Web Access Research Portal

Researcher: Holloway, AF (Dr Adele Holloway)

Research Fields

Biochemistry and Cell Biology
Epigenetics (incl. Genome Methylation and Epigenomics)
Cancer Genetics
Gene Expression (incl. Microarray and other genome-wide approaches)
Cancer Cell Biology
Cell Metabolism
Genome Structure and Regulation
Molecular Targets
Central Nervous System
Oncology and Carcinogenesis
Medical Genetics (excl. Cancer Genetics)
Epidemiology
Respiratory Diseases
Cellular Nervous System
Immunology
Medical and Health Sciences
Basic Pharmacology
Cell Development, Proliferation and Death
Genetics
Solid Tumours
Haematology
Tumour Immunology
Sensory Systems
Cellular Immunology
Education Assessment and Evaluation
Analytical Biochemistry
Biological Sciences
Ophthalmology
Clinical Sciences
Preventive Medicine
Radiation Therapy
Cancer Diagnosis
Medical Biochemistry and Metabolomics
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Medical Bacteriology
Bioinformatics
Cardiology (incl. Cardiovascular Diseases)
Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
Haematological Tumours

Research Impact

Cancer and Related Disorders
Expanding Knowledge in the Environmental Sciences
Expanding Knowledge in the Biological Sciences
Immune System and Allergy
Nervous System and Disorders
Expanding Knowledge in the Medical and Health Sciences
Inherited Diseases (incl. Gene Therapy)
Infectious Diseases
Respiratory System and Diseases (incl. Asthma)
Urogenital System and Disorders
Disease Distribution and Transmission (incl. Surveillance and Response)
Men's Health
Blood Disorders
Endocrine Organs and Diseases (excl. Diabetes)
Learner and Learning Processes
Skeletal System and Disorders (incl. Arthritis)
Hearing, Vision, Speech and Their Disorders
Clinical Health (Organs, Diseases and Abnormal Conditions)
Digestive System Disorders
Expanding Knowledge in the Physical Sciences
Diabetes
Cardiovascular System and Diseases
Human Pharmaceutical Products

Career Best Publications

Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kappaB proteins; Journal of Experimental Medicine
Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells; Journal of Biological Chemistry
GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements; Nucleic Acids Research
Recruitment of SW1/SNF to the human immunodeficiency virus type 1 promotor; Molecular and Cellular Biology
Regulation of cytokine gene transcription in the immune system; Molecular Immunology

