Web Access Research Portal

Researcher: Rattigan, S (Professor Stephen Rattigan)

Fields of Research

Endocrinology
Cardiology (incl. cardiovascular diseases)
Systems physiology
Cell metabolism
Animal physiology - systems
Biochemistry and cell biology
Epidemiology
Medical biochemistry - lipids
Peripheral nervous system
Basic pharmacology
Exercise physiology
Zoology
Medical biotechnology
Agricultural biotechnology diagnostics (incl. biosensors)
Gene and molecular therapy
Medical biochemistry - carbohydrates
Medicinal and biomolecular chemistry
Medical biochemistry - nucleic acids
Health services and systems
Central nervous system
Metabolic medicine
Cell physiology
Medical physiology
Clinical pharmacology and therapeutics
Protein trafficking
Preventative health care
Animal physiology - biophysics
Sensory systems
Nutritional science

Research Objectives

Clinical health
Other health
Expanding knowledge in the environmental sciences
Human diagnostics
Human pharmaceutical treatments
Preventive medicine
Expanding knowledge in the health sciences
Behaviour and health
Disease distribution and transmission (incl. surveillance and response)
Diagnosis of human diseases and conditions
Health related to ageing
Medical instruments
Nutrition

Career Best Publications

Blood flow and muscle metabolism: a focus on insulin action; American Journal of Physiology: Endocrinology and Metabolism
Exercise Training Improves Insulin-Mediated Capillary Recruitment in Association With Glucose Uptake in Rat Hindlimb; Diabetes
Insulin sensitivity of muscle capillary recruitment in vivo; Diabetes
Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo; Diabetes
Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow; Diabetes

