Web Access Research Portal

Researcher: Tristram, SG (Dr Stephen Tristram)

Fields of Research

Medical bacteriology
Respiratory diseases
Infectious diseases
Medical biochemistry - nucleic acids
Pharmaceutical sciences
Bacteriology
Medical infection agents (incl. prions)
Microbial genetics
Nutritional science
Animal physiology - systems
Mycology
Clinical microbiology
Structural biology (incl. macromolecular modelling)
Microbial ecology
Infectious agents
Health services and systems
Medical microbiology
Enzymes
Central nervous system
Infant and child health
Cell neurochemistry
Clinical chemistry (incl. diagnostics)
Veterinary epidemiology
Cell development, proliferation and death
Medical biochemistry - proteins and peptides (incl. medical proteomics)
Exercise physiology
Sports science and exercise
Allergy
Gastroenterology and hepatology
Veterinary bacteriology
Veterinary pathology
Medical parasitology

Research Objectives

Clinical health
Diagnosis of human diseases and conditions
Other health
Prevention of human diseases and conditions
Expanding knowledge in the environmental sciences
Other education and training
Treatment of human diseases and conditions
Fisheries - aquaculture
Expanding knowledge in the chemical sciences
Expanding knowledge in the biological sciences
Veterinary diagnostics
Neonatal and child health
Mental health services
Human pharmaceutical treatments
Expanding knowledge in the health sciences

Career Best Publications

Antimicrobial resistance in H. influenzae
Characterization of extended-spectrum beta-lactamase-producing isolates of Haemophilus parainfluenzae; Journal of Antimicrobial Chemotherapy
Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro; Journal of Medical Microbiology
Prevalence and genotypic characteristics of β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Australia; Journal of Antimicrobial Chemotherapy
Prevalence and mechanisms of B-lactam resistance in Haemophilus haemolyticus; Journal of Antimicrobial Chemotherapy
Role of inter-species recombination of the ftsI gene in the dissemination of altered penicillin-binding-protein-3-mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus; Journal of Antimicrobial Chemotherapy

