Web Access Research Portal

Researcher: Lyons, AB (Dr Bruce Lyons)

Fields of Research

Cellular Immunology
Immunology
Veterinary Immunology
Animal Immunology
Haematology
Medical Bacteriology
Molecular Targets
Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
Clinical Sciences
Zoology
Humoural Immunology and Immunochemistry
Conservation and Biodiversity
Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
Tumour Immunology
Allergy
Innate Immunity
Cell Development, Proliferation and Death
Host-Parasite Interactions
Medical Parasitology
Ecosystem Function
Veterinary Microbiology (excl. Virology)
Immunogenetics (incl. Genetic Immunology)
Respiratory Diseases
Autoimmunity
Veterinary Diagnosis and Diagnostics
Gene Expression (incl. Microarray and other genome-wide approaches)
Veterinary Surgery
Transplantation Immunology
Animal Structure and Function

Research Objectives

Immune System and Allergy
Health
Flora, Fauna and Biodiversity at Regional or Larger Scales
Expanding Knowledge in the Environmental Sciences
Cancer and Related Disorders
Expanding Knowledge in the Agricultural and Veterinary Sciences
Infectious Diseases
Expanding Knowledge in the Biological Sciences
Blood Disorders
Digestive System Disorders
Nervous System and Disorders
Control of Pests, Diseases and Exotic Species at Regional or Larger Scales
Respiratory System and Diseases (incl. Asthma)
Expanding Knowledge in the Medical and Health Sciences

Career Best Publications

Research Publications

A fluorescent aggregation assay which allows the identification of the carbohydrate specificity of adhesion molescules involved in cell-cell interactions; Australasian Flow Cytometry Group 18th Annual M eeting
A monoclonal antibody to a human mast cell/myeloid leukaemia-specific antigen binds to normal haemopoietic progenitor cells and inhibits colony formation in vitro; Leukemia Research
A second transmissible cancer in Tasmanian devils; Proceedings of the National Academy of Sciences
A sound investment in our future health
Acquisition of immune function during the development of the Langerhans cell network in neonatal mice; Immunology
Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry; Experimental Cell Research
An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae; International Journal of Antimicrobial Agents
Analysing Cell Division in vivo Using Flow Cytometric Measurement of CFSE Dye Dilution; Journal of Immunological Methods
Application of metabolomics and proteomics for biomarker discovery and development of therapies for the transmissible cancer, Tasmanian Devil Facial Tumour Disease; The 22nd Annual Lorne Proteomics Symposium 2017
Are murine marginal zone macrophages the splenic white pulp analog of high endothelial venules?; European Journal of Immunology
Assessment of snapper (Pagrus auratus) natural IgM binding to bromelain treated sheep erythrocytes; Fish and Shellfish Immunology
B cell differentiation and isotype switching is related to division cycle number; Journal of Experimental Medicine
B cell proliferation, division and differentiation in T cell dependent B cell immune reaction; Federation of the Immunological Societies of Asia-Oceania
B lymphocyte migration to the spleen increases after Phagocytosis: A role for the chemokine BLC; 38th National Scientific Conference of the Australian Society for Medical Research
CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?
Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4; European Journal of Immunology
CFSE - A valuable tool for investigating T cell proliferation; Australasian Flow Cytometry Group 18th Annual Meeting
Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease; Frontiers in Immunology
Control of lymphocyte entry into the spleen by marginal zone macrophages; 37th Annual Meeting of the Australian Society for Medical Research
Dasatinib inhibits recombinant viral antigen-specific murine CD4(+) and CD8(+) T-cell responses and NK-cell cytolytic activity in vitro and in vivo; Experimental Hematology
Dasatinib suppresses in vitro natural killer cell cytotoxicity; Blood
Deletion of autoreactive B cells - stimulation by self-antigen in the absence of T-cell help; 9th International Congress of Immunology
Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils; Biology Letters
Determination of lymphocyte division by flow cytometry; Journal of Immunological Methods
Discrete subpopulations, defined by CD45 isoforms, coexist within the leukaemic cells of B-chronic lymphocytic leukaemia patients; Leukemia Research
Divided we stand: Tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester; Immunology and Cell Biology
Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A; Experimental Hematology
Essential Immunology - Book Review; Immunology and Cell Biology
Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations; Vaccine
Flow cytometric analysis of cell division by dilution of CFSE and related dyes; Current Protocols in Cytometry
Flow cytometric analysis of cell division by dye dilution; Current Protocols in Cytometry
Fundamental Immunology - Book Review; Immunology and Cell Biology
Human Flt-3-ligand-mobilized dendritic cells require additional activation to drive effective immune responses; Experimental Hematology
Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity; Journal of Cellular Physiology
Human myeloid differentiation antigens identified by monoclonal antibodies to the myelomonocytic leukemia cell line RC-2A; Pathology
Imatinib inhibits the functional capacity of cultured human monocytes; Immunology and Cell Biology
Immunology of a transmissible cancer spreading among Tasmanian devils; Journal of Immunology
In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML; Blood
Inhibition of c-fms by imatinib: expanding the spectrum of treatment; Cell Cycle
Isotype switching in murine B1 cells and its relationship to cell division; 37th Annual Meeting of the Australian Society for Medical Research
Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib; Blood
Marginal zone macrophage regulation of splenic leukocyte migration; 28th Annual meeting of the Australasian Society for Immunology
Medical Research Week
Mitogen activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells; Immunology and Cell Biology
Modification of the Immune Response; 37th National Scientific Conference of the Australian Society for Immunology
Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material; Immunological Investigations: A Journal of Molecular and Cellular Immunology
Natural Killer Cell Mediated Cytotoxic Responses in the Tasmanian Devil; PL o S One
New-age adjuvants: friend or foe?; Biopharm International-The Applied Technologies of Biopharmaceutical Development
Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro; Journal of Cellular and Molecular Medicine
PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment; Frontiers in Immunology
Pertussis toxin pretreatment alters the in vivo cell division behaviour and survival of B lymphocytes after intravenous transfer; Immunology and Cell Biology
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils; Scientific Reports
Resistance to c-KIT kinase inhibitors conferred by V654A mutation; Molecular Cancer Therapeutics
Simultaneous analysis of immunophenotype and apoptosis of murine thymocytes by single laser flow cytometry; Cytometry. Part A
Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils; The Journal of Allergy and Clinical Immunology
Splenic marginal zone macrophages: A multifunctional cell type of dendritic morphology which may interact with dendritic cells; 5th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology
Studies on the differentiation of the human myelomonocytic cell line RC-2A in response to lymphocyte-derived factors; Leukemia Research
The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection; Immunobiology
The effect of recombinant cytokines on the proliferative potential and phenotype of cells of the human myelomonocytic leukaemia line, RC-2A; Leukemia Research
The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help; Journal of Experimental Medicine
The immunomodulatory small molecule imiquimod induces apoptosis in devil facial tumour cell lines; PL o S One
The immunosuppressive compound 2-acetyl-4-tetrahydroxybutyl imidazole inhibits the allogeneic mixed lymphocyte reaction by sequestration of a recirculating subpopulation of T cells; Immunology
The importance of efficacy and partial agonism in evaluating models of B lymphocyte activation; International Review of Immunology
The Src/Abl kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro; Clinical Immunology
The toll-like receptor ligands Hiltonol® (polyICLC) and imiquimod effectively activate antigen-specific immune responses in Tasmanian devils (Sarcophilus harrisii); Developmental and Comparative Immunology
The use of CFSE-like dyes for measuring lymphocyte proliferation: experimental considerations and biological variables; Mathematical Modelling of Natural Phenomena
Toll-like receptor signaling is functional in immune cells of the endangered Tasmanian devil; Developmental and Comparative Immunology

