Web Access Research Portal

Researcher: Roddam, LF (Dr Louise Roddam)

Fields of Research

Medical Bacteriology
Respiratory Diseases
Clinical Microbiology
Infectious Diseases
Medical Biochemistry and Metabolomics
Innate Immunity
Infectious Agents
Microbial Genetics
Structural Biology (incl. Macromolecular Modelling)
Neurology and Neuromuscular Diseases
Immunology
Cellular Nervous System
Cardiorespiratory Medicine and Haematology
Pharmacology and Pharmaceutical Sciences
Medical Genetics (excl. Cancer Genetics)
Mycology
Preventive Medicine
Bacteriology
Cellular Immunology
Central Nervous System
Pharmaceutical Sciences
Medical Microbiology
Dermatology
Microbial Ecology
Enzymes
Otorhinolaryngology
Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)

Research Objectives

Infectious Diseases
Respiratory System and Diseases (incl. Asthma)
Human Pharmaceutical Treatments (e.g. Antibiotics)
Expanding Knowledge in the Medical and Health Sciences
Endocrine Organs and Diseases (excl. Diabetes)
Inherited Diseases (incl. Gene Therapy)
Nervous System and Disorders
Expanding Knowledge in the Biological Sciences
Expanding Knowledge in the Environmental Sciences
Health
Digestive System Disorders
Immune System and Allergy
Skin and Related Disorders
Expanding Knowledge in the Agricultural and Veterinary Sciences
Human Pharmaceutical Products
Surgical Methods and Procedures
Diabetes
Neurodegenerative Disorders Related to Ageing

Career Best Publications

Research Publications

Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells; Cellular Microbiology
Pandoraea pnomenusa Isolated from an Australian Patient with Cystic Fibrosis; Frontiers in microbiology
Pseudomonas aeruginosa uses multiple pathways to acquire iron during chronic infection in cystic fibrosis lungs; Infection and Immunity
A survey of virulence genes in Pseudomonas aeruginosa; Australian Society for Microbiology National Scientific Meeting
Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis; FEMS Immunology and Medical Microbiology
Antimicrobial susceptibility testing of cystic fibrosis and non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa: a comparison of three methods; British Journal of Biomedical Science
Biosignificance of bacterial cyanogenesis in the CF lung; Journal of Cystic Fibrosis
Chelated iron as an anti-Pseudomonas aeruginosa biofilm therapeutic strategy; Journal of Applied Microbiology
Cross kingdom signaling during P. aeruginosa infection of the CF lung results in a decreased capacity of the host to clear the infection; Proceedings of the National Meeting of the Australian Society of Microbiology
Differentially expressed genes from RNASeq and functional enrichment results are affected by the choice of single-end versus paired-end reads and stranded versus non-stranded protocols; Bmc Genomics
Expression of PPARγ and Paraoxonase 2 correlated with Pseudomonas aeruginosa infection in Cystic Fibrosis; PLoS One
Functionalized polyanilines disrupt Pseudomonas aeruginosa and Staphylococcus aureus biofilms; Colloids and Surfaces B: Biointerfaces
Gene expression analysis demonstrates that intravenous antibiotic treatment of a chronic lung infection results in reduced bacterial load but increased virulence of surviving bacteria; National Meeting of the Australian Society of Microbiology
Gene expression analysis of bacterial populations in patient sputum samples during intravenous antibiotic therapy; National Meeting of the Australian Society of Microbiology
Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis; Molecular Microbiology
Genetic characterization of pilin glycosylation in Neisseria meningitidis; Microbiology
Genome sequences of two Pandoraea pnomenusa isolates recovered 11 months apart from a cystic fibrosis patient; Genome Announcements
High peripheral blood Th17 percent associated with poor lung function in cystic fibrosis; PLoS One
Identification of two immune system changes that may contribute to infectious pathology in cystic fibrosis; BacPath 2013
Iron chelation directed against biofilms as an adjunct to conventional antibiotics; American Journal of Physiology: Lung Cellular and Molecular Physiology
Iron-binding compounds impair Pseudomonas aeruginosa biofilm formation, especially under anaerobic conditions; Journal of Medical Microbiology
Isolation and characterisation of Metarhizium anisopliae and Beauveria bassiana from subantarctic Macquarie Island; Journal of Invertebrate Pathology: Devoted to The Pathology and Microbiology of Insects and Other Invertebrates
Microbiology and immune modulation during intravenous antibiotic therapy for pulmonary exacerbations of CF; National Meeting of the Australian Society of Microbiology
Molecular analysis of changes in Pseudomonas aeruginosa load during treatment of a pulmonary exacerbation in cystic fibrosis; Journal of Cystic Fibrosis
Molecular detection of Haemophilus influenzae in COPD sputum is superior to conventional culturing methods; British Journal of Biomedical Science
Monitoring Pseudomonas aeruginosa concentration and virulence gene expression in cystic fibrosis sputum during treatment for exacerbations; Proceedings of the National Meeting of the Australian Society of Microbiology
Prevalence of exoY and exoS genes in clinical and environmental isolates of Pseudomonas aeruginosa; Australian Society for Microbiology National Scientific Meeting
Purification of post-translationally modified proteins from bacteria:: Homologous expression and purification of histidine-tagged pilin from neisseria meningitidis; Protein Expression and Purification
Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea ; Gastroenterology
Role of Pseudomonas in pulmonary exacerbations of CF; Proceedings of the ANZCF Nurses Conference
The immune response of cystic fibrosis patients to different P. aeruginosa strains; Proceedings of the National Meeting of the Australian Society of Microbiology
Two novel chromosomal loci influence cultivar-specific nodulation failure in the interaction between strain ANU794 and subterranean clover cv. Woogenellup; Functional Plant Biology: An International Journal of Plant Function
Virulence gene distribution in clinical, nosocomial and environmental isolates of Pseudomonas aeruginosa; Journal of Medical Microbiology

