Web Access Research Portal

Researcher: Kirkcaldie, MTK (Dr Matthew Kirkcaldie)

Fields of Research

Central nervous system
Neurosciences
Neurology and neuromuscular diseases
Cellular nervous system
Mental health services
Health promotion
Aboriginal and Torres Strait Islander public health and wellbeing
Machine learning
Sensory systems
Medicine, nursing and health curriculum and pedagogy
Health and community services
Biomechanical engineering
Motor control
Health services and systems
Other chemical sciences

Research Objectives

Clinical health
Health related to ageing
Other health
Expanding knowledge in the health sciences
Nutrition
Learner and learning
Prevention of human diseases and conditions
Health education and promotion
Diagnosis of human diseases and conditions
Preventive medicine
Expanding knowledge in the environmental sciences

Career Best Publications

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice; Neurobiology of Aging
Chemoarchitectonic Atlas of the Rat Brain; Elsevier
Focal demyelination in Alzheimer's disease and transgenic mouse models; Acta Neuropathologica
Neocortex; The Mouse Nervous System
Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex; Journal of Chemical Neuroanatomy
The Brain: An Introduction to Functional Neuroanatomy; Elsevier
Transcranial magnetic stimulation as therapy for depression and other disorders; Australian and New Zealand Journal of Psychiatry
When brains expand: mind and the evolution of cortex; Acta Neuropsychiatrica

