Web Access Research Portal

Researcher: Simpson Jr, S (Dr Steve Simpson JR)

Fields of Research

Central Nervous System
Epidemiology
Neurology and Neuromuscular Diseases
Preventive Medicine
Pathology
Cancer Diagnosis
Health Economics
Public Health and Health Services
Respiratory Diseases
Health and Community Services
Primary Health Care
Cell Metabolism
Nutrition and Dietetics
Genomics
Separation Science
Infectious Diseases
Autonomic Nervous System
Endocrinology
Family Care
Autoimmunity
Anaesthesiology
Immunology
Immunogenetics (incl. Genetic Immunology)
Health Information Systems (incl. Surveillance)
Cellular Immunology
Pharmacology and Pharmaceutical Sciences
Health Promotion

Research Objectives

Nervous System and Disorders
Disease Distribution and Transmission (incl. Surveillance and Response)
Preventive Medicine
Cancer and Related Disorders
Public Health (excl. Specific Population Health)
Diabetes
Infectious Diseases
Evaluation of Health Outcomes
Women's Health
Behaviour and Health
Disability and Functional Capacity
Expanding Knowledge in the Biological Sciences
Blood Disorders
Immune System and Allergy
Expanding Knowledge in the Chemical Sciences
Expanding Knowledge in the Medical and Health Sciences
Clinical Health (Organs, Diseases and Abnormal Conditions)
Neurodegenerative Disorders Related to Ageing
Carer Health
Diagnostic Methods
Specific Population Health (excl. Indigenous Health)
Health Status (e.g. Indicators of Well-Being)
Health Inequalities
Health Protection and/or Disaster Response
Health Education and Promotion
Social Structure and Health
Education and Training
Health and Support Services

Career Best Publications

Higher 25-hydroxyvitamin D is associated with lower relapse risk in Multiple Sclerosis; Annals of Neurology
Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS; Neurology
Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis; Journal of Neurology, Neurosurgery and Psychiatry