Research Publications

A role for the BAF remodelling complex in GM-CSF gene regulation; ComBio 2005
A role for the NF-KB family member, Crel, in chromatin remodelling events at the GM-CSF promotor; Combined ASBMB, ANZSCDB and ASPS Annual Meeting
Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes; Toxicology and Applied Pharmacology
Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kappaB proteins; Journal of Experimental Medicine
Chemoprevention Targeting Epigenetic Changes in Cancer; Field Cancerization: Basic Science and Clinical Applications
Chromatin remodelling and transcriptional regulation of cytokine gene transcription in T cells; Cytokines and Autoimmune Disease
Chromatin remodelling: Distinct molecular events during differentiation and activation of T cells; Current Immunology Reviews
Comparison of pre-processing methodologies for Illumina 450k methylation array data in familial analyses; Clinical Epigenetics
Defining the molecular events required for GM-CSF gene activation in T cells; ComBio 2003 Conference
Depletion of c-Rel from cytokine gene promoters is required for chromatin reassembly and termination of gene responses to T cell activation; PLoS One
Determinants of a transcriptionally competent environment at the GM-CSF promoter; Nucleic Acids Research
Disecting the molecular events involved in activation of GM-CSF gene expression in T cells; The Genome Conference
Distinct signals and factors are required for GM-CSF promotor chromatin remodelling and gene transcription; Combined ASBMB, ANZSCDB and ASPS Annual Meeting
Epigenetic regulation of inducible gene expression in the immune system; Immunology
Epigenetic regulation of prostate cancer; Clinical Epigenetics
Expression of mammalian metallothioneins during development; Congress of the European Developmental Biology Organisation
Expression of metallothionein isoforms in mammals; Lorne Genome Conference
Fucoidan and cancer: a multifunctional molecule with anti-tumor potential; Marine Drugs
Fucoidan enhances the therapeutic potential of arsenic trioxide and all-trans retinoic acid in acute promyelocytic leukemia, in vitro and in vivo; OncoTarget
Fucoidan suppresses the growth of human acute promyelocytic leukemia cells in vitro and in vivo; Journal of Cellular Physiology
Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells; Journal of Biological Chemistry
Genetic determinants of epigenetic patterns: providing insight into disease; Molecular Medicine
GM-CSF gene activation; providing an insight into the role of BRG1 in gene regulation; Mechanisms of Eukaryotic Transcription
GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements; Nucleic Acids Research
GM-CSF promotor remodeling and gene transcription in response to T cell activation are distinct events; 25th Annual Conference of the Organisation and Expression of the Genome
Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein; FEBS Letters
Integrins as determinants of genetic susceptibility, tumour behaviour and their potential as therapeutic targets; Prostate Cancer - From Bench to Bedside
Integrins in Prostate Cancer Invasion and Metastasis; Advances in Prostate Cancer
Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia; Frontiers in Immunology
Interplay between transcription factors and the epigenome: insight from the role of RUNX1 in leukemia; Frontiers in Immunology
Localisation and expression of metallothionein immunoreactivity in the developing sheep brain; International Journal of Developmental Neuroscience
Metallothionein expression in the developing sheep brain; International Workshop on Metallothioneins
Metallothionein expression in the mammalian brain; Metallothionein IV
Metallothioneins 1 and 2 are expressed in the olfactory mucosa of mice in untreated animals and during the regeneration of the epithelial layer; Biochemical and Biophysical Research Communications
Methylation of the ITGA2 promoter in Prostate Cancer; Epigenetics Conference
Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes ; Molecular and Cellular Neuroscience
Proteomics approach for identification of coactivators complexes interacting with transcription factors at the hGM-CSF promotor; The Genome Conference
Recruitment of SW1/SNF to the human immunodeficiency virus type 1 promotor; Molecular and Cellular Biology
Regulation of cytokine gene transcription in the immune system; Molecular Immunology
Regulation of gene expression by the RUNX-1 transcription factor; The Genome Conference
Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer; The Prostate
Regulation of the ITGA2 gene in prostate cancer; Lorne Cancer Conference
Research on the Apple Isle
Reversing Aberrant Methylation Patterns in Cancer; Current Medicinal Chemistry
RNA-seq profiling of a radiation resistant and radiation sensitive prostate cancer cell line highlights opposing regulation of DNA repair and targets for radiosensitization; BMC Cancer
Selective remodelling of a single nucleosome precedes GM-CSF transcription in T cells; ComBio 2002
Sheep have an unusual variant of the brain-specific metallothionein, metallothionein-III; Biochemical Journal
Structure and expression of mammalian metallothioneins
Structure and synthesis of the neuroactive metallothionein isoform, MTIII (Growth Inhibitory Factor); Human Genome Meeting, 1999
Targeting Epigentic Modifiers in Cancer; Current Medicinal Chemistry
The leukemia inhibitory factor receptor gene is a direct target of RUNX1; Journal of Cellular Biochemistry
The potential role of epigenetic modifications in the heritability of multiple sclerosis; Multiple Sclerosis Journal
The Role of Epigenetic Regulation in Transcriptional Memory in the Immune System; Advances in protein chemistry and structural biology
Transcription factors and chromatin remodelers involved in activating the GM-CSF gene; The Genome Conference
Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1; Leukemia Research

