Web Access Research Portal

Researcher: Korner, H (Professor Heinrich Korner)

Fields of Research

Innate immunity
Cellular immunology
Animal physiology - systems
Central nervous system
Humoural immunology and immunochemistry
Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
Infectious diseases
Pharmaceutical sciences
Cell development, proliferation and death
Cell neurochemistry
Medical parasitology
Health services and systems
Animal immunology
Biochemistry and cell biology
Rheumatology and arthritis
Cancer cell biology
Metabolic medicine
Medical biotechnology
Genome structure and regulation
Epigenetics (incl. genome methylation and epigenomics)
Cardiovascular medicine and haematology
Medical physiology

Research Objectives

Clinical health
Expanding knowledge in the health sciences
Expanding knowledge in the biological sciences
Allied health therapies (excl. mental health services)
Diagnosis of human diseases and conditions
Public health (excl. specific population health)
Terrestrial biodiversity
Expanding knowledge in psychology

Career Best Publications

Research Publications

β2GP1, anti-β2GP1 antibodies and platelets: key players in the antiphospholipid syndrome; Antibodies
1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells; Innate Immunity
A Versatile High Throughput Screening System for the Simultaneous Identification of Anti-Inflammatory and Neuroprotective Compounds; Journal of Alzheimer's Disease
Absence of TNF leads to alternative activation in peritoneal macrophages in experimental listeria monocytogenes infection; Immunological Investigations
Absence of tumor necrosis factor supports alternative activation of macrophages in the liver after infection with Leishmania major; Frontiers in Immunology
Adenovirus persistence in T-cells - Evidence for AD2 E3/19k-MHC class-I interaction; Journal of Leukocyte Biology
Adenovirus-induced liver pathology is mediated through TNF receptors I and II but is independent of TNF or lymphotoxin; Journal of Immunology
Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice; Journal of Leukocyte Biology
An Essential Role for Tumor Necrosis Factor in Natural Killer Cell-mediated Tumor Rejection in the Peritoneum; The Journal of Experimental Medicine
An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance; Acta Neuropathologica
An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance; Journal of Neuropathology and Experimental Neurology
An immunodominant CD4+ T cell site on the nucleocapsid protein of murine coronavirus contributes to protection against encephalomyelitis; Journal of General Virology
Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells ; Journal of Leukocyte Biology
Analysis of the maturation process of dendritic cells deficient for TNF and lymphotoxin-alpha reveals an essential role for TNF; Journal of Leukocyte Biology
Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-gamma and is independent of perforin and granzymes; European Journal of Immunology
Astrocytes as antigen presenting cells for primary and secondary T cell responses. Effect of astrocyte infection by murine hepatitis virus; Advances in Experimental Medicine and Biology
B cell movement in TNF-deficient mice: Evidence for an involvement of TNF-regulated chemokines in the formation of B cell follicles; Immunobiology: Experimental and Clinical
Beta-1 Integrin Is Not Essential for Hematopoiesis but Is Necessary for the T Cell-Dependent IgM Antibody Response; Immunity
Both lymphotoxin-alpha and TNF are crucial for control of Toxoplasma gondii in the central nervous system; Journal of Immunology
Both Tumor Necrosis Factor Receptor Signaling Pathways Contribute to Mortality but not to Splenomegaly in Generalized Lymphoproliferative Disorder; Antibodies
CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?
CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress; Blood
CCR6 and CCL20: emerging players in the pathogenesis of rheumatoid arthritis; Immunology and Cell Biology
CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse; Immunology and Cell Biology
CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development; Immunology and Cell Biology
CCR6/CCL20 chemokine axis in human immunodeficiency virus immunity and pathogenesis; Journal of General Virology
CCR7 facilitates the pro-inflammatory function of dendritic cells in experimental leishmaniasis; Parasite Immunology
CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity; Blood
CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis; European Journal of Immunology
Challenging cytokine redundancy: Inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice; The Journal of Experimental Medicine
Cognitive dysfunction in mice deficient for TNF and its receptors; American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Coronavirus induced demyelinating encephalomyelitis in rats: Immunopathological aspects of viral persistency; Advances in Experimental Medicine and Biology
Coronavirus-induced encephalomyelitis: an immunodominant CD4(+) T cell site on the nucleocapsid protein contributes to protection; Advances in Experimental Medicine and Biology
Critical points of TNF action in the CNS inflammatory process defined in gene-targeted mice; Brain Pathology
Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting; The Journal of Experimental Medicine
Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes; European Journal of Immunology
Different regulatory mechanisms in protozoan parasitic infections
Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue; European Journal of Immunology
Divergent expression of inflammatory dermal chemokines in cutaneous leishmaniasis; Parasite Immunology
Down-Regulation of HLA Antigens by the Adenovirus Type-2 E3/19k Protein in a T-Lymphoma Cell-Line; Journal of Virology
Early CCR6 expression on B cells modulates germinal centre kinetics and efficient antibody responses; Immunology and Cell Biology
Emerging roles for G-protein coupled receptors in development and activation of macrophages; Frontiers in Immunology
Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma; Journal of Immunology
Everolimus limits aortic aneurysm in the apolipoprotein E-deficient mouse by downregulating C-C chemokine receptor 2 positive monocytes; Arteriosclerosis, Thrombosis, and Vascular Biology
Expression of CCR6 on B cells in systemic lupus erythematosus patients; Clinical Rheumatology
Expression of membrane-bound CC chemokine ligand 20 on follicular T helper cells in T-B-cell conjugates; Frontiers in Immunology
Fatal leishmaniasis in the absence of TNF despite a strong Th1 response; Frontiers in Microbiology
Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration; Cell Reports
Gene knock-out technology - a methodological overview for the interested novice ; Journal of Immunological Methods
Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro; Nucleic Acids Research
Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice; The Journal of Experimental Medicine
Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis; Frontiers in Immunology
Host-Parasite Interactions; Molecular Parasitology: Protozoan Parasites and their Molecules
Immune down-regulation and peripheral deletion of CD8 T cells does not require TNF receptor-ligand interactions nor CD95 (Fas, APO-1); European Journal of Immunology
Immunopathology of murine cerebral malaria; Naunyn-Schmiedebergs Archives of Pharmacology
Implications of the targeted disruption of the genes for TNF and LT for B cell maturation and migration; Immunobiology: Experimental and Clinical
Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice; Cancer Research
Induction of novel cytokines and chemokines by advanced glycation endproducts determined with a cytometric bead array; Cytokine
Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response; Journal of Immunology
Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina; European Journal of Immunology
LIGHT is critical for IL-12 production by dendritic cells, optimal CD4(+) th1 cell response, and resistance to leishmania major; Journal of Immunology
Loss of TNF signaling facilitates the development of a novel Ly-6Clow macrophage population permissive for Leishmania major infection; Journal of Immunology
Lymphotoxin alpha beta 2 (Membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice; Journal of Immunology
Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen; The Journal of Experimental Medicine
Lymphotoxin controls alpha(E)beta 7-integrin expression by peripheral CD8(+) T cells; Immunology and Cell Biology
Mechanism of Cytotoxicity and Cellular Uptake of Lipophilic Inert Dinuclear Polypyridylruthenium(II) Complexes; ChemMedChem: chemistry enabling drug discovery
Meeting of the Australian Flow Cytometry Group; 34th Annual Meeting of the Australasian Flow Cytometry Group
Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs; European Journal of Immunology
Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation; Immunity
MicroRNA-31 negatively regulates Interleukin-34 expression in vitro; Immunological Investigations
Migration of Salmonella typhimurioum-harboring bone marrow-derived dendritic cells towards the chemokines CCL19 and CCL21; Microbial Pathogenesis
Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases; Frontiers in Pharmacology
Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice; Journal of Immunology
NLRP3 inflammasome in colitis and colitis-associated colorectal cancer; Mammalian Genome
Non-anticoagulant fractions of enoxaparin suppress inflammatory cytokine release from peripheral blood mononuclear cells of allergic asthmatic individuals; PLoS One
Nucleocapsid or spike protein specific CD4+ T lymphocytes protect against coronavirus-induced encephalomyelitis in the absence of CD8+ T cells; Journal of Immunology
Prevention of experimental autoimmune encephalomyelitis (EAE) by TNF-R (p55)-huIgG: Mechanisms of action; European Cytokine Network
Protective Immunity and Delayed Type Hypersensitivity Reaction are Uncoupled in Experimental Leishmania major Infection of CCR6-negative Mice; Microbes and Infection: A Journal on Infectious Agents and Host Defenses
Rapidly fatal Leishmaniasis in resistant C57BL/6 mice lacking TNF; Journal of Immunology
Recirculating and marginal zone B cell populations can be established and maintained independently of primary and secondary follicles; Immunology and Cell Biology
Redundancy of interleukin-6 in the differentiation of T cell and monocyte subsets during cutaneous leishmaniasis ; Experimental Parasitology
Rel/NF-kappa B family member RelA regulates NK1.1(-) to NK1.1(+) transition as well as IL-15-induced expansion of NKT cells; European Journal of Immunology
Relevance of the T cell receptor-ligand avidity for immunity to infection; Journal of Microbial & Biochemical Technology
Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in Experimental Autoimmune Encephalomyelitis; Journal of Immunology
Roles of SAMHD1 in antiviral defense, autoimmunity and cancer; Reviews in Medical Virology
Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation; Immunity
Soluble lymphotoxin is an important effector molecule in GVHD and GVL; Blood
Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin; Journal of Immunology
The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis; PLOS One
The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection; Immunobiology
The association between vitamin D and multiple sclerosis risk: 1,25(OH)2D3 induces super-enhancers bound by VDR; Frontiers in Immunology
The attenuation of the gld syndrome in the absence of TNF; Tissue Antigens
The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses; Blood
The CCR6-CCL20 axis in humoral immunity and T-B cell immunobiology; Immunobiology
The Control of Leishmania (Leishmania) major by TNF in vivo is dependent on the Parasite Strain; Microbes and Infection: A Journal on Infectious Agents and Host Defenses
The effects of TNF deficiency on age-related cognitive performance; Psychoneuroendocrinology
The emerging role of voltage-gated sodium channels in tumor biology; Frontiers in Oncology
The relationship between CCR6 and its binding partners: Does the CCR6-CCL20 axis have to be extended?; Cytokine
The role of monocytes in models of infection by protozoan parasites; Molecular Immunology
The role of TNF in parasitic diseases: Still more questions than answers; International Journal for Parasitology
TNF but not Fas ligand provides protective anti-L-major immunity in C57BL/6 mice ; Microbes and Infection: A Journal on Infectious Agents and Host Defenses
TNF controls the infiltration of dendritic cells into the site of Leishmania major infection; Medical Microbiology and Immunology
TNF controls the inflammatory response in peripheral tissues in experimental cutaneous leishmaniasis ; Tissue Antigens
TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection; Proceedings of the National Academy of Sciences of the United States of America
TNF is important for pathogen control and limits brain damage in murine cerebral listeriosis; Journal of Immunology
TNF may negatively regulate phagocytosis of Devil Facial Tumour Disease cells by activated macrophages; Immunological Investigations
TNF modulates susceptibility to UVB-induced systemic immunomodulation in mice by effects on dermal mast cell prevalence; European Journal of Immunology
TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice; Psychoneuroendocrinology
TNF-dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder; European Journal of Immunology
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection; Cell Reports
TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus; Journal of Immunology
Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial; Osteoarthritis and Cartilage: Journal of The Osteoarthritis Research Society International
Tumor necrosis factor alpha stimulates expression of adenovirus early region 3 proteins: implications for viral persistence; National Academy of Sciences of The United States of America. Proceedings
Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system; European Journal of Immunology
Tumor necrosis factor is important for pathogen control, but does not induce brain damage in murine cerebral listeriosis; International Journal of Medical Microbiology
Tumor necrosis factor negative bone marrow-derived dendritic cells exhibit deficient IL-10 expression; Immunology and Cell Biology
Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype; The Journal of Experimental Medicine
Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype; Immunobiology: Experimental and Clinical
Tumor necrosis factor: a master-regulator of leukocyte movement; Immunology Today
Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction; Translational Neuroscience
Tumour necrosis factor and Lymphotoxin: Molecular aspects and role in tissue-specific autoimmunity; Immunology and Cell Biology
Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis; National Academy of Sciences of The United States of America. Proceedings
Unique requirements for reactivation of virus-specific memory B lymphocytes; Journal of Immunology
Voltage-gated sodium channel Nav1.5 promotes proliferation, migration and invasion of oral squamous cell carcinoma; Acta Biochimica et Biophysica Sinica
WNT ligands contribute to the immune response during septic shock and amplify endotoxemia-driven inflammation in mice; Blood Advances

