Web Access Research Portal

Researcher: Laslett, LL (Dr Laura Laslett)

Fields of Research

Rheumatology and Arthritis
Clinical Sciences
Nutritional Physiology
Geriatrics and Gerontology
Radiology and Organ Imaging
Aged Health Care
Oral Medicine and Pathology
Education Assessment and Evaluation
Peripheral Nervous System
Biomedical Instrumentation
Sports Medicine
Cellular Immunology
Primary Health Care

Research Objectives

Skeletal System and Disorders (incl. Arthritis)
Health Related to Ageing
Disability and Functional Capacity
Women's Health
Allied Health Therapies (excl. Mental Health Services)
Evaluation of Health Outcomes
Health Status (e.g. Indicators of Well-Being)
Dental Health
Nervous System and Disorders
Education and Training Systems Policies and Development

Career Best Publications

Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial; Annals of the Rheumatic Diseases

Research Publications

A prospective study of the impact of musculoskeletal pain and radiographic osteoarthritis on health related quality of life in community dwelling older people; BMC Musculoskeletal Disorders
A protocol for a multicentre, randomised, double-blind, placebo-controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients - ZAP2; BMC Musculoskeletal Disorders
A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial; Osteoarthritis and Cartilage
Association between infrapatellar fat pad volume and knee structural changes in patients with knee osteoarthritis; Journal of Rheumatology
Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study; Osteoarthritis and Cartilage
Association Between Pain at Sites Outside the Knee and Knee Cartilage Volume Loss in Elderly People Without Knee Osteoarthritis: A Prospective Study; Arthritis Care & Research
Association of adiposity measures in childhood and adulthood with knee cartilage thickness, volume and bone area in young adults; International Journal of Obesity
Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study; Osteoarthritis and Cartilage
Associations between fat mass and multi-site pain: A 5-year longitudinal study; Arthritis Care & Research
Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study; Osteoarthritis and Cartilage
Associations of dietary patterns with bone mass, muscle strength and balance in a cohort of Australian middle-aged women; British Journal of Nutrition
Associations of Sarcopenic Obesity and Dynapenic Obesity with Bone Mineral Density and Incident Fractures Over 5-10 Years in Community-Dwelling Older Adults; Calcified Tissue International
Both baseline and change in lower limb muscle strength in younger women are independent predictors of balance in middle age: A 12-Year population-based prospective study; Journal of Bone and Mineral Research
Capsaicin for Osteoarthritis Pain; Capsaicin as a Therapeutic Molecule
Change in knee structure and change in tibiofemoral joint space width: a five year longitudinal population–based study; BMC Musculoskeletal Disorders
Changes in quality of life associated with fragility fractures: Australian arm of the International Cost and Utility Related to Osteoporotic Fractures Study (AusICUROS); Osteoporosis International
Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis; Annals of the Rheumatic Diseases: The Euler Journal
Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis; Osteoarthritis and Cartilage
Cross-sectional and longitudinal associations between serum levels of high-sensitivity C-reactive protein, knee bone marrow lesions, and knee pain in patients with knee osteoarthritis; Arthritis Care & Research
Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women; Osteoporosis International
Declining incidence of osteoporotic hip fracture in Australia; Archives of Osteoporosis
Deteriorating tactile sensation in patients with hand syndromes associated with diabetes: a two-year observational study; Journal of Diabetes and Its Complications
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010; Lancet
Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative; Annals of the Rheumatic Diseases
Effect of Zoledronic Acid and Denosumab in patients with low back pain and modic change: A proof-of-principle trial; Journal of Bone and Mineral Research
Effects of Individualized Bone Density Feedback and Educational Interventions on Osteoporosis Knowledge and Self-Efficacy: A 12-Yr Prospective Study; Journal of Clinical Densitometry
Efficacy and safety of plant-derived products for the treatment of osteoarthritis; Botanics: Targets and Therapy
Excess body fat is associated with higher risk of vertebral deformities in older women but not in men: a cross-sectional study; Osteoporosis International
