Web Access Research Portal

Researcher: West, AK (Professor Adrian West)

Research Fields

Central Nervous System
Cellular Nervous System
Cell Neurochemistry
Cell Metabolism
Neurology and Neuromuscular Diseases
Peripheral Nervous System
Sensory Systems
Neurosciences
Medical Biotechnology
Cellular Immunology
Biochemistry and Cell Biology
Neurogenetics
Comparative Physiology
Animal Neurobiology
Medical Biochemistry and Metabolomics
Epidemiology
Respiratory Diseases
Animal Physiology - Cell
Animal Physiology - Systems
Gene Expression (incl. Microarray and other genome-wide approaches)
Biological Sciences
Plant Systematics and Taxonomy
Clinical Chemistry (diagnostics)
Medical and Health Sciences
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Innate Immunity
Tumour Immunology
Psychiatry (incl. Psychotherapy)
Plant Physiology
Proteins and Peptides
Animal Physiology - Biophysics
Medical Physiology
Medical Genetics (excl. Cancer Genetics)
Systems Biology
Nutrition and Dietetics
Autonomic Nervous System
Plant Biology
Dermatology
Population, Ecological and Evolutionary Genetics
Tree Improvement (Selection and Breeding)
Allergy
Genome Structure and Regulation
Protein Trafficking
Clinical Nursing: Secondary (Acute Care)
Cell Physiology
Medical Virology
Geriatrics and Gerontology
Microbial Genetics
Organometallic Chemistry
Cardiology (incl. Cardiovascular Diseases)
Otorhinolaryngology
Molecular Targets
Molecular Evolution
Oncology and Carcinogenesis
Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)

Research Impact

Nervous System and Disorders
Expanding Knowledge in the Environmental Sciences
Neurodegenerative Disorders Related to Ageing
Diabetes
Health
Immune System and Allergy
Plant Production and Plant Primary Products
Expanding Knowledge in the Biological Sciences
Health Related to Ageing
Clinical Health (Organs, Diseases and Abnormal Conditions)
Cancer and Related Disorders
Disease Distribution and Transmission (incl. Surveillance and Response)
Skin and Related Disorders
Respiratory System and Diseases (incl. Asthma)
Expanding Knowledge in the Medical and Health Sciences
Environmental Education and Awareness
Infectious Diseases
Cardiovascular System and Diseases
Skeletal System and Disorders (incl. Arthritis)
Forest and Woodlands Flora, Fauna and Biodiversity
Human Pharmaceutical Treatments (e.g. Antibiotics)
Allied Health Therapies (excl. Mental Health Services)
Hearing, Vision, Speech and Their Disorders
Preventive Medicine
Education and Training Systems
Injury Control
Mountain and High Country Flora, Fauna and Biodiversity
Fisheries - Aquaculture
Plastic Products (incl. Construction Materials)
Inherited Diseases (incl. Gene Therapy)
Hardwood Plantations
Coastal and Estuarine Flora, Fauna and Biodiversity

Career Best Publications

A role for extracellular metallothioneins in CNS injury and repair; Neuroscience
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes; Glia
Metallothionein based neuronal therapeutic and therapeutic methods
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition; NeuroToxicology
Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury; Journal of Neuroscience
Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord; Experimental Neurology
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury; Journal of Biological Chemistry

Research Publications

α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury; Neurobiology of Disease
'Not proper mammals' - Metallothioneins from marsupials; The fourth International Metallothionein Meeting
In vitro models of the key pathological changes in axons associated with neurodegenerative disease and acquired brain injury; 4th Congress of Federation of Asian-Oceanain Neuroscience Societies
A model of metallothionein action in the injured brain; Metals and Metallothionein in Biology and Medicine
A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system; International Society of Neuroimmunology
A novel role for olfactory ensheathing cells in neuroimmunological defence in the rodent olfactory system; The International Neurotrauma Symposium
A novel viviparous pea mutant; Australian Society of Plant Physiology
