Web Access Research Portal

Researcher: Aitken, D (Dr Dawn Aitken)

Fields of Research

Rheumatology and Arthritis
Epidemiology
Geriatrics and Gerontology
Aged Health Care
Podiatry
Primary Health Care
Autonomic Nervous System
Nutritional Physiology
Human Movement and Sports Science
Clinical Sciences
Physiotherapy
Health Counselling
Sports Medicine
Endocrinology
Clinical Pharmacology and Therapeutics
Cellular Immunology
Solid Tumours

Research Objectives

Skeletal System and Disorders (incl. Arthritis)
Health Related to Ageing
Evaluation of Health Outcomes
Allied Health Therapies (excl. Mental Health Services)
Endocrine Organs and Diseases (excl. Diabetes)
Clinical Health (Organs, Diseases and Abnormal Conditions)
Preventive Medicine
Teaching and Instruction
Health Education and Promotion
Expanding Knowledge in the Medical and Health Sciences
Disability and Functional Capacity
Behaviour and Health
Inherited Diseases (incl. Gene Therapy)
Skin and Related Disorders

Career Best Publications

A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial; Osteoarthritis and Cartilage
Longitudinal associations of serum 25-hydroxyvitamin-D, physical activity, and knee pain and dysfunction with muscle loss in community-dwelling older adults; Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Subchondral Bone and Cartilage Damage - A Prospective Study in Older Adults; Arthritis and Rheumatism
The association between ambulatory activity, body composition and hip or knee joint replacement due to osteoarthritis: a prospective cohort study; Osteoarthritis and Cartilage
The association between objectively measured physical activity and knee structural change using MRI; Annals of the Rheumatic Diseases
Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial; Annals of the Rheumatic Diseases

Research Publications

A family history of knee joint replacement increases the progression of knee radiographic osteoarthritis and medial tibial cartilage volume loss over 10 years; Osteoarthritis and Cartilage
A longitudinal study of the association between dietary factors, serum lipids, and bone marrow lesions of the knee; Arthritis Research & Therapy
A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia; Osteoarthritis and Cartilage
A population-based study of the association between hip bone marrow lesions, high cartilage signal, and hip and knee pain; Clinical Rheumatology
A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients - ZAP2; BMC Musculoskeletal Disorders
A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial; Osteoarthritis and Cartilage
Accelerometer-determined physical activity, muscle mass, and leg strength in community-dwelling older adults; Journal of Cachexia, Sarcopenia and Muscle
Association between hip and knee cartilage measured using radiographs and magnetic resonance imaging: the Tasmanian Older Adult Cohort Study; Rheumatology
Association between quantitatively measured infrapatellar fat pad high signal intensity alteration and MRI-assessed progression of knee osteoarthritis; Arthritis Care & Research
Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults; Arthritis Research & Therapy
Constitutive melanin density is associated with higher 25-hydroxyvitamin D and potentially total body BMD in older Caucasian adults via increased sun tolerance and exposure; Osteoporosis International
Correlates of Hip Cartilage Defects: A Cross-sectional Study in Older Adults; Journal of Rheumatology
Correlates of Subchondral BMD: A Cross-Sectional Study; Journal of Bone and Mineral Research
Correlation between changes in global knee structures assessed on Magnetic Resonance Imaging and radiographic osteoarthritis changes over 10 years in a mid-life cohort; Arthritis Care & Research
Cross-sectional and longitudinal associations between systemic, subchondral bone mineral density and knee cartilage thickness in older adults with or without radiographic osteoarthritis; Annals of the Rheumatic Diseases: The Euler Journal
Differentiating knee pain phenotypes in older adults: a prospective cohort study; Rheumatology
Does cartilage volume measurement or radiographic osteoarthritis at baseline independently predict ten-year cartilage volume loss?; BMC Musculoskeletal Disorders
Effect of Zoledronic Acid and Denosumab in patients with low back pain and modic change: A proof-of-principle trial; Journal of Bone and Mineral Research
Factors associated with physical activity promotion by allied and other non-medical health professionals: A systematic review; Patient Education and Counseling
Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose; Annals of the Rheumatic Diseases
Hip shape as a predictor of osteoarthritis progression in a prospective population cohort; Arthritis Care & Research
History of knee injury and MRI-assessed knee structures in middle- and older-aged adults: a cross-sectional study; Clinical Rheumatology
How do MRI-detected subchondral bone marrow lesions (BMLs) on two different MRI sequences correlate with clinically important outcomes?; Calcified Tissue International
Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study; Arthritis Research & Therapy
Infrapatellar fat pad in the knee: Is local fat good or bad for knee osteoarthritis?; Arthritis Research & Therapy
Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults; Australian Family Physician
Light physical activity is positively associated with cognitive performance in older community dwelling adults; Journal of Science and Medicine in Sport
Longitudinal associations between serum 25-hydroxyvitamin D, physical activity, knee pain and dysfunction and physiological falls risk in community-dwelling older adults; Experimental Gerontology
Longitudinal associations of serum 25-hydroxyvitamin-D, physical activity, and knee pain and dysfunction with muscle loss in community-dwelling older adults; Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis; Rheumatology
Maintaining vitamin D sufficiency is associated with improved structural and symptomatic outcomes in knee osteoarthritis; American Journal of Medicine
Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort; BMC Musculoskeletal Disorders
Natural history and clinical significance of MRI-detected bone marrow lesions at the knee: a prospective study in community dwelling older adults; Arthritis Research & Therapy
Natural history of areal bone marrow lesions; Osteoarthritis Research Society International
Operational definitions of sarcopenia and their associations with 5-year changes in falls risk in community-dwelling middle-aged and older adults; Osteoporosis International
Osteoarthritis bone marrow lesions at the knee and large artery characteristics; Osteoarthritis and Cartilage
Physical Activity and Osteoarthritis of the Knee: Can MRI Scans Shed More Light on This Issue?; The Physician and Sportsmedicine: A Peer Reviewed Journal of Medical Aspects of Sports, Exercise and Fitness
Predictors of Beagley-Gibson skin cast grade in older adults; Skin Research and Technology
Predictors of pain severity trajectory in older adults: a 10.7-year follow-up study; Osteoarthritis and Cartilage
Prospective associations of low muscle mass and function with 10-year falls risk, incident fracture and mortality in community-dwelling older adults; Journal of Nutrition, Health and Aging
Reply Letter to the Editor: Knee joint replacement and individual susceptibility for progression of knee osteoarthritis and tibial cartilage volume loss: not only genes run in the family; Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International
Reply to letter by Hayashi et al. commenting on choice of pulse sequences for MRI based semi-quantitative assessment of cartilage defects ; Arthritis & Rheumatism
Responsiveness of Magnetic Resonance Imaging-derived Measures Over 2.7 Years; Journal of Rheumatology
Sarcopenic obesity and dynapenic obesity: 5-year associations with falls risk in middle-aged and older adults; Obesity: a research journal
Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study; ARD Online
Subchondral Bone and Cartilage Damage - A Prospective Study in Older Adults; Arthritis and Rheumatism
The association between ambulatory activity, body composition and hip or knee joint replacement due to osteoarthritis: a prospective cohort study; Osteoarthritis and Cartilage
The association between hip bone marrow lesions and bone mineral density: a cross-sectional and longitudinal population-based study; Osteoarthritis and Cartilage
The Association Between Hip Muscle Cross-Sectional Area, Muscle Strength, and Bone Mineral Density; Calcified Tissue International
The association between leptin, interleukin-6, and hip radiographic osteoarthritis in older people: a cross-sectional study; Arthritis Research & Therapy
The association between objectively measured physical activity and knee structural change using MRI; Annals of the Rheumatic Diseases
The association between physical activity and reduced body fat lessens with age - Results from a cross-sectional study in community-dwelling older adults; Experimental Gerontology
The association of knee structural pathology with pain at the knee is modified by pain at other sites in those with knee osteoarthritis; Clinical Rheumatology
The clinical significance, natural history and predictors of bone marrow lesion change over eight years; Arthritis Research & Therapy
The optimal dosage regimen of vitamin D supplementation for correcting deficiency in adolescents: a pilot randomized controlled trial; European Journal of Clinical Nutrition
The relationship between cumulative lifetime ultraviolet radiation exposure, bone mineral density, falls risk and fractures in older adults; Osteoporosis International
The relationship between objectively assessed physical activity and bone health in older adults differs by sex and is mediated by lean mass; Osteoporosis International
Vitamin D and physical activity status: Associations with five-year changes in body composition and muscle function in community-dwelling older adults; Journal of Clinical Endocrinology and Metabolism
Vitamin D deficiency in Tasmania: A whole of life perspective; Internal Medicine Journal
Vitamin D supplementation and inflammatory and metabolic biomarkers in patients with knee osteoarthritis: post hoc analysis of a randomised controlled trial; The British journal of nutrition
Vitamin D supplementation in infants
Which subchondral bone measure is the best predictor of cartilage damage?
Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial; Annals of the Rheumatic Diseases

