Web Access Research Portal

Researcher: Dickinson, JL (Associate Professor Joanne Dickinson)

Fields of Research

Cancer Genetics
Medical Genetics (excl. Cancer Genetics)
Oncology and Carcinogenesis
Epidemiology
Epigenetics (incl. Genome Methylation and Epigenomics)
Ophthalmology
Haematology
Cancer Cell Biology
Gene Expression (incl. Microarray and other genome-wide approaches)
Molecular Targets
Genetics
Preventive Medicine
Population, Ecological and Evolutionary Genetics
Genomics
Bioethics (human and animal)
Marine and Estuarine Ecology (incl. Marine Ichthyology)
Solid Tumours
Biochemistry and Cell Biology
Neurology and Neuromuscular Diseases
Medical Biochemistry and Metabolomics
Cellular Immunology
Property Law (excl. Intellectual Property Law)
Neurogenetics
Public Health and Health Services
Clinical Chemistry (diagnostics)
Cancer Diagnosis
Haematological Tumours
Aboriginal and Torres Strait Islander Health
Probability Theory
Medical Biochemistry: Nucleic Acids
Paediatrics
Law
Immunological and Bioassay Methods
Law and Society
Immunology
Primary Health Care
Pathology
Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
Health and Community Services
Rural Sociology
Applied Ethics
Genome Structure and Regulation
Anaesthesiology
Physiotherapy
Respiratory Diseases
Cell and Nuclear Division
Applied Statistics
Medical Biotechnology
Computer Software
Biocatalysis and Enzyme Technology
Geriatrics and Gerontology

Research Objectives

Cancer and Related Disorders
Inherited Diseases (incl. Gene Therapy)
Hearing, Vision, Speech and Their Disorders
Men's Health
Urogenital System and Disorders
Nervous System and Disorders
Expanding Knowledge in the Biological Sciences
Health
Preventive Medicine
Blood Disorders
Immune System and Allergy
Marine Flora, Fauna and Biodiversity
Bioethics
Disease Distribution and Transmission (incl. Surveillance and Response)
Clinical Health (Organs, Diseases and Abnormal Conditions)
Public Health (excl. Specific Population Health)
Aboriginal and Torres Strait Islander Health - Determinants of Health
Expanding Knowledge in the Medical and Health Sciences
Rural Health
Skeletal System and Disorders (incl. Arthritis)
Health Status (e.g. Indicators of Well-Being)
Expanding Knowledge in Economics
Mental Health
Specific Population Health (excl. Indigenous Health)
Health Inequalities
Human Diagnostics
Digestive System Disorders
Endocrine Organs and Diseases (excl. Diabetes)
Health Related to Ageing
Allied Health Therapies (excl. Mental Health Services)
Respiratory System and Diseases (incl. Asthma)
Dental Health
Indigenous Health
Skin and Related Disorders
Diagnostic Methods
Child Health
Expanding Knowledge in the Environmental Sciences
Behaviour and Health
Application Software Packages (excl. Computer Games)

Career Best Publications

Analysis of myocilin mutations in 1703 glaucoma patients from five different populations; Human Molecular Genetics
Anticipation in familial hematologic malignancies; Blood
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease; European Journal of Human Genetics
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study; Nature Genetics
Melanocortin 1 receptor genotype, past environmental sun exposure, and risk of multiple sclerosis; Neurology
Plasminogen activator inhibitor type 2 inhibits tumour necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function; Journal of Biological Chemistry
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study; Nature Genetics
The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF- induced apoptosis; Cell Death and Differentiation
The serine proteinase inhibitor (Serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming; Journal of Experimental Medicine