A rat spinal lesion model to investigate olfactory ensheathing cell transplantation in CNS injury; Combio, 2000
A role for extracellular metallothioneins in CNS injury and repair; Neuroscience
A specific increase in metallothionein I/II immunolabeled glial cells in the early stages of Alzheimer's disease; 28th Annual Meeting of the Society for Neuroscience
A specific increase in metallothionein I/II immunolabeled glial cells in the early stages of Alzheimer's disease; 28th Annual Meeting of the Society for Neuroscience
Alpha-internexin in Alzheimer's disease pathology demonstrates hierarchy of neuronal degeneration and neuropathic role of plaque formation
Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection; Experimental Neurology
ALS-like axonal pathology in cultured spinal motor neurons; 18th Symposium on ALS/MND
ALS-like pathology in cultured spinal motor neurons following excitoxicity; IBRO International Conference
Alterations in α-internexin distribution in Alzheimer's disease and experimental models of neuronal trauma
An extracellular role for metallothionein in recovery from brain injury; Symposium on Neural Regeneration
An extracellular role for metallothoinein in recovery from brain injury; 23rd Annual Meeting of the Australian Neuroscience Society
Association of Metallothionein-III with Oligodendroglial Cytoplasmic Inclusions in Multiple System Atrophy; Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration
Axonopathy, excitotoxicity and neuronal degeneration in ALS 2008; Australian Neuroscience Society Conference
Bacteria and PAMPs activate nuclear factor κB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells; Glia
Burn injury has a systemic effect on reinnervation of skin and restoration of nociceptive function; Wound Repair and Regeneration
Cellular and Molecular Biology of Ensheathing Cells; Microscopy Research and Technique
Cultured olfactory ensheathing cells express nerve growth factor, brain-derived neurotrophic factor, glia cell line-derived neurotrophic factor and their receptors; Molecular Brain Research
Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway; Journal of Neuroinflammation
Detection and prediction of heterosis in Eucalyptus globulus; Forest Genetics
Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice; Histology and histopathology
Do olfactory ensheathing cells play a role in the defense of the brain against infection?; Neuroembryology and Aging
Does Beta-Amyloid Plaque Formation Cause Structural Injury to Neuronal Processes?; Neurotoxicity Research
Does metallothionein attenuate mutant SOD1 aggregation in MND; 22nd Symposium on ALS/MND
Effect of glial growth factor II on ensheathing cell culture; 15th Australian Conference for Electron Microscopy
Effect of olfactory ensheathing cells on reactive astrocytes in vitro; Cellular and Molecular Life Sciences
Effect of prior, low-level cadmium exposure in vivo on metallothionein expression in cultured lymphocytes; Journal of Applied Toxicology
Effects of olfactory ensheathing cells on astrogliosis; Australian Neuroscience Society
Encapsulated olfactory ensheathing cells in spinal cord repair; International Society for Developmental Neuroscience
Excitotoxicity mediated by non-NMDA receptors causes distal axonopathy in long-term cultured spinal motor neurons; European Journal of Neuroscience
Exogenous metallothionein-IIA promotes accelerated healing after a burn wound; Wound Repair and Regeneration
Expression of mammalian metallothioneins during development; Congress of the European Developmental Biology Organisation
Expression of metallothionein isoforms in mammals; Lorne Genome Conference
Extracellular, neuroactive properties of metallothioneins; Society for Neuroscience
Gene expression profile of rat olfactory ensheathing cells; The International Neurotrauma Symposium
Genetic expression profile of olfactory ensheathing cells is distinct from that of Schwann cells and astrocytes; Glia
Glial Growth Factor 2 induces proliferation and structural changes in ensheathing cells; Brain Research
Glial modulation of the innate immune response olfactory enseathing cells join the melee?; New Research On Innate Immunity
Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro; Experimental Neurology
Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein; FEBS Letters
Identification of a new noradrenaline induced gene in the rat heart by differential messenger-RNA display; Cardiovascular Research
Identification of genes which mediate norepinephrine-induced cardiac hypertrophy; Lorne Genome Conference
Identification of novel neurotrophic-like factors: a candidate for promoting nerve regeneration in neuropathy; ANS Adelaide 2014
Immune responses in the compromised olfactory pathway of CX3CR1+/GFP and CX3CR1GFP/GFP mice; European Macrophage and Dendritic Society 24th annual Meeting
Immune responses to bacterial challenge in olfactory tissues of CX3CR1+/GFP and CX3CR1GFP/GFP mice; 10th annual meeting of the Asia-Pacific Society for Neuroscience
Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice; Journal of Neuroinflammation
Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease; Neurobiology of Disease
Inducible nitric oxide synthase expression in the primary olfactory pathway of wild type CX3CR1+/GFP and CX3CR1GFP/GFP mice following damage and bacterial challenge; Australian Neuroscience Society
Inducible nitric oxide synthase in response to bacterial challenge in nasal tissues of wild type, CX3CR1+/GFP and CX3 CR1GFP/GFP mice; TLROZ 2009: Pattern recognition receptors in health and disease
Inducible production of nitric oxide by olfactory ensheathing cells in response to bacteria; Infectious diseases of the nervous system: pathogenesis and worldwide impact, Institut Pasteur
Inducible production of nitric oxide by olfactory ensheathing cells in response to bacteria; Australian Neuroscience Society
Injury to neurons induces metallothionein expression in adjacent astrocytes: role of soluble factors; 21st Annual National Neurotrauma Society Symposium
Interaction of olfactory ensheathing cells with other cell types in vitro and after transplantation: Glial scars and inflammation ; Experimental Neurology: A Journal of Neuroscience Research
Intracellular dialysis disrupts Zn2+ dynamics and enables selective detection of Zn2+ influx in brain slice preparations; Journal of Neurochemistry
Localisation and expression of metallothionein immunoreactivity in the developing sheep brain; International Journal of Developmental Neuroscience
Localisation of α-, β- and γ- synuclein in neuron and oligodendrocyte cultures; Society for Neuroscience
Localization of -, -, and -synuclein during neuronal development and alterations associated with the neuronal response to axonal trauma; Experimental Neurology
Low-density lipoprotein receptor-related proteins guide navigating PNS axons; 2015 PNS Meeting
Low-density lipoprotein receptor-related proteins in a novel mechanism of axon guidance and peripheral nerve regeneration; Journal of Biological Chemistry
LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration; Neuroscience 2014
LRP receptors in a novel mechanism of axon pathfinding and peripheral nerve regeneration; Neuroscience 2014
Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury; Pl o S One
Metallothionein based neuronal therapeutic and therapeutic methods
Metallothionein biology in the ageing and neurodegenerative brain; Neurotoxicity Research
Metallothionein expression by NG2 glial cells following CNS injury; Cellular and Molecular Life Sciences
Metallothionein expression in the developing sheep brain; International Workshop on Metallothioneins
Metallothionein expression in the mammalian brain; Metallothionein IV
Metallothionein I/II and metallothionein III induce growth cone chemotaxis via disparate mechanisms; Australian Neuroscience Society 31st Annual Meeting
Metallothionein I/II induces growth cone chemotaxis via an LRP1 and LRP2 dependent mechanism; Neuroscience 2012
Metallothionein I/II induces growth cone chemotaxis via an LRP1 and LRP2 dependent mechanism; Neuroscience 2012
Metallothionein I/II: A possible role in preclinical Alzheimer's disease; 18th Annual Meeting of the Australian Neuroscience Society
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition; NeuroToxicology
Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways ; Experimental Neurology: A Journal of Neuroscience Research
