Fields of Research

Rheumatology and arthritis
Proteomics and intermolecular interactions (excl. medical proteomics)
Aquaculture
Pharmacology and pharmaceutical sciences
Separation science
Orthopaedics
Protein trafficking
Crop and pasture protection (incl. pests, diseases and weeds)
Cell metabolism
Animal immunology
Bacteriology
Microbial ecology
Cardiology (incl. cardiovascular diseases)
Respiratory diseases
Tumour immunology
Medical bacteriology
Animal physiology - systems
Proteins and peptides
Microbiology
Industrial microbiology (incl. biofeedstocks)
Medical biochemistry - proteins and peptides (incl. medical proteomics)
Basic pharmacology
Veterinary diagnosis and diagnostics
Medical biochemistry and metabolomics
Cancer cell biology
Conservation and biodiversity
Chemical oceanography
Neurology and neuromuscular diseases
Flow analysis
Food packaging, preservation and processing
Ophthalmology
Signal transduction
Proteomics and metabolomics
Fish physiology and genetics
Cellular nervous system
Pharmaceutical sciences
Nephrology and urology
Cell development, proliferation and death
Cellular interactions (incl. adhesion, matrix, cell wall)
Gastroenterology and hepatology
Enzymes
Aquaculture and fisheries stock assessment
Molecular targets
Other chemical sciences
Clinical pharmacology and therapeutics
Food sustainability
Veterinary immunology
Biostatistics
Plant physiology
Atmospheric composition, chemistry and processes
Analytical biochemistry
Radiation therapy
Gene expression (incl. microarray and other genome-wide approaches)
Otorhinolaryngology
Environmental management
Ecosystem function
Wildlife and habitat management
Zoology

Research Objectives

Expanding knowledge in the health sciences
Clinical health
Expanding knowledge in the biological sciences
Aquaculture fin fish (excl. tuna)
Expanding knowledge in the chemical sciences
Field grown vegetable crops
Diagnosis of human diseases and conditions
Fisheries - aquaculture
Terrestrial biodiversity
Expanding knowledge in the environmental sciences
Control of pests, diseases and exotic species in terrestrial environments
Prevention of human diseases and conditions
Biodiversity in Antarctic and Southern Ocean environments
Food safety
Horticultural crops
Other health
Non-dairy milk
Cheese
Treatment of human diseases and conditions
Measurement and assessment of marine water quality and condition
Aboriginal and Torres Strait Islander determinants of health
National security
Aquaculture prawns
Dairy products
Public health (excl. specific population health)
Ecosystem adaptation to climate change
Effects of climate change on Australia (excl. social impacts)
Expanding knowledge in the agricultural, food and veterinary sciences
Environmentally sustainable commercial services and tourism

Career Best Publications

Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development; Molecular and Cellular Proteomics
Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome; Journal of Biological Chemistry
Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics; Molecular and Cellular Proteomics
The extracellular matrix: an underexplored but important proteome; Expert Review of Proteomics

