Web Access Research Portal

Researcher: Atkinson, RAK (Dr Rachel Atkinson)

Fields of Research

Cellular nervous system
Neurology and neuromuscular diseases
Central nervous system
Cell development, proliferation and death
Clinical chemistry (incl. diagnostics)

Research Objectives

Clinical health
Treatment of human diseases and conditions
Expanding knowledge in the health sciences
Diagnosis of human diseases and conditions
Expanding knowledge in the biomedical and clinical sciences
Prevention of human diseases and conditions

Career Best Publications

Research Publications

ALS-associated mutant FUS inhibits macroautophagy which is restored by overexpression of Rab1; Cell Death Discovery
C9ORF72 expression and cellular localization over mouse development; Acta neuropathologica communications
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking; Human Molecular Genetics
Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse; Neurobiology of Aging: Experimental and Clinical Research
Combination treatment with leptin and pioglitazone in a mouse model of Alzheimer’s disease; Alzheimer's & Dementia: Translational Research & Clinical Interventions
Effects of TDP-43 overexpression on neuron proteome and morphology in vitro; Molecular and Cellular Neurosciences
Enhanced anti-amyloid effect of combined leptin and pioglitazone in app/ps1 transgenic mice; Current Alzheimer Research
Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer's disease; Neurobiology of Aging
Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice; BMC Anesthesiology
TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy; Disease Models & Mechanisms

Research Projects

A potential metabolic-targeted therapeutic for Amyotrophic lateral sclerosis (ALS): Leptin; Fundacion Hospital Nacional de Paraplejicos (FHNP)
Do Renshaw cells have a role in amyotrophic lateral sclerosis disease progression; University of Tasmania (UTAS)
Proteomic analysis of exosomes from iPS cell-derived neurons with mislocalised TDP-43; Motor Neurone Disease Research Australia (MNDRA)
The role of FTLD proteins in neurite health, function and dysfunction; Dementia Australia Research Foundation Ltd (DARF)
To die or not to die: What is the mechanism of axon degeneration in ALS?; Motor Neurone Disease Research Australia (MNDRA)

Research Candidate Supervision