Web Access Research Portal

Researcher: Foote, SJ (Professor Simon Foote)

Fields of Research

Medical genetics (excl. cancer genetics)
Infectious diseases
Central nervous system
Cancer genetics
Epidemiology
Neurology and neuromuscular diseases
Genetics
Haematology
Medical parasitology
Gene expression (incl. microarray and other genome-wide approaches)
Oncology and carcinogenesis
Preventative health care
Health services and systems
Genomics
Ophthalmology
Clinical chemistry (incl. diagnostics)
Immunogenetics (incl. genetic immunology)
Neurosciences
Cardiology (incl. cardiovascular diseases)
Cancer cell biology
Haematological tumours
Rheumatology and arthritis
Bioassays
Cellular nervous system
Epigenetics (incl. genome methylation and epigenomics)
Cellular immunology
Biological mathematics
Cancer diagnosis
Innate immunity
Mental health services
Organic chemical synthesis
Medical microbiology
Neurogenetics
Probability theory
Infectious agents
Immunology
Bioethics
Cell metabolism
Aboriginal and Torres Strait Islander public health and wellbeing
Nephrology and urology
Agricultural molecular engineering of nucleic acids and proteins
Separation science
Modelling and simulation
Molecular targets
Endocrinology
Health informatics and information systems
Primary health care
Genetic immunology
Respiratory diseases
Decision support and group support systems
Applied statistics
Biochemistry and cell biology
Animal physiology - systems
Medical biochemistry and metabolomics
Organometallic chemistry
Solid tumours
Medical biochemistry - proteins and peptides (incl. medical proteomics)

Research Objectives

Clinical health
Preventive medicine
Other health
Diagnosis of human diseases and conditions
Disease distribution and transmission (incl. surveillance and response)
Men's health
Expanding knowledge in the health sciences
Aboriginal and Torres Strait Islander determinants of health
Bioethics
Expanding knowledge in economics
Mental health
Neonatal and child health
Human pharmaceutical treatments
Public health (excl. specific population health)
Human diagnostics
Aboriginal and Torres Strait Islander health system performance
Aboriginal and Torres Strait Islander health status and outcomes
Other plant production and plant primary products
Expanding knowledge in the environmental sciences
Dental health
Expanding knowledge in the biological sciences
Health education and promotion
Information systems, technologies and services
Plastics
Coastal or estuarine biodiversity

Career Best Publications

Anticipation in familial hematologic malignancies; Blood
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20; Nature Genetics
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study; Nature Genetics
Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection; Science

