Web Access Research Portal

Researcher: Lyons, AB (Associate Professor Bruce Lyons)

Fields of Research

Cellular immunology
Animal immunology
Veterinary immunology
Tumour immunology
Animal cell and molecular biology
Conservation and biodiversity
Host-parasite interactions
Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
Cell development, proliferation and death
Veterinary diagnosis and diagnostics
Respiratory diseases
Medical bacteriology
Humoural immunology and immunochemistry
Forestry management and environment
Molecular targets
Clinical sciences
Innate immunity
Proteomics and intermolecular interactions (excl. medical proteomics)
Veterinary epidemiology
Ecosystem function
Medical parasitology
Biological oceanography
Infectious agents
Transplantation immunology
Bioavailability and ecotoxicology
Behavioural ecology
Ecological physiology
Immunogenetics (incl. genetic immunology)
Veterinary bacteriology
Population ecology
Gene expression (incl. microarray and other genome-wide approaches)
Animal physiological ecology
Veterinary surgery
Medical virology
Animal structure and function
Wildlife and habitat management
Pollution and contamination

Research Objectives

Clinical health
Terrestrial biodiversity
Other health
Expanding knowledge in the biological sciences
Expanding knowledge in the environmental sciences
Control of pests, diseases and exotic species in terrestrial environments
Expanding knowledge in the agricultural, food and veterinary sciences
Diagnosis of human diseases and conditions
Other environmental management
Expanding knowledge in the health sciences
Fisheries - aquaculture
Efficacy of medications
Veterinary biological preventatives
Prevention of human diseases and conditions
Expanding knowledge in the biomedical and clinical sciences
Assessment and management of terrestrial ecosystems
Control of pests, diseases and exotic species in coastal and estuarine environments
Coastal or estuarine biodiversity
Rehabilitation or conservation of terrestrial environments
Environmentally sustainable commercial services and tourism
Disease distribution and transmission (incl. surveillance and response)