Research Projects

2012: The Australian Society for Microbiology 2012 Annual Specific Meeting, Brisbane; University of Tasmania (UTAS)
A human paraoxonase 2-based therapy for cystic fibrosis A; Australian Cystic Fibrosis Research Trust (ACFRT)
Clinical research equipment to accelerate research outputs in molecular and genetic studies; Royal Hobart Hospital Research Foundation (RHHRF)
Demonstration of the efficacy of a new therapy against lung infections in a mouse model; University of Tasmania (UTAS)
Do adaptive regulatory cells or activated T cells dominate in cystic fibrosis?; Royal Hobart Hospital Research Foundation (RHHRF)
Identification of a New Target for Therapy in Cystic Fibrosis Lung Infections; Royal Hobart Hospital Research Foundation (RHHRF)
Investigation of Antibiotic Sensitivity & Virulence Factors of the Tasmanian Clonal Strain of Pseudomonas aeuruginosa Isolated from Cystic Fibrosis Patients; Clifford Craig Foundation (CCFoundation)
Mechanism of exacerbations in cystic fibrosis lung disease; National Health & Medical Research Council (NHMRC)
Mechanism of worsening lung disease in cystic fibrosis; Rebecca L Cooper Medical Research Foundation (RLCMRF)
Non-conventional antimicrobial testing of emerging pathogens; Royal Hobart Hospital Research Foundation (RHHRF)
PPAR-gamma as a therapeutic target in cystic fibrosis and chronic obstructive pulmonary disease; Royal Hobart Hospital Research Foundation (RHHRF)
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients; Royal Hobart Hospital Research Foundation (RHHRF)
Pseudomonas Aeruginosa Isolated from Cystic Fibrosis Patients; Royal Hobart Hospital Research Foundation (RHHRF)
Pseudomonas infection as an indirect cause of CF related diabetes; Australian Cystic Fibrosis Research Trust (ACFRT)
Testing a new therapy against lung infections for people with cystic fibrosis; Clifford Craig Foundation (CCFoundation)
The Acquisition of New Strains of Non-Typeable Haemophilus Influenzae Is The Leading Cause of Acute Exacerbations in Tasmanian COPD Patients; Clifford Craig Foundation (CCFoundation)
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota

Research Candidate Supervision

Cross Kingdom Signaling During P.auruginosa Infection of the CF Lung Results in a Decreased Capacity of the Host to Clear the Infection
Fermentation Studies on Biofuel Production
Immune Responses in People with Cystic Fibrosis
Insights into the Nature and Immune Escape of a Transmissible Cancer in Tasmanian Devils
Intrinsic Versus Disease-Mediated Defects in the Immune System of People with Cystic Fibrosis
Paraoxonase and Pseudomonas Infection in Cystic Fibrosis
Regulation of the LIFR and gp130 Genes by the RUNX1 Transcription Factor
Studies on Stress Response Pathways in Cellular Models of Cystic Fibrosis