Web Access Research Portal

Researcher: Southam, K (Dr Katherine Southam)

Fields of Research

Neurology and Neuromuscular Diseases
Central Nervous System
Cellular Nervous System
Peripheral Nervous System
Cardiology (incl. Cardiovascular Diseases)

Research Objectives

Nervous System and Disorders
Expanding Knowledge in the Medical and Health Sciences
Neurodegenerative Disorders Related to Ageing
Diabetes

Career Best Publications

Research Publications

A Novel In Vitro Primary Culture Model of the Lower Motor Neuron–Neuromuscular Junction Circuit; Microfluidic and Compartmentalized Platforms for Neurobiological Research
Amyloid β precursor protein regulates neuron survival and maturation in the adult mouse brain; Molecular and Cellular Neurosciences
An in vitro investigation of the role of interneurons in the development of ALS; 22nd Symposium on ALS/MND
App
Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis; Journal of Chemical Neuroanatomy
Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model; ASN Neuro
Degeneration of axons in spinal white matter in G93A mSOD1 mouse characterized by NFL and alpha internexin immunoreactivity; Brain Research
Do microglia default on network maintenance in Alzheimer's disease?; Journal of Alzheimer's Disease
Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol; Acta Neuropathologica Communications
Focal Damage to the Adult Rat Neocortex Induces Wound Healing Accompanied by Axonal Sprouting and Dendritic Structural Plasticity ; Cerebral Cortex
Focal damage to the neocortex induces dendritic structural plasticity; Australian Neuroscience Society/Australian Physiological Society
Focal damage to the neocortex induces dendritic structural plasticity; Dementia, Ageing and Neurodegenerative Diseases Group Conference
Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity; Disease Models & Mechanisms
Microfluidic investigation of excitotoxin induced ALS-like axonal degeneration; 20th Symposium on ALS/MND
Microfluidic primary culture model of the lower motor neuron-neuromuscular junction circuit; Journal of Neuroscience Methods
Modelling ALS pathology in vitro; 22nd Symposium on ALS/MND
Modelling site specific excitotixicity in vitro; University of Tasmania Sharing Excellence in Research meeting
Modelling site-specific excitotoxicity in vivo; 22nd International Symposium on ALS/MND
Novel alpha-internexin pathological alterations in both the spinal cord and brain of the G93A SOD1 model of amytrophic lateral sclerosis; Society for Neuroscience
Novel alpha-internexin pathological alterations in both the spinal cord and forebrain of the G93A SOD1 model of Amyotrophic Lateral Sclerosis; Australian Society for Medical Research
Rab1-dependent ER-Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS; Acta Neuropathologica
Site-specific excitotoxin exposure in vivo leads to neuronal excitotoxicity and axonal dysfunction; 32nd Annual Meeting Australian Neuroscience Society

Research Projects

12th International Conference on Alzheimer's & Parkinson's Diseases (AD/PD); University of Tasmania (UTAS)
Are microglia the villains of AB toxicity in Alzheimer's disease; Alzheimer's Australia Dementia Research Foundation (AADRF)
Investigating the function of the amyloid precursor protein in neurons; University of Tasmania (UTAS)
Nina Buscombe Award Travel Grant; Motor Neurone Disease Victoria (MNDVIC)
Nina Buscombe Award Travel Grant; Motor Neurone Disease Victoria (MNDVIC)

Research Candidate Supervision