Research Publications

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease; Human Molecular Genetics
A novel mutation in the Connexin 46 gene causes autosomal dominant congenital cataract with incomplete penetrance; Journal of Medical Genetics
A potentiation of the adverse effect of human leukocyte antigen-DR15 on the risk of multiple sclerosis by low infant sibling exposure: a population based case-control study; 13th Annnual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis
A retrospective examination of mean relative telomere length in the Tasmanian Familial Hematological Malignancies Study; Oncology Reports
A role for integrin alpha 2 in familial prostate cancer susceptibility; kConFab: Familial Aspects of Cancer: Research and Practice
Accumulation of p16CDKN2A in response to ultraviolet irradiation correlates with late S-G(2)-phase cell cycle delay; Cancer Research
Adiposity Gain During Childhood, ACE I/D Polymorphisms and Metabolic Outcomes; Obesity
Analysis of myocilin mutations in 1703 glaucoma patients from five different populations; Human Molecular Genetics
Anticipation in familial hematologic malignancies; Blood
APOE Genotype and Cardio-Respiratory Fitness Interact to Determine Adiposity in 8-Year-Old Children from the Tasmanian Infant Health Survey; PL o S One
Association between birth weight and adolescent systolic blood pressure in a caucasian birth cohort differs according to skin type, CRH promoter or 11β-HSD2 genotype; Archives of Disease in Childhood
Body ownership and research; Journal of Law and Medicine
Broad Phenotypic variability in a Single Pedigree With a Novel 1410delC Mutation in the PST Domain of the PAX6 Gene; Human Mutation
Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk; Neurology
Community Engagement for Big Epidemiology: Deliberative Democracy as a Tool; Journal of Personalized Medicine
Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips; BMC Bioinformatics
Comparison of pre-processing methodologies for Illumina 450k methylation array data in familial analyses; Clinical Epigenetics
Control of plasminogen-activator inhibitor type 2 gene expression in the differentiation of monocytic cells; European Journal of Biochemistry
CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population; Journal of Neuroimmunology
DNase I hypersensitive sites in the 5 ' flanking region of the human plasminogen activator inhibitor type 2 (PAI-2) gene are associated with basal and tumor necrosis factor-alpha-induced transcription in monocytes; European Journal of Biochemistry
Does the Addition of Information on Genotype Improve Prediction of the Risk of Melanoma and Nonmelanoma Skin Cancer beyond That Obtained from Skin Phenotype?; American Journal of Epidemiology
Emerging Putative Biomarkers: The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment and Prognosis; Prostate Cancer
Epigenetic regulation of prostate cancer; Clinical Epigenetics
Ethical genetic research in Indigenous communities: challenges and successful approaches; Trends in Molecular Medicine
Evaluating a CLL susceptibility variant in ITGB2 in families with multiple sub-types of hematological malignancies; Blood
Evidence for a common genetic aetiology in high-risk families with multiple haematological malignancy subtypes ; British Journal of Haematology
Evidence for Genetic Heterogeneity within Eight Glaucoma Families, with the GLC1A Gln368STOP Mutation Being an Important Phenotypic Modifier; Ophthalmology
Evidence that the Active Site and the C-D interhelical region of plasminogen activator inhibitor type 2 are required for protection from TNFa induced apoptosis; Fifth International Workshop on the Molecular and Cellular Biology of Plasminogen Activation
Familial aggregation of glaucoma: Experience with the glaucoma inheritance study in Tasmania (GIST); Annual Meeting
Familial Haematological Malignancies; GeneMappers
Familial Haematological malignancies: The Tasmanian experience; Haematology Society of Australia and New Zealand, Australia and New Zealand Society for Blood Transfusion & Australasian Society for Thrombosis and Homeostasis
Fucoidan and cancer: a multifunctional molecule with anti-tumor potential; Marine Drugs
Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo; OncoTarget
Fucoidan suppresses the growth of human acute promyelocytic leukemia cells in vitro and in vivo; Journal of Cellular Physiology
Genetic and epigenetic variation in vulvar cancer: Current research and future clinical practice; The Australian and New Zealand Journal of Obstetrics and Gynaecology
Genetic determinants of epigenetic patterns: providing insight into disease; Molecular Medicine
Genetic dissection of the human leukocyte antigen region by use of haplotypes of Tasmanians with multiple sclerosis; American Journal of Human Genetics
Human Leukocyte Antigen-DR15, Low Infant Sibling Exposure and Multiple Sclerosis: Gene-Environment Interaction; Annals of Neurology
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease; European Journal of Human Genetics
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study; Nature Genetics
Identification of Susceptibility Genes for Haematological Maligancies; GeneMappers
Implementing values-based governance for a new bioresource model; Journal of Law and the Biosciences
Impressions on the Body, Property and Research; Persons, Parts and Property: How Should We Regulate Human Tissue in the 21st Century?
Integrins as determinants of genetic susceptibility, tumour behaviour and their potential as therapeutic targets; Prostate Cancer - From Bench to Bedside
Integrins in Prostate Cancer Invasion and Metastasis; Advances in Prostate Cancer
