Web Access Research Portal

Researcher: Eri, RD (Dr Raj Eri)

Fields of Research

Genetic Immunology
Animal Physiology - Systems
Cell Development, Proliferation and Death
Pharmaceutical Sciences
Gastroenterology and Hepatology
Immunology
Cell Neurochemistry
Respiratory Diseases
Pharmacology and Pharmaceutical Sciences
Optometry and Ophthalmology
Nutritional Physiology
Biochemistry and Cell Biology
Higher Education
Nutrition and Dietetics
Community Child Health
Animal Physiology - Cell
Cancer Cell Biology
Haematological Tumours
Haematology
Health and Community Services
Medical and Health Sciences
Education Assessment and Evaluation
Medical Biochemistry and Metabolomics
Innate Immunity
Science, Technology and Engineering Curriculum and Pedagogy
Vision Science
Complementary and Alternative Medicine
Receptors and Membrane Biology
Metabolic Medicine
Epigenetics (incl. Genome Methylation and Epigenomics)
Genetics
Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
Computer-Human Interaction
Cell Metabolism
Traditional Chinese Medicine and Treatments
Visual Arts and Crafts
Pharmacogenomics
Cellular Immunology
Exercise Physiology
Medical Bacteriology
Clinical and Sports Nutrition
Food Engineering
Infectious Diseases
Cell Physiology
Tumour Immunology

Research Objectives

Digestive System Disorders
Nervous System and Disorders
Respiratory System and Diseases (incl. Asthma)
Neurodegenerative Disorders Related to Ageing
Immune System and Allergy
Expanding Knowledge in the Medical and Health Sciences
Public Health (excl. Specific Population Health)
Disease Distribution and Transmission (incl. Surveillance and Response)
Expanding Knowledge in the Biological Sciences
Diagnostic Methods
Clinical Health (Organs, Diseases and Abnormal Conditions)
Infectious Diseases
Health Status (e.g. Indicators of Well-Being)
Human Pharmaceutical Treatments (e.g. Antibiotics)
Learner and Learning Processes
Teaching and Instruction Technologies
Workforce Transition and Employment
Cancer and Related Disorders
Child Health
Injury Control
Preventive Medicine
Nursing
Education and Training
Personnel
Social Structure and Health
Blood Disorders
Emerging Defence Technologies
Aboriginal and Torres Strait Islander Health - Determinants of Health

Career Best Publications

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity; Gut: An International Journal of Gastroenterology and Hepatology
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis; PLoS Med
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins; The Journal of Experimental Medicine
Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis; Development (Cambridge)
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model; Inflammatory Bowel Diseases
The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression; Gut pathogens
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis; American Journal of Physiology: Gastrointestinal and Liver Physiology