Research Projects

A randomised controlled trial evaluating community walking for knee osteoarthritis; Arthritis Australia (AFA)
2012: 6th International Workshop on Osteoarthritis Imaging combined with the OARSI OA Biomarkers Workshop II - Imaging Biomarker Validation and Qualification, USA; University of Tasmania (UTAS)
A randomised trial of zoledronic acid for osteoarthritis of the knee; National Health & Medical Research Council (NHMRC)
DICKENS - A randomised controlled trial of DIaCerein to treat KneE osteoarthritis with effusioN-Synovitis; National Health & Medical Research Council (NHMRC)
Improving musculoskeletal pain by matching the right treatment with the right patient; Medical Research Future Fund (MRFF)
Improving outcomes in patients with knee osteoarthritis: identifying pain phenotypes with relationships to long-term health outcomes; University of Tasmania (UTAS)
Scientific Exchange to University of California, San Francisco to work on Osteoarthritis Initiative Study (OAI); Osteoarthritis Research Society International (OARSI)
Structural predictors of knee replacement surgery; Arthritis Australia (AFA)
Testing new treatments for back pain: a randomised open label pilot study; Tasmanian Community Fund (TasCF)
The effect of krill oil on cartilage composition; Menzies Institute for Medical Research (MIMR)
Unlocking the potential of a novel setting to promote physical activity (PA) among patients with Knee Osteoarthritis (KOA) - parkrun; Medibank Better Health Foundation (MBHF)
Using magnetic resonance imaging (MRI) to improve understanding of knee osteoarthritis and develop effective therapeutic treatments; National Health & Medical Research Council (NHMRC)
Vitamin D for correcting deficiency in adolescents: a general practice-based RCT ; Royal Australian College of General Practitioners/Osteoporosis Australia (RACGP/OA)
Osteoarthritis research

Research Candidate Supervision

A Controlled Longtitudinal Study of Knee Cartilage Volume in the Offspring of Subjects with Osteoarthritis of the Knee
Hip Structure Assessment Using MRI and Radiographic Assessment of OA, Statistical Analysis and Development of Epidemiological Methods