Metallothionein induction following neuronal injury reveals neuron - astrocyte interactions; Society for Neuroscience Annual Meeting
Metallothionein is expressed in adipocytes of brown fat and is induced by catecholamines and zinc; American Journal of Physiology
Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy; Cellular and Molecular Life Sciences
Metallothionein Treatment Attenuates Microglial Activation and Expression of Neurotoxic Quinolinic Acid Following Traumatic Brain Injury ; Neurotoxicity Research: An International Journal on Processes and Mechanisms in Neurodegeneration, Apoptosis, Neuroprotection and Regeneration
Metallothionein-IIA Promotes Initial Neurite Elongation and Postinjury Reactive Neurite Growth and Facilitates Healing after Focal Cortical Brain Injury; Journal of Neuroscience
Metallothionein-IIA promotes neurite growth via the megalin receptor; Experimental Brain Research
Metallothionein-III Inhibits Initial Neurite Formation in Developing Neurons as Well as Postinjury, Regenerative Neurite Sprouting; Experimental Neurology
Metallothioneins 1 and 2 are expressed in the olfactory mucosa of mice in untreated animals and during the regeneration of the epithelial layer; Biochemical and Biophysical Research Communications
Metallothioneins: new tricks for an old dog; Today's Life Science
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Changes in arginase1 and inducible nitric oxide synthase; Journal of Neuroinflammation
Molecular differentiation within and between Eucalyptus risdonii, E. amygdalina and their hybrids using RAPD markers; Australian Journal of Botany
Molecular identification of uncoupling proteins (UCP2 and UCP3) and absence of UCP1 in the marsupial Tasmanian bettong, Bettongia gaimardi; Comparative Biochemistry and Physiology Part B - Biochemistry & Molecular Biology
Molecular Identification of Uncoupling Proteins 2 and 3 in a Carnivorous Marsupial, the Tasmanian Devil (Sarcophilus harrisii); Physiological and Biochemical Zoology
Morphological and functional plasticity of olfactory ensheathing cells; Journal of Neurocytology
Morphological plasticity of olfactory ensheathing cells; Australian Neuroscience Society
Morphological Plasticity of Olfactory Ensheathing Cells Is Regulated by cAMP and Endothelin-1; Glia
Morphological plasticity of olfactory ensheathing cells is regulated by cyclic AMP and endothelin-1; Symposium on Neural Regeneration
Nerve growth factor promotes olfactory axonal elongation; Neuroreport
Neuorn-glia communication: metallothionein expression is rapidly increased by astrocytes in response to neuronal injury; Symposium on Neural Regeneration
Neuregulin and nogo expression in olfactory ensheathing cells after transplantation into the injured spinal cord; Symposium on Neural Regeneration
Neuron-astrocyte interactions following neuronal injury activate a novel, metallothionein based neuroprotective mechanism; The International Neurotrauma Symposium
Neuron-astrocyte signalling regulates astrocytic expression of neuroprotective metallothionein protein following neuronal injury; Asia-Pacific Society for Neurochmistry
Neuron-glia communication: metallothionein expression is rapidly increased by astrocytes in response to neuronal injury; First Joint Symposium of the National and International Neurotrauma Societies
Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury; Journal of Neurochemistry
Neuron-glia interaction and metallothionein expression in a culture model of axonal injury; The Australian Neuroscience Society
Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain ; The F E B S Journal
Neuronally released factors induce metallothionein in neighbouring astrocytes following injury; Combio 2003
Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins; Journal of Biological Inorganic Chemistry
New insight into the molecular pathways of metallothionein-mediated neuroprotection and regeneration; Journal of Neurochemistry
New strategies in neuroprotection and neurorepair; Neurotoxicity Research
No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases; Neurobiology of Disease
