Web Access Research Portal

Researcher: McMorran, BJ (Associate Professor Brendan McMorran)

Fields of Research

Infectious diseases
Medical parasitology
Animal physiology - cell
Genomics
Genetics
Gene expression (incl. microarray and other genome-wide approaches)
Cancer genetics
Medical genetics (excl. cancer genetics)
Innate immunity
Oncology and carcinogenesis
Preventative health care
Health services and systems
Central nervous system
Cell metabolism
Biochemistry and cell biology
Haematology
Bioassays
Animal physiology - systems
Microbial genetics
Infectious agents
Medical biochemistry - proteins and peptides (incl. medical proteomics)
Probability theory
Organic chemical synthesis
Neurogenetics
Solid tumours
F-block chemistry
Cellular immunology
Primary health care
Immunogenetics (incl. genetic immunology)
Genetic immunology
Organometallic chemistry
Catalysis and mechanisms of reactions

Research Objectives

Clinical health
Aboriginal and Torres Strait Islander determinants of health
Preventive medicine
Diagnosis of human diseases and conditions
Expanding knowledge in the health sciences
Human diagnostics
Men's health
Human pharmaceutical treatments
Expanding knowledge in economics
Disease distribution and transmission (incl. surveillance and response)
Inorganic industrial chemicals
Organic industrial chemicals (excl. resins, rubber and plastics)
Aboriginal and Torres Strait Islander health system performance
Other health
Expanding knowledge in the chemical sciences

Career Best Publications

Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to pseudomonas aeruginosa infection; Infection and Immunity
Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia; FASEB Journal
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities; Human Molecular Genetics
Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients; Clinical Chemistry

Research Publications

A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice; PLoS One
Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips; BMC Bioinformatics
CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population; Journal of Neuroimmunology
Effector ExoU from the type III secretion system is an important modulator of gene expression in lung epithelial cells in response to pseudomonas aeruginosa infection; Infection and Immunity
First encounter: How pathogens compromise epithelial transport
Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia; FASEB Journal
G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease; American Journal of Physiology-Lung Cellular and Molecular Physiology
Gene complementation of airway epithelium in the cystic fibrosis mouse is necessary and sufficient to correct the pathogen clearance and inflammatory abnormalities; Human Molecular Genetics
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20; Nature Genetics
GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon; Journal of Membrame Biology
Host resistance to malaria: using mouse models to explore the host response; Mammalian Genome
Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa; Microbiology
Mass spectrometry for the determination of renal disease biomarkers in urine; 24th meeting of the Australian and New Zealand Society for Mass Spectrometry
Novel neutrophil-derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients; Clinical Chemistry
Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum; Science
Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection; Science
Saliva-Derived DNA Performs Well in Large-Scale, High-Density Single-Nucleotide Polymorphism Microarray Studies; Cancer Epidemiology, Biomarkers and Prevention
Searching for rare variants conferring susceptibility to multiple sclerosis; Progress in MS Research Conference
The role of TNF in parasitic diseases: Still more questions than answers; International Journal for Parasitology

Research Projects

An ENU mutagenesis program to identify candidate targets for host-directed therapy against malaria; National Health & Medical Research Council (NHMRC)
Analysing the Protective Role of Platelets During Malarial Infection; Australian Research Council (ARC)
Clare Smith Post Graduate Support Grant - Investigating host haem targets as a novel antimalarial therapy; GlaxoSmithKline Australia (GSKA)
Development of novel, host-directed antimalarial compounds; University of Tasmania (UTAS)
Elucidation of the role of a novel susceptibility gene in prostate cancer; Royal Hobart Hospital Research Foundation (RHHRF)
Elucidation of the role of a novel susceptibility gene in prostate cancer; Cancer Council of Tasmania (CCT)
Elucidation of the role of the integrin alpha 2 gene (ITGA2) in prostate cancer; Cancer Council of Tasmania (CCT)
Eradication of malaria through the development of host-directed therapy; Bill & Melinda Gates Foundation (BMGF)
Identifying rare genetic variants conferring susceptibility to multiple sclerosis; National Health & Medical Research Council (NHMRC)
ITGA2: characterisation as a potential biomarker in prostate cancer; Cancer Council of Tasmania (CCT)
Prostate cancer risk variants in integrin genes & their role in prostate cancer development; Cancer Council of Tasmania (CCT)
Prostate cancer risk variants in integrin genes and their role in tumour development; Cancer Council of Tasmania (CCT)
To search for genetic causes of renal disease in the Tiwi Island Aboriginal population; National Health & Medical Research Council (NHMRC)
Upgrade of the flow cytometry facility of the Menzies Research Institute with a multi-parameter analytical flow cytometer CyAn ADP 9 Color for key applications ; Clive & Vera Ramaciotti Foundation (CVRF)

Research Candidate Supervision

An Investigation of Novel Host-directed Antimalarial Therapeutics through Genetic and Pharmacological Targeting of Haem Biosynthetic Enzymes
Developing Host Directed Therapies for Treating Malarial Infection
Discovering a New Generation of Antimalarial Drugs Using Chemical Mutagenisis in Mice
Malaria-ENU Mutations for a Host Target Therapy Against Malaria