Web Access Research Portal

Researcher: Leung, JY (Dr Jacqueline Leung)

Fields of Research

Central nervous system
Cellular nervous system
Neurology and neuromuscular diseases
Neurosciences
Peripheral nervous system
Clinical sciences
Gene and molecular therapy
Cell development, proliferation and death
Ophthalmology
Gene expression (incl. microarray and other genome-wide approaches)

Research Objectives

Clinical health
Health related to ageing
Expanding knowledge in the biological sciences
Expanding knowledge in the environmental sciences
Expanding knowledge in the health sciences

Career Best Publications

Research Publications

743.10 / P4 - Oligodendrocyte and myelin alterations in Alzheimer’s disease; Neuroscience 2018
A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization; Angiogenesis
Metallothionein expression by NG2 glial cells following CNS injury; Cellular and Molecular Life Sciences
Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways ; Experimental Neurology: A Journal of Neuroscience Research
Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy; Cellular and Molecular Life Sciences
Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury ; Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration
Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins; Journal of Biological Inorganic Chemistry
Olfactory ensheathing cells are attracted to, and are capable of phagocytosing bacteria; The 28th Annual Meeting of the Australian Neuroscience Society
Olfactory ensheathing cells are attracted to, and can endocytose, bacteria; Cellular and Molecular Life Sciences
Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes ; Molecular and Cellular Neuroscience
Poster 107 - Modelling the effect of Amyloid Beta in oligodendrocyte differentiation and maturation; Australasian Neuroscience Society Annual Scientific Meeting 2016
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury; Journal of Biological Chemistry
TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy; Disease Models & Mechanisms
The impact of metallothionein-II on microglial response to tumor necrosis factor-alpha (TNFα) and downstream effects on neuronal regeneration; Journal of Neuroinflammation
Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro; Journal of Cellular and Molecular Medicine

Research Projects

HDAC6 inhibition to rescue axon degeneration in ALS; FightMND (FMND)
Identifying the role of oligodendrocytes in disease onset and the progression in Amyotrophic Lateral Sclerosis ; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Investigating the role of oligodendrocytes in Amyotrophic Lateral Sclerosis; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Investigating the role of oligodendrocytes in Amyotrophic Lateral Sclerosis (ALS); University of Tasmania (UTAS)
Investigating the role of oligodendrocytes in frontotemporal lobar dementia (FTLD); Dementia Australia Research Foundation Ltd (DARF)
Targeting dysregulated miRNAs and transforming growth factor-B-activated kinase 1 (TAK1) to stop the growth of leaky blood vessels in diabetic eyes; University of Tasmania (UTAS)
Towards Axon Protection in ALS; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)

Research Candidate Supervision