Non-shivering thermogenesis in a carnivorous marsupial, Sarcophilus harrisii, in the absence of UCPI; Journal of Thermal Biology
Nonshivering Thermogenesis in a Marsupial (the Tasmanian Bettong Bettongia gaimardi) Is Not Attributable to Brown Adipose Tissue; Physiological and Biochemical Zoology
Olfactory ensheathing cell phenotype following implantation in the lesioned spinal cord; Cellular and Molecular Life Sciences
Olfactory ensheathing cells are attracted to, and are capable of phagocytosing bacteria; The 28th Annual Meeting of the Australian Neuroscience Society
Olfactory ensheathing cells are attracted to, and can endocytose, bacteria; Cellular and Molecular Life Sciences
Olfactory ensheathing cells display antimicrobial activity in culture and may contribute to the innate immune defense of the olfactory system; Australian Neuroscience Society
Olfactory ensheathing cells exhibit different rates of proliferation and apoptosis in the presence of uninjured and injured spinal cord tissue; The International Neurotrauma Symposium
Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes ; Molecular and Cellular Neuroscience
Olfactory Ensheathing Cells Produce BDNF and GDNF; 19th Annual Meeting of the Australian Neuroscience Society
Olfactory ensheathing cells produce NGF, BDNF, GDNF and neuregulins in culture; International Congress on Differentiation and Cell Biology
Olfactory ensheathing cells promote collateral axonal branching in the injured adult rat spinal cord; Experimental Neurology
Olfactory ensheathing cells promote collateral axonal branching in the lesioned adult rat spinal cord; Symposium on Neural Regeneration
Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors; Cellular and Molecular Life Sciences
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; 21st Annual National Neurotrauma Society Symposium
Olfactory ensheathing cells promote reactive neurite sprouting in vitro through both direct and indirect mechanisms; Society for Neuroscience Annual Meeting
Olfactory ensheathing cells, innate immunity and nitric oxide; Institute of Neurology, University College
Olfactory Ensheathing Cells: Nitric Oxide Production and Innate Immunity; Glia
Partitioning and distribution of RAPD variation in a forest tree species, Eucalyptus globulus (Myrtaceae); Heredity
Pathogens induce nitric oxide production by olfactory ensheathing cells; 7th IBRO World Congress of Neuroscience
Peripheral effects of metallothionein in brain injury: Altered immune system response in metallothionein-1/2 null mice; 4th International Congress on Stress Responses in Biology and Medicine
Production of neuro-active metallothionein-III isoforms and assay of their action in a rat model of cortical damage; Combio, 2000
Proliferation, apoptosis and migration of ensheathing cells in response to spinal cord tissue; The Australian Neuroscience Society
Prolonged Aβ treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca+ homeostasis; Molecular Neurodegeneration
Protective role of metallothioneins in the injured mammalian brain; Reviews in the Neurosciences
Proteins and genes related to apoptosis are not elevated in pathological brain aging or Alzheimer's disease; Society for Neuroscience
RAPD variation in Eucalyptus globulus (Myrtaceae); CRCTHF-IUFRO
Recent insights into the neuroprotective role of metallothionein in the injured brain; The Australian Neuroscience Society
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury; Journal of Biological Chemistry
Redox-active Cu(II)Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner; Experimental Neurology
Relationships within Eucalyptus (Myrtaceae) using PCR-amplification and southern hybridisation of chloroplast DNA; Australian Systematic Botany
Relationships within Eucalyptus using Chloroplast DNA; Australian Systematic Botany
Response of neurons to injury in coculture with olfactory ensheathing cells; International Society for Developmental Neuroscience
Restriction fragment length polymorphisms in chloroplast DNA from six species of eucalyptus; Australian Journal of Botany
Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III; Biochemical Journal
Shivering, muscle tone, and uncoupling proteins in a developing marsupial, the Tasmanian bettong (Bettongia gaimardi); Journal of Thermal Biology
