Web Access Research Portal

Researcher: Eri, RD (Associate Professor Raj Eri)

Fields of Research

Genetic immunology
Pharmaceutical sciences
Cell development, proliferation and death
Animal physiology - systems
Gastroenterology and hepatology
Cellular immunology
Respiratory diseases
Immunology
Cell neurochemistry
Nutritional science
Pharmacology and pharmaceutical sciences
Medical bacteriology
Ophthalmology and optometry
Nutrition and dietetics
Higher education
Signal transduction
Cell metabolism
Innate immunity
Biochemistry and cell biology
Central nervous system
Microbial ecology
Metabolic medicine
Rheumatology and arthritis
Community child health
Mental health services
Cancer cell biology
Animal physiology - cell
Haematological tumours
Haematology
Clinical pharmacology and therapeutics
Health and community services
Animal physiology - biophysics
Fine arts
Receptors and membrane biology
Science, technology and engineering curriculum and pedagogy
Medical biochemistry and metabolomics
Aboriginal and Torres Strait Islander public health and wellbeing
Vision science
Education assessment and evaluation
Educational technology and computing
Bacteriology
Infectious agents
Microbiology
Cancer diagnosis
Cardiology (incl. cardiovascular diseases)
Health services and systems
Psychiatry (incl. psychotherapy)
Occupational and workplace health and safety
Geriatrics and gerontology
Traditional, complementary and integrative medicine
Clinical microbiology
Exercise physiology
Epigenetics (incl. genome methylation and epigenomics)
Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
Genetics
Genomics
Visual arts
Solid tumours
Behavioural neuroscience
Traditional Chinese medicine and treatments
Clinical neuropsychology
Human information interaction and retrieval
Health care administration
Health promotion
Cellular nervous system
Clinical pharmacy and pharmacy practice
Chemotherapy
Health surveillance
Sport and exercise nutrition
Cognition
Sports science and exercise
Cell physiology
Food nutritional balance
Pharmacogenomics
Medical biochemistry - nucleic acids
Medical biotechnology
Food properties (incl. characteristics and health benefits)
Cancer genetics
Food engineering
Infectious diseases
Tumour immunology

Research Objectives

Clinical health
Expanding knowledge in the health sciences
Other health
Diagnosis of human diseases and conditions
Public health (excl. specific population health)
Expanding knowledge in the biological sciences
Human pharmaceutical treatments
Human pharmaceutical products
Disease distribution and transmission (incl. surveillance and response)
Prevention of human diseases and conditions
Learner and learning
Treatment of human diseases and conditions
Human biological preventatives
Expanding knowledge in the biomedical and clinical sciences
Health status (incl. wellbeing)
The creative arts
Plant extracts
Workforce transition and employment
Expanding knowledge in the environmental sciences
Preventive medicine
Higher education
Efficacy of medications
Mental health services
Other education and training
Teaching and instruction technologies
Injury prevention and control
Nursing
Neonatal and child health
Nutraceuticals and functional foods
Personnel
Social structure and health
Health inequalities
Expanding knowledge in psychology
Health education and promotion
Women's and maternal health
Emerging defence technologies
Nutrition
Aboriginal and Torres Strait Islander determinants of health

Career Best Publications

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity; Gut: An International Journal of Gastroenterology and Hepatology
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis; PLoS Med
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins; The Journal of Experimental Medicine
Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis; Development (Cambridge)
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model; Inflammatory Bowel Diseases
The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression; Gut pathogens
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis; American Journal of Physiology: Gastrointestinal and Liver Physiology

