Web Access Research Portal

Researcher: Cook, AL (Dr Tony Cook)

Fields of Research

Cancer Genetics
Cell Development, Proliferation and Death
Cellular Nervous System
Optometry and Ophthalmology
Cell Metabolism
Ophthalmology
Epigenetics (incl. Genome Methylation and Epigenomics)
Signal Transduction
Biochemistry and Cell Biology
Central Nervous System
Neurosciences
Genetic Immunology
Animal Physiology - Systems
Nanotoxicology, Health and Safety
Cancer Cell Biology
Nutrition and Dietetics
Vision Science
Medical Biochemistry and Metabolomics
Education Assessment and Evaluation
Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Nutritional Physiology
Molecular Medicine
Neurology and Neuromuscular Diseases
Science, Technology and Engineering Curriculum and Pedagogy
Gastroenterology and Hepatology
Sensory Systems
Cell Neurochemistry
Animal Physiology - Cell
Cellular Immunology
Animal Immunology
Genomics
Cell Physiology

Research Objectives

Neurodegenerative Disorders Related to Ageing
Cancer and Related Disorders
Hearing, Vision, Speech and Their Disorders
Digestive System Disorders
Expanding Knowledge in the Medical and Health Sciences
Clinical Health (Organs, Diseases and Abnormal Conditions)
Nervous System and Disorders
Inherited Diseases (incl. Gene Therapy)
Public Health (excl. Specific Population Health)
Flora, Fauna and Biodiversity at Regional or Larger Scales
Learner and Learning Achievement
Education and Training
Health
Diagnostic Methods
Health Status (e.g. Indicators of Well-Being)
Immune System and Allergy
Aboriginal and Torres Strait Islander Health - Determinants of Health

Career Best Publications

Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5 and OCA2/P loci; The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology
Disease-specific, neurosphere-derived cells as models for brain disorders; Disease models & mechanisms
Human Melanoblasts in Culture: Expression of BRN2 and Synergistic Regulation by Fibroblast Growth Factor-2, Stem Cell Factor and Endothelin-3; The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology
TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients; Molecular Vision

Research Publications

Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5 and OCA2/P loci; The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology
Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes; Toxicology and Applied Pharmacology
BRN2 in melanocytic cell development, differentiation and transformation; From Melanocytes to Melanoma: The Progression of Malignancy
CDKN2A is not the principle target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin; International Journal of Cancer
Characterisation of colonic dysplasia-like epithelial atypia in murine colitis; World journal of gastroenterology
Characterization of the Melanoma miRNAome by Deep Sequencing; PLoS One
Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro. Experimental Cell Research; Experimental Cell Research
Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage; Narrowing the Gap Between Stem Cell Science and Cell Therapy
Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage; 2014 Australian Health and Medical Research Congress (AHMRC)
Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage; Australian Health & Medical Research Congress
Deletion mapping on the short arm of chromosome 1 in Merkel cell carcinoma; Cancer Detection and Prevention
Disease-specific, neurosphere-derived cells as models for brain disorders; Disease models & mechanisms
Enriched retinal ganglion cells derived from human embryonic stem cells; Scientific Reports
Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx; Cell Biochemistry and Function
Expression of developmentally regulated transcription factors in Merkel cell carcinoma; The Merkel Cell Structure-Development-Function-Cancerogenesis
Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma; International Journal of Cancer
Gene expression profiling reveals distinct expression patterns for Classic versus Variant Merkel cell phenotypes and new classifier genes to distinguish Merkel cell from small cell lung carcinoma; Oncogene
Gene expression profiling reveals two distinct subtypes of Merkel Cell Carcinoma; In: The Merkel Cell Structure-Development-Function-Cancerogensesis
Human Melanoblasts in Culture: Expression of BRN2 and Synergistic Regulation by Fibroblast Growth Factor-2, Stem Cell Factor and Endothelin-3; The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology
Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor; Pigment Cell & Melanoma Research
NRF2 Activation Restores Disease Related Metabolic Deficiencies in Olfactory Neurosphere-Derived Cells from Patients with Sporadic Parkinson's Disease; PLoS ONE
Nrf2 dysfunction in patient-derived cell lines in a new model of sporadic Parkinsons disease; Keystone Symposium on Aging and Diseases of Aging
Participant understanding and recall of informed consent for induced pluripotent stem cell biobanking; Cell and Tissue Banking
Peeking into the molecular trove of discarded surgical specimens; Clinical and Experimental Ophthalmology
Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes; Journal of Investigative Dermatology
POU domain transcription factors: BRN2 as a regulator of melanocytic growth and tumourigenesis
PPAR gamma agonists attenuate proliferation and modulate Wnt/‚-catenin signalling in melanoma cells; International Journal of Biochemistry and Cell Biology
Proneural and Proneuroendocrine Transcription Factor Expression In Cutaneous Mechanoreceptor (Merkel) Cells and Merkel Cell Carcinoma; International Journal of Cancer
Red hair is the null phenotype of MC1R; Human Mutation
Reflections on the value of mapping the final theory examination in a molecular biochemistry unit; Journal of Microbiology and Biology Education
Researchers see hope for glaucoma sufferers using stem cells
Rotenone susceptibility phenotype in olfactory derived patient cells as a model of idiopathic Parkinsonís disease; PloS One
Screening of human primary melanocytes of defined melanocortin-1 receptor genotype: pigmentation marker, ultrastructural and UV-survival studies; Pigment Cell & Melanoma Research
Self-reported Student Confidence in Troubleshooting Ability Increases After Completion of an Inquiry-Based PCR Practical; Biochemistry and Molecular Biology Education
SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes; Toxicology and Applied Pharmacology
SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes; Journal of Dermatological Science
SOX9 and SOX10 but Not BRN2 Are Required for Nestin Expression in Human Melanoma Cells; The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology
Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells; Particle and Fibre Toxicology
The Recycling Endosome Protein Rab17 Regulates Melanocytic Filopodia Formation and Melanosome Trafficking; Traffic: The International Journal of Intracellular Transport
TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients; Molecular Vision