Research Publications

A novel method for calculating prevalence of multiple sclerosis in Australia; Multiple Sclerosis
A profile of the Multiple Sclerosis Longitudinal Study: Evaluating environmental, behavioural and genetic predictors of clinical outcomes in multiple sclerosis; Australasian Epidemiologist
Admission blood glucose predicts mortality and length of stay in patients admitted through the emergency department; Internal Medicine Journal
Adverse lipid profile is not associated with relapse risk in MS: Results from an observational cohort study; Journal of the Neurological Sciences
An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event; Journal of Neurology, Neurosurgery and Psychiatry
An adverse lipid profile is associated with disability and progression in disability, in people with MS; Multiple Sclerosis Journal
Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis; Multiple sclerosis journal
Anxiety, depression and fatigue at 5-year review following CNS demyelination; Acta Neurologica Scandinavica
Apolipoprotein E4 mediates the association between midlife dyslipidemia and cerebral amyloid in aging women; Journal of Alzheimer's Disease
Assessing possible selection bias in a national voluntary MS longitudinal study in Australia; Multiple Sclerosis
Association between human herpesvirus & human endogenous retrovirus and MS onset & progression; Journal of the Neurological Sciences
Association between multiple sclerosis risk-associated SNPs and relapse and disability - a prospective cohort study; Multiple Sclerosis
Associations of demographic and clinical factors with depression over 2.5-years in an international prospective cohort of people living with MS; Multiple Sclerosis and Related Disorders
Cervical determinants of anal HPV infection and high-grade anal lesions in women: a collaborative pooled analysis; Lancet Infectious Diseases
Challenges in the detection and verification of acute infections in epidemiologic studies, and methods by which they can be overcome; Australasian Epidemiologist
Change in multiple sclerosis prevalence over time in Australia 2010-2017 utilising disease modifying therapy prescription data; Multiple Sclerosis Journal
Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis; Neurological Sciences
Differential multiple sclerosis treatment allocation between Australia and New Zealand associated with clinical outcomes but not mood or quality of life; Multiple Sclerosis and Related Disorders
EBV & HHV6 reactivation is infrequent and not associated with MS clinical course; Acta Neurologica Scandinavica
Effects of multiple sclerosis disease-modifying therapies on employment measures using patient-reported data; Journal of Neurology, Neurosurgery and Psychiatry
Estimating MS-related work productivity loss and factors associated with work productivity loss in a representative Australian sample of people with multiple sclerosis; Multiple Sclerosis Journal
Estimation of annual probabilities of changing disability levels in Australians with relapsing-remitting multiple sclerosis; Multiple Sclerosis Journal
Four decades of anal cancer in Tasmania, Australia: what do the case data tell us?; Sexual Health
Frequency of comorbidities and their association with clinical disability and relapse in Multiple Sclerosis; Neuroepidemiology
Front-to-back and dabbing wiping behaviour post-toilet associated with anal neoplasia and HR-HPV carriage in women with previous HPV-mediated gynaecological neoplasia; Cancer Epidemiology
Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis; Multiple Sclerosis Journal
Genetic variation in PBMC-produced IFN-γ and TNF-α associations with relapse in multiple sclerosis; Journal of The Neurological Sciences
Genetic variation in the gene LRP2 increases relapse risk in multiple sclerosis; Journal of Neurology, Neurosurgery and Psychiatry
Geographical variations in sex ratio trends over time in multiple sclerosis; PLoS ONE
Health outcomes and lifestyle in a sample of people with multiple sclerosis (HOLISM): longitudinal and validation cohorts; Frontiers in Neurology
Higher 25-hydroxyvitamin D is associated with lower relapse risk in Multiple Sclerosis; Annals of Neurology
Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis; Journal of Neurology, Neurosurgery and Psychiatry
Higher levels of reported sun exposure, and not vitamin D status, are associated with less depressive symptoms and fatigue in multiple sclerosis; Acta Neurologica Scandinavica
Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature; Pituitary
Individual and Joint Action of Environmental Factors and Risk of MS
Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS; Neurology
Is your association real or just reverse causality? Some examples from analyses of multiple sclerosis clinical course and tools to assess it; Australasian Epidemiologist
Latitude continues to be significantly associated with the prevalence of multiple sclerosis: an updated meta-analysis; Journal of Neurology, Neurosurgery and Psychiatry
Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis; Journal of Neurology, Neurosurgery and Psychiatry
Lipid-related genetic polymorphisms significantly modulate the association between lipids and disability progression in multiple sclerosis; Journal of Neurology, Neurosurgery and Psychiatry
Longitudinal associations of modifiable lifestyle factors with positive depression-screen over 2.5-years in an international cohort of people living with multiple sclerosis; Frontiers in Psychiatry
Longitudinal associations of the healthy lifestyle index score with quality of life in people with multiple sclerosis: A prospective cohort study; Frontiers in Neurology
Meta-analyses to investigate gene-environment interactions in neuroepidemiology; Neuroepidemiology
Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: A multicentre Australian cohort study; Journal of Medical Imaging and Radiation Oncology
Modelling the impact of multiple sclerosis on life expectancy, quality-adjusted life years and total lifetime costs: Evidence from Australia; Multiple Sclerosis Journal
Modifiable factors associated with depression and anxiety in multiple sclerosis; Acta Neurologica Scandinavica
Modulating effects of WT1 on interferon-β-vitamin D association in MS; Acta Neurologica Scandinavica
Multiple Quantitative Trait Loci for Anti-EBNA-1 IgG Titres are Associated with Risk of Multiple Sclerosis
Non-Obese Diabetes and Its Associated Factors in an Underdeveloped Area of South China, Guangxi; International Journal of Environmental Research and Public Health
Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis; Journal of Neurology, Neurosurgery and Psychiatry
Oil tea improves glucose and lipid levels and alters gut microbiota in type 2 diabetic mice; Nutrition Research
On-line sample preconcentration in capillary electrophoresis: Fundamentals and applications; Journal of Chromatography A
Onset symptoms, tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset; Frontiers in Neurology
Patient-reported outcomes are worse for progressive-onset multiple sclerosis than relapse-onset multiple sclerosis, particularly early in the disease process; European Journal of Neurology
Polymorphism in the serotonin transporter gene polymorphisms (5-HTTLPR) modifies the association between significant life events and depression in people with multiple sclerosis; Multiple Sclerosis Journal
Role of PCK1 gene on oil tea-induced glucose homeostasis and type 2 diabetes: An animal experiment and a case-control study; Nutrition & Metabolism
Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: a cohort study; Journal of Neurology, Neurosurgery and Psychiatry
Role of vitamin D in multiple sclerosis: implications for disease management
Self-reported cognitive function in a large international cohort of people with multiple sclerosis: associations with lifestyle and other factors; European Journal of Neurology
Sexual health literacy of the student population of the University of Tasmania: results of the RUSSL Study; Sexual Health (Print): an interdisciplinary journal of sexual health including HIV/AIDS and sexually transmitted infections
Sexuality-related attitudes significantly modulate demographic variation in sexual health literacy in Tasmanian university students; Sexual Health
Stimulated PBMC-produced IFN-γ and TNF-α are associated with altered relapse risk in multiple sclerosis: Results from a prospective cohort study; Journal of Neurology, Neurosurgery and Psychiatry
Stressful life events and the risk of initial central nervous system demyelination; Multiple Sclerosis Journal
Sun exposure across the life course significantly modulates early multiple sclerosis clinical course; Frontiers in Neurology
Synergetic and antagonistic effects of combined calcitriol and interferon-β treatment on cytokine production by stimulated PBMCs; Journal of Neuroimmunology
The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology; Journal of the Neurological Sciences
The epidemiology of multiple sclerosis in the Isle of Man: 2006-2011; Acta Neurologica Scandinavica
The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults; Multiple Sclerosis and Related Disorders
The potential role of epigenetic modifications in the heritability of multiple sclerosis; Multiple Sclerosis Journal
The role of epidemiology in MS research: Past successes, current challenges and future potential; Multiple Sclerosis Journal
The role of vitamin D in multiple sclerosis: biology & biochemistry, epidemiology and potential roles in treatment; Medicinal Chemistry
The Scandinavian paradox revisited: Editorial comment on Berg-Hansen et al. 'High prevalence and no latitude gradient of multiple sclerosis in Norway'; Multiple Sclerosis Journal
The Varied Mechanisms of Vitamin D in the Onset and Clinical Course of MS: Potential Roles in Modulating Other Etiological Pathways
Trends in the epidemiology of multiple sclerosis in Greater Hobart, Tasmania: 1951 to 2009; Journal of Neurology, Neurosurgery and Psychiatry
Variation within MBP gene predicts disease course in multiple sclerosis; Brain and Behavior
Vascular comorbidities in the onset and progression of multiple sclerosis; Journal of The Neurological Sciences
Vitamin D supplementation to prevent acute respiratory tract infections: Systematic review and meta-analysis of individual participant data; BMJ
Weekly cholecalciferol supplementation results in significant reductions in infection risk among the vitamin D deficient: results from the CIPRIS pilot RCT; BMC Nutrition