Research Publications

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity; Gut: An International Journal of Gastroenterology and Hepatology
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis; PLoS Med
Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis; Cell and Tissue Research
Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis; AJP: Gastrointestinal and Liver Physiology
An intestinal epithelial defect conferring ER stress results in inflammation involving both innate and adaptive immunity; Mucosal Immunology
Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease; Journal of Medical Genetics
Bitter melon protects against ER stress in LS174T colonic epithelial cells; Bmc Alternative Medicine
Can probiotic yogurt prevent diarrhoea in children on antibiotics? A double-blind, randomised, placebo-controlled study; BMJ
CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?
CCR5-Delta32 mutation is strongly associated with primary sclerosing cholangitis; Genes and Immunity
CD80 binding polyproline helical peptide inhibits T cell activation; Journal of Biological Chemistry
Characterisation of colonic dysplasia-like epithelial atypia in murine colitis; World journal of gastroenterology
Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer; The Journal of Pathology
Conjugate products of pyocyanin–glutathione reactions; Chemico-Biological Interactions: a journal of molecular, cellular and biochemical toxicology
Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview; International Journal of Medical and Biological Frontiers
Defining conditions to direct human pluripotent stem cells towards the glaucoma-affected trabecular meshwork cell lineage; 2014 Australian Health and Medical Research Congress (AHMRC)
Efficacy of probiotics in the prevention of antibiotic-associated diarrhoea (AAD) in children - a review
Empirical evaluation of a virtual laboratory approach to teach lactate dehydrogenase enzyme kinetics; Annals of Medicine and Surgery
Endothelin and vascular remodelling in colitis pathogenesis - Appendicitis and appendectomy limit colitis by suppressing endothelin pathways; International Journal of Colorectal Disease
ER stress and the unfolded protein response in intestinal inflammation; American Journal of Physiology: Gastrointestinal and Liver Physiology
Exposure of colonic epithelial cells to oxidative and endoplasmic reticulum stress causes rapid potassium efflux and calcium influx; Cell Biochemistry and Function
Fecal Microbiota and Metabolome in a Mouse Model of Spontaneous Chronic Colitis: Relevance to Human Inflammatory Bowel Disease; Inflammatory bowel diseases
Fucoidan extracts ameliorate acute colitis; PLoS One
GLTNFalpha and IL10 SNPs act together to predict disease behaviour in Crohn's disease; Journal of Medical Genetics
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins; The Journal of Experimental Medicine
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition); Autophagy
Health Benchmarking Project Final Report
Hemps, a novel EGF-like protein plays a central role in ascidian metamorphosis; Development (Cambridge)
Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes; Expert Review of Clinical Pharmacology
Intestinal barrier dysfunction in inflammatory bowel diseases; Inflamm. Bowel Dis
Intestinal epithelium and autophagy: partners in gut homeostasis
Intestinal secretory cell ER stress and inflammation; Biochemical Society Transactions
Messages from the inside. The dynamic environment that favors intestinal homeostasis
Modulation of interferon activity-associated soluble molecules by appendicitis and appendectomy limits colitis-identification of novel anti-colitic targets; Journal of Interferon and Cytokine Research
Neutralizing IL-23 is superior to blocking IL-17 in suppressing intestinal inflammation in a spontaneous murine colitis model; Inflammatory Bowel Diseases
NLRP3 inhibitors as potential therapeutic agents for treatment of inflammatory bowel disease
Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis; Advances in Medicine and Biology
Novel gene containing multiple epidermal growth factor-like motifs transiently expressed in the papillae of the ascidian tadpole larvae; Developmental Dynamics
Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses; PLoS One
Overriding Elements in Colon Cancer Progression: Some Less Known Facts; Gastro
Peer observation of teaching: reflections of an early career academic; Universal Journal of Educational Research
Probiotic yoghurt and incidence of diarrhoea in children: a double blind, randomised, controlled trial; Thirty-Eighth Annual Scientific Meeting of The Nutrition Society of Australia
Rectal prolapse in Winnie mice with spontaneous chronic colitis: changes in intrinsic and extrinsic innervation of the rectum; Cell and tissue research
Reflections on the value of mapping the final theory examination in a molecular biochemistry unit; Journal of Microbiology and Biology Education
Role of Chemokine Ligand CCL20 and its Receptor CCR6 in lntestinal Inflammation
Role of corticosteroids in chronic obstructive pulmonary disease (COPD); Corticosteroids and Steroid Therapy: New Research
Secretory leukoprotease inhibitor is required for efficient quercetin-mediated suppression of TNFα secretion; Oncotarget
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease; Journal of Immunology
Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease; Inflammatory Bowel Disease
Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent; Arthritis & Rheumatism
T cell transfer model of colitis: a great tool to assess the contribution of T cells in chronic intestinal inflammation; Leucocytes: Methods and Protocols, Methods in Molecular Biology
The feedback process: Perspectives of first and second year undergraduate students in the disciplines of education, health science and nursing; Journal of University Teaching & Learning Practice
The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression; Gut pathogens
The Role of Inflammasomes in Intestinal Inflammation
TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients; Molecular Vision
Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis; American Journal of Physiology: Gastrointestinal and Liver Physiology

Research Projects

2013: The 16th International Congress of Mucosal Immunology (ICMI 2013) Canada 17 to 20 July 2013; University of Tasmania (UTAS)
Can blockade of inflammasomes be a therapeutic option in inflammatory bowel disease (IBD)?- A pilot study; Clifford Craig Foundation (CCFoundation)
Epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): role in both airway fibrosis and lung cancer; Clifford Craig Foundation (CCFoundation)
Exploring the Mechanisms of Generation of Intestinal TH17 Responses and the Mechanisms of TH17 mediated Pathology; National Health & Medical Research Council (NHMRC)
Exploring the mechanisms responsible for the early transformation from chronic colitis to colorectal cancer; Cancer Council of Tasmania (CCT)
Extracellular matrix remodelling in the glaucomatous trabecular meshwork; Clifford Craig Foundation (CCFoundation)
Fucoidan and gut health; Department of Industry and Science (DoIS)
International Congress of Mucosal Immunology Conference - 5 to 9 July 2011, France (June 2011); University of Tasmania (UTAS)
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer; Clifford Craig Foundation (CCFoundation)
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer (Scholarship Sarron Randall-Demllo) ; Australian Rotary Health Research Fund (ARHRF)
Making sense of biology data through artistic interactions; University of Tasmania (UTAS)
Non anticoagulant molecules of heparin for the management of ulcerative colitis; Royal Hobart Hospital Research Foundation (RHHRF)
The INK4 locus in glaucoma - functional assessment of the non-coding RNA gene ANRIL in patient-specific cells; Clifford Craig Foundation (CCFoundation)
Understanding the role of inflammasomes in inflammatory bowel disease (IBD); Clifford Craig Foundation (CCFoundation)
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota
Fucoidan and stem cell mobilisation
Glaucoma Fibroblast Cultures
Investigation of carcinogenesis pathways in colitis-associated colorectal cancer
Vaccine Immunomodulation Throughout the Aging Lifespan

Research Candidate Supervision

Analysing the Regulatory and Effector T Cell Balance in Inflammatory Bowel Disease- Can the CCR6-CCL20 axis be exploited as a therapeutic Target
Identification of genes involved in increased invasiveness of transformed non-invasive nontypeable Haemophilus influenzae (NTHi) strain with invasive strain DNA using whole genome sequencing.
The Role of Inflammasomes in the Pathogenesis of Inflammatory Bowel Disease
The Role of the Inflammasome in the Pathogenesis of IBD
Trabecular Meshwork Dysfunction in Glaucoma using Patient-specific iPS Cells