Research Publications

A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis; PLoS One
A Cav3.2 T-Type Calcium Channel Point Mutation Has Splice-Variant-Specific Effects on Function and Segregates with Seizure Expression in a Polygenic Rat Model of Absence Epilepsy ; Journal of Neuroscience
A new standard for the assessment of disease progression in murine cutaneous leishmaniasis; Parasite Immunology
A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice; PLoS One
A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis; PLoS ONE
A potentiation of the adverse effect of human leukocyte antigen-DR15 on the risk of multiple sclerosis by low infant sibling exposure: a population based case-control study; 13th Annnual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis
A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in Multiple Sclerosis ; P L o S One
An Ethyl-Nitrosourea-Induced Point Mutation in Phex causes exon skipping, X-linked Hypophosphatemia, and Rickets; American Journal of Pathology
Analysis of 15 primary open-angle glaucoma families from Australia identifies a founder effect for the Q368STOP mutation of myocilin; Human genetics
Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class 1 region in Tasmanian MS patients; Immunogenetics
Anticipation in familial hematologic malignancies; Blood
Apolipoprotein E4 genotype does not influence multiple sclerosis phenotype, severity, cognition or brain atrophy in a large Australian cohort; 13th Annnual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis
Apolipoprotein genotype does not influence MS severity, cognition, or brain atrophy; Neurology
B-cell-targeted therapy for systemic lupus erythematosus: an update
Can nature's defence against malaria be mimcked by the development of host-directed therapies?
Can nature's defence against malaria be mimicked by the development of host-directed therapies; Pharmacogenomics
Can nature's defence against malaria be mimicked by the development of host-directed therapies?
Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects; Journal of Medical Genetics
Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips; BMC Bioinformatics
Controlling malaria and African trypanosomiasis: the role of the mouse
CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population; Journal of Neuroimmunology
Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats; Epilepsia
Designing new drugs through DNA
Detecting genome wide haplotype sharing using SNP or microsatellite haplotype data; Human Genetics
Dissociation of disease susceptibility, inflammation and cytokine profile in Imr1/2 congenic mice infected with Leishmania major; Genes and Immunity
Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis; Human Molecular Genetics
Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes ; British Journal of Haematology
Evidence for a novel glaucoma locus at chromosome 3p21-22; Human Genetics
Extended haplotype analysis in the HLA complex reveals an increased frequency of the HFE-C282Y mutation in individuals with multiple sclerosis; Human Genetics
Familial focal epilepsy with variable foci mapped to chromosome 22q12: Expansion of the phenotypic spectrum; Epilepsia
Familial Haematological Malignancies; GeneMappers
Familial Haematological malignancies: The Tasmanian experience; Haematology Society of Australia and New Zealand, Australia and New Zealand Society for Blood Transfusion & Australasian Society for Thrombosis and Homeostasis
Fine Mapping of Leishmania major Susceptibility Locus lmr2 and Evidence of a Role for Fli1 in Disease and Wound Healing; Infection and Immunity
Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus; Journal of Neuroimmunology
Fine-mapping the genetic association of the major histocompatibility complex in Multiple Sclerosis: HLA and non-HLA effects; PLoS Genetics
Fragmentation Reactions of All 64 Deprotonated Trinucleotide and 16 Mixed Base Tetranucleotide Anions via Tandem Mass Spectrometry in an Ion Trap; Australian Journal of Chemistry
Genes and susceptibility to leishmaniasis; Advances in Parasitology
Genes implicated in multiple sclerosis pathogenesis fromconsilience of genotyping and expression profiles in relapse and remission; BMC Medical Genetics
Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin; Neurobiology of Disease
Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis; American Journal of Human Genetics
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis; Nature
Genetics of murine leishmaniasis
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20; Nature Genetics
Genome-Wide Meta-Analysis Identifies Novel Multiple Sclerosis Susceptibility Loci; Annals of Neurology
Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition ; Multiple Sclerosis
HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis; Tissue Antigens
Host resistance to malaria: using mouse models to explore the host response; Mammalian Genome
Host-parasite interactions in Leishmaniasis
Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction; Annals of Neurology
Identification and Analysis of Error Types in High-Throughput Genotyping; American Journal of Human Genetics
Identification of a genetic locus modulating splenomegaly induced by granulocyte colony-stimulating factor in mice; Leukemia
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease; European Journal of Human Genetics