Research Publications

In planta transcriptome and proteome profiles of Spongospora subterranea in resistant and susceptible host environments illuminates regulatory principles underlying host-pathogen interaction; Biology
A cautionary note when using pepsin as a probe for the formation of a collagen triple helix; Matrix Biology: Clinical and Experimental
A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers; Journal of Biological Chemistry
A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae; Molecular Microbiology
A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and 2-D electrophoresis; World Congress of the OsteoArthritis Research Society International
A robust method for proteomic characterization of mouse cartilage using solubility-based sequential fractionation and two-dimensional gel electrophoresis; Matrix Biology: Clinical and Experimental
A simple apparatus for electrokinetic removal of sodium dodecyl sulfate from protein digests; Journal of Chromatography A
Aberrant disulfide bond formation and endoplasmic reticulum stress is associated with disease-causing collagen X mutations; XIVth Meeting of the Federation of European Connective Tissues Societies
Ablation of the miRNA cluster 24 has profound effects on extracellular matrix protein abundance in cartilage; International Journal of Molecular Sciences
An integrative multi-omics analysis reveals microRNA-143 as a potential therapeutic to attenuate retinal angiogenesis; Nucleic Acid Therapeutics
Analysis of cartilage development in normal mice and in mice lacking collagen IX or COMP; The 18th Lorne Proteomics Symposium
Application of metabolomics and proteomics for biomarker discovery and development of therapies for the transmissible cancer, Tasmanian Devil Facial Tumour Disease; 22nd Annual Lorne Proteomics Symposium 2017
Attached and planktonic Listeria monocytogenes global proteomic responses and associated influence of strain genetics and temperature; Journal of Proteome Research
Bioactivity in an aggrecan 32mer fragment is mediated via toll-like receptors; PPCTSS 2013
Cartilage proteomics: Challenges, solutions and recent advances; Proteomics Clinical Applications
Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization; Osteoarthritis and Cartilage
Cathelicidin-3 associated with serum extracellular vesicles enables early diagnosis of a transmissible cancer; Frontiers in Immunology
Challenges of an emerging disease: The evolving approach to diagnosing devil facial tumour disease; Pathogens
Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development; Molecular and Cellular Proteomics
Chromatographic methods for the isolation, separation and characterisation of dissolved organic matter; Environmental Science Processes and Impacts
Chronic β₂-adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men; Journal of Physiology
Collagen X chains harboring Schmid metaphyseal chondrodysplasia NC1 domain mutations are selectively retained and degraded in stably transfected cells; Journal of Biological Chemistry
Comment on “Structural characterization of dissolved organic matter: a review of current techniques for isolation and analysis” by E. C. Minor, M. M. Swenson, B. M. Mattson, and A. R. Oyler, Environ. Sci.: Processes Impacts, 2014, 16, 2064; Environmental Science: Processes and Impacts
Comparative Proteomic Analysis of Normal and Collagen IX Null Mouse Cartilage Reveals Altered Extracellular Matrix Composition and Novel Components of the Collagen IX Interactome; Journal of Biological Chemistry
Comparative proteomic analysis of normal mouse cartilage and cartilage lacking collagen IX: Altered extracellular matrix composition and interactions; 7th International Conference on the Biology of Proteoglycans
Comparative Proteomic Analysis of Normal, Collagen VI null and Collagen IX Null Mouse Cartilage; Gordon Research Conference on Cartilage Biology and Pathology
Comparative proteomic analysis of potato roots from resistant and susceptible cultivars to Spongospora subterranea zoospore root attachment in vitro; Molecules: A Journal of Synthetic Organic and Natural Product Chemistry
Comprehensive profiling of cartilage extracellular matrix formation and maturation using sequential extraction and label-free quantitative proteomics; Molecular and Cellular Proteomics
Dark metabolism: a molecular insight into how the Antarctic sea-ice diatom Fragilariopsis cylindrus survives long-term darkness; New Phytologist
Differentially expressed proteins in gill and skin mucus of Atlantic salmon (Salmo salar) affected by amoebic gill disease; Fish and Shellfish Immunology
Discovery of biomarkers for Tasmanian devil cancer (DFTD) by metabolic profiling of serum; Journal of Proteome Research
Discovery of serum biomarkers for Tasmanian Devil cancer (DFTD); The Australian & New Zealand Metabolomics Conference (ANZMET)
Effects of downstream drug metabolites of spironolactone on aortic stiffness and ambulatory blood pressure; 24th Scientific Meeting of the International Society of Hypertension
Effects of TDP-43 overexpression on neuron proteome and morphology in vitro; Molecular and Cellular Neurosciences
ER stress disrupts chondrocyte differentiation; phenocopying a metaphyseal chondrodysplasia by introducing targeted ER stress in vivo; 15th Meeting of the Federation of European Connective Tissues Societies
Expression profiling of mouse femoral head cultures stimulated with interleukin-1alpha or retinoic acid; World Congress of the OsteoArthritis Research Society International
Extensive gene acquisition in the extremely psychrophilic bacterial species Psychroflexus torquis and the link to sea-ice ecosystem specialism; Genome Biology and Evolution
Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker; Cellular and Molecular Life Sciences
Fibrillin assembly: dimer formation mediated by amino-terminal sequences; Journal of Cell Science
Fractionation of dissolved organic matter on coupled reversed-phase monolithic columns and characterisation using reversed-phase liquid chromatography-high resolution mass spectrometry; Chromatographia