Career Best Publications

Research Publications

A devil of a transmissible cancer; Tropical Medicine and Infectious Disease
A fluorescent aggregation assay which allows the identification of the carbohydrate specificity of adhesion molescules involved in cell-cell interactions; Australasian Flow Cytometry Group 18th Annual M eeting
A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I; Journal of General Virology
A monoclonal antibody to a human mast cell/myeloid leukaemia-specific antigen binds to normal haemopoietic progenitor cells and inhibits colony formation in vitro; Leukemia Research
A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers; Science Advances
A second transmissible cancer in Tasmanian devils; Proceedings of the National Academy of Sciences
A sound investment in our future health
Absence of tumor necrosis factor supports alternative activation of macrophages in the liver after infection with Leishmania major; Frontiers in Immunology
Abstract B040: Imiquimod initiates tumor specific overload of the ER stress response in Tasmanian devil facial cancer cells; Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: translating science into survival
Acquisition of immune function during the development of the Langerhans cell network in neonatal mice; Immunology
Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry; Experimental Cell Research
An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae; International Journal of Antimicrobial Agents
An oral bait vaccination approach for the Tasmanian devil facial tumor diseases; Expert Review of Vaccines
Analysing Cell Division in vivo Using Flow Cytometric Measurement of CFSE Dye Dilution; Journal of Immunological Methods
Analysis of toll-like receptor responses in the endangered Tasmanian devil; International Congress of Immunology
Application of metabolomics and proteomics for biomarker discovery and development of therapies for the transmissible cancer, Tasmanian Devil Facial Tumour Disease; 22nd Annual Lorne Proteomics Symposium 2017
Are murine marginal zone macrophages the splenic white pulp analog of high endothelial venules?; European Journal of Immunology
Assessment of snapper (Pagrus auratus) natural IgM binding to bromelain treated sheep erythrocytes; Fish and Shellfish Immunology
B cell differentiation and isotype switching is related to division cycle number; Journal of Experimental Medicine
B cell proliferation, division and differentiation in T cell dependent B cell immune reaction; Federation of the Immunological Societies of Asia-Oceania
B lymphocyte migration to the spleen increases after Phagocytosis: A role for the chemokine BLC; 38th National Scientific Conference of the Australian Society for Medical Research
Cathelicidin-3 associated with serum extracellular vesicles enables early diagnosis of a transmissible cancer; Frontiers in Immunology
CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?
Cell division number regulates IgG1 and IgE switching of B cells following stimulation by CD40 ligand and IL-4; European Journal of Immunology
CFSE - A valuable tool for investigating T cell proliferation; Australasian Flow Cytometry Group 18th Annual Meeting
Challenges of an emerging disease: The evolving approach to diagnosing devil facial tumour disease; Pathogens
Chapter 17 Flow cytometric analysis of cell division history using dilution of Carboxyfluorescein Diacetate Succinimidyl Ester, a stably integrated fluorescent probe; Methods in Cell Biology
Chromosome social distancing and crowd control: the dual role of Ki67; Immunology and Cell Biology
Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours; Open biology
Comparative analysis of immune checkpoint molecules and their potential role in the transmissible Tasmanian Devil facial tumor disease; Frontiers in Immunology
Control of lymphocyte entry into the spleen by marginal zone macrophages; 37th Annual Meeting of the Australian Society for Medical Research
Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
Cytokines: Signalling improved immunotherapy?; Current Oncology Reports
Dasatinib inhibits recombinant viral antigen-specific murine CD4(+) and CD8(+) T-cell responses and NK-cell cytolytic activity in vitro and in vivo; Experimental Hematology
Dasatinib suppresses in vitro natural killer cell cytotoxicity; Blood
Deletion of autoreactive B cells - stimulation by self-antigen in the absence of T-cell help; 9th International Congress of Immunology
Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils; Biology Letters
Determination of lymphocyte division by flow cytometry; Journal of Immunological Methods
Discrete subpopulations, defined by CD45 isoforms, coexist within the leukaemic cells of B-chronic lymphocytic leukaemia patients; Leukemia Research
Divided we stand: Tracking cell proliferation with carboxyfluorescein diacetate succinimidyl ester; Immunology and Cell Biology
Drug-interaction studies evaluating T-cell proliferation reveal distinct activity of dasatinib and imatinib in combination with cyclosporine A; Experimental Hematology
Emerging roles for G-protein coupled receptors in development and activation of macrophages; Frontiers in Immunology
Essential Immunology - Book Review; Immunology and Cell Biology
Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations; Vaccine
Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker; Cellular and Molecular Life Sciences
Flow cytometric analysis of cell division by dilution of CFSE and related dyes; Current Protocols in Cytometry
Flow cytometric analysis of cell division by dye dilution; Current Protocols in Cytometry
Fundamental Immunology - Book Review; Immunology and Cell Biology
Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease; PLoS ONE
Human Flt-3-ligand-mobilized dendritic cells require additional activation to drive effective immune responses; Experimental Hematology
Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity; Journal of Cellular Physiology
Human myeloid differentiation antigens identified by monoclonal antibodies to the myelomonocytic leukemia cell line RC-2A; Pathology