Investigation of a possible role for the Norrie Disease gene in Retinopathy of Prematurity; Human Genome Society Conference
Investigation of albinism genes in congenital esotropia; Molecular Vision
Investigation of chromosome 2q in osteoarthritis of the hand: no significant linkage in a Tasmanian population; Annals of the Rheumatic Diseases
Investigation of crystallin genes in familial cataract, and report of two disease associated mutations; British Journal of Ophthalmology
Investigation of the prevalence of the myocilin Q368STOP mutation in Ugandan glaucoma patients; Ophthalmic Genetics
Laboratory methods in ophthalmic genetics: obtaining DNA from patients; Ophthalmic Genetics
Linkage analysis of a large Tasmanian haematological cancer family; GeneMappers
Linkage analysis of a second large prostate cancer family from southern Tasmania, Australia; American Society of Human Genetics Conference
Melanocortin 1 receptor genotype, past environmental sun exposure, and risk of multiple sclerosis; Neurology
Methylation of the ITGA2 promoter in Prostate Cancer; Epigenetics Conference
Multiple Sclerosis: a haplotype association study; Novartis Foundations Symposium
Mutations in the NDP gene: contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity; Clinical and Experimental Ophthalmology
New avenues within community engagement: addressing the ingenuity gap in our approach to health research and future provision of health care; Journal of Responsible Innovation
Now all I need is a wife; Australasian Research Management Conference
Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction ; Multiple Sclerosis
Phenotypic variability in a large aniridia pedigree with a novel PAX6 1410delC; Annual Meeting
Plasminogen activator inhibitor type 2 inhibits tumour necrosis factor alpha-induced apoptosis. Evidence for an alternate biological function; Journal of Biological Chemistry
Precision medicine: drowning in a regulatory soup?; Journal of Law and the Biosciences
Predictive DNA testing for glaucoma with the GLC1A gene: experience with a large Australian family; International Human Genome Conference
Prostate Cancer Sun Exposure and Genes Modifying Risk; 11th International Congress of Human Genetics
Prostate Cancer: Sun Exposure and Genes Modifying Risk; American Society of Human Genetics Conference
Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer; The Prostate
Regulation of the ITGA2 gene in prostate cancer; Lorne Cancer Conference
Retinoic acid protests Langerhans' cells from the effects of the tumour promoter 12-O-tetradecanoylphorbol 13-acetate; Immunology
Retinopathy of prematurity: recent advances in our understanding; British Journal of Ophthalmology
Retinopathy of prematurity: recent advances in our understanding; Archives of Disease in Childhood
Risk analysis of prostate cancer in PRACTICAL, a multinational consortium, using 25 known prostate cancer susceptibility loci; Cancer Epidemiology, Biomarkers and Prevention
RNA-seq profiling of a radiation resistant and radiation sensitive prostate cancer cell line highlights opposing regulation of DNA repair and targets for radiosensitization; BMC Cancer
Runs of homozygosity and a cluster of vulvar cancer in young Australian Aboriginal women; Gynecologic Oncology
Saliva-Derived DNA Performs Well in Large-Scale, High-Density Single-Nucleotide Polymorphism Microarray Studies; Cancer Epidemiology, Biomarkers and Prevention
Sequence variants of α-methylacyl-CoA racemase are associated with prostate cancer risk: A replication study in an ethnically homogeneous population; The Prostate
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study; Nature Genetics
Smoking as an independent risk factor for multiple sclerosis: considering possible combined effects with the human leukocyte antigen DR15 genotype and anti-EBNA antibody titers; 13th Annnual Meeting of the Amer-Comm-for-Treatment-and-Res-in-Multiple-Sclerosis
Sodium butyrate differentially modulates plasminogen activator inhibitor type-1 urokinase plasminogen activator, and its receptor in a human colon carcinoma cell; Teratogenesis, Carcinogenesis, and Mutagenesis
Testisin, a New Human Serine Proteinase Expressed by Premeiotic Testicular Germ Cells and Lost in Testicular Germ Cell Tumors; Cancer Research
The Taa1 Restriction Enzyme Provides a Simple Means to Identify the Q368STOP Mutation of the Myocilin Gene in Primary Open Angle Glaucoma; American Journal of Ophthalmology
The advantages of dense marker sets for linkage analysis with very large families; Human Genetics
The apolipoprotein epsilon 4 gene is associated with elevated risk of normal tension glaucoma; Molecular Vision
The C-D interhelical domain of the serpin plasminogen activator inhibitor-type 2 is required for protection from TNF- induced apoptosis; Cell Death and Differentiation
The Familial Tasmanian Haematological Malignancies Study (FaTHMS): its origins, its history and the phenomenon of anticipation; Transfusion and Apheresis Science
The leukemia inhibitory factor receptor gene is a direct target of RUNX1; Journal of Cellular Biochemistry
The serine proteinase inhibitor (Serpin) plasminogen activation inhibitor type 2 protects against viral cytopathic effects by constitutive interferon alpha/beta priming; Journal of Experimental Medicine
The Tasmanian familial leukaemia and lymphoma research study; Haematology Society of Australia and New Zealand, Australia and New Zealand Society for Blood Transfusion & Australasian Society for Thrombosis and Homeostasis
The Tasmanian familial leukaemia and lymphoma research study; GeneMappers
Tissue factor and plasminogen activator inhibitor expression in the differentiation of myeloid leukemic cells; Leukemia
Whole genome sequencing of CLL case; GeneMappers

