Web Access Research Portal

Researcher: Wilson, RR (Dr Richard Wilson)

Fields of Research

Rheumatology and Arthritis
Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
Orthopaedics
Pharmacology and Pharmaceutical Sciences
Protein Trafficking
Separation Science
Cell Metabolism
Aquaculture
Microbial Ecology
Cardiology (incl. Cardiovascular Diseases)
Microbiology
Animal Physiology - Systems
Medical Biochemistry and Metabolomics
Chemical Oceanography
Flow Analysis
Nephrology and Urology
Exercise Physiology
Signal Transduction
Bacteriology
Medical Bacteriology
Respiratory Diseases
Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
Enzymes
Food Packaging, Preservation and Safety
Industrial Microbiology (incl. Biofeedstocks)
Basic Pharmacology
Veterinary Immunology
Plant Physiology
Biostatistics
Analytical Biochemistry
Environmental Chemistry (incl. Atmospheric Chemistry)
Animal Immunology
Otorhinolaryngology
Environmental Management
Gene Expression (incl. Microarray and other genome-wide approaches)
Ecosystem Function
Zoology

Research Objectives

Expanding Knowledge in the Medical and Health Sciences
Skeletal System and Disorders (incl. Arthritis)
Expanding Knowledge in the Biological Sciences
Cardiovascular System and Diseases
Fisheries - Aquaculture
Expanding Knowledge in the Chemical Sciences
Diagnostic Methods
Expanding Knowledge in the Environmental Sciences
Respiratory System and Diseases (incl. Asthma)
Aquaculture Fin Fish (excl. Tuna)
Antarctic and Sub-Antarctic Flora, Fauna and Biodiversity
Neurodegenerative Disorders Related to Ageing
Public Health (excl. Specific Population Health)
Processed Food Products and Beverages (excl. Dairy Products)
Blood Disorders
Physical and Chemical Conditions of Water in Marine Environments
Aboriginal and Torres Strait Islander Health - Determinants of Health
National Security
Food Safety
Cancer and Related Disorders
Aquaculture Prawns
Infectious Diseases
Flora, Fauna and Biodiversity at Regional or Larger Scales
Effects of Climate Change and Variability on Australia (excl. Social Impacts)
Ecosystem Adaptation to Climate Change
Expanding Knowledge in the Agricultural and Veterinary Sciences

Career Best Publications

Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development; Molecular and Cellular Proteomics
Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome; Journal of Biological Chemistry
Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics; Molecular and Cellular Proteomics
The extracellular matrix: an underexplored but important proteome; EXPERT REVIEW OF PROTEOMICS