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study; Nature Genetics
Identification of Susceptibility Genes for Haematological Maligancies; GeneMappers
Identification of the Mhc Region as an Asthma Susceptibility Locus in Recombinant Congenic Mice; American Journal of Respiratory Cell and Molecular Biology
Identifying nineteenth century genealogical links from genotypes; Human Genetics
Identity-by-descent approach to gene localisation in eight individuals affected by keratoconus from north-west Tasmania, Australia; Human Genetics
Improvements in allelic discrimination of microsatellite markers using denaturing polyacrylamide gel electrophoresis; Mammalian Genome
Leishmaniasis host response loci (Imr1-3) modify disease severity through a Th1/Th2-independent pathway; Genes and Immunity
Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level; Cellular and Molecular Life Sciences
Linkage analysis of a large Tasmanian haematological cancer family; GeneMappers
Linkage to 10q22 for maximum intraocular pressure and 1p32 for maximum cup-to-disc ratio in an extended primary open-angle glaucoma pedigree; Investigative Ophthalmology & Visual Science
Mapping of the Plasmodium chabaudi Resistance Locus Char2; Infection and Immunity
Mass spectrometry for the determination of renal disease biomarkers in urine; 24th meeting of the Australian and New Zealand Society for Mass Spectrometry
Mediating immunity to mycobacteria
Mice that are congenic for the char2 locus are susceptible to malaria; Infection and Immunity
MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood; P L o S One
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data; Genome Medicine
Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in Eu-v-abl transgenic mice; National Academy of Sciences of The United States of America. Proceedings
Multiple Sclerosis Susceptibility-Associated SNPs Do Not Influence Disease Severity Measures in a Cohort of Australian MS Patients; P L o S One
Multiple Sclerosis: a haplotype association study; Novartis Foundations Symposium
Mutation detection using mass spectrometric separation of tiny oligonucleotide fragments; Genome Research
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis; Human Molecular Genetics
No maternally inherited diabetes and deafness mutations in a sample of 193 Tasmanian diabetics with glaucoma; Ophthalmic Genetics
Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant; Blood
Now all I need is a wife; Australasian Research Management Conference
On the utility of data from the International HapMap Project for Australian association studies; Human Genetics
Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum; Science
Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection; Science
Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene Are Associated with Multiple Sclerosis Susceptibility; PL o S One
Progenitor cell mobilization by granulocyte colony-stimulating factor controlled by loci on chromosomes 2 and 11; Blood
PU.1 is a suppressor of myeloid leukemia, inactivated in mice by gene deletion and mutation of its DNA binding domain; Blood
Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians; Genes and Immunity
Saliva-Derived DNA Performs Well in Large-Scale, High-Density Single-Nucleotide Polymorphism Microarray Studies; Cancer Epidemiology, Biomarkers and Prevention
Science, medicine, and future - Leishmaniasis; British Medical Journal
Searching for rare variants conferring susceptibility to multiple sclerosis; Progress in MS Research Conference
Second Stage of a Genome Scan of Schizophrenia: Study of Five Positive Regions in an Expanded Sample; American Journal of Medical Genetics
SNP mapping and candidate gene sequencing in the class 1 region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians; Tissue Antigens
Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg ; Neurobiology of Disease
The advantages of dense marker sets for linkage analysis with very large families; Human Genetics
The application of a population based ascertainment correction for the variance components analysis of quantitative traits in a single extended pedigree; 5th Australasian Human Gene Mapping Conference Incorporating the 9th Australian Twin Registry Conference
The current state of multiple sclerosis genetic research
The HLA-DR2 genotype does not affect MS severity, cognition or brain atrophy; 25th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis
The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis ; Human Molecular Genetics
The Nobel Prize and mainstream medicine
The role of host genetics in leishmaniasis; Trends in Parasitology
The Tasmanian familial leukaemia and lymphoma research study; GeneMappers
The Tasmanian familial leukaemia and lymphoma research study; Haematology Society of Australia and New Zealand, Australia and New Zealand Society for Blood Transfusion & Australasian Society for Thrombosis and Homeostasis
The wound repair response controls outcome to cutaneous leishmaniasis; Proceedings of the National Academy of Sciences of the United States of America
Variants of ST8SIA1 Are Associated with Risk of Developing Multiple Sclerosis; PLoS One
Whole genome sequencing of CLL case; GeneMappers
Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection; Parasite Immunology