Research Publications

Ccr6 Deficiency attenuates spontaneous chronic colitis in Winnie; Gastrointestinal Disorders
Lactobacillus acidophilus DDS-1 modulates the gut microbiota and improves metabolic profiles in aging mice; Nutrients
Streptococcus thermophilus UASt-09 upregulates goblet cell activity in colonic epithelial cells to a greater degree than other probiotic strains; Microorganisms
A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics; International Journal of Medical Sciences
A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity; Gut: An International Journal of Gastroenterology and Hepatology
A specific mutation in Muc2 determines early dysbiosis in colitis-prone Winnie mice; Inflammatory Bowel Diseases
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis; PLoS Med
Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis; Cell and Tissue Research
Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis; AJP: Gastrointestinal and Liver Physiology
An appraisal of the current scenario in vaccine research for COVID-19; Viruses
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity; Mucosal Immunology
Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease; Journal of Medical Genetics
Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study; Nutrients
Asperuloside enhances taste perception and prevents weight gain in high-fat fed mice; Frontiers in Endocrinology
Beyond just bacteria: Functional biomes in the gut ecosystem including virome, mycobiome, archaeome and helminths; Microorganisms
Beyond the technical skills: a case for internationalization of graduate attributes in PhD programs; Universal Journal of Educational Research
Bilirubin attenuates ER Stress-Mediated Inflammation, escalates Apoptosis and reduces Proliferation in the LS174T Colonic Epithelial Cell Line; International journal of medical sciences
Biosimilars in inflammatory bowel disease: copycats or genuine replacements?; The Biomedical & Life Sciences Collection, Henry Stewart Talks
Bitter melon protects against ER stress in LS174T colonic epithelial cells; BMC Alternative Medicine
Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study; BMJ
CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis; Genes and Immunity
CCR6–CCL20 Axis in IBD: What Have We Learnt in the Last 20 Years?
CCR6–CCL20-Mediated Immunologic Pathways in Inflammatory Bowel Disease
CD80 binding polyproline helical peptide inhibits T cell activation; Journal of Biological Chemistry
Characterisation of colonic dysplasia-like epithelial atypia in murine colitis; World Journal of Gastroenterology
Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer; The Journal of Pathology
Conjugate products of pyocyanin–glutathione reactions; Chemico-Biological Interactions: a journal of molecular, cellular and biochemical toxicology
Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview; International Journal of Medical and Biological Frontiers
Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage; 2014 Australian Health and Medical Research Congress (AHMRC)
Digital resilience in higher education in response to COVID-19 pandemic: student perceptions from Asia and Australia; Journal of University Teaching and Learning Practice
Does NLRP3 inflammasome and aryl hydrocarbon receptor play an interlinked role in bowel inflammation and colitis-associated colorectal cancer?; Molecules
Dysbiosis triggers ACF development in genetically predisposed subjects; Cancers
Efficacy of probiotics in the prevention of antibiotic-associated diarrhoea (AAD) in children - a review
Empirical evaluation of a virtual laboratory approach to teach lactate dehydrogenase enzyme kinetics; Annals of Medicine and Surgery
Endogenous anti-cancer candidates in GPCR, ER stress, and EMT; Biomedicines
Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology
Endothelin and vascular remodelling in colitis pathogenesis - Appendicitis and appendectomy limit colitis by suppressing endothelin pathways; International Journal of Colorectal Disease
ER stress and the unfolded protein response in intestinal inflammation; American Journal of Physiology: Gastrointestinal and Liver Physiology
Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx; Cell Biochemistry and Function
Fecal microbiota and metabolome in a mouse model of spontaneous chronic colitis: relevance to human inflammatory bowel disease; Inflammatory Bowel Diseases
Fucoidan extracts ameliorate acute colitis; PLoS One
GLTNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease; Journal of Medical Genetics
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins; The Journal of Experimental Medicine
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition); Autophagy
Gut microbial changes, interactions, and their implications on human lifecycle: An ageing perspective; BioMed Research International
Health Benchmarking Project Final Report
Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis; Development (Cambridge)
Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes; Expert Review of Clinical Pharmacology
Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms; International Journal of Molecular Sciences
Idebenone protects against spontaneous chronic murine colitis by alleviating endoplasmic reticulum stress and inflammatory response; Biomedicines
Idebenone: when an antioxidant is not an antioxidant; Redox Biology
Identification of key pro-survival proteins in isolated colonic goblet cells of Winnie, a murine model of spontaneous colitis; Inflammatory Bowel Diseases
Inhibition of APE1/Ref-1 redox signaling alleviates intestinal dysfunction and damage to myenteric neurons in a mouse model of spontaneous chronic colitis; Inflammatory Bowel Diseases
Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells; Cells
Intestinal barrier dysfunction in inflammatory bowel diseases; Inflamm. Bowel Dis
