Web Access Research Portal

Researcher: Tovar Lopez, CD (Dr Cesar Tovar Lopez)

Fields of Research

Animal immunology
Veterinary immunology
Cellular immunology
Animal cell and molecular biology
Humoural immunology and immunochemistry
Veterinary epidemiology
Urban geography
Tourism management
Immunogenetics (incl. genetic immunology)
Aquaculture
Medical parasitology
Tumour immunology
Veterinary diagnosis and diagnostics
Proteomics and intermolecular interactions (excl. medical proteomics)
Microbial ecology
Veterinary pathology
Cancer cell biology
Veterinary sciences

Research Objectives

Terrestrial biodiversity
Clinical health
Socio-cultural issues in tourism
Control of pests, diseases and exotic species in terrestrial environments
Veterinary biological preventatives
Other health
Aquaculture fin fish (excl. tuna)
Expanding knowledge in the health sciences

Career Best Publications

The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer ; Science

Research Publications

A murine xenograft model for a transmissible cancer in Tasmanian devils; Veterinary Pathology
A second transmissible cancer in Tasmanian devils; Proceedings of the National Academy of Sciences
Abstract B040: Imiquimod initiates tumor specific overload of the ER stress response in Tasmanian devil facial cancer cells; Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: translating science into survival
Analysis of toll-like receptor responses in the endangered Tasmanian devil; International Congress of Immunology
Curse of the Devil: Devil Facial Tumour Disease; Australasian Cytometry Society 38th Annual Scientific Meeting
Evidence for induction of humoral and cytotoxic immune responses against devil facial tumor disease cells in Tasmanian devils (Sarcophilus harrisii) immunized with killed cell preparations; Vaccine
Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease; PLoS ONE
Identification of dendritic cells, B cell and T cell subsets in Tasmanian devil lymphoid tissue; evidence for poor immune cell infiltration into devil facial tumors; Anatomical Record
Immunisation of Tasmanian devils (Sarcophilus harrisii) against Devil Facial Tumour Disease Tumour Cells; The 5th International Veterinary Vaccines and Diagnostics Conference
Immunology of a transmissible cancer spreading among Tasmanian devils; Journal of Immunology
Mesenchymal plasticity of devil facial tumour cells during in vivo vaccine and immunotherapy trials; Immunology and Cell Biology
Mitogen activated Tasmanian devil blood mononuclear cells kill devil facial tumour disease cells; Immunology and Cell Biology
Novel application of a fish gill cell line assay to assess ichthyotoxicity of harmful marine microalgae; Harmful Algae
Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils; Scientific Reports
Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer; Proceedings of the National Academy of Sciences of the United States of America
Social impacts of tourism: an Australian regional case study; International Journal of Tourism Research
The effects of tourism in Northwest Tasmania; School of Geography and Environmental Studies Conference 2006
The immune response of Tasmanian devils to devil facial tumour disease cell preparations; The 5th Australasian Vaccines & Immunotherapeutics Development Meeting
The immunomodulatory small molecule imiquimod induces apoptosis in devil facial tumour cell lines; PL o S One
The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer; Elife
The Tasmanian Devil Transcriptome Reveals Schwann Cell Origins of a Clonally Transmissible Cancer ; Science
The toll-like receptor ligands Hiltonol® (polyICLC) and imiquimod effectively activate antigen-specific immune responses in Tasmanian devils (Sarcophilus harrisii); Developmental and Comparative Immunology
Toll-like receptor signaling is functional in immune cells of the endangered Tasmanian devil; Developmental and Comparative Immunology
Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells; OncoTarget
Tumor-specific diagnostic marker for transmissible facial tumors of Tasmanian devils: immunohistochemistry studies; Veterinary Pathology
Two decades of the impact of Tasmanian Devil Facial Tumour Disease (DFTD); Integrative and Comparative Biology
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences

Research Projects

Analysis of Devil Tumour Disease to identify unique tumour antigens for diagnosis and vaccination; University of Tasmania Foundation Inc (UTF)
Can the DFTD tumour microenvironment influence vaccine responses in the Tasmanian devil?; University of Tasmania Foundation Inc (UTF)
Characterisation of DFTD tumour proteins eliciting immune responses in Tasmanian devils; University of Tasmania Foundation Inc (UTF)
Characterisation of immunological targets for the development of a vaccine to protect Tasmanian devils against a contagious cancer; University of Tasmania (UTAS)
Deciphering the cellular origin of the second Devil Facial Tumour Disease (DFT2); University of Tasmania Foundation Inc (UTF)
Establishment of a mouse model to study the biology of Devil Facial Tumour Disease (DFTD); University of Tasmania Foundation Inc (UTF)
MHC-I expression on DFTD tumour cells and monoclonal antibodies as a strategy to induce and analyse an immune response to DFTD; University of Tasmania Foundation Inc (UTF)
Selection of devil facial tumour associated antigens as a tool for the development of a prophylactic vaccine; University of Tasmania Foundation Inc (UTF)
Bioplatforms Australia (BPA) - collaborative research

Research Candidate Supervision

In Vitro Identification of Vaccination Strategies for the Stimulation of an Immune Response against Devil Facial Tumour Disease