Research Publications

A cautionary note when using pepsin as a probe for the formation of a collagen triple helix; Matrix Biology: Clinical and Experimental
A disintegrin and metalloproteinase with thrombospondin motifs - 5 (ADAMTS - 5) forms catalytically active oligomers; Journal of Biological Chemistry
A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and 2-D electrophoresis; World Congress of the OsteoArthritis-Research-Society-International
A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and two-dimensional gel electrophoresis; Matrix Biology: Clinical and Experimental
Aberrant disulfide bond formation and endoplasmic reticulum stress is associated with disease-causing collagen X mutations; XIVth Meeting of the Federation of European Connective Tissues Societies
Analysis of cartilage development in normal mice and in mice lacking collagen IX or COMP; The 18th Lorne Proteomics Symposium
Application of metabolomics and proteomics for biomarker discovery and development of therapies for the transmissible cancer, Tasmanian Devil Facial Tumour Disease; The 22nd Annual Lorne Proteomics Symposium 2017
Attached and planktonic Listeria monocytogenes global proteomic responses and associated influence of strain genetics and temperature; Journal of Proteome Research
Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors; PPCTSS 2013
Cartilage proteomics: Challenges, solutions and recent advances; Proteomics - Clinical Applications
Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization; Osteoarthritis and Cartilage
Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development; Molecular and Cellular Proteomics
Chromatographic methods for the isolation, separation and characterisation of dissolved organic matter; Environmental Science Processes and Impacts
Chronic β2-adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men; Journal of Physiology
Collagen X chains harboring Schmid metaphyseal chondrodysplasia NC1 domain mutations are selectively retained and degraded in stably transfected cells; Journal of Biological Chemistry
Comment on “Structural characterization of dissolved organic matter: a review of current techniques for isolation and analysis” by E. C. Minor, M. M. Swenson, B. M. Mattson, and A. R. Oyler, Environ. Sci.: Processes Impacts, 2014, 16, 2064; Environmental Science: Processes and Impacts
Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome; Journal of Biological Chemistry
Comparative proteomic analysis of normal mouse cartilage and cartilage lacking collagen IX: Altered extracellular matrix composition and interactions; 7th International conference on the biology of proteoglycans
Comparative Proteomic Analysis of Normal, Collagen VI null and Collagen IX Null Mouse Cartilage; Gordon Research Conference on Cartilage Biology and Pathology
Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics; Molecular and Cellular Proteomics
Differentially expressed proteins in gill and skin mucus of Atlantic salmon (Salmo salar) affected by amoebic gill disease; Fish and Shellfish Immunology
Discovery of biomarkers for Tasmanian devil cancer (DFTD) by metabolic profiling of serum; Journal of Proteome Research
Discovery of serum biomarkers for Tasmanian Devil cancer (DFTD); The Australian & New Zealand Metabolomics Conference (ANZMET)
Effects of downstream drug metabolites of spironolactone on aortic stiffness and ambulatory blood pressure; 24th Scientific Meeting of the International Society of Hypertension
ER stress disrupts chondrocyte differentiation; phenocopying a metaphyseal chondrodysplasia by introducing targeted ER stress in vivo; XVth Meeting of the Federation of European Connective Tissues Societies
Expression profiling of mouse femoral head cultures stimulated with interleukin-1alpha or retinoic acid; World Congress of the OsteoArthritis-Research-Society-International
Extensive gene acquisition in the extremely psychrophilic bacterial species Psychroflexus torquis and the link to sea-ice ecosystem specialism; Genome Biology and Evolution
Fibrillin assembly: dimer formation mediated by amino-terminal sequences; Journal of Cell Science
Fractionation of dissolved organic matter on coupled reversed-phase monolithic columns and characterisation using reversed-phase liquid chromatography-high resolution mass spectrometry; Chromatographia
From non-targeted metabolomics to quantitative analysis of uremic compounds in chronic kidney disease; The Australian & New Zealand Metabolomics Conference (ANZMET)
Identification of vitamin D sensitive pathways during lung development; Respiratory Research
Identifying novel markers of late onset neonatal sepsis using proteomic analysis; The 20th Annual Congress of the Perinatal Society of Australia and New Zealand
Impact of lactose starvation on the physiology of Lactobacillus casei GCRL 163 in the presence or absence of Tween 80; Journal of Proteome Research
Increasing deposition efficiency of N-3 LC-PUFA in Altlantic Salmon smolt using high DHA and ALA oils; 2015 Aquaculture Europe
Intracellular and extracellular consequences of collagen X misfolding; 29th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Intracellular retention and degradation of collagen X chains harboring disease-causing mutations; XIIIth Meeting of the Federation of European Connective Tissues Societies
Investigation into dissolved neutral sugars and their microbial conversion in natural and artificially produced dissolved organic matter using ion chromatography with pulsed amperometric detection and reversed-phase liquid chromatography-high resolution mass spectrometry; Analytical Methods
Light stimulated growth of proteorhodopsin bearing sea-ice psychrophile Psychroflexus torquis is salinity-dependent; Strategic Science in Antarctica 2013 Conference
Light-stimulated growth of proteorhodopsin-bearing sea-ice psychrophile Psychroflexus torquis is salinity dependent; The ISME Journal
Mass spectrometry for the determination of renal disease biomarkers in urine; 24th meeting of the Australian and New Zealand Society for Mass Spectrometry
Metabolomics Data Normalization with EigenMS; PLoS One
Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion; Journal of Lipid Research
Method development for protein enrichment in gel-free proteomic analysis of whole fish; 16th International Symposium on Fish Nutrition and Feeding
Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response; Journal of Biological Chemistry
Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia; Human Mutation
New insights into cartilage biology and pathology using mouse cartilage proteomics; 9th World Congress of the International Cartilage Repair Society
