Web Access Research Portal

Researcher: Gell, DA (Dr David Gell)

Fields of Research

Structural Biology (incl. Macromolecular Modelling)
Enzymes
Medical Bacteriology
Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
Cell Development, Proliferation and Death
Cellular Nervous System
Central Nervous System
Biochemistry and Cell Biology
Bacteriology
Epidemiology
Infectious Diseases
Medical Biochemistry and Metabolomics
Cell Metabolism
Biologically Active Molecules
Plant Biology
Separation Science
Transition Metal Chemistry

Research Objectives

Expanding Knowledge in the Biological Sciences
Infectious Diseases
Blood Disorders
Nervous System and Disorders
Human Pharmaceutical Treatments (e.g. Antibiotics)
Cardiovascular System and Diseases
Expanding Knowledge in the Medical and Health Sciences
Preventive Medicine
Health Education and Promotion
Human Pharmaceutical Products
Expanding Knowledge in the Chemical Sciences
Respiratory System and Diseases (incl. Asthma)
Diagnostic Methods
Endocrine Organs and Diseases (excl. Diabetes)
Health and Support Services

Career Best Publications

A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin; Journal of Biological Chemistry
A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP; Journal of Molecular Biology
Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein; Journal of Biological Chemistry
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin; Cell
Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem; Nature: International Weekly Journal of Science

Research Publications

α-Hemoglobin-stabilizing Protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond; Journal of Biological Chemistry
A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin; Journal of Biological Chemistry
A DNA double-strand break defective fibroblast cell line (180BR) derived from a radiosensitive patient represents a new mutant phenotype ; Cancer Research
A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination ; Mutation Research - DNA Repair
A new zinc binding fold underlines the versatility of zinc binding modules in protein evolution ; Structure
A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP; Journal of Molecular Biology
AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state; Biochemical Journal
An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke; The International Journal of Chronic Obstructive Pulmonary Disease
An antagonist of the platelet-activating factor receptor inhibits streptococcus pneumoniae and non-typeable haemophilus influenzae infection of human bronchial epithelial cells exposed to cigarette smoke; Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting
An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis; Journal of Clinical Investigation
An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae; International Journal of Antimicrobial Agents
Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein; Journal of Biological Chemistry
Characterization of the conserved interaction between GATA and FOG family proteins; Journal of Biological Chemistry
Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression; Nature Genetics
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product ; Cell
Effects of calcium binding and the hypertrophic cardiomyopathy A8V mutation on the dynamic equilibrium between closed and open conformations of the regulatory N-domain of isolated cardiac troponin C; Biochemistry
Engineering a protein scaffold from a PHD finger; Structure
Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus; National Academy of Sciences of The United States of America. Proceedings
Hemoglobin variants: biochemical properties and clinical correlates; Cold Spring Harbor Perspectives in Medicine
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse ; National Academy of Sciences of The United States of America. Proceedings
Ikaros: a key regulator of haematopoiesis; International Journal of Biochemistry and Cell Biology
Insights into Hemoglobin Assembly through in Vivo Mutagenesis of α-Hemoglobin Stabilizing Protein; Journal of Biological Chemistry
Interdomain orientation of cardiac Troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state; Protein Science
IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus; Journal of Infectious Diseases
Loss of alpha-hemoglobin-stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia; Journal of Clinical Investigation
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex; Nucleic Acids Research
Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury; Pl o S One
Modified mRNA rescue of maternal CK1/8 mRNA depletion in Xenopus oocytes; Antisense and Nucleic Acid Drug Development
Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20; Nucleic Acids Research
Molecular and biochemical characterization of xrs mutants defective in Ku80; Molecular and Cellular Biology
Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin; Cell
NMR spectroscopy in the analysis of protein-protein interactions; Modern Magnetic Resonance
Role of alpha hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia; New York Academy of Sciences. Annals
Staphylococcus aureus uses a novel multidomain receptor to break apart human hemoglobin and steal its heme; Journal of Biological Chemistry
Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH; Journal of Biological Chemistry
Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem; Nature: International Weekly Journal of Science
Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus; Journal of Biological Chemistry
Synthesis, Characterization, and Bioactivity of Mid-Functional PolyHPMA-Lysozyme Bioconjugates ; Macromolecules
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity ; Immunity
The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen; The Journal of biological chemistry
The cell adhesion molecule, connectin, and the development of the Drosophila neuromuscular system; Journal of Cell Science
The detection and quantitation of protein oligomerization; Advances in Experimental Medicine and Biology: Protein Dimerization and Oligomerization in Biology
The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme; PloS one
The PRE-derived NMR model of the 38.8-kDa tri-domain IsdH protein from Staphylococcus aureus suggests that it adaptively recognizes human hemoglobin; Journal of Molecular Biology
The structure of α-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive α-haemoglobin dimerization interface; Acta Crystallographica. Section F: Structural Biology and Crystallization Communications
The structure of haemoglobin bound to the haemoglobin receptor IsdH from Staphylococcus aureus shows disruption of the native α-globin haem pocket; Acta Crystallographica. Section D: Biological Crystallography
Two-state conformational equilibrium in the Par-4 leucine zipper domain; Proteins: Structure, Function, and Genetics
Zinc-finger Genes; Encyclopedia of the Human Genome

Research Projects

Australian Synchrotron Beamline Proposal Access Travel Award; Australian Synchrotron (ASynch)
Biophysical characterisation of the haemoglobin receptor from Streptococcus pyogenes; The Select Foundation (SelF)
How does the LRP receptor megalin promote regenerative neuronal growth?; National Health & Medical Research Council (NHMRC)
Investigating the molecular function of alpha-Haemoglobin stabilising protein; Australian Research Council (ARC)
Purchase of a high resolution NMR spectrometer with liquid chromatography module; Australian Research Council (ARC)
Rising Stars 3; University of Tasmania (UTAS)
The role of alpha-haemoglobin stabilising protein in haemoglobin production and as a therapeutic for thalassaemia; National Health & Medical Research Council (NHMRC)
The role of store-operated calcium entry in neuronal development; National Health & Medical Research Council (NHMRC)
David Gell - Discretionary Account

Research Candidate Supervision

Fermentation Studies on Biofuel Production
Molecular Mechanisms Used by Staphylococcus Aureus to Access Iron from Human Haemoglobin
Pharmaceutical Studies on Jack Jumper Ant Venom Immunotherapy Products
The Role of the CC-Chemokine Receptor 6 in B Cell Autoimmunity