Research Publications

1-Methylxanthine Metabolism in Rat Skeletal Muscle Indicative of Nutritive Blood flow in Vitro and in Vivo; 10th International Conference on the Biochemistry of Exercise
A comparison of ultrasound and laser Doppler for Measuring Capillary Recruitment Using Models in vitro; ACSM Conference on Integrative Physiology of Exercise
A new method to study changes in microvascular blood volume in muscle and adipose tissue: real-time imaging in humans and rat; American Journal of Physiology: Heart and Circulatory Physiology
A vascular mechanism for high-sodium-induced insulin resistance in rats; Diabetologia: Clinical and Experimental Diabetes and Metabolism
Activation of AMP-Activated Protein Kinase by 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside in the Muscle Microcirculation Increases Nitric Oxide Synthesis and Microvascular Perfusion; Arteriosclerosis, Thrombosis, and Vascular Biology
Active role for the vasculature in the delivery of insulin to skeletal muscle; Clinical and Experimental Pharmacology and Physiology
Acute AICAR infusion stimulates capillary recruitment in skeletal muscle; American Diabetes Assocaition, 66th Scientific Sessions
Acute blockade by endothelin-1 of haemodynamic insulin action in rats; Diabetologia
Acute divergent effects of AICAR on insulin action in vivo; American Diabetes Association, 63rd Scientific Sessions
Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo; American Journal of Physiology: Endocrinology and Metabolism
Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment; Diabetologia
Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha; Diabetes
Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle; Journal of Nutritional Biochemistry
Acute vasoconstriction-induced insulin resistance in rat muscle in vivo; Diabetes
Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle; Cardiovascular Research
Adiponectin opposes endothelin-1-mediated vasoconstriction in the perfused rat hindlimb; American Journal of Physiology: Heart and Circulatory Physiology
Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?; American Journal of Physiology: Endocrinology and Metabolism
Axially symmetric semi-infinite domain models of microdialysis and their application to the determination of nutritive flow in rat muscle; Journal of Physiology
Barriers to the management of Diabetes Mellitus - is there a future role for Laser Doppler Flowmetry?
Blood flow and glucose uptake by muscle; 42nd Annual Conference
Blood flow and muscle metabolism: a focus on insulin action; American Journal of Physiology: Endocrinology and Metabolism
Blueberry tea enhances insulin sensitivity by augmenting insulin-mediated metabolic and microvascular responses in skeletal muscle of high fat fed rats; International Journal of Diabetology & Vascular Disease Research
Capillary recruitment in muscle is a highly sensitive event in insulin action in vivo; American Diabetes Association, 63rd Scientific Sessions
Cardiac Ca2+ Channels and Sarcolemma Redox; Plasma Membrane Oxidoreductases in Control of Animal and Plant Growth
cGMP degrading phosphodiesterases are expressed differentially in skeletal muscle vasculature; American Diabetes Association, 66th Scientific Sessions
cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle; American Journal of Physiology: Endocrinology and Metabolism
Circulating triglyceride and muscle; Seventh Scientific Meeting
Contraction-mediated capillary recruitment is not impaired in muscle of insulin-resistant obese Zucker rats; American Diabetes Assocaition, 62nd Scientific Sessions
Contraction-mediated muscle capillary recruitment and metabolic responses in vivo are resistant to TNFα; 18th International Diabetes Federation Congress
Contrast-enhanced ultrasound measurement of microvascular perfusion relevant to nutrient and hormone delivery in skeletal muscle: A model study in vitro; Microvascular Research
CrossTalk proposal: De novo capillary recruitment in healthy muscle is necessary; Journal of Physiology
Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance; Journal of Physiology
Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound; Ultrasound in Medicine and Biology
Differential effects of glucagon-like peptide-1 on microvascular recruitment and glucose metabolism in short- and long-term insulin resistance; Journal of Physiology
Differential expression of cGMP degrading phosphodiesterases in skeletal muscle vasculature; COMBIO 2006 Meeting
Effect of blueberry tea on improving metabolic and vascular function in people with and without type 2 diabetes - A Pilot Study; Australian Diabetes Society and the Australian Diabetes Educators Association Annual Scientific Meeting 2016
Effect of Muscle Contraction on Metabolism of 1-Methylxanthine and L-Arginine in the Constant-Flow Perfused Rat Hindlimb; 10th International Biochemistry of Exercise Conference
Effect of Phorbol Esters on the Distribution and Total Activity of Protein Kinase C in the Perfused Rat Heart; International Journal of Biochemistry
Effects of central administration of insulin or L-NMMA on rat skeletal muscle microvascular perfusion; Diabetes Obesity & Metabolism
Effects of wortmannin on insulin-mediated action in vivo; American Diabetes Association, 63rd Scientific Sessions
Enantioselective disposition of (R/S)-albuterol in skeletal and cardiac muscle; Drug Testing and Analysis
Endothelial Na+ -D-glucose cotransporter: No Role in Insulin-mediated Glucose Uptake ; Hormone and Metabolic Research
Endothelin-1 as a messenger for insulin has both stimulatory and inhibitory effects on perfused muscle metabolism via its vascular actions; American Diabetes Association, 64th Scientific Sessions
Endothelin-1 inhibits insulin action in vivo; 42nd Annual Meeting of the EASD
Endothelin-1 vascular and resultant metabolic actions in perfused rat hindlimb are opposed by insulin; 41st EASD Annual Meeting
Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; Cardiovascular Diabetology
Evidence of Capillary Recruitment by Insulin but not Epinephrine in Rat Muscle in Vivo; 34th Meeting of the American Diabetes Association
Exercise and insulin-mediated capillary recruitment in muscle; Exercise and Sport Sciences Reviews
Exercise aortic stiffness: Reproducibility and relation to end-organ damage in men; Journal of Human Hypertension
Exercise increases human skeletal muscle insulin sensitivity via coordinated increases in microvascular perfusion and molecular signaling; Diabetes
Exercise training by rats enhances insulin's microvascular effects in skeletal muscle; 7th World Congress for Microcirculation
Exercise Training Improves Insulin-Mediated Capillary Recruitment in Association With Glucose Uptake in Rat Hindlimb; Diabetes
Factors influencing the hemodynamic and metabolic effects of insulin in muscle; Current Diabetes Reviews
Failure of laser Doppler signal to correlate with total flow in muscle: Is this a question of vessel architecture?; Microvascular Research
Fatty acids as potential mediators of skeletal muscle thermogenesis; 1st Colloquium on Mitochondria and Myopathies
Flow motion in skeletal muscle is associated with increased nutritive flow and insulin action; 71st Scientific Sessions of the American Diabetes Association
Flow motion in skeletal muscle microvasculature is associated with increased nutritive flow; Australia and New Zealand Microcirculation Society Conference
GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle; American Journal of Physiology: Endocrinology and Metabolism
Glucosamine induces acute insulin resistance in muscle in vivo assocaited with impaired capillary recruitment; 41st EASD Annual Meeting
Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice; Journal of Applied Physiology
Graded occlusion of perfused rat muscle vasculature decreases insulin action; Clinical Science
Haemodynamic insulin resistance increases fatty acid uptake by connective tissue adipocytes in red muscles; EASD, 36th Annual Meeting
Hemodynamic actions of insulin in rat skeletal muscle: evidence of capillary recruitment; Diabetes
Hemodynamic Effects of Insulin Action in Rat Skeletal Muscle in Vivo; Federation of American Societies of Experimental Biology
Heterogeneity of laser Doppler flowmetry in perfused muscle indicative of nutritive and non nutritive flow; American Journal of Physiology
Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes; Diabetologia
Impairments in adipose tissue microcirculation in Type 2 diabetes mellitus assessed by real-time contrast-enhanced ultrasound; Circulation: Cardiovascular Imaging
Improved method of measuring changes in microvascular capillary blood flow
Improved method of measuring changes in microvascular capillary blood flow
Increased chylomicron triglyceride hydrolysis by connective tissue flow in perfused rat hindlimb: Implications for lipid storage; Journal of Lipid research
Increased metabolism of infused 1-methylxanthine by working muscle; Acta Physiologica Scandinavica
Increased resting muscle thermogenesis using pharmacological intervention; Fourth Scientific Meeting of the Australian Society for the Study of Obesity
Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin; American Journal of Physiology: Endocrinology and Metabolism
Inhibition of insulin-mediated glucose uptake in rat hindlimb by an alpha-adrenergic vascular effect; American Journal of Physiology: Endocrinology and Metabolism
Inhibition of nitric oxide synthase prevents insulin-stimulated capillary recruitment and glucose uptake in skeletal muscle in vivo; American Diabetes Association, 61st Scientific Sessions
Insulin action and blood flow within muscle; 37th National Scientific Conference
Insulin Action in Skeletal Muscle and Skin Microcirculation; 7th World Congress for Microcirculation
Insulin alters the distribution of volume of blood flow in rat skeletal muscle in vivo: Assessment by 1-methylxanthine metabolism and ultrasound; American Diabetes Association Meeting
Insulin and contraction increase nutritive blood flow in rat muscle in vivo: determined by microdialysis of L-[14C]glucose; Journal of Physiology
Insulin delivery to muscle is sensitive to tissue perfusion; 42nd Annual Meeting of the EASD
Insulin sensitivity of muscle capillary recruitment in vivo; Diabetes
Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment; Clinical Science
Insulin-induced microvascular recruitment in skin and muscle are related and both are associated with whole-body glucose uptake; Microcirculation
Insulin-mediated capillary recruitment and glucose uptake in rat hindlimb enhanced by voluntary exercise training; American Diabetes Association, 61st Scientific Sessions
Insulin-mediated capillary recruitment in muscle: implications for glucose uptake and insulin resistance; Diabetic Complications: Mechanisms Underlying Neuronal and Vascular Changes
Insulin-mediated Capillary Recruitment in Skeletal Muscle: Is This a Mediator of Insulin Action on Glucose Metabolism?; Current Diabetes Reports
Insulin-mediated capillary recruitment is impaired in muscle of obese Zucker rats; American Diabetes Association, 61st Scientific Sessions
Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats; Diabetes
Interaction between blood flow, metabolism and exercise; Biochemistry of Exercise X
Interaction between metabolism and flow in tendon and muscle; Scandinavian Journal of Medicine and Science in Sports
Interleukin-6 attenuates insulin-mediated increases in endothelial cell signaling but augments skeletal muscle insulin action via differential effects on tumor necrosis factor- expression; Diabetes
Interleukin-6 increases glucose uptake but does not increase AMPK activity in L6 myotubes and perfused rat hindlimb; AMPK 2004, 3rd International Symposium on AMP-activated protein kinase
