Web Access Research Portal

Researcher: Horne, HJ (Dr James Horne)

Fields of Research

Structural biology (incl. macromolecular modelling)
Pharmaceutical sciences
Organic chemical synthesis
Other chemical sciences
Characterisation of biological macromolecules
Primary health care
Cell metabolism
Natural products and bioactive compounds
Transition metal chemistry
Physical properties of materials
Cardiology (incl. cardiovascular diseases)
Medical biochemistry and metabolomics
Plant physiology
Medical bacteriology
Metal organic frameworks
Biologically active molecules
Fish pests and diseases
Analytical spectrometry
Animal nutrition

Research Objectives

Expanding knowledge in the chemical sciences
Expanding knowledge in the biological sciences
Clinical health
Expanding knowledge in the health sciences
Paper products and pulp
Public health (excl. specific population health)
Aquaculture fin fish (excl. tuna)
Human pharmaceutical products
Expanding knowledge in the environmental sciences
Prepared animal feed

Career Best Publications

Research Publications

ent-Labdane Diterpenoids from Dodonaea viscosa; Journal of Natural Products
In-vitro suppression of IL-6 and IL-8 release from human pulmonary epithelial cells by non-anticoagulant fraction of enoxaparin; PLoS One
Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA; Angewandte Chemie
Biosynthesis of the halogenated auxin, 4-chloroindole-3-acetic acid; Plant Physiology
Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase ; Chemistry and Biology
Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay; Chemistry and Biology
High Glass Transition Temperature Fluoropolymers for Hydrophobic Surface Coatings via RAFT Copolymerization; Australian Journal of Chemistry
Isolation and characterization of 1β-Acetoxypolygodial from Tasmannia Lanceolata; Asian Journal of Organic Chemistry
Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion; Journal of Lipid Research
Non-anticoagulant fractions of enoxaparin suppress inflammatory cytokine release from peripheral blood mononuclear cells of allergic asthmatic individuals; PLoS One
Preparation of thermoresponsive hydrogels: Via polymerizable deep eutectic monomer solvents; Polymer Chemistry
Probing the fibrate binding specificity of rat liver fatty acid binding protein; Journal of Medicinal Chemistry
Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus; Acta Diabetologica
Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 from Neisseria meningitidis; Journal of Biological Chemistry
Structural properties of a haemophore facilitate targeted elimination of the pathogen Porphyromonas gingivalis; Nature Communications
Synthesis of arylpalladium(II) boronates: confirming the structure and chemical competence of pre-transmetalation intermediates in the Suzuki-Miyaura reaction; Angewandte Chemie
Synthesis of guar gum-graft-poly (acrylamide-co-diallyldimethylammonium chloride) and its application in the pulp and paper industry; BioResources
The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain; Metabolomics
The structural impact of a polyglutamine tract is location dependent; Biophysical Journal
The structure of the bacterial oxidoreductase enzyme DsbA in complex with a peptide reveals a basis for substrate specificity in the catalytic cycle of DsbA enzymes; Journal of Biological Chemistry
Unraveling the mechanism of polymerisation with the Phillips catalyst; Organometallics
Using NMR and SEM, to study the behaviour of pitch; 64th Appita

Research Projects

Chemical and physical changes in fish feed
Chemika impurity characterisation - ICH guidelines
Supply Chain Integrity Testing of Medications for GP2U Telehealth

Research Candidate Supervision