Web Access Research Portal

Researcher: Sohal, SS (Dr Sukhwinder Sohal)

Fields of Research

Respiratory Diseases
Pharmaceutical Sciences
Cell Metabolism
Receptors and Membrane Biology
Genetic Immunology
Medical Bacteriology
Analytical Biochemistry
Cancer Genetics
Clinical Sciences
Veterinary Diagnosis and Diagnostics
Health and Community Services
Neurosciences
Community Child Health
Cancer Cell Biology
Pathology
Complementary and Alternative Medicine
Allergy
Autoimmunity
Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
Solid Tumours
Innate Immunity

Research Objectives

Respiratory System and Diseases (incl. Asthma)
Diabetes
Public Health (excl. Specific Population Health)
Flora, Fauna and Biodiversity at Regional or Larger Scales
Digestive System Disorders
Cardiovascular System and Diseases
Human Pharmaceutical Treatments (e.g. Antibiotics)
Expanding Knowledge in the Medical and Health Sciences
Disease Distribution and Transmission (incl. Surveillance and Response)
Neurodegenerative Disorders Related to Ageing
Diagnostic Methods
Preventive Medicine
Social Structure and Health

Career Best Publications

Research Publications

β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction; Scientific Reports
2013 Young Scientist of the Year
In-vitro suppression of IL-6 and IL-8 release from human pulmonary epithelial cells by non-anticoagulant fraction of enoxaparin; PLoS One
A lethal epithelial transition in COPD
A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial-mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study; International Journal of COPD
Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD); Scientific reports
Airway Angiogenesis And basement Membrane Remodeling In Smokers And Chronic Obstructive pulmonary Disease: cross-sectional And Longitudinal Studies
Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease; The International Journal of Chronic Obstructive Pulmonary Disease
Airway histone deacetylase-2 increases after smoking cessation, but is not affected by inhaled corticosteroids in Chronic Obstructive Pulmonary Disease (COPD): A randomized controlled trial; American Thoracic Society (ATS)
Airway inflammation and inhaled corticosteroids in COPD; The European Respiratory Journal
Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox; Expert review of respiratory medicine
Airway Remodeling in Chronic Obstructive Pulmonary Disease (COPD), a Review
An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke; The International Journal of Chronic Obstructive Pulmonary Disease
Basement membrane and vascular remodelling in smokers and chronic obstructive pulmonary disease: a cross-sectional study ; Respiratory Research
Basement membrane remodelling in COPD responds to inhaled corticosteroids; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting
Changes in airway histone deacetylase2 in smokers and COPD with inhaled corticosteroids: A randomized controlled trial; PLoS One
Characterisation of colonic dysplasia-like epithelial atypia in murine colitis; World journal of gastroenterology
Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer: Epithelial Mesenchymal Transition (EMT), the Missing Link?; EBioMedicine
Cigarette smoke and platelet-activating factor receptor dependent adhesion of Streptococcus pneumoniae to lower airway cells; Thorax
Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer; Clinical and Translational Medicine
Comparing factor VIII with collagen IV for immuno-staining of vessels; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting
Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview; International Journal of Medical and Biological Frontiers
Department of Industry, Innovation and Science Innovative Science and Technology Award 2016
Distinctive characteristics of bronchial reticular basement membrane and vessel remodelling in chronic obstructive pulmonary disease (COPD) and in asthma: they are not the same disease; Histopathology
Endothelial to mesenchymal transition (EndMT): an active process in Chronic Obstructive Pulmonary Disease (COPD)?; Respiratory Research (Print)
Enhanced platelet activating factor receptor (PAFR) expression in smoker airways; European Respiratory Society, 2011 Annual Congress
Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD); Respiratory investigation
Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease; Medical Oncology
Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD) airways is attenuated by inhaled corticosteroids (ICS); British Thoracic Society
Epithelial mesenchymal transition (EMT) in large airways is attenuated by inhaled fluticasone propionate (FP) in COPD: a randomized controlled trial; The 8th International Young Investigators’ Meeting (YIM) on Airway Smooth Muscle and Fibroblast Biology
Epithelial mesenchymal transition (EMT) in patients with chronic obstructive disease (COPD); The Thoracic Society of Australia & New Zealand Annual Scientific Meeting
Epithelial mesenchymal transition (EMT) in small airways of COPD patients; Thorax
Epithelial mesenchymal transition (EMT) in small and large airways of smokers: potential role in both airway fibrosis and cancer; The 8th International Young Investigators’ Meeting (YIM) on Airway Smooth Muscle and Fibroblast Biology
Epithelial mesenchymal transition (EMT) in the small and large airways of lung cancer patients undergoing thoracotomy; European Respiratory Society Annual Congress
Epithelial Mesenchymal Transition in Chronic Obstructive Pulmonary Disease, a Precursor for Epithelial Cancers: Understanding and Translation to Early Therapy; Annals of the American Thoracic Society
Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction; International Journal of Chronic Obstructive Pulmonary Disease
Epithelial to mesenchymal transition in cultured cells: a potential in vitro model of COPD; Thoracic Society of Australia and New Zealand
Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer; Expert Reviews in Respiratory Medicine
Epithelial–Mesenchymal Transition, a Spectrum of States: Role in Lung Development, Homeostasis, and Disease; Developmental dynamics
Epithelial–Mesenchymal Transition: A Necessary New Therapeutic Target in Chronic Obstructive Pulmonary Disease?; American Journal of Respiratory and Critical Care Medicine
ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1); PLOS One
Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis; The International Journal of Chronic Obstructive Pulmonary Disease
Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis; International journal of chronic obstructive pulmonary disease
Evaluation of epithelial mesenchymal transition in patients with chronic obstructive pulmonary disease; Respiratory Research
Evidence of epithelial-mesenchymal transition in COPD?; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting
Expert Review: European Respiratory Society (ERS) Hot Topic; Breath
Fluticasone propionate attenuates epithelial mesenchymal transition (EMT) in COPD; Respirology, 17 (Supp 1)
Global honour for UTAS researcher
Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes; Expert Review of Clinical Pharmacology
Identification of pro-and anti-proliferative oligosaccharides of heparins; Integrative Biology
Importance of epithelial mesenchymal transition (EMT) in COPD and asthma; Thorax
Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD; International Journal of COPD
Inhaled corticosteroids (ICS) attenuate epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD) - implications for lung cancer prophylaxis; Australian Lung Cancer Conference (ALCC)
Inhaled corticosteroids (ICS) attenuates epithelial mesenchymal transition (EMT) in COPD: a key to understanding long term benefits; European Respiratory Society Annual Congress
Inhaled corticosteroids in airway remodelling in COPD; Thorax
Inhaled corticosteroids is effective on only some aspects of bronchial vascular remodelling in COPD; Thoracic Society of Australia and New Zealand
Inhaled fluticasone propionate (FP) restores angiogenesis in the airway lamina propria of current smokers with COPD: a randomized controlled trial; European Respiratory Society Annual Congress
Intermediate filament vimentin and potential role in epithelial mesenchymal transition (EMT); Vimentin Concepts and Molecular Mechanisms
International recognition for University researcher’s work on lung disease
Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis; European Respiratory Journal
Neutrophil numbers are decreased in bronchial biopsies from patients with COPD; European Respiratory Society Annual Congress
New study challenges description of airway inflammation in smokers and COPD patients
Non-anticoagulant derivatives of heparin for the management of asthma: distant dream or close reality?; Expert Opinion on Investigational Drugs: Authoritative Analysis of Randd Trends
Non-anticoagulant fractions of enoxaparin suppress inflammatory cytokine release from peripheral blood mononuclear cells of allergic asthmatic individuals; PLoS One
Novel insights into chronic obstructive pulmonary disease (COPD): an overview; EMJ Respiratory
Opposing effects of low molecular weight heparins on the release of inflammatory cytokines from peripheral blood mononuclear cells of asthmatics; PLoS One
Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses; PLoS One
Pathological changes in the COPD lung mesenchyme - Novel lessons learned from in vitro and in vivo studies; Pulmonary Pharmacology and Therapeutics
Platelet activating factor receptor (PAFR) expression increases in airways of current smokers; Respirology, 17 (Supp 1)
Platelet activating factor receptor (PAFr) expression is increased in airways of COPD patients but is not attenuated by inhaled corticosteroids; European Respiratory Society Annual Congress
Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target; Expert Review of Respiratory Medicine
Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients; Respirology
Potential epithelial mesenchymal transition (EMT) in the small airways of lung cancer patients; Thoracic Society of Australia and New Zealand
Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease; Chest
Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease; Chest
Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD; Respirology
Recent advance in understanding inflammation and remodelling in the airways in COPD
Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease ; Respirology
Reticular basement membrane vessels are increased in COPD bronchial mucosa by both factor VIII and collagen IV immunostaining and are hyperpermeable; Journal of Allergy
Role of corticosteroids in chronic obstructive pulmonary disease (COPD); Corticosteroids and Steroid Therapy: New Research
Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD); Respiratory Research
Scholarship Award: National Emphysema Foundation Honouring Claude Lenfant by the American Thoracic Society (ATS)
Smoking cessation but not inhaled corticosteroids (ICS) can increase histone deacetylase 2 (HDAC2)] in COPD ; The European Respiratory Journal
Smoking has potential to initiate basement membrane disruption and epithelial mesenchymal transition in COPD ; European Respiratory Society Annual Congress
Smoking has potential to initiate epithelial mesenchymal transition (EMT) in the airway mucosa
Smoking is not directly tied to airway inflammation in COPD
The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL); Respiratory research
Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis; Respirology
Transforming growth factor - beta 1 (TGF-β 1) expression is related to reticular basement membrane (Rbm) hypervascularity in smokers and COPD; European Respiratory Society Annual Congress
UTAS lung cancer research breakthrough
Vascular and basement membrane remodelling in smokers and COPD; European Respiratory Journal
Ventilatory efficiency slope as a predictor of suitability for surgery in chronic obstructive pulmonary disease patients with lung cancer; The Annals of Translational Medicine
Vessel-associated transforming growth factor-beta1 (TGF-β 1) is increased in the bronchial reticular basement membrane in COPD and normal smokers; PLoS One
Vessel-associated transforming growth factor-Beta1 (TGF-β1) expression is increased in COPD airway; Respirology, 17 (Supp 1)
Zinc and Gastrointestinal Disorders: A Role for the Zinc Transporters Zips and ZnTs; Current pharmaceutical design
Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease; Journal of Biomedical Science

