Web Access Research Portal

Researcher: Keske, MAV (Dr Michelle Keske)

Fields of Research

Systems physiology
Cardiology (incl. cardiovascular diseases)
Peripheral nervous system
Animal physiology - systems
Medical biotechnology
Preventative health care
Nutrition and dietetics
Medical biochemistry - carbohydrates
Exercise physiology
Cell metabolism
Nutritional science
Basic pharmacology
Medical physiology
Public health nutrition
Medical biochemistry - amino acids and metabolites
Sensory systems
Traditional, complementary and integrative medicine
Geriatrics and gerontology
Proteins and peptides
Neurology and neuromuscular diseases
Clinical pharmacology and therapeutics
Central nervous system
Sports medicine
Foetal development and medicine
Animal physiology - biophysics
Health services and systems

Research Objectives

Clinical health
Other health
Preventive medicine
Human pharmaceutical treatments
Human diagnostics
Expanding knowledge in the health sciences
Expanding knowledge in the environmental sciences
Diagnosis of human diseases and conditions
Behaviour and health
Health related to ageing
Allied health therapies (excl. mental health services)
Expanding knowledge in the biological sciences
Medical instruments
Health education and promotion
Aboriginal and Torres Strait Islander health system performance
Public health (excl. specific population health)

Career Best Publications

Research Publications

A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents; Scientific Reports
A vascular mechanism for high-sodium-induced insulin resistance in rats; Diabetologia: Clinical and Experimental Diabetes and Metabolism
Active role for the vasculature in the delivery of insulin to skeletal muscle; Clinical and Experimental Pharmacology and Physiology
Acute vascular and metabolic actions of the green tea polyphenol epigallocatechin 3-gallate in rat skeletal muscle; Journal of Nutritional Biochemistry
Acute, local infusion of angiotensin II impairs microvascular and metabolic insulin sensitivity in skeletal muscle; Cardiovascular Research
Age-related anabolic resistance after endurance-type exercise in healthy humans; The FASEB Journal: (Federation of American Societies for Experimental Biology)
Are the metabolic benefits of resistance training in type 2 diabetes linked to improvements in adipose tissue microvascular blood flow?; American Journal of Physiology: Endocrinology and Metabolism
Association of exercise intolerance in type 2 diabetes with skeletal muscle blood flow reserve; JACC: Cardiovascular Imaging
Blood flow and muscle metabolism: a focus on insulin action; American Journal of Physiology: Endocrinology and Metabolism
Blueberry tea enhances insulin sensitivity by augmenting insulin-mediated metabolic and microvascular responses in skeletal muscle of high fat fed rats; International Journal of Diabetology & Vascular Disease Research
Brachial-to-radial SBP amplification: implications of age and estimated central blood pressure from radial tonometry; Journal of Hypertension
Brachial-to-radial systolic blood pressure amplification in patients with type 2 diabetes mellitus; Journal of Human Hypertension
Contraction stimulates nitric oxide independent microvascular recruitment and increases muscle insulin uptake ; Diabetes
CrossTalk proposal: De novo capillary recruitment in healthy muscle is necessary; Journal of Physiology
Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound; Ultrasound in Medicine and Biology
Effect of blueberry tea on improving metabolic and vascular function in people with and without type 2 diabetes - A Pilot Study; Australian Diabetes Society and the Australian Diabetes Educators Association Annual Scientific Meeting 2016
Effect of Muscle Contraction on Metabolism of 1-Methylxanthine and L-Arginine in the Constant-Flow Perfused Rat Hindlimb; 10th International Biochemistry of Exercise Conference
Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; Cardiovascular Diabetology
Exercise aortic stiffness: Reproducibility and relation to end-organ damage in men; Journal of Human Hypertension
Flow motion in skeletal muscle is associated with increased nutritive flow and insulin action; 71st Scientific Sessions of the American Diabetes Association
Flow motion in skeletal muscle microvasculature is associated with increased nutritive flow; Australia and New Zealand Microcirculation Society Conference
Functional and desensitizing effects of the novel synthetic vanilloid-like agent 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) in the perfused rat hindlimb; British Journal of Pharmacology
Glucose tolerance is improved by supplementation with carpobrotus rossii flavanoids in insulin resistant mice; Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia
Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes; Diabetologia
Impairments in adipose tissue microcirculation in Type 2 diabetes mellitus assessed by real-time contrast-enhanced ultrasound; Circulation: Cardiovascular Imaging
Increased metabolism of infused 1-methylxanthine by working muscle; Acta Physiologica Scandinavica
Increased muscle blood supply and transendothelial nutrient and insulin transport induced by food intake and exercise: effect of obesity and ageing; Journal of Physiology
Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin; American Journal of Physiology: Endocrinology and Metabolism
Inhibition of nitric oxide synthase prevents insulin-stimulated capillary recruitment and glucose uptake in skeletal muscle in vivo; American Diabetes Association, 61st Scientific Sessions
Insulin sensitivity of muscle capillary recruitment in vivo; Diabetes
Interaction between blood flow, metabolism and exercise; Biochemistry of Exercise X
Last word on Point:Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise; Journal of Applied Physiology
Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo; American Journal of Physiology: Endocrinology and Metabolism
Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance ; Diabetes Obesity & Metabolism
Metformin improves vascular and metabolic insulin action in insulin resistant muscle; Journal of Endocrinology
Microsphere infusion reverses vasoconstrictor-mediated changes in hindlimb oxygen uptake and energy status; Acta Physiologica Scandinavica
Microvascular blood flow responses to muscle contraction are not altered by high-fat feeding in rats; Diabetes, Obesity and Metabolism
Microvascular contributions to insulin resistance; Diabetes
Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo; Diabetes
Microvascular responses to insulin are abnormal in type 2 diabetes and are reversed by ACE-inhibitor therapy: assessment of microvascular recruitment by contrast ultrasound; American Society of Echocardiography. Journal
Mixed meal and light exercise each recruit muscle capillaries in healthy humans ; American Journal of Physiology: Endocrinology and Metabolism
Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium; Current Diabetes Reports
Muscle insulin resistance resulting from impaired microvascular insulin sensitivity in Sprague Dawley rats; Cardiovascular Research
Muscle microvascular blood flow responses in insulin resistance and ageing; The Journal of Physiology
No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats; American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Nutritive and non-nutritive blood flow: rest and exercise; Acta Physiologica Scandinavica
Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle ; Diabetes
Obesity Blunts Microvascular Recruitment in Human Forearm Muscle After a Mixed Meal; Diabetes Care
Oral glucose challenge impairs skeletal muscle microvascular blood flow in healthy people; American Journal of Physiology - Endocrinology and Metabolism
Perfusion controls muscle glucose uptake by altering the rate of glucose dispersion in viv; American Journal of Physiology: Endocrinology and Metabolism
Point: Counterpoint: There is/is not capillary recruitment in active skeletal muscle during exercise; Journal of Appliedy Physiology
Postprandial microvascular blood flow in skeletal muscle: Similarities and disparities to the hyperinsulinaemic-euglycaemic clamp; Clinical and Experimental Pharmacology and Physiology
Preparation and properties of isolated hepatocytes from sheep; The Hepatocyte Review
Rebuttal from Eugene J. Barrett, Michelle A. Keske, Stephen Rattigan and Etto C. Eringa; The Journal of physiology
Regulation of microvascular flow and metabolism: An overview; Clinical and Experimental Pharmacology and Physiology
Resting muscle thermogenesis: novel mechanisms; Tenth International Hibernation Symposium
Role for the Microvasculature in Glucose Uptake in Skeletal Muscle; Glucose Uptake: Regulation, Signaling Pathways and Health Implications (Endocrinology Research and Clinical Developments)
Sciatic Nerve Severance Produces Haemodynamic Changes and Insulin Resistance in Muscle; 16th International Diabetes Federation Congress
Size-Dependent Effects of Microspheres on Vasoconstrictor-Mediated Change in Oxygen Uptake by Perfused Rat Hindlimb; Microvascular Research
Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition ; American Journal of Physiology: Endocrinology and Metabolism
Skeletal muscle microvascular-linked improvements in glycemic control from resistance training in individuals with Type 2 Diabetes; Diabetes Care
Spatial Distribution of Nutritive and Nonnutritive Vascular Routes in Perfused Rat Hindlimb Muscle Using Microspheres; Microvascular Research
The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake; Diabetes/Metabolism Reseach and Reviews
Validation and advantages of FAWSETS perfusion measurements in skeletal muscle ; N M R in Biomedicine: (Nuclear Magnetic Resonance)
Vascular and metabolic actions of the green tea polyphenol epigallocatechin gallate; Current Medicinal Chemistry
Vascular and metabolic regulation of muscle; Physiology, Stress and Malnutrition
Vascular effects of vasoconstrictors on muscle metabolism