Novel aspects of chondrocyte biology and changes in the cartilage ECM revealed by proteomic analysis of mouse cartilage development in vivo; Australian Health and Medical Research Congress 2010
Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation; The 21st Annual Lorne Proteomics Symposium
Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation; Proceedings of the 38th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation; Journal of Proteome Research
Novel methods for cartilage proteomic analysis; 32nd Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Preliminary validation of a high docosahexaenoic acid (DHA) and -linolenic acid (ALA) dietary oil blend: tissue fatty acid composition and liver proteome response in Atlantic salmon (Salmo salar) smolts; PLoS One
Protein disulfide isomerase acts as a molecular chaperone during the assembly of procollagen; Journal of Biological Chemistry
Proteomic analysis of cartilage proteins; Methods: A Companion to Methods in Enzymology
Proteomic analysis of cytokine-induced cartilage degradation in normal cartilage and cartilage lacking ADAMTS-5 activity; 38th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Proteomic analysis of mouse cartilage degradation in vitro; 7th Pan-pacific Connective Tissue Societies Symposium
Proteomic analysis of mouse growth plate cartilage; Proteomics
Proteomic analysis of mouse growth plate cartilage using microdissection and 2-D electrophoresis; 3rd Australian Health and Medical Research Congress
Proteomic characterization of cartilage matrix synthesis and breakdown; 8th Pan-Pacific Connective Tissue Societies Symposium (PPCTSS)
Proteomic characterization of mouse cartilage degradation in vitro; World Congress of the OsteoArthritis-Research-Society-International
Proteomic characterization of mouse cartilage degradation in vitro; Arthritis and Rheumatism
Proteomic identification of novel extracellular matrix components and cartilage protein fragments; 30nd Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Proteomic insight into functional changes of proteorhodopsin-containing bacterial species Psychroflexus torquis under different illumination and salinity levels; Journal of Proteome Research
Proteomic profiling of cartilage degradation in vitro; XVth Meeting of the Federation of European Connective Tissues Societies
Proteomic profiling of cartilage ECM formation and maturation using sequential protein extraction and quantitative mass spectrometry; XVIIth Meeting of the Federation of European Connective Tissues Societies
Proteomic profiling of cartilage extracellular matrix maturation; World Congress of the OsteoArthritis-Research-Society-International
Proteomics makes progress in cartilage and arthritis research; Matrix Biology: Clinical and Experimental
S100A8 and S100A9 in experimental osteoarthritis; Arthritis Research and Therapy
Schmid Metaphyseal Chondrodysplasia mutations in collagen X elicit the unfolded protein response; Protein misfolding and disease satellite meeting of the 2006 Lorne Protein Conference
Semi-permeabilized cells to study procollagen assembly; EXTRACELLULAR MATRIX PROTOCOLS
Sequential protein extraction as an efficient method for improved proteome coverage in larvae of Atlantic salmon (Salmo salar); Proteomics
Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus; Acta Diabetologica
Simple, quantitative method for low molecular weight dissolved organic matter extracted from natural waters based upon high performance counter-current chromatography; Analytica Chimica Acta
Spironolactone reduces aortic stiffness in people with a hypertensive response to exercise via the blood pressure dependent effects of canrenoate; 12th meeting of the Association for Research into Arterial Structure and Physiology
Spironolactone reduces aortic stiffness via blood pressure-dependent effects of canrenoate; Metabolomics
Targeted induction of endoplasmic reticulum stress induces cartilage pathology; Plos Genetics
That Old Devil Called Tasmanian; The Column
The extracellular matrix: an underexplored but important proteome; EXPERT REVIEW OF PROTEOMICS
The light-driven proton pump proteorhodopsin promotes growth of sea-ice psychrophile during salinity stress; The Australian Society for Microbiology Annual Scientific Meeting
The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain; Metabolomics
The protein landscape of Listeria monocytogenes ScottA within its supraoptimal temperature growth range reveals a weakness to oxidative stress; 5th Congress of European Microbiologists (FEMS 2013)
The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells; Biochemical Journal
Triploid Atlantic salmon shows similar performance, fatty acid composition and proteome response to diploids during early freshwater rearing; Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
Type-III procollagen assembly in semi-intact cells: Chain association, nucleation and triple-helix folding do not require formation of inter-chain disulphide bonds but triple-helix nucleation does require hydroxylation; Biochemical Journal
Ultra-fast continuous-flow photo degradation of organic peroxide explosives for their efficient conversion into hydrogen peroxide and possible application; Propellants, Explosives, Pyrotechnics
Umbilical cord stromal cell differentiation: little correlation with known markers of the chondrocyte phenotype or cartilage extracellular matrix; Molecular and Cellular Proteomics
WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan; Journal of Biological Chemistry

Research Projects

2013: Cartilage biology and pathology gordon research conference, Switzerland 7-12 April 2013; University of Tasmania (UTAS)
Development of Protein Analysis Methods to Facilitate Proteomic Analysis by Mass Spectometry ; University of Tasmania (UTAS)
Metabolomics for Tasmanian devil DFTD biomarkers discovery; University of Tasmania Foundation Inc (UTF)
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients; Royal Hobart Hospital Research Foundation (RHHRF)
Proteomic analysis of protein growth and n-3 PUFA synthesis in Atlantic salmon; CSIRO-Commonwealth Scientific & Industrial Research Organisation (CSIRO)
Proteomics for Tasmanian devils: a DFTD pre-clinical test; University of Tasmania Foundation Inc (UTF)
Resolving Dissolved Organic Matter: New Multi-dimensional Separation Approaches.; Australian Research Council (ARC)
Bioplatforms Australia (BPA) - collaborative research

Research Candidate Supervision

Identifying Sustainable Feeding Strategies for Salmon
Spirulina- Dual-Purpose Lamb Supplement - Breed and Sex Effects on Productivity and Product Quality