Research Publications

blaROB-1 Location on pB1000 in Haemophilus influenzae is widespread and variable cefaclor resistance is associated with altered penicillin-binding proteins; Antimicrobial Agents and Chemotherapy
Haem at the interface between pathogenic and commensal bacterial species in the human respiratory tract; ComBio2018
Haemophilus haemolyticus is infrequently misidentified as Haemophilus influenzae in diagnostic specimens in Australia; Diagnostic Microbiology and Infectious Disease
Haemophilus haemolyticus secretes a novel bacteriocin-like substance that inhibits nontypeable Haemophilus influenzae; Australian Society for Microbiology Annual Scientific Meeting 2017
Streptococcus thermophilus UASt-09 upregulates goblet cell activity in colonic epithelial cells to a greater degree than other probiotic strains; Microorganisms
A comparison of Etest, M.I.C.Evaluator strips and CLSI broth microdilution for determining B-lactam antimicrobial susceptibility in Haemophilus influenzae; Journal of Antimicrobial Chemotherapy
A Comparison of Etest®, M.I.C.EvaluatorTM Strips and CLSI Microbroth Dilution for determining â-lactam Antimicrobial Susceptibility in Haemophilus influenzae; Australian Society for Microbiology
A comparison of MIC-based screening tests for betalactamase-negative ampicillin-resistant Haemophilus influenzae; European Congress on Clinical Microbiology and Infectious Diseases
A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae; Molecular Microbiology
A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics; International Journal of Medical Sciences
A multiplex PCR for β-lactamase genes of Haemophilus influenzae and description of a new blaTEM promoter variant; Journal of Antimicrobial Chemotherapy
A screening test for ESBLs in H. Influenzae; Interscience Conference on Antimicrobials and Chemotherapy
Acquired macrolide resistance genes in Haemophilus influenzae?; Journal of Antimicrobial Chemotherapy
Alternative oxidase: a possible target of anti-Candida therapy; Health & Medical Research Week Scientific Meeting
An in silico model of the alternative oxidase; International Journal of Biosciences and Technology
An evaluation of SNP-based PCR methods for the detection of â-lactamase-negative ampicillin-resistant Haemophilus influenzae; Journal of Infection and Chemotherapy
An isolate of Haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable Haemophilus influenzae; International Journal of Antimicrobial Agents
Antimicrobial resistance in cystic fibrosis isolates of Haemophilus influenzae; British Journal of Biomedical Science
Antimicrobial resistance in H. influenzae
Antimicrobial susceptibility testing of cystic fibrosis and non-cystic fibrosis clinical isolates of Pseudomonas aeruginosa: a comparison of three methods; British Journal of Biomedical Science
Book review - An Atlas of Medical Microbiology by DI Slater, T. Lo and L Narayan; Australian Journal of Medical Science
Can the pathogenicity of Candida spp. be related to growth rate?; Health & Medical Research Week Scientific Meeting
Chapter 7: Haemophilus influenzae and antimicrobial susceptibility; Antimicrobial Susceptibility Testing Methods and Practices with an Australian Perspective
Characterisation of Novel ß-lactamase genes in Haemophilus influenzae; Australian Society for Microbiology National Scientific Meeting
Characterisation of ROB-1 producing strains of H. influenzae; Australian Society for Microbiology
Characterization of extended-spectrum beta-lactamase-producing isolates of Haemophilus parainfluenzae; Journal of Antimicrobial Chemotherapy
Cloned ermTR gene confers low level erythromycin but high level clindamycin resistance in Streptococcus pyogenes NZ131; Microbial Drug Resistance
Combination of altered PBPs and expression of cloned extended-spectrum beta-lactamases confers cefotaxime resistance in Haemophilus influenzae; Journal of Antimicrobial Chemotherapy
Could ESBL's Emerge in â-Lactamase Positive Amoxicillan/Clavulanate Resistant Strains of H. influenzae; Australian Society for Microbiology Scientific Conferrence in Canberra
Development and Evaluation of Pyocin Supplemented Chocolate Agar for the Selective Isolation of Haemophilus influenzae from Cystic Fibrosis Patients; Australian Society for Microbiology
Disc diffusion based screening tests for ESBLs in H. Influenzae; Proceedings of the Australian Society for Antimicrobials
Disc diffusion-based screening tests for extended-spectrum β-lactamases in Haemophilus influenzae; Journal of Antimicrobial Chemotherapy
Editorial: Clifford Craig Foundation researchers
Effect of Altered PBP3 on Haemophilus Influenzae expressing cloned ESBL's; Interscience Conference on Antimicrobial Agents and Chemotherapy
Effect of cloned inhibitor resistant TEM B-lactamases on the susceptibility of H. influenzae to amoxicillin/clavulanate; Journal of Antimicrobial Chemotherapy
Effect of epithelial cell type on in vitro invasion of non-typeable Haemophilus influenzae; Journal of Microbiological Methods
Effect of extended-spectrum â-lactamases on the susceptibility of Haemophilus influenzae to cephalosporins; Journal of Antimicrobial Chemotherapy
Effect of promoter type on relative fitness of H. Influenzae and E. Coli; Australioan Society for Microbiology National Scientific Meeting
Eosinophilic enteritis caused by Enterbius vermicularis; 1998 National Scientific Meeting of the Australian Institute of Medical Scientists
Exploiting the struggle for haem: A new respiratory probiotic candidate?; Australian Society for Microbiology Annual Scientific Meeting