Laser Doppler flowmetry, but not contrast enhanced ultrasound, influenced by flow when measuring changes in muscle capillary recruitment - a study in vitro; Exercise, Insulin Sensitivity and Diabetes - What is new?
Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise; Journal of Applied Physiology
Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo; Diabetes
Local hindlimb antioxidant infusion does not affect muscle glucose uptake during in situ contractions in rat; Journal of Applied Physiology
Local infusion of an inhibitor of Ca2+ dependent K+ channels (TEA), but not L-NAME blocks insulin-mediated capillary recruitment and glucose uptake in muscle in vivo; American Diabetes Association, 65th Scientific Sessions
Local methacholine but not bradykinin potentiates insulin-mediated capillary recruitment and glucose uptake in muscle in vivo; American Diabetes Association, 64th Scientific Sessions
Local methacholine but not bradykinin potentiates insulin-mediated capillary recruitment and glucose uptake in muscle in vivo; Diabetologia
Local nitric oxide synthase inhibition reduces skeletal muscle glucose uptake but not capillary blood flow during in situ muscle contraction in rats; Diabetes
Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo; American Journal of Physiology: Endocrinology and Metabolism
Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance ; Diabetes Obesity & Metabolism
Metabolic and vascular actions of endothelin-1 are inhibited by insulin-mediated vasodilation in perfused rat hindlimb muscle; British Journal of Pharmacology
Methods and pharmaceuticals for treating muscle insulin resistance and related conditions
Methods and pharmaceuticals for treating muscle insulin resistance and related conditions
Microsphere infusion reverses vasoconstrictor-mediated changes in hindlimb oxygen uptake and energy status; Acta Physiologica Scandinavica
Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats; Diabetes, Obesity and Metabolism
Microvascular contributions to insulin resistance; Diabetes
Microvascular flow routes in muscle controlled by vasoconstrictors; Microvascular Research
Microvascular involvement in insulin resistance of skeletal muscle; 7th World Congress for Microcirculation
Microvascular involvement in insulin resistance of skeletal muscle; 7th World Congress for Microcirculation
Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo; Diabetes
Muscle capillary recruitment and glucose uptake of genetically obese rats respond to contractions but not insulin; American Diabetes Association, 64th Scientific Sessions
Muscle insulin resistance resulting from impaired microvascular insulin sensitivity in Sprague Dawley rats; Cardiovascular Research
Muscle metabolism and control of capillary blood flow: insulin and exercise; Essays in Biochemistry
Muscle microvascular blood flow responses in insulin resistance and ageing; The Journal of Physiology
Muscle perfusion: its measurement and role in metabolic regulation; Diabetes
N Acetylcysteine infusion does not affect glucose disposal during prolonged moderate-intensity exercise in humans; Journal of Physiology
Na+ channel and Na+/K+ ATPase involvement in norepinephrine- and veratridine-stimulated metabolism in perfused rat hind limb; Canadian Journal of Physiology and Pharmacology
Nitric oxide is required for the insulin sensitizing effects of contraction in mouse skeletal muscle; Journal of Physiology
No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats; American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Nonnutritive flow impairs uptake of fatty acids by white muscles of the perfused rat hindlimb; American Journal of Physiology: Endocrinology and Metabolism
Norepinephrine and serotonin vasoconstriction in rat hindlimb control different vascular flow routes; American Journal of Physiology
Nutritive and non-nutritive blood flow in muscle affects microdialysis outflow/inflow ratio; 7th World Congress for Microcirculation
Nutritive and non-nutritive blood flow: rest and exercise; Acta Physiologica Scandinavica
Nutritive blood flow affects microdialysis O/I ratio for [14C]ethanol and 3H2O in perfused rat hindlimb; American Journal of Physiology-Heart and Circulatory Physiology
Nutritive blood flow as an essential element supporting muscle anabolism; Current Opinion in Clinical Nutrition and Metabolic Care
Nutritive blood flow improves interstitial glucose and lactate exchange in perfused rat hindlimb; American Journal of Physiology - Heart and Circulatory Physiology
Obesity, Insulin Resistance, and Capillary Recruitment; Microcirculation
Oral glucose challenge impairs skeletal muscle microvascular blood flow in healthy people; American Journal of Physiology - Endocrinology and Metabolism
Oxygen uptake stimulated by veratridine but not phenylephrine in the constant-flow arrested rat heart: absence of vasoconstrictor-mediated thermogenesis in heart; 43rd Annual Conference
Partial microsphere embolism of muscle leads to acute impairment of insulin-mediated glucose uptake without compromising resting energetics; American Diabetes Association, 65th Scientific Sessions
Perfused skeletal muscle contraction and metabolism improved by angiotensin II-mediated vasoconstriction; American Journal of Physiology
Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in viv; American Journal of Physiology: Endocrinology and Metabolism
Physiologic Hyperinsulinemia Enhances Human Skeletal Muscle Perfusion by Capillary Recruitment; Diabetes
Point: Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise; Journal of Appliedy Physiology
Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic-euglycaemic clamp; Clinical and Experimental Pharmacology and Physiology
Potential defect in the vascular control of nonshivering thermogenesis in the obese Zucker rat hind limb; Canadian Journal of Physiology and Pharmacology
Potential for endothelin-1-mediated impairment of contractile activity in hypertension; Clinical and Experimental Physiology and Pharmacology