Imatinib inhibits the in vitro development of the monocyte/macrophage lineage from normal human bone marrow progenitors; Leukemia
Imatinib inhibits the functional capacity of cultured human monocytes; Immunology and Cell Biology
Immune strategies to combat DFTD; Saving the Tasmanian Devil: Recovery through Science-based Management
Immunization strategies producing a humoral IgG immune response against devil facial tumor disease in the majority of Tasmanian devils destined for wild release; Frontiers in Immunology
Immunology of a transmissible cancer spreading among Tasmanian devils; Journal of Immunology
In utero exposure to diesel exhaust particles, but not silica, alters post-natal immune development and function; Chemosphere
In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML; Blood
Inducible IFN-γ expression for MHC-I upregulation in devil facial tumor cells; Frontiers in Immunology
Inhibition of c-fms by imatinib: expanding the spectrum of treatment; Cell Cycle
Isotype switching in murine B1 cells and its relationship to cell division; 37th Annual Meeting of the Australian Society for Medical Research
Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib; Blood
Marginal zone macrophage regulation of splenic leukocyte migration; 28th Annual meeting of the Australasian Society for Immunology
Maternal exposure to particulate matter alters early post-natal lung function and immune cell development; Environmental Research
Medical Research Week
Mesenchymal plasticity of devil facial tumour cells during in vivo vaccine and immunotherapy trials; Immunology and Cell Biology
Mitogen activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells; Immunology and Cell Biology
Modification of the Immune Response; 37th National Scientific Conference of the Australian Society for Immunology
Modulation of lymphocyte migration to the murine spleen after macrophage phagocytosis of blood-borne particulate material; Immunological Investigations: A Journal of Molecular and Cellular Immunology
Natural Killer Cell Mediated Cytotoxic Responses in the Tasmanian Devil; PL o S One
New-age adjuvants: friend or foe?; Biopharm International-The Applied Technologies of Biopharmaceutical Development
Nilotinib inhibits the Src-family kinase LCK and T-cell function in vitro; Journal of Cellular and Molecular Medicine
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in 3 transmissible cancers; Journal of Cancer Research and Clinical Oncology
PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment; Frontiers in Immunology
Pertussis toxin pretreatment alters the in vivo cell division behaviour and survival of B lymphocytes after intravenous transfer; Immunology and Cell Biology
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development, B-cell antigen receptor (BCR)-mediated activation, and autoimmune disease; Blood
Post-release immune responses of Tasmanian devils vaccinated with an experimental devil facial tumour disease vaccine; Wildlife Research
Pregnancy protects against the pro-inflammatory respiratory responses induced by particulate matter exposure; Chemosphere
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils; Scientific Reports
Resistance to c-KIT kinase inhibitors conferred by V654A mutation; Molecular Cancer Therapeutics
Simultaneous analysis of immunophenotype and apoptosis of murine thymocytes by single laser flow cytometry; Cytometry. Part A
Snapper (Pagrus auratus) leucocyte proliferation is synergistically enhanced by simultaneous stimulation with LPS and PHA; Fish & Shellfish Immunology
Specific binding of human interleukin-3 and granulocyte-macrophage colony-stimulating factor to human basophils; The Journal of Allergy and Clinical Immunology
Splenic marginal zone macrophages: A multifunctional cell type of dendritic morphology which may interact with dendritic cells; 5th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology
Studies on the differentiation of the human myelomonocytic cell line RC-2A in response to lymphocyte-derived factors; Leukemia Research
Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells; Developmental and Comparative Immunology
The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection; Immunobiology
The effect of recombinant cytokines on the proliferative potential and phenotype of cells of the human myelomonocytic leukaemia line, RC-2A; Leukemia Research
The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help; Journal of Experimental Medicine
The immunomodulatory small molecule imiquimod induces apoptosis in devil facial tumour cell lines; PL o S One
The immunosuppressive compound 2-acetyl-4-tetrahydroxybutyl imidazole inhibits the allogeneic mixed lymphocyte reaction by sequestration of a recirculating subpopulation of T cells; Immunology
The importance of efficacy and partial agonism in evaluating models of B lymphocyte activation; International Review of Immunology
The Src/Abl kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro; Clinical Immunology
The toll-like receptor ligands Hiltonol® (polyICLC) and imiquimod effectively activate antigen-specific immune responses in Tasmanian devils (Sarcophilus harrisii); Developmental and Comparative Immunology
The use of CFSE-like dyes for measuring lymphocyte proliferation: experimental considerations and biological variables; Mathematical Modelling of Natural Phenomena
TNF may negatively regulate phagocytosis of Devil Facial Tumour Disease cells by activated macrophages; Immunological Investigations
Toll-like receptor signaling is functional in immune cells of the endangered Tasmanian devil; Developmental and Comparative Immunology
Tracing the rise of malignant cell lines: distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils; Evolutionary Applications
Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells; OncoTarget
Two decades of the impact of Tasmanian Devil Facial Tumour Disease (DFTD); Integrative and Comparative Biology
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
We developed tools to study cancer in Tasmanian devils. They could help fight disease in humans