Expression of acquired macrolide resistance genes in Haemophilus influenzae; Journal of Antimicrobial Chemotherapy
Extended spectrum beta-lactamases in Haemophilus?
Extended spectrum beta-lactamases: are we losing the battle?
Extended spectrum â-lactamases in Haemophilus influenzae; ASM Annual Scientific Meeting
Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro; Journal of Medical Microbiology
Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective; BioMed Research International
Haemophilin-producing strains of Haemophilus haemolyticus protect respiratory epithelia from NTHi colonisation and internalisation; Pathogens
Haemophilus haemolyticus as a potential reservoir for ftsI gene mutations and altered penicillin-binding protein 3 mediated resistance in Haemophilus influenzae; European Congress on Clinical Microbiology and Infectious Diseases
Identifying Haemophilus haemolyticus and Haemophilus influenzae by SYBR Green real-time PCR; Journal of Microbiological Methods
In vitro anti-NTHi activity of haemophilin-producing strains of Haemophilus haemolyticus; Pathogens
Inability of Haemophilus haemolyticus to invade respiratory epithelial cells in vitro; Journal of Medical Microbiology
Inorganic particulate matter modulates non-typeable Haemophilus influenzae growth: a link between chronic bacterial infection and geogenic particles; Environmental Geochemistry and Health
Interspecies transfer of the penicillin-binding protein 3-encoding gene ftsI between Haemophilus influenzae and Haemophilus haemolyticus can confer reduced susceptibility to β-lactam antimicrobial agents; Antimicrobial Agents and Chemotherapy
Iron Oxide Particles Alter Bacterial Uptake and the LPS-Induced Inflammatory Response in Macrophages; International Journal of Environmental Research and Public Health
Lactobacillus acidophilus DDS-1 modulates intestinal-specific microbiota, short-chain fatty acid and immunological profiles in aging mice; Nutrients
Maternal and neonatal sepsis caused by Haemophilus influenzae type d; Journal of Medical Microbiology
Molecular detection of Haemophilus influenzae in COPD sputum is superior to conventional culturing methods; British Journal of Biomedical Science
New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways; Clinical Science
Novel blaTEM-positive ampicillin-susceptible strains of Haemophilus influenzae; Journal of Infection and Chemotherapy
Novel ß-Lactamase Positive Ampicillin Susceptible Strains of H. influenzae; Australian Society for Microbiology
Optimization of Multiples PCR to Detect blaGenes in Haemophilius influenzae; Australian Society for Microbiology Conference
Oropharyngeal carriage of hpl-containing Haemophilus haemolyticus predicts lower prevalence and density of NTHi colonisation in healthy adults; Pathogens
PCR screening for beta-lactamase-negative ampicillin-resistant strains of Haemophilus influenzae; European Congress on Clinical Microbiology and Infectious Diseases
PCR screening for the N526K substitution in isolates of Haemophilus influenzae and Haemophilus haemolyticus; Journal of Antimicrobial Chemotherapy
Prevalence and genotypic characteristics of β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Australia; Journal of Antimicrobial Chemotherapy
Prevalence and mechanisms of B-lactam resistance in Haemophilus haemolyticus; Journal of Antimicrobial Chemotherapy
Prevalence of BLNAR strains of H. influenzae in Australia; Australian Society for Antimicrobials
Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation; Journal of Functional Foods
Relationship between clinical site of isolation and ability to form biofilms in vitro in nontypeable Haemophilus influenzae; Canadian Journal of Microbiology
Reliability of Haemophilus influenzae biofilm measurement via static method, and determinants of in vitro biofilm production; Canadian Journal of Microbiology
Role of inter-species recombination of the ftsI gene in the dissemination of altered penicillin-binding-protein-3-mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus; Journal of Antimicrobial Chemotherapy
Salicylhydroxamic Acid Inhibits the Growth of Candida albicans; International Journal of Biological and Life Sciences
Screening and Identifying BLNAR and BLPACR strains of H. influenzae; Australian Society for Antimicrobials
Sequences of small blaTEM-encoding plasmids in Haemophilus influenzae and description of variants falsely negative for blaTEM by PCR; Journal of Antimicrobial Chemotherapy
Surgical masks: operative field contamination following visor-to-visor contact; ANZ Journal of Surgery
Survival, adhesion and immunomodulatory efficacy of spore-forming probiotic Bacillus coagulans; Australian Society for Microbiology National Scientific Meeting, Hobart 2017
Susceptibility testing of H. influenzae: is a â-lactamase test enough?; Australian Society for Microbiology
Susceptibility Testing of H. influenzae: is it worth bothering?; Australian Society for Microbiology National Scientific Meeting
TEM-15 ESBL and altered PBP3 in multi-resistant strains of H. parainfluenzae; Australian Society for Antimicrobials
The effect of artificially introduced inhibitor resistant TEM â-lactamases (IRT's) on the susceptibility of H. influenzae to amoxycillin-clavulanate; Australian Society for Antimicrobials
The Impacts of Iron Laden Particulate Matter on NTHi Growth; Australian Society for Microbiology Annual Scientific Meeting 2017
Variation in selected regions of blaTEM genes and promoters in Haemophilus influenzae; Journal of Antimicrobial Chemotherapy
Â-Lactam Resistance in Haemophilus influenzae; Australian Society for Microbiology