Research Projects

Actions of the polyphenol epigallocatechin 3-gallate on insulin sensitivity; National Health & Medical Research Council (NHMRC)
Adipose tissue blood flow: the link between obesity and disease risk?; The Select Foundation (SelF)
Blood Flow Routes in Muscle; Australian Research Council (ARC)
Can anti-diabetic agents improve blood flow and outcome following stroke in type 2 diabetes?; Royal Hobart Hospital Research Foundation (RHHRF)
Cardiometabolic benefits of exercise training in type 2 diabetes independent of weight loss; University of Tasmania (UTAS)
Metabolic and vascular actions of EGCG on insulin sensitivity; Diabetes Tasmania (DTas)
Microvascular Defects and Insulin Resistance; Heart Foundation (HF)
Microvascular dysfunction in adult offspring of type 2 diabetics; Royal Hobart Hospital Research Foundation (RHHRF)
Mixed Meal Challenge A new diagnostic test for screening pre diabetes; Royal Hobart Hospital Research Foundation (RHHRF)
Neural regulation of skeletal muscle insulin sensitivity; The Select Foundation (SelF)
NHMRC Standard Equipment Grant - 2008; National Health & Medical Research Council (NHMRC)
Promoting regrowth of nerve fibres into the epidermis during diabetic neuropathy by LRP agonists; National Health & Medical Research Council (NHMRC)
Role of microvascular flowmotion in skeletal muscle glucose metabolism; National Health & Medical Research Council (NHMRC)
The physiological benefits of anthocyanins as a functional food
Quantum Leap Fellowship

Research Candidate Supervision

Develop a Greater Understanding of the Relationship between Neurons and Muscle with Respect to Type II Diabetes Specifically, How Inactivity and Denervation Impact Glucose Transportation
Effect of the Green Tea Polyphenol, EGCG, on Insulin Sensitivity
Impaired adipose tissue blood flow in obesity and the development of hypoxia
Microvascular Dysfunction and the Development of Muscle Insulin Resistance
The Pharmaceutical and Nutraceutical Potential of the Halophytic Plant Carpobrotus rossii
The role of Flowmotion in Regulating Basal and Insulin-mediated Skeletal Glucose Uptake
The Role of iNOS in Vascular Dysfunction in Insulin Resistant States