Research Projects

Absence of CC chemokine receptor 6 dysregulates the humoral immune response; National Health & Medical Research Council (NHMRC)
Do adaptive regulatory cells or activated T cells dominate in cystic fibrosis?; Royal Hobart Hospital Research Foundation (RHHRF)
Epigenetic regulation of T-cell gene expression programs; The Select Foundation (SelF)
Functional consequences of Multiple Sclerosis-associated genetic changes in Vitamin D metabolism genes in T cells and the pathogenesis of autoimmunity; Multiple Sclerosis Australia (MSA)
Human SLE: Searching new biomarkers and potential targets for therapy; The Lupus Association of Tasmania (LAT)
Is Vitamin D really involved in MS?; Multiple Sclerosis Australia (MSA)
Modulation of leishmaniasis by the proinflammatory cytokines TNF; National Health & Medical Research Council (NHMRC)
Reversible and irreversible TNF-mediated cognitive decline; National Health & Medical Research Council (NHMRC)
The biological role of CCR6 - CCL20 chemokine axis in humoral immunity; The Select Foundation (SelF)
Upgrade of the flow cytometry facility of the Menzies Research Institute with a multi-parameter analytical flow cytometer CyAn ADP 9 Color for key applications ; Clive & Vera Ramaciotti Foundation (CVRF)

Research Candidate Supervision

Analysing the Regulatory and Effector T Cell Balance in Inflammatory Bowel Disease- Can the CCR6-CCL20 axis be exploited as a therapeutic Target
C-Rel driven chromatin change in immunological models of inflammation.
Investigate the role of tumour necrosis factor (TNF) in the defense against bacterial infection and cancer cells
Role of TNF in the regulation of the adaptive T cell response in Leishmaniasis
The Role of the CC-Chemokine Receptor 6 in B Cell Autoimmunity
The Role of the Inflammasome in the Pathogenesis of IBD