Specific increase in metallothionein I/II labelled glial cells in early stage Alzheimer's disease; 37th Annual Meeting of the Australian Society for Medical Research
Specific increase in metallotionein I/II labelled glial cells in early stage Alzheimer's disease; 37th Annual Meeting of the Australian Society for Medical Research
Spinal cord tissue affects ensheathing cell proliferation and apoptosis; NeuroReport
Structure and synthesis of the neuroactive metallothionein isoform, MTIII (Growth Inhibitory Factor); Human Genome Meeting, 1999
Tg2576 cortical neurons that express human Aβ are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration ; PL o S One
The apolipoprotein epsilon 4 gene is associated with elevated risk of normal tension glaucoma; Molecular Vision
The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions; Molecular and Cellular Neuroscience
The global gene expression of olfactory ensheathing cells and comparisons to astrocytes and Schwann cells; The Australian Neuroscience Society
The link between cellular changes associated with axonal injury and Alzheimer's Disease; The International Neurotrauma Symposium
The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons; P L o S One
The role of extracellular metallothionein in cortical wound healing; 23rd Annual Meeting of the Australian Neuroscience Society
The Role of Metallothionein and Astrocyte-Neuron Interactions in Injury to the CNS; Metallothioneins in Biochemistry and Pathology
The role of metallothionein in neurological disorders
Transcriptional insights on the regenerative mechanics of axotomized neurons in vitro; Journal of Cellular and Molecular Medicine
Trinucleotide expansion in Tasmanian HD families; Australian & New Zealand Journal of Psychiatry
Understanding excitotoxicity and neuron death: focus upon the axonal cytoskeleton; The Australian Neuroscience Society
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; Society for Neuroscience Annual Meeting
What is an olfactory ensheathing cell? A microarray comparison of ensheathing cells, Schwann cells and astrocytes; 21st Annual National Neurotrauma Society Symposium
Whole bacteria, but not specific ligands for Toll-like receptors 2 or 4, activate NF kB and cytokine production in olfactory ensheathing cells in vitro; Society for Neuroscience
Zn(II)- and Cu(II)- induced non-fibrillar aggregates of amyloid- (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators; Journal of Neurochemistry

Research Projects

Analysis of a methanogenic Antarctic microbial community by molecular probes and flow cytometry; Antarctic Science Advisory Committee (ASAC)
Assessing the Ability of Metallothionein to Promote Functional Recovery in an Animal Model of Traumatic Spinal Cord Injury; Royal Hobart Hospital Research Foundation (RHHRF)
Assessing the role of metallothionein in the development of non-melanoma skin cancer; Royal Hobart Hospital Research Foundation (RHHRF)
Cellular mechanisms that protect against copper-bound beta-amyloid; Australian Research Council (ARC)
Characterization and Molecular Cloning of a Novel and Ubiquitous P-glycoprotein Homologue; Australian Research Council (ARC)
Characterization of metallothionein in three novel marine species: a potential index for environmental cadmium exposure; Australian Research Council (ARC)
Developing metallothioneine as a therapeutic agent for the treatment of traumatic brain injury; MAIB Injury Prevention & Management Foundation (MAIB)
Development of a novel early diagnostic test for Alzheimer's Disease; The Mason Foundation (ANZCT-Mason Fdn)
Development of a therapeutic agent for a chemotherapy-induced neuropathy; Royal Hobart Hospital Research Foundation (RHHRF)
Do metallothioneins promote and direct regenerative growth of epidermal nerve fibres in diabetic peripheral neuropathy?; Brain Foundation (BrainF)
Do metallothioneins protect DNA from oxidative damage in vivo; Australian Research Council (ARC)
Early events in cardiac hypertrophy: regulation of protooncogene expression in the rat heart by hypertrophic stimuli; National Heart Foundation (NHF)