Research Projects

2012: Ageing and Diseases of Ageing, Japan; University of Tasmania (UTAS)
CRISPR screen to identify key genes driving DFTD; University of Tasmania Foundation Inc (UTF)
CRISPR/Cas gene editing of Batten disease genes in patient-specific stem cells; Batten Disease Support and Research Association (BDSRA)
Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies; University of Tasmania Foundation Inc (UTF)
Epigenetic Regulation of Tumour Supressors in Skin Cancer; Cancer Council of Tasmania (CCT)
Extracellular matrix remodelling in the glaucomatous trabecular meshwork; Clifford Craig Foundation (CCFoundation)
Investigating Batten disease-causing CLN3 mutations in patient-specific stem cells and neurons; Royal Hobart Hospital Research Foundation (RHHRF)
Investigating the utility of retinal Base-Editing; Royal Hobart Hospital Research Foundation (RHHRF)
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer; Clifford Craig Foundation (CCFoundation)
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (Scholarship Sarron Randall-Demllo) ; Australian Rotary Health Research Fund (ARHRF)
Optimisation of CRISPR/Cas gene editing in the retina.; Bayer Pharma AG (BPAG)
Optimizing trabecular meshwork differentiation; University of Tasmania (UTAS)
Protein Recycling is Disrupted in Parkinson's Disease; Brain Foundation (BrainF)
Protein recycling is disrupted in Parkinson's disease; University of Tasmania (UTAS)
The INK4 locus in glaucoma - functional assessment of the non-coding RNA gene ANRIL in patient-specific cells; Clifford Craig Foundation (CCFoundation)
The landscape of gene expression changes in the aqueous humor drainage pathway of glaucoma patients; Clifford Craig Foundation (CCFoundation)
Towards a patient-specific stem cell model of the blinding eye disease glaucoma; Clifford Craig Foundation (CCFoundation)
Understanding the role of inflammasomes in inflammatory bowel disease (IBD); Clifford Craig Foundation (CCFoundation)
Using stem cells to understand glaucoma; Ophthalmic Research Institute of Australia (ORIA)
Glaucoma Fibroblast Cultures

Research Candidate Supervision

A Novel Human Embryonic Stem Cell Derived Model of Trabecular Meshwork Tissue- Investigation of the Molecular Mechanisms of Complex Disease
Analysing the Regulatory and Effector T Cell Balance in Inflammatory Bowel Disease- Can the CCR6-CCL20 axis be exploited as a therapeutic Target
Epigenetic mechanisms of arsenic-induced transformation in human keratinocytes
The Role of Inflammasomes in the Pathogenesis of Inflammatory Bowel Disease
The Role of the Inflammasome in the Pathogenesis of IBD
Trabecular Meshwork Dysfunction in Glaucoma using Patient-specific iPS Cells