Research Projects

An Amoeba Co-culture Assay Alternative to Mammalian Models of Bacterial Virulence Testing; The MAWA Trust (MAWA)
Are altered penicillin binding proteins in H.influenzae associated with increased capacity to invade respiratory epithelial cells?; Clifford Craig Foundation (CCFoundation)
Are newly introduced electronic smoking devices safe for smoking cessation and implications for SARS-CoV-2 infection (COVID-19); Clifford Craig Foundation (CCFoundation)
Characterisation of Extended Spectrum B-Lactamases and Cephalosporin Resistance in Clinical Isolates of H. parainfluenzae; Clifford Craig Foundation (CCFoundation)
Development and Evaluation of Laboratory Tests to Detect Important Emerging Antibiotic Resistance in Haemophilus Influenzae; Clifford Craig Foundation (CCFoundation)
Development and Evaluation of New Selective Culture Medium for Isolation of Haemophilus Influenzae from Cystic Fibrosis Patients; Clifford Craig Foundation (CCFoundation)
Effect of Variant Gene Expression on Antibiotic Resistance in Haemophilus Influenzae and the Implications for Dissemination of Resistance Genes; Clifford Craig Foundation (CCFoundation)
Enhancement and further in-vitro validation of a potential probiotic to reduce ear and lung infections caused by Haemophilus influenzae.; Clifford Craig Foundation (CCFoundation)
Evaluation of an antibiotic-producing bacterial strain to prevent ear infections; Wesfarmers Limited (WCVID)
Extended Spectrum B-Lactamase in Haemophilus; Clifford Craig Foundation (CCFoundation)
Genetic Variation in B-Lactamase Genes in Haemophilus Influenzae; Clifford Craig Foundation (CCFoundation)
Influence of Specific Prescribing Practices on the Rapid Emergence of Antibiotic Resistance in Haemophilus Influenzae; Clifford Craig Foundation (CCFoundation)
Investigation of Antibiotic Sensitivity & Virulence Factors of the Tasmanian Clonal Strain of Pseudomonas aeuruginosa Isolated from Cystic Fibrosis Patients; Clifford Craig Foundation (CCFoundation)
Is Haemophilus haemolyticus a pathogen?; Royal Hobart Hospital Research Foundation (RHHRF)
Macrolide resistance in patients with chronic respiratory infections; Clifford Craig Foundation (CCFoundation)
Platypus Partnership - A Community and Science-based Conservation Programme; Natural Heritage Trust (NHT)
Potential therapeutic value of normal throat bacteria that produce a novel inhibitory substance for the prevention of respiratory infections; Clifford Craig Foundation (CCFoundation)
Preliminary development of a probiotic to minimise respiratory infection with Haemophilus influenzae; Clifford Craig Foundation (CCFoundation)
Resistance to Macrolide and Fluoroquinolone Antibiotics in Haemophilus Influenzae; Clifford Craig Foundation (CCFoundation)
Testing a new therapy against lung infections for people with cystic fibrosis; Clifford Craig Foundation (CCFoundation)
The Acquisition of New Strains of Non-Typeable Haemophilus Influenzae Is The Leading Cause of Acute Exacerbations in Tasmanian COPD Patients; Clifford Craig Foundation (CCFoundation)
Whole genome sequencing of non-typeable H. influenzae to unravel pathogenesis and persistence; University of Tasmania (UTAS)

Research Candidate Supervision

Acquired Macrolide Resistance Genes in Non-typeable Haemophilus influenzae
Application of Raman Spectroscopy to the Evaluation of Biofilm Formation and Virulence of Pathogenic Microorganisms
Identification of genes involved in increased invasiveness of transformed non-invasive nontypeable Haemophilus influenzae (NTHi) strain with invasive strain DNA using whole genome sequencing.
Microbial Interference with the Pathagenicity of Nontypeable Haemophilus Influenzae
Phenotypic and genotypic characterisation of altered penicillin-binding protein 3 (PBP3) mediated resistance in Haemophilus influenzae and Haemophilus haemolyticus