Intestinal epithelium and autophagy: partners in gut homeostasis
Intestinal secretory cell ER stress and inflammation; Biochemical Society Transactions
Lactobacillus acidophilus DDS-1 modulates intestinal-specific microbiota, short-chain fatty acid and immunological profiles in aging mice; Nutrients
Mainstreaming microbes across biomes; Bioscience
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice; Scientific Reports
Messages from the inside. The dynamic environment that favors intestinal homeostasis
Micro RNA expression after ingestion of fucoidan; a clinical study; Marine Drugs
Microbiome-focused asthma management strategies; Current Opinion in Pharmacology
Microbiota modulating nutritional approaches to countering the effects of viral respiratory infections including SARS-CoV-2 through promoting metabolic and immune fitness with probiotics and plant bioactives; Microorganisms
Modulation of interferon activity-associated soluble molecules by appendicitis and appendectomy limits colitis-identification of novel anti-colitic targets; Journal of Interferon and Cytokine Research
Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic Target in Inflammation and Cancer
Navigating the internal landscape: an artistic interpretation of disease
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model; Inflammatory Bowel Diseases
NLRP3 inflammasome in colitis and colitis-associated colorectal cancer; Mammalian Genome
NLRP3 inhibitors as potential therapeutic agents for treatment of inflammatory bowel disease; Current Pharmaceutical Design
NLRP3-dependent and -independent processing of interleukin (IL)-1β in active ulcerative colitis; International Journal of Molecular Sciences
Nod-like receptor pyrin-containing protein 6 (NLRP6) is up-regulated in ileal Crohn’s disease and differentially expressed in goblet cells; Cellular and Molecular Gastroenterology and Hepatology
Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis; Advances in Medicine and Biology
Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae; Developmental Dynamics
Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses; PLoS One
Overriding Elements in Colon Cancer Progression: Some Less Known Facts; Gastro
Pathway analysis of fucoidan activity using a yeast gene deletion library screen; Marine drugs
Peer observation of teaching: reflections of an early career academic; Universal Journal of Educational Research
Pleiotropic immune functions of chemokine receptor 6 in health and disease; Medicines
Preparation for the Treatment of Inflammatory Bowel Disease using a Whole Plant Fibre Extract from Sugar Cane
Probiotic Bacillus coagulans MTCC 5856 spores exhibit excellent in-vitro functional efficacy in simulated gastric survival, mucosal adhesion and immunomodulation; Journal of Functional Foods
Probiotic yoghurt and incidence of diarrhoea in children: a double blind, randomised, controlled trial; Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia
Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum; Cell and Tissue Research
Reflections on the value of mapping the final theory examination in a molecular biochemistry unit; Journal of Microbiology and Biology Education
Regulation and sensing of inflammasomes and their impact on intestinal health
Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation
Role of corticosteroids in chronic obstructive pulmonary disease (COPD); Corticosteroids and Steroid Therapy: New Research
Role of lactic acid probiotic bacteria in IBD
Role of oxidative stress in the pathology and management of human tuberculosis; Oxidative Medicine and Cellular Longevity
Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion; Oncotarget
Short-chain naphthoquinone protects against both acute and spontaneous chronic murine colitis by alleviating inflammatory responses; Frontiers in Pharmacology
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease; Journal of Immunology
Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease; Inflammatory Bowel Disease
Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent; Arthritis & Rheumatism
Survival, adhesion and immunomodulatory efficacy of spore-forming probiotic Bacillus coagulans; Australian Society for Microbiology National Scientific Meeting, Hobart 2017
Synbiotic supplementation containing whole plant sugar cane Fibre and probiotic spores potentiates protective synergistic effects in mouse model of IBD; Nutrients
Synbiotic supplementation with prebiotic green banana resistant starch and probiotic Bacillus coagulans spores ameliorates gut inflammation in mouse model of inflammatory bowel diseases; European Journal of Nutrition
T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation; Leucocytes: Methods and Protocols, Methods in Molecular Biology
The feedback process: Perspectives of first and second year undergraduate students in the disciplines of education, health science and nursing; Journal of University Teaching & Learning Practice
The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility; Seminars in Immunopathology
The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression; Gut pathogens
The Role of Inflammasomes in Intestinal Inflammation
Therapeutic interventions for gut dysbiosis and related disorders in the elderly: Antibiotics, probiotics or faecal microbiota transplantation?; Beneficial Microbes
TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients; Molecular Vision
TNFα deficiency results in increased IL-1β in an early onset of spontaneous murine colitis; Cell Death and Disease
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis; American Journal of Physiology: Gastrointestinal and Liver Physiology
Urban-associated diseases: candidate diseases, environmental risk factors, and a path forward; Environment International
Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients; BMC Ophthalmology