Research Publications

046.08 / O6 - Neither sleep disruption nor induced cortical plasticity precipitates the onset of amyloid-β pathology in an Alzheimer’s disease mouse model: preliminary data from a study of sleep and plasticity as risk factors; Neuroscience 2018
743.10 / P4 - Oligodendrocyte and myelin alterations in Alzheimer’s disease; Neuroscience 2018
Accurate and unbiased quantitation of Amyloid-β fluorescence images using ImageSURF; Current Alzheimer Research
Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice; Journal of Neurotrauma
Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease; Brain Research Bulletin
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice; Neurobiology of Aging
Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system ; Brain Research Bulletin
Bridging the Skull: Electroconvulsive Therapy (ECT) and Repetitive Transcranial Magnetic Stimulation (rTMS) in Psychiatry; Convulsive Therapy
Cellular distribution of the GABAA receptor-modulating 3 α-hydroxy, 5 α-reduced pregnane steroids in the adult rat brain; Journal of Neuroendocrinology
Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse; Neurobiology of Aging: Experimental and Clinical Research
Chemoarchitectonic Atlas of the Rat Brain; Elsevier
Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net; Brain structure & Function
Constituents, organization and processes of the human brain; The Constitution of Visual Consciousness: Lessons from Binocular Rivalry. Advances in Consciousness Research
Cortical effects of capsaicin-induced peripheral fine-fibre deafferentation; 19th Annual Meeting of the Australian Neuroscience Society
Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice; The Journal of Comparative Neurology
Defining the earliest pathological changes of Alzheimer's disease; Current Alzheimer research
Developmental gene expression redefines the mammalian brain stem; Evolution of Nervous Systems
Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments; Frontiers in Cellular Neuroscience
Effects of sleep disruption and induced cortical plasticity on early amyloid-β accumulation and gene expression in a mouse model of Alzheimer’s disease; Australasian Neuroscience Societies' 38th Annual Scientific Meeting
Examining gene expression following sleep disruption and induced plasticity in Alzheimer’s model mice; Australian Dementia Forum 2019 - Shinning a light on the impact of dementia research
Examining the physiological basis of clinical applications of transcranial magnetic stimulation; Australian Neuroscience Society
Excitotoxicity in ALS: Overstimulation, or overreaction?; Experimental Neurology
Focal demyelination in Alzheimer's disease and transgenic mouse models; Acta Neuropathologica
Focal demyelination in Alzheimer's disease and transgenic mouse models; Gordon Conference on Myelin
ImageSURF: An ImageJ plugin for batch pixel-based image segmentation using random forests; Journal of Open Research Software
Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice; Journal of Neuroinflammation
Investigating the role of inhibition in neurological disease; 32nd Annual Meeting Australian Neuroscience Society
Making the most of Alzheimer’s models: accurate measurement of amyloid from microscope images using ImageSURF; Australian Dementia Forum
Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury; Pl o S One
Multichannel surface recordings on the visual cortex: implications for a neuroprosthesis; Journal of Neural Engineering
Neocortex; The Mouse Nervous System
Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models; Frontiers in Neuroanatomy
Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex; Journal of Chemical Neuroanatomy
Novel alpha-internexin pathological alterations in both the spinal cord and brain of the G93A SOD1 model of amytrophic lateral sclerosis; Society for Neuroscience
Novel alpha-internexin pathological alterations in both the spinal cord and forebrain of the G93A SOD1 model of Amyotrophic Lateral Sclerosis; Australian Society for Medical Research
Partial correlation between the numbers of fetuin-immunoreactive neurons and the levels of fetuin in plasma in the developing rat; Australian Neuroscience Society
Peripheral effects of metallothionein in brain injury: Altered immune system response in metallothionein-1/2 null mice; 4th International Congress on Stress Responses in Biology and Medicine
Poster 107 - Modelling the effect of Amyloid Beta in oligodendrocyte differentiation and maturation; Australasian Neuroscience Society Annual Scientific Meeting 2016
Poster 286 - ImageSURF: an ImageJ plugin for accurate and unbiased segmentation of fluorescent images; Austalasian Neuroscience Society Annual Scientific Meeting 2016
Poster 5.5 - Induced neuroplasticity, when combined with sleep disruption, reduces the quantity of amyloid-β pathology in an Alzheimer’s disease mouse model; Australia Dementia Forum 2019 - Shining a light on the impact of dementia research
Straightening out the mouse neocortex; Australian Neuroscience Society Annual Conference
TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy; Disease Models & Mechanisms
The axon as a physical structure in health and acute trauma; Journal of Chemical Neuroanatomy
The Brain: An Introduction to Functional Neuroanatomy; Elsevier
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease; Experimental Neurology
The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer’s disease; Society for Neuroscience Meeting 2014
The third wave: Intermediate filaments in the maturing nervous system
The Wicking Dementia Research and Education Centre – Paving the way forward in online dementia education; Teaching Matters 2014 – Places and Spaces
Transcranial magnetic stimulation (TMS) in melancholic dexamethasone suppression test (DST) positive patients; The Science and Art of Psychiatry
Transcranial magnetic stimulation as therapy for depression and other disorders; Australian and New Zealand Journal of Psychiatry
Translating dementia knowledge to non-traditional settings and students; Alzheimer’s Disease International (ADI)
When brains expand: mind and the evolution of cortex; Acta Neuropsychiatrica
Whisker trimming, when combined with sleep disruption, reduces the quantity of amyloid-β pathology in an Alzheimer’s disease mouse model; Federation of European Neuroscience Society (FENS) Forum

Research Projects

A mouse model of mild maternal iodine deficiency and its effect on brain structure; Brain Foundation (BrainF)
Does plasticity drive Alzheimers disease and can sleep help; The Mason Foundation (ANZCT-Mason Fdn)
Paving the way for future stroke drug development: creating a new gold-standard model of stroke; Royal Hobart Hospital Research Foundation (RHHRF)
Staying connected: determining targets to protect neuronal circuitry in ALS; Motor Neurone Disease Research Australia (MNDRA)
PhD top-up - Ellie Bucher

Research Candidate Supervision

Axonal and Synaptic Pathology in Alzheimer's Disease
Effects of General Anaesthesia on the Potentiation and Capacity to Resist Alzheimer's Disease pathology
Immune System Modulation in the Brain Injury of the Metallothionein-I/II null Mutant Mouse
Traumatic Brain Injury- Characterisation of Healing, Reactive and Plasticity Response