Council (ARC)
Interactions between injured neurons, astrocytes and metallothionein; National Health & Medical Research Council (NHMRC)
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast; National Health & Medical Research Council (NHMRC)
Metallothionein in Olfactory Mucosa of Alzheimer's disease patients; Brain Foundation (Tasmania) (BrainFTas)
Neural Protection by MT-III Following Head Injury; MAIB Injury Prevention & Management Foundation (MAIB)
Protection of the brain from infection: Immune properties of olfactory ensheathing cells; Royal Hobart Hospital Research Foundation (RHHRF)
Redefining the Metallothionein's role in the Injured Brain: Extracellular Metallothioneins Play an Important Role in Astrocyte-neuron Responses to Injury; Australian Research Council (ARC)
Refrigerated Benchtop Centrifuge; National Health & Medical Research Council (NHMRC)
Response of ensheathing cells to degeneration of olfactory epithelium following intranasal irrigation with zinc sulphate; Australian Research Council (ARC)
Response of Olfactory Ensheathing Cells to Contused Spinal Cord Tissue; University of Tasmania (UTAS)
Synthesis of Metallothionein III, and its Growth Inhibitory Properties in a Model of Alzheimer's Disease; Clifford Craig Medical Research Trust/UTAS (CCMRT/UTAS)
Tissue culture of ensheathing cells.; University of Tasmania (UTAS)
Unravelling the cellular pathology underlying neuronal degeneration in motor neuron disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Use of Ensheathing Cells to Promote Nervous Tissue Recovery Following Injury; MAIB Injury Prevention & Management Foundation (MAIB)
Using Metallothioneins as a Model for Understanding Cellular and Biochemical Interactions between Neurons and Astrocytes within the Brain; Australian Research Council (ARC)

Research Candidate Supervision

Anti-bacterial Properties of Olfactory Ensheathing Cells and the Primary Olfactory Pathway
Elucidating the Roles of Aurora B Kinase in Neurons
Evaluation of Antioxidant and Neuroprotective Therapies in a Mouse Model of Amyotrophic Lateral Sclerosis
Homer, TRP Channels and Calcium- The Signalling Triad of Growth Cone Motility
Interactions Between Metallathionein and Neurons of the CNS
Interactions Between Olfactory Ensheathing abd Cells of the Central Nervous System
Metallothionein release from astrocytes in the brain and culture as a response to injury
Molecular and Cellular Events Underlying the Response of CNS Neurons to Structural Injury
Olfactory Ensheathing Cell Phenotype after Implantation into the Lesioned Spinal Cord
Olfactory Ensheathing Cells Moderate Astrocyte Inflammatory Activation
Role of Lipoprotein Receptor-Related Proteins (LPRs) in Directing Neuronal Biology
The Morphological and Molecular Characterisation of Olfactory Ensheathing Cells
The role of extracellular metallothioneins in the cellular response to neuronal injury
The Role of Metallothionein I/II in Promoting Axonal Sprouting in Both Central Nervous System and Peripheral Nervous System