Effect of metallothionein and exercise on progression of motor neurone disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Ensheathing cells and neurotrophic factors; Australian Research Council (ARC)
Establishment of a Confocal/multiphoton Microscope for Imaging of Living Systems; Australian Research Council (ARC)
Establishment of a DNA Sequencing Facility at the University of Tasmania; University of Tasmania (UTAS)
Establishment of a Fluorescent Stereo-microscope Facility to Determine the Ability of Mature Neurons to Recover from Trauma; National Health & Medical Research Council (NHMRC)
Evaluation of the ability of vitamin D and metallothionein to protect against UV-radiation induced skin cancer ; Cancer Council of Tasmania (CCT)
Focal demyelination in Alzheimer's disease; National Health & Medical Research Council (NHMRC)
Genetic Analysis of Olfactory Ensheathing Cell Action During the Implantation into Lesioned Spinal Cords; International Institute for Research in Paraplegia (IRIP)
Healthy and Pathological Ageing of the Human Brain: Cellular, Gene Expression and Diagnostic Studies; National Health & Medical Research Council (NHMRC)
How do Olfactory Ensheathing Cells Repair Injured Nerve Cells; National Health & Medical Research Council (NHMRC)
How does the LRP receptor megalin promote regenerative neuronal growth?; National Health & Medical Research Council (NHMRC)
How Does the Neuroactive Peptide, MT-III Inhibit Sprouting Microarray Analysis of its Action on Cultured Neurons; University of Tasmania (UTAS)
Human metallothionein locus: structure, regulaton and expression; National Health & Medical Research Council (NHMRC)
Identifying the Specific Structural Features of Metallothionein that Regulate its Ability to Modulate Astrogliosis; Australian Research Council (ARC)
Interactions between injured neurons, astrocytes and metallothionein; National Health & Medical Research Council (NHMRC)
Involvement of Nitric Oxide in Capillary Regrowth in Insulin Resistant Muscle; Diabetes Australia Research Trust (DART)
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast; National Health & Medical Research Council (NHMRC)
Luminometry System; National Health & Medical Research Council (NHMRC)
Mechanism of Metallothionein Action on Injured Neurons; Royal Hobart Hospital Research Foundation (RHHRF)
Metallothionein levels in the blood - a new indicator of cadmium exposure in industry; Pasminco Metals-EZ (EZ)
Metallothionein-based Neuroprotection in a Transgenic Mouse Model of Motor Neurone Disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Metallothionein-based therapeutic for Alzheimer's Disease; Alzheimer's Australia Dementia Research Foundation (AADRF)
Modulating beta-amyloid aggregation and toxicity with natural metal-binding proteins; National Health & Medical Research Council (NHMRC)
Neural Protection by MT-III Following Head Injury; MAIB Injury Prevention & Management Foundation (MAIB)
Olfactory Ensheathing Cells in the Defence of the Brain Against Viral and Bacterial Infection; University of Tasmania (UTAS)
Olympus Fluorescence and phase contrast optics; National Health & Medical Research Council (NHMRC)
Oxidative damage, Alzheimer's disease and the neural expression of metallothionein; National Health & Medical Research Council (NHMRC)
Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists; National Health & Medical Research Council (NHMRC)
Protection of the brain from infection: Immune properties of olfactory ensheathing cells; Royal Hobart Hospital Research Foundation (RHHRF)
Purchase of a High Resolution Organic Mass Spectrometer; Australian Research Council (ARC)
Redefining the Metallothionein's role in the Injured Brain: Extracellular Metallothioneins Play an Important Role in Astrocyte-neuron Responses to Injury; Australian Research Council (ARC)
Refrigerated Benchtop Centrifuge; National Health & Medical Research Council (NHMRC)
Regulation of leaf development in Pisum; Australian Research Council (ARC)
Regulation of the beta-secretase (BACE1) by glycosaminoglycans; National Health & Medical Research Council (NHMRC)
Repulsion and Attraction: How do LRPs turn growth cones? ; National Health & Medical Research Council (NHMRC)