From non-targeted metabolomics to quantitative analysis of uremic compounds in chronic kidney disease; The Australian & New Zealand Metabolomics Conference (ANZMET)
Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease; PLoS ONE
Identification of key pro-survival proteins in isolated colonic goblet cells of Winnie, a murine model of spontaneous colitis; Inflammatory Bowel Diseases
Identification of vitamin D sensitive pathways during lung development; Respiratory Research
Identifying novel markers of late onset neonatal sepsis using proteomic analysis; The 20th Annual Congress of the Perinatal Society of Australia and New Zealand
Impact of lactose starvation on the physiology of Lactobacillus casei GCRL 163 in the presence or absence of Tween 80; Journal of Proteome Research
Increasing deposition efficiency of N-3 LC-PUFA in Altlantic Salmon smolt using high DHA and ALA oils; 2015 Aquaculture Europe
Intracellular and extracellular consequences of collagen X misfolding; 29th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Intracellular retention and degradation of collagen X chains harboring disease-causing mutations; XIIIth Meeting of the Federation of European Connective Tissues Societies
Investigation into dissolved neutral sugars and their microbial conversion in natural and artificially produced dissolved organic matter using ion chromatography with pulsed amperometric detection and reversed-phase liquid chromatography-high resolution mass spectrometry; Analytical Methods
Large-scale protein and phosphoprotein profiling to explore potato resistance mechanisms to Spongospora subterranea infection; Frontiers in Plant Science
Light stimulated growth of proteorhodopsin bearing sea-ice psychrophile Psychroflexus torquis is salinity-dependent; Strategic Science in Antarctica 2013 Conference
Light-stimulated growth of proteorhodopsin-bearing sea-ice psychrophile Psychroflexus torquis is salinity dependent; The ISME Journal
Liver proteome response of pre-harvest Atlantic salmon following exposure to elevated temperature; BMC Genomics
Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons; Disease Models & Mechanisms
Mass spectrometry for the determination of renal disease biomarkers in urine; 24th meeting of the Australian and New Zealand Society for Mass Spectrometry
Metabolomics Data Normalization with EigenMS; PLoS One
Metabolomics reveals increased isoleukotoxin diol (12,13-DHOME) in human plasma after acute Intralipid infusion; Journal of Lipid Research
Method development for protein enrichment in gel-free proteomic analysis of whole fish; 16th International Symposium on Fish Nutrition and Feeding
Misfolding of collagen X chains harboring Schmid metaphyseal chondrodysplasia mutations results in aberrant disulfide bond formation, intracellular retention, and activation of the unfolded protein response; Journal of Biological Chemistry
Mitochondrial respiratory chain function promotes extracellular matrix integrity in cartilage; Journal of Biological Chemistry
Multi‑omics reveals mechanisms of resistance to potato root infection by Spongospora subterranea; Scientific Reports
Multi-lumen capillary based trypsin micro-reactor for the rapid digestion of proteins; Analyst
Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia; Human Mutation
New insights into cartilage biology and pathology using mouse cartilage proteomics; 9th World Congress of the International Cartilage Repair Society
Novel aspects of chondrocyte biology and changes in the cartilage ECM revealed by proteomic analysis of mouse cartilage development in vivo; Australian Health and Medical Research Congress 2010
Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation; The 21st Annual Lorne Proteomics Symposium
Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation; Proceedings of the 38th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Novel elements of the chondrocyte stress response identified using an in vitro model of mouse cartilage degradation; Journal of Proteome Research
Novel methods for cartilage proteomic analysis; 32nd Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Optimisation of sporosori purification and protein extraction techniques for the biotrophic protozoan plant pathogen Spongospora subterranea; Molecules
p53 mutants G245S and R337H associated with the Li-Fraumeni syndrome regulate distinct metabolic pathways; Biochimie
Preliminary validation of a high docosahexaenoic acid (DHA) and -linolenic acid (ALA) dietary oil blend: tissue fatty acid composition and liver proteome response in Atlantic salmon (Salmo salar) smolts; PLoS One
Prolonged heat stress of Lactobacillus paracasei GCRL163 improves binding to human colorectal adenocarcinoma HT-29 cells and modulates the relative abundance of secreted and cell surface-located proteins; Journal of Proteome Research
Properties of an acid-tolerant, persistent Cheddar cheese isolate, Lacticaseibacillus paracasei GCRL163; Journal of Industrial Microbiology and Biotechnology
Protein disulfide isomerase acts as a molecular chaperone during the assembly of procollagen; Journal of Biological Chemistry
Protein levels, air pollution and vitamin D deficiency: links with allergy; ERJ Open Research
Protein metabolism in the liver and white muscle is associated with feed efficiency in Chinook salmon (Oncorhynchus tshawytscha) reared in seawater: evidence from proteomic analysis; Comparative Biochemistry and Physiology - Part D
Proteome analysis of Campylobacter jejuni poultry strain 2704 survival during 45 min exposure to peracetic acid; International Journal of Food Microbiology
Proteomic analysis of Lactobacillus casei GCRL163 cell-free extracts reveals a SecB homolog and other biomarkers of prolonged heat stress; PLoS One
Proteomic analysis of cartilage proteins; Methods: A Companion to Methods in Enzymology