Research Projects

An ENU mutagenesis program to identify candidate targets for host-directed therapy against malaria; National Health & Medical Research Council (NHMRC)
Analysing the Protective Role of Platelets During Malarial Infection; Australian Research Council (ARC)
Atlantic Philanthropies Research Funds: New Building; The Atlantic Philanthropies (USA) Inc. (API)
Attendance at inaugural Australia-US Science and Technology Joint Commission meeting (JCM) 14 - 15 February 2011 Washington DC; Department of Industry, Science, Energy and Resources (DISER)
Australian Phenomics Network - Super Science Project; Department of Industry, Science, Energy and Resources (DISER)
Clare Smith Post Graduate Support Grant - Investigating host haem targets as a novel antimalarial therapy; GlaxoSmithKline Australia (GSKA)
Development of novel, host-directed antimalarial compounds; University of Tasmania (UTAS)
Epidemiological Research; Department of Health and Human Services Tasmania (DHHS)
Eradication of malaria through the development of host-directed therapy; Bill & Melinda Gates Foundation (BMGF)
Establishment of a Confocal/multiphoton Microscope for Imaging of Living Systems; Australian Research Council (ARC)
Familial Haematological Malignancies: understanding the role of inherited causative factors; Cancer Council of Tasmania (CCT)
Genetic analysis of complex disease processes; National Health & Medical Research Council (NHMRC)
Genetic and Bioinformatic Analysis of Complex Human Diseases; National Health & Medical Research Council (NHMRC)
Genetic and Bioinformatic Analysis of Complex Human Diseases; National Health & Medical Research Council (NHMRC)
Identification of Genes that Influence MS Progression by Pathways that Involve UV Exposure: a Prospective Cohort Study; Ian Potter Foundation (IPF)
Identification of susceptibility genes for familial haematological malignancies; Leukaemia Foundation (LF)
Identification of susceptibility genes for haematological malignancies; David Collins Leukaemia Foundation (DCLF)
Identifying Genes that Influence Clinical Course and Susceptibility in Multiple Sclerosis; Australian Research Council (ARC)
Identifying target genes for novel anti-epileptic therapies in the mouse; National Health & Medical Research Council (NHMRC)
Implementing the Australian Phenomics Network for the National Collaborative Research Infrastructure Strategy's Research Capability known as 'Integrated Biological Systems'; Department of Industry, Science, Energy and Resources (DISER)
Infectious Diseases and Parasitology - International Research Scholars Program; Howard Hughes Medical Institute (HHMI)
Integrative genomic approaches to understanding the genetics of prostate cancer; Cancer Australia (CANCA)
Investigating the genetics of familial haematological cancers in Tasmania; David Collins Leukaemia Foundation (DCLF)
Investigating the genetics of familial haematological cancers in Tasmania; David Collins Leukaemia Foundation (DCLF)
NHMRC Standard Equipment Grant - 2009; National Health & Medical Research Council (NHMRC)
NHMRC Standard Equipment Grant - 2010; National Health & Medical Research Council (NHMRC)
Purchase of a High Resolution Organic Mass Spectrometer; Australian Research Council (ARC)
Sanyo Upright Freezer; National Health & Medical Research Council (NHMRC)
Tasmanian community network of mentors and smart information technology solutions (SITS) for families affects by cystic fibrosis; Tasmanian Community Fund (TasCF)
Tasmanian familial haematological malignancy research study; Pfizer (PFIZER)
The ACRF Tasmanian Inherited Cancer Centre (ATICC); Australian Cancer Research Foundation (ACRF)
The Tasmanian Leukaemia and Other Haematopoietic Malignancies Research Study; Perpetual Trustees (PT)
MENZIES - salary support (David Johns)
MENZIES - salary support (Jenny Cochrane)
Simon Foote - Discretionary Account
Discovery of Genes
Fellowship
Finding Genes for Host Response to Leishmania major
Finding genes for Multiple Sclerosis
Genetic Analysis of Complex Disease Processes
Genome Research
Identifying Host Response Genes for Malaria
Identifying modifiers for plasmacytoma susceptibility
Major National Research Programme
Mapping disease modifiers for HPV tumorgenesis
Mutation detection
Studies of the host response to malaria
Studies of the host response to malaria

Research Candidate Supervision

An Investigation of Novel Host-directed Antimalarial Therapeutics through Genetic and Pharmacological Targeting of Haem Biosynthetic Enzymes
Consumer Centred Approaches to Health Care Needs and Choices For The Older Person
Developing Host Directed Therapies for Treating Malarial Infection
Discovering a New Generation of Antimalarial Drugs Using Chemical Mutagenisis in Mice
Identification of Susceptibility Genes for Familial Haematological Malignancies
Immune Responses in People with Cystic Fibrosis
Investigating the Genetic Predisposition for Familial Haematological Malignancies
Malaria-ENU Mutations for a Host Target Therapy Against Malaria
Structure and Functional Development of the Marsupial Respiratory System
Study of the Role of Fucoidan on Leukemia Cells and on Hematopoietic Stem Cell Release
The Role of the CC-Chemokine Receptor 6 in B Cell Autoimmunity