Research Projects

Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): role in both airway fibrosis and lung cancer; Clifford Craig Foundation (CCFoundation)
Epithelial mesenchymal transition (EMT) in the lungs and airways in Idiopathic Pulmonary Fibrosis (IPF); Clifford Craig Foundation (CCFoundation)
Epithelial mesenchymal transition (EMT) in the lungs of patients with chronic obstructive pulmonary disease (COPD) and lung cancer undergoing thoracotomy: role in both airway fibrosis and lung cancer; Royal Hobart Hospital Research Foundation (RHHRF)
Exploring zinc to improve insulin sensitivity and glucose metabolism in human insulin-resistant skeletal muscle; Clifford Craig Foundation (CCFoundation)
Identification of Progressive Disease in Idiopathic Pulmonary Fibrosis ; National Health & Medical Research Council (NHMRC)
Immunohistochemical expression patterns of a Devil Facial Tumour Tissue Microarray; University of Tasmania Foundation Inc (UTF)
Novel molecules of heparin for the management of asthma; Royal Hobart Hospital Research Foundation (RHHRF)
Partnership with the Australian Lung Foundation for Lung Cancer PhD Scholarship; Lung Foundation Australia (LFAus)
The effect of current and investigational COPD pharmacological agents on the airway Epithelial-Mesenchymal Transition (EMT) process in smokers and COPD; Clifford Craig Foundation (CCFoundation)
Zinc contributes to glucose control in the absence of insulin in skeletal muscle; Clifford Craig Foundation (CCFoundation)
Supporting respiratory research
The effect of currently used COPD pharmacological agents on Platelet Activating Factor re-ceptor (PAFr) expression in human epithelial cell culture systems from smokers and COPD

Research Candidate Supervision

Airway Inflammation in Smokers- Response to Quitting
Anti-Asthmatic Activity of Heparin
Drivers of Epithelial Mesenchymal Transition (EMT) in Chronic Obstructive Pulmonary Disease (COPD)
Immuno-pathology/Immunology of Airway Diseases
Physiological consequences of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD)
Therapeutic Potential of Heparin in the Management of Ulcerative Colitis