Research Projects

A double-blind randomised controlled trial to evaluate the efficacy of 20,000 IU/wk cholecalciferol in reducing respiratory tract infection in a cohort of healthy young adults; Royal Hobart Hospital Research Foundation (RHHRF)
Assessing the HR-HPV types in stored cervical excision samples for comparison with anal HR-HPV carriage in TasGANS; Royal Hobart Hospital Research Foundation (RHHRF)
Case-control study in Primary Progressive MS: Are the risk factors the same as for people with RRMS onset and can we identify new ones?; Multiple Sclerosis Research Australia (MSRA)
DEVA MS: DEvelopment and VAlidation of a cost effectiveness simulation model for Multiple Sclerosis and implications for health policy; Multiple Sclerosis Research Australia (MSRA)
Does treating multiple sclerosis alter long-term disease outcomes? a natural history study; Multiple Sclerosis Research Australia (MSRA)
Examining the role of blood lipids and apolipoproteins on the progression of MS in a prospective clinical cohort; Royal Hobart Hospital Research Foundation (RHHRF)
The Cholecalciferol Intervention to Prevent Respiratory Infections Study (CIPRIS); The Select Foundation (SelF)
The effect of vitamin D and Interferon-beta on the immune response; Royal Hobart Hospital Research Foundation (RHHRF)
The relationship between Immunoglobulin E (IgE), disease severity and the immune response in multiple sclerosis; Royal Hobart Hospital Research Foundation (RHHRF)
The Tasmanian Gynaecological & Anal Neoplasia Study (TasGANS) (Northern Tasmania); Clifford Craig Foundation (CCFoundation)
The Tasmanian Women's Anal Neoplasia study (TasWAN); Cancer Council of Tasmania (CCT)
Towards an algorithm for predicting the development and progression of multiple sclerosis utilising environmental and behavioural determinants; Multiple Sclerosis Research Australia (MSRA)

Research Candidate Supervision

Determinations of MS progression
Dissecting the Genetics Architecture of Multiple Sclerosis
The Role of Epstein-Bar Virus and Human Herpes Virus 6 on the Progression of Multiple Sclerosis