Research Projects

1999 Supplementary Funding; University of Tasmania (UTAS)
A live-attenuated vaccine (DFT-Off) to promote long-term anti-DFTD immunity; University of Tasmania Foundation Inc (UTF)
Australasian Society for Immunology 41st Annual Meeting, Adelaide - 11 to 15 December 2011 (Sept 2011); University of Tasmania (UTAS)
B1 cell migration, isotype switching and antigen presentation; Clifford Craig Medical Research Trust/UTAS (CCMRT/UTAS)
Bait Expectations; CSIRO-Commonwealth Scientific & Industrial Research Organisation (CSIRO)
Can DFTD cells be made visible to the Tasmanian devil immune system?; University of Tasmania Foundation Inc (UTF)
Can the DFTD tumour microenvironment influence vaccine responses in the Tasmanian devil?; University of Tasmania Foundation Inc (UTF)
Detection of activated Tasmanian devil cytotoxic lymphocytes by a rapid RNA detection assay; University of Tasmania Foundation Inc (UTF)
Developing DFTD vaccination approaches to favour cell mediated anti-tumour immunity; University of Tasmania Foundation Inc (UTF)
Development of a devil facial tumour bait-vaccine for landscape-level distribution; University of Tasmania (UTAS)
Development of an early diagnostic liquid biopsy for DFT2; University of Tasmania Foundation Inc (UTF)
Development of an early diagnostic test for Devil facial tumour disease; University of Tasmania Foundation Inc (UTF)
Development of an immune enhancing vaccine to protect Tasmanian devils against a contagious cancer; Australian Research Council (ARC)
Elite workstation for Flow Cytometry (single user); National Health & Medical Research Council (NHMRC)
Evaluation of the role natural killer (NK) cells in protection against DFTD; University of Tasmania Foundation Inc (UTF)
Good cells battling bad cells: Cell-mediated immunity and transmissible cancer in the Tasmanian devil; Holsworth Wildlife Research Endowment (HWRE)
Host-tumour Interplay in Tasmanian Devils with Devil Facial Tumour Disease: Can Immune Cells be Harnessed for Therapy?; Australian Research Council (ARC)
Identification of devil facial tumour-associated antigens for vaccine development; University of Tasmania Foundation Inc (UTF)
Identification of host-tumour interactions driving immune evasion and survival of devil facial tumor disease; University of Tasmania (UTAS)
Immunisation to protect against transmissible cancers in Tasmanian devils; Australian Research Council (ARC)
Improving the DFTD vaccine by targeting key immune signalling molecules; University of Tasmania Foundation Inc (UTF)
Investigation into an overlooked pathway towards anti-cancer immunity. Inhibitory motifs in the extracellular domains of immune checkpoint molecules; University of Tasmania Foundation Inc (UTF)
Lymphocyte recirculation and lifespan.; University of Tasmania (UTAS)
Mechanistic studies of Jack Jumper Venom desensitisation at the T cell level; Royal Hobart Hospital Research Foundation (RHHRF)
MHC-I expression on DFTD tumour cells and monoclonal antibodies as a strategy to induce and analyse an immune response to DFTD; University of Tasmania Foundation Inc (UTF)
Monitoring DFTD-immunised devils after their release to the wild; University of Tasmania Foundation Inc (UTF)
Recirculation and antigen presentation by B-1 B lymphocytes; Clive & Vera Ramaciotti Foundation (CVRF)
Recirculation, Isotope Switching and Antigen Presentation by B-1 B lympphocytes; Clifford Craig Medical Research Trust/UTAS (CCMRT/UTAS)
Regulation of lymphocyte entry into the spleen by marginal zone macrophages; National Health & Medical Research Council (NHMRC)
Studying cancer in wild Tasmanian devils to develop vaccination and early diagnosis methods; National Geographic Society (NGS)
Superspeed Centrifuge.; National Health & Medical Research Council (NHMRC)
Supplementary funding; University of Tasmania (UTAS)
The effects of plantation forestry operations on Tasmanian devil behaviour and health; Holsworth Wildlife Research Endowment (HWRE)
Immunological approach to protect Tasmanian devils against devil facial tumour disease
Tasmanian Devil Vaccine research
The effects of plantation forestry operations on Tasmanian devil behaviour and health
The effects of plantation forestry operations on Tasmanian devil behaviour and health
Translating human cancer immunotherapy techniques for use in pets and Tasmanian devils

Research Candidate Supervision

A multifaceted approach towards the development of a protective vaccine for DFTD
C-Rel driven chromatin change in immunological models of inflammation.
In Vitro Identification of Vaccination Strategies for the Stimulation of an Immune Response against Devil Facial Tumour Disease
Investigate the role of tumour necrosis factor (TNF) in the defense against bacterial infection and cancer cells
Manipulating the Immune Response of Tasmanian Devils to Target Devil Facial Tumour Disease
Microbial Interference with the Pathagenicity of Nontypeable Haemophilus Influenzae
Role of TNF in the regulation of the adaptive T cell response in Leishmaniasis