Research Projects

1999 Supplementary Funding; University of Tasmania (UTAS)
A live-attenuated vaccine (DFT-Off) to promote long-term anti-DFTD immunity; University of Tasmania Foundation Inc (UTF)
Australasian Society for Immunology 41st Annual Meeting, Adelaide - 11 to 15 December 2011 (Sept 2011); University of Tasmania (UTAS)
B1 cell migration, isotype switching and antigen presentation; Clifford Craig Medical Research Trust/UTAS (CCMRT/UTAS)
Can DFTD cells be made visible to the Tasmanian devil immune system?; University of Tasmania Foundation Inc (UTF)
Detection of activated Tasmanian devil cytotoxic lymphocytes by a rapid RNA detection assay; University of Tasmania Foundation Inc (UTF)
Developing DFTD vaccination approaches to favour cell mediated anti-tumour immunity; University of Tasmania Foundation Inc (UTF)
Development of an immune enhancing vaccine to protect Tasmanian devils against a contagious cancer; Australian Research Council (ARC)
Elite workstation for Flow Cytometry (single user); National Health & Medical Research Council (NHMRC)
Evaluation of the role natural killer (NK) cells in protection against DFTD; University of Tasmania Foundation Inc (UTF)
Host-tumour Interplay in Tasmanian Devils with Devil Facial Tumour Disease: Can Immune Cells be Harnessed for Therapy?; Australian Research Council (ARC)
Improving the DFTD vaccine by targeting key immune signalling molecules; University of Tasmania Foundation Inc (UTF)
Lymphocyte recirculation and lifespan.; University of Tasmania (UTAS)
Mechanistic studies of Jack Jumper Venom desensitisation at the T cell level; Royal Hobart Hospital Research Foundation (RHHRF)
MHC-I expression on DFTD tumour cells and monoclonal antibodies as a strategy to induce and analyse an immune response to DFTD; University of Tasmania Foundation Inc (UTF)
Recirculation and antigen presentation by B-1 B lymphocytes; Clive & Vera Ramaciotti Foundation (CVRF)
Recirculation, Isotope Switching and Antigen Presentation by B-1 B lympphocytes; Clifford Craig Medical Research Trust/UTAS (CCMRT/UTAS)
Regulation of lymphocyte entry into the spleen by marginal zone macrophages; National Health & Medical Research Council (NHMRC)
Superspeed Centrifuge.; National Health & Medical Research Council (NHMRC)
Supplementary funding; University of Tasmania (UTAS)
Tasmanian Devil Vaccine
Translating human cancer immunotherapy techniques for use in pets and Tasmanian devils

Research Candidate Supervision

A multifaceted approach towards the development of a protective vaccine for DFTD
C-Rel driven chromatin change in immunological models of inflammation.
In Vitro Identification of Vaccination Strategies for the Stimulation of an Immune Response against Devil Facial Tumour Disease
Investigate the role of tumour necrosis factor (TNF) in the defense against bacterial infection and cancer cells
Manipulating the Immune Response of Tasmanian Devils to Target Devil Facial Tumour Disease
Microbial Interference with the Pathagenicity of Nontypeable Haemophilus Influenzae
Role of TNF in the regulation of the adaptive T cell response in Leishmaniasis