Pulsatile interaction between the macro-vasculature and micro-vasculature: proof-of-concept among patients with type 2 diabetes; European Journal of Applied Physiology
Rebuttal from Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa; The Journal of physiology
Reduced nutritive flow in experimental hypertension: the cause of hyperglycemia and hyperlipidemia?; American Diabetes Association, 62nd Scientific Sessions
Regulation of microvascular flow and metabolism: An overview; Clinical and Experimental Pharmacology and Physiology
Regulation of muscle glucose uptake in vivo by insulin-mediated capillary recruitment; 41st Annual Conference
Relationship of MTT reduction to stimulants of muscle metabolism; Chemico-Biological Interactions
Resiniferatoxin treatment reverses impaired capillary recruitment and insulin resistance in the obese Zucker rat; American Diabetes Association, 65th Scientific Sessions
Role for the Microvasculature in Glucose Uptake in Skeletal Muscle; Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments)
Role of capillary recruitment in the potentiation of insulin action by prior exercise; American Diabetes Association, 64th Scientific Sessions
Sciatic Nerve Severance Produces Haemodynamic Changes and Insulin Resistance in Muscle; 16th International Diabetes Federation Congress
Sciatic nerve severance produces insulin resistance without changes in 1-MX metabolism; ADA, 60th Scientific Sessions
Serotonin inhibition of 1-methylxanthine metabolism parallels its vasoconstrictor activity and inhibition of oxygen uptake in perfused rat hindlimb; Acta Physiologica Scandinavica
Similarities between vasoconstrictor- and veratridine-stimulated metabolism in perfused rat hind limb; Canadian Journal of Physiology and Pharmacology
Size-Dependent Effects of Microspheres on Vasoconstrictor-Mediated Change in Oxygen Uptake by Perfused Rat Hindlimb; Microvascular Research
Skeletal muscle contraction stimulates capillary recruitment and glucose uptake in insulin resistant obese Zucker rats; American Journal of Physiology - Endocrinology and Metabolism
Skeletal Muscle Microvascular Recruitment by Physiological Hyperinsulinemia Precedes Increases in Total Blood Flow; Diabetes
Skeletal muscle microvascular-linked improvements in glycemic control from resistance training in individuals with Type 2 Diabetes; Diabetes Care
Skeletal muscle nitric oxide signaling and exercise: a focus on glucose metabolism; American Journal of Physiology: Endocrinology and Metabolism
Skeletal muscle vascular involvement in insulin action and insulin resistance; International Symposium on Resistance Arteries 1996
Spatial Distribution of Nutritive and Nonnutritive Vascular Routes in Perfused Rat Hindlimb Muscle Using Microspheres; Microvascular Research
Stimulation of oxygen uptake (VO2) in muscle by alpha1- and beta3-adrenoceptors; Fourth Scientific Meeting of the Australian Society for the Study of Obesity
T-1032 a cyclic GMP phosphodiesterase-5 inhibitor blocks physiologic insulin-mediated muscle hemodynamic effects and glucose uptake in vivo; American Diabetes Association, 63rd Scientific Sessions
T-1032, a cyclic GMP phosphodiesterase-5 inhibitor, acutely blocks physiologic insulin-mediated muscle haemodynamic effects and glucose uptake in vivo; British Journal of Pharmacology
The Microvasculature in Insulin Resistance and Type 2 Diabetes; Seminars in Vascular Medicine
The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake; Diabetes/Metabolism Reseach and Reviews
There is / is not capillary recruitment in active skeletal muscle during exercise; Journal of Applied Physiology
Thermogenesis in resting muscle: a role for sodium channels?; 43rd Annual Conference of the Australian Society for Biochemistry and Molecular Biology
Thermogenesis of resting muscle: key roles for sodium channels and Na+/K+ ATPase in catecholamine effects; 42nd Annual Conference
TNFα and IL-6 differently affect insulin action in vivo; 18th International Diabetes Federation Congress
TNF? inhibits low physiologic but not high insulin-mediated capillary recruitment and glucose uptake in vivo; American Diabetes Association, 62nd Scientific Sessions
TNFalpha acutely inhibits vascular effects of physiological but not high insulin or contraction; American Journal of Physiology: Endocrinology and Metabolism
Treatment with the thiazolidinedione (BRL 49653) decreases insulin resistance in obese Zucker hindlimb; Hormone and Metabolic Research
Use of microdialysis to assess capillary recruitment in muscle - a study in vitro; Exercise, Insulin Sensitivity and Diabetes - What is nes?
Vascular and endocrine control of muscle metabolism; American Journal of Physiology: Endocrinology and Metabolism
Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate; Current Medicinal Chemistry
Vascular and metabolic effects of methacholine in relation to insulin action in muscle; Diabetologia
Vascular and metabolic regulation of muscle; Physiology, Stress and Malnutrition
Vascular control of nutrient delivery by flow distribution within muscle: implications for exercise and post-exercise muscle metabolism; International Journal of Sports Medicine
Vascular induced insulin resistance; Annual Scientific Meetings
Vasoconstrictor-mediated blood flow redistribution and acute insulin resistance in rat skeletal muscle in vivo; European Association for the Study of Diabetes
Vasoconstrictor-mediated increase in muscle resting thermogenesis is inhibited by membrane-stabilizing agents; Canadian Journal of Physiology and Pharmacology
Vasoconstrictor-mediated thermogenesis present in perfused skeletal muscle but absent from perfused heart; Journal of Thermal Biology
Vasoconstrictors alter oxygen, lactate, and glycerol metabolism in the perfused rat hindlimb of a rat kangaroo; American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