Factors associated with prevalent and incident foot pain: data from the Tasmanian Older Adult Cohort Study; Maturitas
Hand syndromes associated with diabetes: impairments and obesity predict disability; Journal of Rheumatology
How do MRI-detected subchondral bone marrow lesions (BMLs) on two different MRI sequences correlate with clinically important outcomes?; Calcified Tissue International
Individualized fracture risk feedback and long-term benefits after 10 years; American Journal of Preventive Medicine
Knee pain predicts subsequent shoulder pain and the association is mediated by leg weakness: Longitudinal observational data from the osteoarthritis initiative; Journal of Rheumatology
Lack of Association Between TESPA1 Gene Polymorphisms (rs1801876, rs2171497, rs4758994, and rs997173) and Ankylosing Spondylitis in a Chinese Population; Inflammation
Lifestyle modifications to improve musculoskeletal and bone health and reduce disability – A life-course approach; Best Practice & Research: Clinical Rheumatology
Longitudinal associations between adiposity and change in knee pain: Tasmanian older adult cohort study; Seminars in Arthritis and Rheumatism
Lower limb muscle strength is associated with poor balance in middle-aged women: linear and nonlinear analyses; Osteoporosis International
Measuring Disease Progression in Osteoarthritis; Current Treatment Options in Rheumatology
Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study; Annals of the Rheumatic Diseases
Moderate-to-vigorous physical activity but not sedentary time is associated with musculoskeletal health outcomes in a cohort of Australian middle-aged women; Journal of Bone and Mineral Research
Oral contraceptive use and bone; Current Osteoporosis Reports
Osteoporosis education improves osteoporosis knowledge and dietary calcium: comparison of a 4 week and a one-session education course; International Journal of Rheumatic Diseases
Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene; European Journal of Pain
Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults; Osteoarthritis and Cartilage
Patellofemoral bone marrow lesions: natural history and associations with pain and structure; Arthritis Care & Research
Physical interventions (orthoses, splints, exercise and manual therapy) for treating plantar heel pain; Cochrane Database of Systematic Reviews
Predictors of shoulder pain and shoulder disability after one year in diabetic outpatients; Rheumatology
The association between oral contraceptive use, bone mineral density and fractures in women aged 50-80 years; Contraception
The cost of osteoporosis, osteopenia, and associated fractures in Australia in 2017; Journal of Bone and Mineral Research
The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study; Annals of the Rheumatic Diseases
The global burden of hip and knee osteoarthritis: Estimates from the Global Burden of Disease 2010 study; Annals of the Rheumatic Diseases
The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis; Annals of The Rheumatic Diseases: The Eular Journal
Threshold effects of vitamin D status on bone health in Chinese adolescents with low calcium intake; Journal of Clinical Endocrinology and Metabolism
Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial; Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010; Lancet
Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial; Annals of the Rheumatic Diseases

Research Projects

2012 OARSI Young Investigator Scholarship; Osteoarthritis Research Society International (OARSI)
A randomised trial of krill oil for osteoarthritis of the knee; National Health & Medical Research Council (NHMRC)
Assessing the Australian osteoarthritis landscape - GPs' surgeons' and patients attitudes towards and understandings of osteoarthritis; University of Tasmania (UTAS)
Clinical trials in osteoarthritis; National Health & Medical Research Council (NHMRC)
Does either zoledronic acid or denosumab change back pain and morphology of Modic changes: a randomised open label pilot study; Arthritis Australia (AFA)
Humira for treatment of erosive hand osteoarthritis; Arthritis Australia (AFA)
Testing new treatments for back pain: a randomised open label pilot study; Tasmanian Community Fund (TasCF)
The effect of krill oil on cartilage composition; Menzies Institute for Medical Research (MIMR)
Is the use of thermocyclopad effective for knee pain?

Research Candidate Supervision

Strategies to Address the Long Term Mainteance of Bone Density in Younger Women- Fracture Risk Feedback and Vitamin D
Vitamin D Effects on Osteoarthritis (VIDEO) Study