Web Access Research Portal

Researcher: Rathjen, J (Dr Joy Rathjen)

Fields of Research

Cell Development, Proliferation and Death
Cell Metabolism
Bioethics (human and animal)
Law
Central Nervous System
Applied Sociology, Program Evaluation and Social Impact Assessment
Signal Transduction
Gene Expression (incl. Microarray and other genome-wide approaches)
Medical Biochemistry: Amino Acids and Metabolites
Cellular Nervous System
Foetal Development and Medicine
Epigenetics (incl. Genome Methylation and Epigenomics)

Research Objectives

Expanding Knowledge in the Biological Sciences
Education and Training Systems Policies and Development
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in Law and Legal Studies
Justice and the Law
Reproductive System and Disorders
Expanding Knowledge in the Medical and Health Sciences
Livestock Raising
Flora, Fauna and Biodiversity of environments

Career Best Publications

Research Publications

Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis; Genome Research
A novel role for gamma-secretase in the formation of primitive streak-like intermediates from ES cells in culture; Stem Cells: Reporting on Clinical and Experimental Research in The Field of Progenitor Cell Differentiation and Proliferation
A requirement for FGF signalling in the formation of primitive streak-like intermediates from primitive ectoderm in culture; PL o S One
A system to enrich for primitive streak-derivatives, definitive endoderm and mesoderm, from pluripotent cells in culture; PLoS One
Biology of embyonic stem cells; Human Embryonic Stem cells
Characterisation of sequences required for RNA initiation from the PGK promoter of Saccharomyces cerevisiae; Nucleic Acids Research
CPF1, a yeast protein which functions in centromeres and promoters; The E M B O Journal: (European Molecular Biology Organization)
Culture environment regulates amino acid turnover and glucose utilisation in human ES cells; Reproduction, Fertility and Development
Developmental complexity of early mammalian pluripotent cell populations in vivo and in vitro
Differentiation of embryonic stem cells to a neural fate: a route to re-building the nervous system?
Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population; Development (Cambridge)
Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen; Reproduction
DNA binding of CPF1 is required for optimal centromere function but not for maintaining methionine prototrophy in yeast; Nucleic Acids Research
Embryonic stem cell-derived glial precursors as a vehicle for sulfamidase production in the MPS-IIIA mouse brain; Cell Transplantation
Embryonic stem cells; isolation and application of pluripotent cells from the pre-gastrulation mammalian embryo; Stem Cells Handbook
Endoderm complexity in the mouse gastrula is revealed through the expression of spink3; BioResearch Open Access
ES cells as a model system for understanding mammalian embryogenesis
Ethics and Governance of Stem Cell Banks; Stem Cell Banking: Concepts and Protocols
Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors; Journal of Cell Science
Formation of neural cell populations by differentiation of embryonic stem cells in vitro
Identification of a biological activity that supports maintenance and proliferation of pluripotent cells from the primitive ectoderm of the mouse; Biology of Reproduction
L-proline induces differentiation of ES cells: a novel role for an amino acid in the regulation of pluripotent cells in culture; American Journal of Physiology: Cell Physiology
Lineage specific differentiation of mouse ES cells: formation and differentiation of early primitive ectoderm-like (EPL) cells; Methods in Enzymology
Lineage specific differentiation of pluripotent cells in vitro: A role for extraembryonic cell types
Manipulation of cell: cell contacts and mesoderm suppressing activity direct lineage choice from pluripotent primitive ectoderm-like cells in culture; PL o S One
Metaboloepigenetic regulation of pluripotent stem cells; Stem Cells International
Mouse ES cells: experimental exploitation of pluripotent cell differentiation potential
Oxygen modulates human embryonic stem cell metabolism in the absence of changes in self-renewal; Reproduction, Fertility and Development
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities; Oncogene
Properties and therapeutic potential of stem cells
Properties and uses of embryonic stem cells: prospects for application to human biology and gene therapy
Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters; Mechanisms of Development
Regulation of pluripotent cell differentiation by a small molecule, staurosporine; Differentiation
Response to BMP4 signalling during ES cell differentiation defines novel differentiation intermediates of the ectoderm lineage; Journal of Cell Science
Reversible programming of pluripotent cell differentiation; Journal of Cell Science
Sequence, genomic organisation, and expression of the novel homeobox gene Hesx1; Journal of Biological Chemistry
Src family kinases and p38 mitogen-activated protein kinases regulate pluripotent cell differentiation in culture; PLoS ONE
Stem cells and regenerative medicine: From research to clinical applications; Journal of Law and Medicine
Structure, sequence and function of a marsupial LIF gene: Conservation of IL-6 cytokines; Cytogenetics and Cell Genetics
The Amino Acid Transporter SNAT2 Mediates L-proline induced differentiation of ES cells; American Journal of Physiology: Cell Physiology
The formation of proximal and distal definitive endoderm populations in culture requires p38 MAPK activity; Journal of Cell Science
The metabolic framework of pluripotent stem cells and potential mechanisms of regulation; Stem Cells in Reproductive Medicine Basic Science and Therapeutic Potential 3rd Edition
The States of Pluripotency: Pluripotent Lineage Development in the Embryo and in the Dish; ISRN Stem Cells
Transcriptional control of pluripotency: decisions in early development
Transient pluripotent cell populations during primitive ectoderm formation: Correlation of in vivo and in vitro pluripotent cell development; Journal of Cell Science
Understanding pluripotency how embryonic stem cells keep their options open

Research Projects

Building research and project management skills in fisheries staff in PNG; Australian Centre for International Agricultural Research (ACIAR)
Characterising chemical inducers of embryonic stem cell differentiation; The Select Foundation (SelF)

Research Candidate Supervision