Research Projects

A haemodynamic basis for insulin resistance in skeletal muscle; National Health & Medical Research Council (NHMRC)
A muscle haemodynamic basis for hypertriglyceridemia and insulin resistance of hypertension.; Heart Foundation (HF)
Actions of the polyphenol epigallocatechin 3-gallate on insulin sensitivity; National Health & Medical Research Council (NHMRC)
Ambulatory central blood pressure as a novel explanation for diabetes-associated brain damage; Diabetes Australia Research Trust (DART)
Augmenting Microvascular Blood Flow in Muscle; National Health & Medical Research Council (NHMRC)
Blood Flow Routes in Muscle; Australian Research Council (ARC)
Cardiometabolic benefits of exercise training in type 2 diabetes independent of weight loss; University of Tasmania (UTAS)
Central and Peripheral Actions of Insulin for the Control of Muscle Capillary Recruitment; National Health & Medical Research Council (NHMRC)
Detrimental Haemodynamic Changes in Skeletal Muscle From Chronic Heart Failure; Heart Foundation (HF)
Development of Laser Doppler Flowmetry for Assessment of Muscle Microvascular Flow in Insulin Resistance; Clifford Craig Foundation (CCFoundation)
Development of pharmacological and dietary factors for the control of obesity; National Health & Medical Research Council (NHMRC)
Diode array detector; National Health & Medical Research Council (NHMRC)
Does exercise increase skeletal muscle insulin sensitivity via nitric oxide?; National Health & Medical Research Council (NHMRC)
Effects of vasomodulators on lipid clearance by perfused muscle; National Health & Medical Research Council (NHMRC)
Endothelin-1, type2 diabetes and hypertension; Heart Foundation (HF)
Glucose transport in normal and diabetic vascular smooth muscle; Diabetes Australia Research Trust (DART)
Gradient Thermal Cycler for PCR; National Health & Medical Research Council (NHMRC)
Haemodynamic Effects of Tumour Necrosis Factor-A to cause Muscle Insulin Resistance; Diabetes Australia Research Trust (DART)
Heart Foundation Career Development Fellowship; Heart Foundation (HF)
Insulin resistance and obesity from vascular shunting in muscle; National Health & Medical Research Council (NHMRC)
Insulin resistance in muscle from haemodynamic changes; National Health & Medical Research Council (NHMRC)
Insulin resistant diabetes resulting from haemodynamic changes within muscle; Australian Mutual Provident Society (AMPS)
Interaction between adiponectin and insulin in vascular control of glucose uptake in muscle; Heart Foundation (HF)
Isoelectric Focussing System; National Health & Medical Research Council (NHMRC)
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast; National Health & Medical Research Council (NHMRC)
Mechanisms Linking Insulin-Mediated Muscle Capillary Recruitment and Glucose Uptake; National Health & Medical Research Council (NHMRC)
Microvascular Defects and Insulin Resistance; Heart Foundation (HF)
Microvascular dysfunction in adult offspring of type 2 diabetics; Royal Hobart Hospital Research Foundation (RHHRF)
Mixed Meal Challenge A new diagnostic test for screening pre diabetes; Royal Hobart Hospital Research Foundation (RHHRF)
Muscle Vascular Research and Gene Therapy Using Ultrasound; Australian Research Council (ARC)
Near Miss - Microvascular Blood Flow in Cardiovascular Disease; University of Tasmania (UTAS)
Neural regulation of skeletal muscle insulin sensitivity; The Select Foundation (SelF)
NHMRC Research Fellowship (SRFA); National Health & Medical Research Council (NHMRC)
NHMRC Standard Equipment Grant - 2008; National Health & Medical Research Council (NHMRC)
Novel Therapeutic Interventions to Increase Blood Flow to Skeletal Muscle; National Health & Medical Research Council (NHMRC)
Nutrient and Hormone Delivery to Muscle: Interactions between Insulin and Exercise; National Health & Medical Research Council (NHMRC)
Refrigerated Benchtop Centrifuge; National Health & Medical Research Council (NHMRC)
Relationship Between Muscle Insulin Resistance and High Blood Pressure; Heart Foundation (HF)
Role of microvascular flowmotion in skeletal muscle glucose metabolism; National Health & Medical Research Council (NHMRC)
Skeletal Muscle Capillary Recruitment and Insulin Action; American Diabetes Association (ADA)
The Effects of Insulin on the Microvasculature; National Institutes of Health (NIH)
The Physiological Effect of Insulin on Microvascular Flow; National Institutes of Health (NIH)
The Role of Nutritive and Non-nutritive Blood Flow on Lipid Clearance by Normal and Insulin-resistant Muscle; Heart Foundation (HF)
The Role of the Endothelium in Insulin's In Vivo Action Upon Skeletal Muscle Metabolism; National Health & Medical Research Council (NHMRC)
NIDDM-GSK-Comparing Rosiglitazone and Metformnum for Microvascular Action in Muscle
Steve Rattigan_Discretionary Account