Research Projects

A Pilot Study to Examine Biological, Lifestyle and Genetic Risk Factors Associated with the Development of Multiple Non-melanoma Skin Cancers; University of Tasmania (UTAS)
A Pilot Study to Examine Biological, Lifestyle and Genetic Risk Factors Associated with the Development of Second and Subsequent Non-melanoma Skin Cancers in People with a History of Skin Cancer; Cancer Council of Tasmania (CCT)
A vulvar cancer cluster caused by genetic susceptibility: investigating the genetic mechanism; National Health & Medical Research Council (NHMRC)
A vulvar cancer cluster in young Indigenous women in Arnhem Land: investigation of community knowledge, genetic susceptibility and supportive care response ; National Health & Medical Research Council (NHMRC)
Cancer Council Tasmania, Research Fellow; Cancer Council of Tasmania (CCT)
Combining deep sequencing and linkage approaches to identify rare variants contributing to familial prostate cancers; Cancer Council of Tasmania (CCT)
Development of the Tasmanian Familial Prostate Cancer Genetic Resource; Tasmanian Community Fund (TasCF)
DNA sequencer for genetic research; Ian Potter Foundation (IPF)
Elucidation of the role of a novel susceptibility gene in prostate cancer; Cancer Council of Tasmania (CCT)
Elucidation of the role of a novel susceptibility gene in prostate cancer; Royal Hobart Hospital Research Foundation (RHHRF)
Elucidation of the role of the integrin alpha 2 gene (ITGA2) in prostate cancer; Cancer Council of Tasmania (CCT)
Epigenetic regulation of inegrin beta 4 as a predictor of prostate cancer progression; Cancer Council of Tasmania (CCT)
Epigenetic Regulation of the integrin, ITGA2, in Tumour Development; Cancer Council of Tasmania (CCT)
Epigenomics of familial prostate cancer; Cancer Council of Tasmania (CCT)
Evaluation of the Norrie Disease, VEGF-B and VEGF-A Genes in Retinopathy of Prematurity; University of Tasmania (UTAS)
Familial Haematological Malignancies: understanding the role of inherited causative factors; Cancer Council of Tasmania (CCT)
Genetic aetiology of familial haematological malignancies; Cancer Council of Tasmania (CCT)
Genetic and Bioinformatic Analysis of Complex Human Diseases; National Health & Medical Research Council (NHMRC)
Identification of a Gene that Increases Risk of MS Via a Pathway Involving UV Exposure; National Health & Medical Research Council (NHMRC)
Identification of Genes Causing Congenital Cataract; Royal Hobart Hospital Research Foundation (RHHRF)
Identification of Genes that Influence MS Progression by Pathways that Involve UV Exposure: a Prospective Cohort Study; Ian Potter Foundation (IPF)
Identification of Genomic Regions Implicated in Hereditary Prostate Cancer in Tasmania by Genome-wide Scan; Royal Hobart Hospital Research Foundation (RHHRF)
Identification of susceptibility genes for familial haematological malignancies; Leukaemia Foundation (LF)
Identification of susceptibility genes for haematological malignancies; David Collins Leukaemia Foundation (DCLF)
Identifying inherited factors underlying familial haematological malignancies; David Collins Leukaemia Foundation (DCLF)
Inherited determinants of Cancer Aetiology; Australian Research Council (ARC)
Integrative genomic approaches to understanding the genetics of prostate cancer; Cancer Australia (CANCA)
Intersection of RUNX and integrin families in leukaemia; David Collins Leukaemia Foundation (DCLF)
Investigating the genetics of familial haematological cancers in Tasmania; David Collins Leukaemia Foundation (DCLF)
Investigating the genetics of familial haematological cancers in Tasmania; Cancer Council of Tasmania (CCT)
Investigating the genetics of familial haematological cancers in Tasmania; David Collins Leukaemia Foundation (DCLF)
