Web Access Research Portal

Researcher: Howells, C (Ms Claire Howells)

Fields of Research

Central Nervous System
Cellular Nervous System
Neurology and Neuromuscular Diseases

Research Objectives

Nervous System and Disorders

Career Best Publications

Research Publications

Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain ; The F E B S Journal
Prolonged Aβ treatment leads to impairment in the ability of primary cortical neurons to maintain K+ and Ca+ homeostasis; Molecular Neurodegeneration
Redox-active Cu(II)Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner; Experimental Neurology
Tg2576 cortical neurons that express human Aβ are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration ; PL o S One
The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons; P L o S One
Zn(II)- and Cu(II)- induced non-fibrillar aggregates of amyloid- (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators; Journal of Neurochemistry

Research Projects

Research Candidate Supervision