Research Candidate Supervision

Changes in gene expression in insulin resistant muscle
Develop a Greater Understanding of the Relationship between Neurons and Muscle with Respect to Type II Diabetes Specifically, How Inactivity and Denervation Impact Glucose Transportation
Effect of the Green Tea Polyphenol, EGCG, on Insulin Sensitivity
Effect of vascular flow on insulin resistance in skeletal muscle
Enhancing Blood Flow and Glucose Uptake in Insulin-Resistant Skeletal Muscle
Exercise and Insulin- Muscle Haemodynamics and Metabolism
Exercise Haemodynamics- Physiology and Clinical Consequences
Glucose Uptake in Skeletal Muscle
Hemodynamic and Metabolic Actions of Adiponectin in Muscle
Hemodynamic and metabolic changes in muscle in relation to insulin action
Impaired adipose tissue blood flow in obesity and the development of hypoxia
Insulin-Mediated Capillary Recruitment- Regulatory and Anatomical Aspects
Interactions between contraction, insulin and thiazolidinediones in skeletal muscle; a focus on capillary recruitment
Microvascular Dysfunction and the Development of Muscle Insulin Resistance
Muscle capillary recruitment and insulin action
Muscle fuel uptake- a result of hormone and substrate interaction affecting regional blood flow
Novel Technologies and Measurement of Microvascular Blood Flow in Muscle
Nutritive and Non-Nutritive Blood Flow in Muscle
Regulation of skeletal muscle metabolism
Relationship of microvascular flow distibution to skeletal muscle metabolism
Role of the endothelium in insulin mediated capillary recruitment.
Role of the Microvasculature in the Development of Muscle Insulin Resistance
The role of Flowmotion in Regulating Basal and Insulin-mediated Skeletal Glucose Uptake
The Role of iNOS in Vascular Dysfunction in Insulin Resistant States
Vascular & metabolic actions of insulin
Vascular and Metabolic Actions of Insulin and AMPK Activation in Muscle
Vascular effects of vasoconstrictors on muscle metabolism