Web Access Research Portal

Researcher: Bennett, WR (Dr Bill Bennett)

Fields of Research

Central Nervous System
Developmental Genetics (incl. Sex Determination)
Cell Development, Proliferation and Death
Cellular Nervous System
Neurology and Neuromuscular Diseases
Neurosciences
Structural Biology (incl. Macromolecular Modelling)
Cancer Cell Biology
Neurogenetics
Pathology
Cellular Immunology
Peripheral Nervous System
Tumour Immunology
Geriatrics and Gerontology
Molecular Targets

Research Objectives

Nervous System and Disorders
Neurodegenerative Disorders Related to Ageing
Inherited Diseases (incl. Gene Therapy)
Skin and Related Disorders
Cancer and Related Disorders
Diabetes
Health

Career Best Publications

Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome; Human Molecular Genetics
Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin ; Development (Cambridge)

Research Publications

An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non-imprinted tissues ; Developmental Biology: An International Journal
Biochemical properties of a keratan sulphate/chondroitin sulphate proteoglycan expressed in primate pluripotent stem cells ; Journal of Anatomy: Molecular, Cellular and Experimental Morphology
Construction and Evaluation of Rodent-Specific rTMS Coils; Frontiers in Neural Circuits
Construction and evaluation of rodent-specific TMS coils; 1st International Brain Stimulation Conference
Deletion of long-range sequences at Sox10 compromises developmental expression in a mouse model of Waardenburg-Shah (WS4) syndrome; Human Molecular Genetics
Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism; National Academy of Sciences of The United States of America. Proceedings
Does metallothionein attenuate mutant SOD1 aggregation in MND; 22nd Symposium on ALS/MND
Fission of pancreatic islets during postnatal growth of the mouse; Journal of Anatomy: Molecular, Cellular and Experimental Morphology
Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice ; Molecular Genetics and Metabolism: An International Journal
Hematopoietic stem cell and gene therapy corrects primary neuropathology and behavior in Mucopolysaccharidosis IIIA mice; Molecular Therapy
Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice; Journal of Neuroinflammation
Investigating the mechanisms of repetitive transcranial magnetic stimulation using motor learning paradigms and in vivo 2 photon imaging; 1st International Brain Stimulation Conference
Metallothionein promotes regenerative axonal sprouting of dorsal root ganglion neurons after physical axotomy; Cellular and Molecular Life Sciences
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Changes in arginase1 and inducible nitric oxide synthase; Journal of Neuroinflammation
Microscopic and histological examination of the mouse hindpaw digit and flexor tendon arrangement with 3D reconstruction ; Journal of Anatomy: Molecular, Cellular and Experimental Morphology
Perivascular cells in a skin graft are rapidly repopulated by host cells; Journal of Plastic, Reconstructive & Aesthetic Surgery
Redox-active Cu(II)ľAβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner; Experimental Neurology
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance; Journal of Clinical Investigation
Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin ; Development (Cambridge)
Tg2576 cortical neurons that express human Aβ are susceptible to extracellular Aβ-induced, K+ efflux dependent neurodegeneration ; PL o S One
The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons; P L o S One
The two faces of metallothionein in carcinogenesis: photoprotection against UVR-induced cancer and promotion of tumour survival

Research Projects

Assessing the role of metallothionein in the development of non-melanoma skin cancer; Royal Hobart Hospital Research Foundation (RHHRF)

Research Candidate Supervision

Investigating the Potential Theraputic Value of Metallothionein-Like Derivatives in Neurodegenrative Disorders