Research Projects

2013: The 16th International Congress of Mucosal Immunology (ICMI 2013) Canada 17 to 20 July 2013; University of Tasmania (UTAS)
Basic understanding of Tasmanian older adult gut microbiota; Clifford Craig Foundation (CCFoundation)
Can blockade of inflammasomes be a therapeutic option in inflammatory bowel disease (IBD)?- A pilot study; Clifford Craig Foundation (CCFoundation)
Cognition in multiple sclerosis: Associations with gut-brain biomarkers and exploration of cognitive symptom change in response to a nutrition intervention; Clifford Craig Foundation (CCFoundation)
Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies; University of Tasmania Foundation Inc (UTF)
Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): role in both airway fibrosis and lung cancer; Clifford Craig Foundation (CCFoundation)
Exploring the Mechanisms of Generation of Intestinal TH17 Responses and the Mechanisms of TH17 mediated Pathology; National Health & Medical Research Council (NHMRC)
Exploring the mechanisms responsible for the early transformation from chronic colitis to colorectal cancer; Cancer Council of Tasmania (CCT)
Extracellular matrix remodelling in the glaucomatous trabecular meshwork; Clifford Craig Foundation (CCFoundation)
Fucoidan and gut health; Department of Industry, Science, Energy and Resources (DISER)
International Congress of Mucosal Immunology Conference - 5 to 9 July 2011, France (June 2011); University of Tasmania (UTAS)
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer; Clifford Craig Foundation (CCFoundation)
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (Scholarship Sarron Randall-Demllo) ; Australian Rotary Health Research Fund (ARHRF)
Investigation of the role of NLRP3 in inflammatory Bowel Diseases; Gastroenterological Society of Australia (GESA)
Making sense of biology data through artistic interactions; University of Tasmania (UTAS)
Non anticoagulant molecules of heparin for the management of ulcerative colitis; Royal Hobart Hospital Research Foundation (RHHRF)
The INK4 locus in glaucoma - functional assessment of the non-coding RNA gene ANRIL in patient-specific cells; Clifford Craig Foundation (CCFoundation)
The Role of NLRP3 Inflammasome in Colitis-associated Colorectal Cancer; Cancer Council of Tasmania (CCT)
Understanding the role of inflammasomes in inflammatory bowel disease (IBD); Clifford Craig Foundation (CCFoundation)
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota
Efficacy of K-Fibre in gastrointestinal health
Fucoidan and stem cell mobilisation
Glaucoma Fibroblast Cultures
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer
Vaccine Immunomodulation Throughout the Aging Lifespan

Research Candidate Supervision

Analysing the Regulatory and Effector T Cell Balance in Inflammatory Bowel Disease- Can the CCR6-CCL20 axis be exploited as a therapeutic Target
Identification of genes involved in increased invasiveness of transformed non-invasive nontypeable Haemophilus influenzae (NTHi) strain with invasive strain DNA using whole genome sequencing.
The Role of Inflammasomes in the Pathogenesis of Inflammatory Bowel Disease
The Role of the Inflammasome in the Pathogenesis of IBD
Trabecular Meshwork Dysfunction in Glaucoma using Patient-specific iPS Cells