Web Access Research Portal

Researcher: Ambrose, M (Dr Mark Ambrose)

Fields of Research

Medical bacteriology
Anthropological genetics
Pharmaceutical sciences
Infectious diseases
Respiratory diseases
Conservation and biodiversity
Cancer cell biology
Health and community services
Ecology
Higher education
Pharmacology and pharmaceutical sciences
Cancer genetics
Radiation therapy
Epigenetics (incl. genome methylation and epigenomics)
Cell development, proliferation and death
Cellular nervous system
Innate immunity

Research Objectives

Clinical health
Human pharmaceutical treatments
Expanding knowledge in the health sciences
Women's and maternal health
Human pharmaceutical products
Control of pests, diseases and exotic species in terrestrial environments
Plastics
Expanding knowledge in the biological sciences
Other education and training
Terrestrial biodiversity

Career Best Publications

Research Publications

Pandoraea fibrosis sp. nov., a novel Pandoraea species isolated from clinical respiratory samples; International Journal of Systematic and Evolutionary Microbiology
Pandoraea pnomenusa isolated from an Australian patient with cystic fibrosis; Frontiers in microbiology
Broad spectrum antimicrobial activity of functionalized polyanilines; Acta Biomaterialia
Catabolite repression of SOS-dependent and SOS-independent spontaneous mutagenesis in stationary-phase Escherichia coli; Mutation Research
Catabolite repressors are potent antimutagens in Escherichia coli plate incorporation assays: experiments with glucose, glucose-6-phosphate and methyl-alpha-D-glucopyranoside; Mutation Research
DNA methylation changes following DNA damage in prostate cancer cells; Epigenetics
Functionalized polyanilines disrupt Pseudomonas aeruginosa and Staphylococcus aureus biofilms; Colloids and Surfaces B: Biointerfaces
Genome sequences of two Pandoraea pnomenusa isolates recovered 11 months apart from a cystic fibrosis patient; Genome Announcements
Glucose and related catabolite repressors are powerful inhibitors of pKM101-enhanced UV mutagenesis in Escherichia coli; Mutation Research
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells; Human Molecular Genetics
Learning global health: a pilot study of an online collaborative intercultural peer group activity involving medical students in Australia and Indonesia; BMC Medical Education
Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions; Blood
Pathway analysis of fucoidan activity using a yeast gene deletion library screen; Marine drugs
Reciprocal intercultural peer e-learning in global health: Experiences and perceptions of Australian and Indonesian third-year medical students; 7th International Conference on Public health among the Greater Mekong Sub-Regional Countries
Regulation of mutagenesis in Pseudomonas aeruginosa; Molecular Genetics of Bacteria and Phages Meeting
Spontaneous mutations in bacteria: chance or necessity?; Genetica
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation; Journal of Clinical Investigation
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates; PLoS One

Research Projects

A human paraoxonase 2-based therapy for cystic fibrosis A; Australian Cystic Fibrosis Research Trust (ACFRT)
Characterisation of newly identified Pandoraea isolates from paediatric Tasmanian CF patients; Royal Hobart Hospital Research Foundation (RHHRF)
Characterising the regulation of antibiotic resistance mutations in the cystic fibrosis pathogen Pseudomonas aeruginosa; The MPST Foundation Ltd (MPST)
Cystic Fibrosis: Investigating the acute stage of infection by Pseudomonas aeruginosa; Royal Hobart Hospital Research Foundation (RHHRF)
Molecular profiling of the post radiotherapy chromatin landscape in prostate cancer cells; Cancer Council of Tasmania (CCT)
Non-conventional antimicrobial testing of emerging pathogens; Royal Hobart Hospital Research Foundation (RHHRF)
Pre-clinical toxicity assessment to select drug development candidates against mitochondrial dysfunction; National Foundation for Medical Research and Innovation (NFMRI)
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients; Royal Hobart Hospital Research Foundation (RHHRF)
Testing a new therapy against lung infections for people with cystic fibrosis; Clifford Craig Foundation (CCFoundation)
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota

Research Candidate Supervision

Cross Kingdom Signaling During P.auruginosa Infection of the CF Lung Results in a Decreased Capacity of the Host to Clear the Infection
Studies on Stress Response Pathways in Cellular Models of Cystic Fibrosis
The microbial ecology of transmission sites of Tasmanian devil facial tumour disease