Web Access Research Portal

Researcher: Lewis, KE (Dr Katherine Lewis)

Fields of Research

Neurology and neuromuscular diseases
Cellular nervous system
Central nervous system
Systems biology

Research Objectives

Clinical health
Expanding knowledge in the biomedical and clinical sciences
Expanding knowledge in the health sciences

Career Best Publications

Research Publications

C9orf72 expansion disrupts ATM-mediated chromosomal break repair; Nature Neuroscience
AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice; Molecular Therapy - Methods & Clinical Development
Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function; Disease Models & Mechanisms
Distribution of exogenous metallothionein following intraperitoneal and intramuscular injection of metallothionein-deficient mice; Histology and histopathology
Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity; Disease Models & Mechanisms
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: Changes in arginase1 and inducible nitric oxide synthase; Journal of Neuroinflammation
Mislocalisation of TDP‐43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex; Journal of Neurochemistry
Plastin 3 promotes motor neuron axonal growth and extends survival in a mouse model of spinal muscular atrophy; Molecular Therapy - Methods & Clinical Development
The influence of metallothionein treatment and treadmill running exercise on disease onset and survival in SOD1G93A amyotrophic lateral sclerosis mice; European Journal of Neuroscience
Translating SOD1 gene silencing toward the clinic: a highly efficacious, off-target-free, and biomarker-supported strategy for fALS; Molecular Therapy - Nucleic Acids
Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits; Disease Models & Mechanisms

Research Projects

Do therapeutically targetable deficits in neuroplasticity drive Frontotemporal Dementia?; Dementia Australia Research Foundation Ltd (DARF)
Targeting ALS cortical excitability dysfunction through nasal delivery of neuropeptide Y; Motor Neurone Disease Research Australia (MNDRA)

Research Candidate Supervision