Proteomic analysis of cytokine-induced cartilage degradation in normal cartilage and cartilage lacking ADAMTS-5 activity; 38th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Proteomic analysis of mouse cartilage degradation in vitro; 7th Pan-Pacific Connective Tissue Societies Symposium
Proteomic analysis of mouse growth plate cartilage; Proteomics
Proteomic analysis of mouse growth plate cartilage using microdissection and 2-D electrophoresis; 3rd Australian Health and Medical Research Congress
Proteomic characterization of cartilage matrix synthesis and breakdown; 8th Pan-Pacific Connective Tissue Societies Symposium (PPCTSS)
Proteomic characterization of mouse cartilage degradation in vitro; World Congress of the OsteoArthritis Research Society International
Proteomic characterization of mouse cartilage degradation in vitro; Arthritis and Rheumatism
Proteomic identification of novel extracellular matrix components and cartilage protein fragments; 30th Annual Scientific Meeting of the Matrix Biology Society of Australia and New Zealand
Proteomic insight into functional changes of proteorhodopsin-containing bacterial species Psychroflexus torquis under different illumination and salinity levels; Journal of Proteome Research
Proteomic investigation of brain, liver and intestine in high feed intake and low feed intake Chinook salmon (Oncorhynchus tshawytscha); Aquaculture
Proteomic investigation of liver and white muscle in efficient and inefficient Chinook salmon (Oncorhynchus tshawytscha): fatty acid metabolism and protein turnover drive feed efficiency; Aquaculture
Proteomic profiling of cartilage degradation in vitro; 15th Meeting of the Federation of European Connective Tissues Societies
Proteomic profiling of cartilage ECM formation and maturation using sequential protein extraction and quantitative mass spectrometry; 17th Meeting of the Federation of European Connective Tissues Societies
Proteomic profiling of cartilage extracellular matrix maturation; World Congress of the OsteoArthritis Research Society International
Proteomics makes progress in cartilage and arthritis research; Matrix Biology: Clinical and Experimental
Quantitative proteomics provides an insight into germination-related proteins in the obligate biotrophic plant pathogen Spongospora subterranea; Environmental Microbiology Reports
S100A8 and S100A9 in experimental osteoarthritis; Arthritis Research and Therapy
Salinity effects on guard cell proteome in Chenopodium quinoa; International Journal of Molecular Sciences
Schmid Metaphyseal Chondrodysplasia mutations in collagen X elicit the unfolded protein response; Protein misfolding and disease satellite meeting of the 2006 Lorne Protein Conference
Semi-permeabilized cells to study procollagen assembly; Extracellular Matrix Protocols
Sequential protein extraction as an efficient method for improved proteome coverage in larvae of Atlantic salmon (Salmo salar); Proteomics
Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus; Acta Diabetologica
Shotgun proteomics as a powerful tool for the study of the proteomes of plants, their pathogens, and plant-pathogen interactions; Proteomes
Simple, quantitative method for low molecular weight dissolved organic matter extracted from natural waters based upon high performance counter-current chromatography; Analytica Chimica Acta
Spironolactone reduces aortic stiffness in people with a hypertensive response to exercise via the blood pressure dependent effects of canrenoate; 12th meeting of the Association for Research into Arterial Structure and Physiology
Spironolactone reduces aortic stiffness via blood pressure-dependent effects of canrenoate; Metabolomics
Sugar beet (Beta vulgaris) guard cells responses to salinity stress: a proteomic analysis; International Journal of Molecular Sciences
T-type calcium channel inhibitors induce apoptosis in medulloblastoma cells associated with altered metabolic activity; Molecular Neurobiology
Targeted induction of endoplasmic reticulum stress induces cartilage pathology; Plos Genetics
Temporal changes in the microglial proteome of male and female mice after a diffuse brain injury using label-free quantitative proteomics; Glia
That Old Devil Called Tasmanian; The Column
The extracellular matrix: an underexplored but important proteome; Expert Review of Proteomics
The light-driven proton pump proteorhodopsin promotes growth of sea-ice psychrophile during salinity stress; The Australian Society for Microbiology Annual Scientific Meeting
The metabolomics of alpha-synuclein (SNCA) gene deletion and mutation in mouse brain; Metabolomics
The protein landscape of Listeria monocytogenes ScottA within its supraoptimal temperature growth range reveals a weakness to oxidative stress; 5th Congress of European Microbiologists (FEMS 2013)
The proteomic response is linked to regional lung volumes in ventilator-induced lung injury; Journal of Applied Physiology
The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells; Biochemical Journal
Towards complete identification of allergens in Jack Jumper (Myrmecia pilosula) ant venom and their clinical relevance: An immunoproteomic approach; Clinical and Experimental Allergy
Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells; OncoTarget
Triploid Atlantic salmon shows similar performance, fatty acid composition and proteome response to diploids during early freshwater rearing; Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
Type-III procollagen assembly in semi-intact cells: Chain association, nucleation and triple-helix folding do not require formation of inter-chain disulphide bonds but triple-helix nucleation does require hydroxylation; Biochemical Journal
Ultra-fast continuous-flow photo degradation of organic peroxide explosives for their efficient conversion into hydrogen peroxide and possible application; Propellants, Explosives, Pyrotechnics
Umbilical cord stromal cell differentiation: little correlation with known markers of the chondrocyte phenotype or cartilage extracellular matrix; Molecular and Cellular Proteomics
WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan; Journal of Biological Chemistry