Study of an inherited disease in Tasmania which causes multiple hormone-producing tumours; National Health & Medical Research Council (NHMRC)
Synthesis of Metallothionein III, and its Growth Inhibitory Properties in a Model of Alzheimer's Disease; Clifford Craig Medical Research Trust/UTAS (CCMRT/UTAS)
Synthesis of the Growth Inhibitory Factor, MT-III, and its trophic actions on cortical neurons in culture and in vivo; Australian Research Council (ARC)
Ultracentrifuge for molecular biological studies; National Health & Medical Research Council (NHMRC)
Ultracentrifuge for molecular biological studies; Australian Research Council (ARC)
Unravelling the cellular pathology underlying neuronal degeneration in motor neuron disease; Motor Neurone Disease Research Institute of Australia Inc (MNDRIA)
Upgrade of the flow cytometry facility of the Menzies Research Institute with a multi-parameter analytical flow cytometer CyAn ADP 9 Color for key applications ; Clive & Vera Ramaciotti Foundation (CVRF)
Uptake of environmental cadmium by metallothionien in marine organisms; Australian Research Council (ARC)
Use of Ensheathing Cells to Promote Nervous Tissue Recovery Following Injury; MAIB Injury Prevention & Management Foundation (MAIB)
Using Metallothioneins as a Model for Understanding Cellular and Biochemical Interactions between Neurons and Astrocytes within the Brain; Australian Research Council (ARC)
Validation of Phylomer peptides in neurotrauma-related brain injury models; Western Australian Institute of Medical Research (WAIMR)
Visualising neuron-glia interactions in the injured central nervous system; Australian Research Council (ARC)
Contract research on neuroactivity of Phylogica compounds
Investigation of neuroprotection and neuroregeneration by metallothionein

Research Candidate Supervision

Alpha-, Beta-, and Gamma-Synuclein- Developmental Localisation and Response to Cellular Insult in Neurons and Oligodendrocytes.
Anti-bacterial Properties of Olfactory Ensheathing Cells and the Primary Olfactory Pathway
Defining the Molecular Events Required for GM-CSF Gene Activation in T Cells
Functional analysis and genetic mapping of mouse centromere protein genes
Homer, TRP Channels and Calcium- The Signalling Triad of Growth Cone Motility
Immune System Modulation in the Brain Injury of the Metallothionein-I/II null Mutant Mouse
Interactions Between Metallathionein and Neurons of the CNS
Interactions Between Olfactory Ensheathing abd Cells of the Central Nervous System
Investigating the Genetics of Primary Open-Angle Glaucoma in Tasmania
Investigating the Potential Theraputic Value of Metallothionein-Like Derivatives in Neurodegenrative Disorders
Investigation of the therapeutic potential of metallothionein IIA in a model of motor neurone disease, the G93A SOD1 transgenic mouse
Investigations of Cataract Genetics
Leaf and seed development in Pea (Pisum sativum L.)
LRP Receptors in a Novel Mechanism of Axon Pathfinding and Peripheral Nerve Regeneration
Metallothionein release from astrocytes in the brain and culture as a response to injury
Metallothioneins of Monodelphis Domestica
Molecular biology
Molecular Studies of Tachykinin and Vanilloid Receptors- Expression and Function
Olfactory Ensheathing Cell Phenotype after Implantation into the Lesioned Spinal Cord
Olfactory Ensheathing Cells Moderate Astrocyte Inflammatory Activation
Pathological Changes Leading to Neuronal Degeneration in Alzheimer's Disease
Role of Lipoprotein Receptor-Related Proteins (LPRs) in Directing Neuronal Biology
Structure and Expression of Mammalian Metallothioneins
The Application of DNA-Based Methods to the Diet of Antarctic Krill (Euphausia Superba)
The Morphological and Molecular Characterisation of Olfactory Ensheathing Cells
The Physiological Mechanisms of Endothermy in Marsupials- Identification of Thermogenic Abilities and Expression of Uncoupling Proteins
The role of extracellular metallothioneins in the cellular response to neuronal injury
The use of random amplified polymorphic DNA (RAPD) technology in Eucalyptus glubulus.
Title- Expression of Nuclear-Acting Early-Response Genes in the Rat Heart- implications for cardiac hypertrophy