Research Projects

A Functional Proteomics Approach to the Study of Inducible Gene Transcription in a Chromatin Context; National Health & Medical Research Council (NHMRC)
Bi-functional opioids as a novel cancer treatment; Cancer Council of Tasmania (CCT)
Characterising aberrant RUNX1 transcriptional complexes; David Collins Leukaemia Foundation (DCLF)
Combining deep sequencing and linkage approaches to identify rare variants contributing to familial prostate cancers; Cancer Council of Tasmania (CCT)
Deregulation of Gene Expression by RUNX1 Fusion Proteins in Leukaemia; David Collins Leukaemia Foundation (DCLF)
Development of a Screen for AML1 Target Genes; Royal Hobart Hospital Research Foundation (RHHRF)
Elucidation of the role of a novel susceptibility gene in prostate cancer; Cancer Council of Tasmania (CCT)
Elucidation of the role of a novel susceptibility gene in prostate cancer; Royal Hobart Hospital Research Foundation (RHHRF)
Elucidation of the role of the integrin alpha 2 gene (ITGA2) in prostate cancer; Cancer Council of Tasmania (CCT)
Embedding the benefits of undergraduate research experiences for medical research and health professional students; Office for Learning & Teaching (OLT)
EMBO Conference on Chromatin and Epigenetics attendance ; Cancer Council of Tasmania (CCT)
Epigenetic regulation of inegrin beta 4 as a predictor of prostate cancer progression; Cancer Council of Tasmania (CCT)
Epigenetic regulation of T-cell gene expression programs; The Select Foundation (SelF)
Epigenetic Regulation of the integrin, ITGA2, in Tumour Development; Cancer Council of Tasmania (CCT)
Epigenetic Regulation of Tumour Supressors in Skin Cancer; Cancer Council of Tasmania (CCT)
Epigenomics of familial prostate cancer; Cancer Council of Tasmania (CCT)
Exploring the mechanisms responsible for the early transformation from chronic colitis to colorectal cancer; Cancer Council of Tasmania (CCT)
Familial Haematological Malignancies: understanding the role of inherited causative factors; Cancer Council of Tasmania (CCT)
How does basal chromatin structure predict cytokine gene responses; National Health & Medical Research Council (NHMRC)
Identifying Genes Regulated by AML1 in Myeloid Cells; David Collins Leukaemia Foundation (DCLF)
Intersection of RUNX and integrin families in leukaemia; David Collins Leukaemia Foundation (DCLF)
Investigating novel targets of the RUNX1 transcription factor; David Collins Leukaemia Foundation (DCLF)
Investigating the Role of the RUNX1 Protein in the Regulation of Gene Expression in Myeloid Cells; David Collins Leukaemia Foundation (DCLF)
ITGA2: characterisation as a potential biomarker in prostate cancer; Cancer Council of Tasmania (CCT)
Leica DMIRB Inverted Microscope Configured for Fluorescence and Bright Field with Phase Contrast; National Health & Medical Research Council (NHMRC)
Luminometry System; National Health & Medical Research Council (NHMRC)
Molecular profiling of the post radiotherapy chromatin landscape in prostate cancer cells; Cancer Council of Tasmania (CCT)
Philippa Oakford: Epigenetics 2007 Australian Scientific Conference; David Collins Leukaemia Foundation (DCLF)
Prostate cancer risk variants in integrin genes & their role in prostate cancer development; Cancer Council of Tasmania (CCT)
Prostate cancer risk variants in integrin genes and their role in tumour development; Cancer Council of Tasmania (CCT)
Refrigerated Benchtop Centrifuge; National Health & Medical Research Council (NHMRC)
Regulation of Gene Expression by the AML1 Transcription Factor in Myeloid Cells; David Collins Leukaemia Foundation (DCLF)
Regulation of Integrin Gene Expression Programs by RUNX in Cancer; Cancer Council of Tasmania (CCT)
Regulation of integrins by RUNX1 in leukaemia; David Collins Leukaemia Foundation (DCLF)
Regulation of the Leukaemia Inhibitory Factor Receptor complex by RUNX1; David Collins Leukaemia Foundation (DCLF)
Regulation of the LIFR Receptor by RUNX1; David Collins Leukaemia Foundation (DCLF)
Rising Stars 3; University of Tasmania (UTAS)
Role of NF-kB Remodelling Complexes in Inducible Gene Expression in T Cells; National Health & Medical Research Council (NHMRC)
Scarring and angiogenesis in the airway wall in smoking and COPD: links between inflammation and remodelling; National Health & Medical Research Council (NHMRC)
Silencing the AML1/ETO fusion gene as a treatment strategy for acute myeloid leukaemia; Clifford Craig Foundation (CCFoundation)
Switching genes on in immune cells: how does basal chromatin structure predict cytokine gene responses?; Royal Hobart Hospital Research Foundation (RHHRF)
The role of epigenetic changes in the progression of clinical disease in Multiple Endocrine Neoplasia Type 1 (MEN 1); Royal Hobart Hospital Research Foundation (RHHRF)
Transcriptome analysis for predicting response to radiotherapy in prostate cancer patients; Royal Hobart Hospital Research Foundation (RHHRF)
Upgrade of the flow cytometry facility of the Menzies Research Institute with a multi-parameter analytical flow cytometer CyAn ADP 9 Color for key applications ; Clive & Vera Ramaciotti Foundation (CVRF)
David Collins Leukaemia Foundation Elite Research Scholarship - Epigenetic and Transcriptional regulation of leukaemia
Regulation of gene expression in cancer

Research Candidate Supervision

C-Rel driven chromatin change in immunological models of inflammation.
Defining the Molecular Events Required for GM-CSF Gene Activation in T Cells
Differential Expression of the GM-CSF Gene in the Immune System is Regulated By Epigenetic Factors
Epigenetic mechanisms of arsenic-induced transformation in human keratinocytes
Epigenomic and Genomic Analysis of Familial Prostrate Cancer.
Molecular Mechanisms Used by Staphylococcus Aureus to Access Iron from Human Haemoglobin
Regulation of Gene Expression by the RUNX1 Transcription Factor
Regulation of Inducible Immune Gene Expression in T Cells Compared to Macrophages
Regulation of Integrins by RUNX Transcription Factors in Cancer
Regulation of the ITGA2 Gene in Prostate Cancer
Regulation of the LIFR and gp130 Genes by the RUNX1 Transcription Factor
Study of the Role of Fucoidan on Leukemia Cells and on Hematopoietic Stem Cell Release