Research Projects

2013: Cartilage biology and pathology gordon research conference, Switzerland 7-12 April 2013; University of Tasmania (UTAS)
Advanced high resolution biomolecular analysis facility for Tasmania; Australian Research Council (ARC)
Development of an early diagnostic liquid biopsy for DFT2; University of Tasmania Foundation Inc (UTF)
Development of Protein Analysis Methods to Facilitate Proteomic Analysis by Mass Spectometry ; University of Tasmania (UTAS)
Exosome proteomics to detect biomarkers of erythropoietin (EPO) use in athletes; World Anti-Doping Agency (WADA)
Experimental Platforms for Aquaculture Production; Blue Economy CRC Co (BECRC)
Identification of devil facial tumour-associated antigens for vaccine development; University of Tasmania Foundation Inc (UTF)
Identifying shared mechanisms in response to radiotherapy; Cancer Council of Tasmania (CCT)
Metabolomics for Tasmanian devil DFTD biomarkers discovery; University of Tasmania Foundation Inc (UTF)
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients; Royal Hobart Hospital Research Foundation (RHHRF)
Proteomic analysis of protein growth and n-3 PUFA synthesis in Atlantic salmon; CSIRO-Commonwealth Scientific & Industrial Research Organisation (CSIRO)
Proteomics for Tasmanian devils: a DFTD pre-clinical test; University of Tasmania Foundation Inc (UTF)
Resolving Dissolved Organic Matter: New Multi-dimensional Separation Approaches.; Australian Research Council (ARC)
Bioplatforms Australia (BPA) - collaborative research
Cawthron Collaborative Research for three PhD Operating & TAG Travel Costs
New therapeutic approaches for genetic skeletal disorders
The impact of culture condition on biochemical egg content in Tasmanian Atlantic salmon

Research Candidate Supervision

Identifying Sustainable Feeding Strategies for Salmon
Spirulina- Dual-Purpose Lamb Supplement - Breed and Sex Effects on Productivity and Product Quality