Investigation of chromosomal loss and gain at 7p21 in a Tasmanian hereditary prostate cancer family; Royal Hobart Hospital Research Foundation (RHHRF)
ITGA2: characterisation as a potential biomarker in prostate cancer; Cancer Council of Tasmania (CCT)
Molecular biomarkers for seabird age estimation; Linnean Society of New South Wales (LSNSW)
Molecular biomarkers for seabird age estimation.; Holsworth Wildlife Research Endowment (HWRE)
Molecular Genetics of Familial Prostate Cancer in Tasmania; Cancer Council of Tasmania (CCT)
Prostate cancer risk variants in integrin genes & their role in prostate cancer development; Cancer Council of Tasmania (CCT)
Prostate cancer risk variants in integrin genes and their role in tumour development; Cancer Council of Tasmania (CCT)
Prostate Cancer: Sun Exposure And Candidate Genes Modifying Risk; Commonwealth Department of Veterans Affairs (DVA)
Regulation of Integrin Gene Expression Programs by RUNX in Cancer; Cancer Council of Tasmania (CCT)
Regulation of integrins by RUNX1 in leukaemia; David Collins Leukaemia Foundation (DCLF)
Role of NF-kB in radiosensitivity and resistance in prostate cancer; Cancer Council of Tasmania (CCT)
Sanyo Upright Freezer; National Health & Medical Research Council (NHMRC)
Study of Molecular Events in Large Tasmanian Prostate Cancer Families; Cancer Council of Tasmania (CCT)
Tasmanian familial haematological malignancy research study; Pfizer (PFIZER)
Tasmanian genealogical and genetic resource for cancer research; Tasmanian Community Fund (TasCF)
Tasmanian Prostate Cancer Study; Mazda Foundation (MAZDA)
Tasmanian Prostate Cancer Study (TASPAC); Perpetual Trustees (PT)
Tasmanian Prostate Cancer Study: Study of Molecular Events in large Tasmanian Prostate Cancer Families ; Estate of Dr R.A. Parker (PARKER)
The ACRF Tasmanian Inherited Cancer Centre (ATICC); Australian Cancer Research Foundation (ACRF)
The Glaucoma Inheritance Study in Tasmania (GIST): Investigating the Prevalence, Penetrance and Phenotype of Mutations in Genes Resulting in the Eye Disease, Glaucoma; Royal Hobart Hospital Research Foundation (RHHRF)
The MSR1 Gene and Risk of Prostate Cancer in the Tasmanian Population; Royal Hobart Hospital Research Foundation (RHHRF)
The role of epigenetic changes in the progression of clinical disease in Multiple Endocrine Neoplasia Type 1 (MEN 1); Royal Hobart Hospital Research Foundation (RHHRF)
The Tasmanian Leukaemia and Other Haematopoietic Malignancies Research Study; Perpetual Trustees (PT)
The Tasmanian Parkinson's Disease Research Project: A Feasibility Study; Royal Hobart Hospital Research Foundation (RHHRF)
The Tasmanian prostate cancer genetics study; Max Bruce Trust (MBT)
Transcriptome analysis for predicting response to radiotherapy in prostate cancer patients; Royal Hobart Hospital Research Foundation (RHHRF)
David Collins Leukaemia Foundation Elite Research Scholarship - Epigenetic and Transcriptional regulation of leukaemia

Research Candidate Supervision

A study of Aortopathy Associated with Bicuspid Aortic Valves, with particular relevance to the Tasmanian/Australian population
Epigenomic and Genomic Analysis of Familial Prostrate Cancer.
Genetics of Complex Diseases
Identification of Susceptibility Genes for Familial Haematological Malignancies
Investigating the Genetic Predisposition for Familial Haematological Malignancies
Investigating the Genetics of Primary Open-Angle Glaucoma in Tasmania
Regulation of Inducible Immune Gene Expression in T Cells Compared to Macrophages
Regulation of Integrins by RUNX Transcription Factors in Cancer
Regulation of the ITGA2 Gene in Prostate Cancer
Regulation of the LIFR and gp130 Genes by the RUNX1 Transcription Factor
Study of the Role of Fucoidan on Leukemia Cells and on Hematopoietic Stem Cell Release
The Genetics of Familial Prostate Cancer in Tasmania