Web Access Research Portal

Researcher: Ambrose, M (Dr Mark Ambrose)

Fields of Research

Medical Bacteriology
Anthropological Genetics
Pharmaceutical Sciences
Infectious Diseases
Respiratory Diseases
Higher Education
Conservation and Biodiversity
Health and Community Services
Cancer Cell Biology
Pharmacology and Pharmaceutical Sciences
Cancer Genetics
Radiation Therapy
Epigenetics (incl. Genome Methylation and Epigenomics)
Cellular Nervous System
Cell Development, Proliferation and Death
Innate Immunity

Research Objectives

Infectious Diseases
Endocrine Organs and Diseases (excl. Diabetes)
Respiratory System and Diseases (incl. Asthma)
Human Pharmaceutical Treatments (e.g. Antibiotics)
Cancer and Related Disorders
Expanding Knowledge in the Medical and Health Sciences
Plastics in Primary Forms
Flora, Fauna and Biodiversity at Regional or Larger Scales
Women's Health
Immune System and Allergy
Digestive System Disorders
Human Pharmaceutical Products
Control of Pests, Diseases and Exotic Species at Regional or Larger Scales
Education and Training
Nervous System and Disorders
Hearing, Vision, Speech and Their Disorders
Inherited Diseases (incl. Gene Therapy)

Career Best Publications

Research Publications

Pandoraea fibrosis sp. nov., a novel Pandoraea species isolated from clinical respiratory samples; International Journal of Systematic and Evolutionary Microbiology
Pandoraea pnomenusa isolated from an Australian patient with cystic fibrosis; Frontiers in microbiology
Broad spectrum antimicrobial activity of functionalized polyanilines; Acta Biomaterialia
Catabolite repression of SOS-dependent and SOS-independent spontaneous mutagenesis in stationary-phase Escherichia coli; Mutation Research
Catabolite repressors are potent antimutagens in Escherichia coli plate incorporation assays: experiments with glucose, glucose-6-phosphate and methyl-alpha-D-glucopyranoside; Mutation Research
DNA methylation changes following DNA damage in prostate cancer cells; Epigenetics
Functionalized polyanilines disrupt Pseudomonas aeruginosa and Staphylococcus aureus biofilms; Colloids and Surfaces B: Biointerfaces
Genome sequences of two Pandoraea pnomenusa isolates recovered 11 months apart from a cystic fibrosis patient; Genome Announcements
Glucose and related catabolite repressors are powerful inhibitors of pKM101-enhanced UV mutagenesis in Escherichia coli; Mutation Research
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells; Human Molecular Genetics
Learning global health: a pilot study of an online collaborative intercultural peer group activity involving medical students in Australia and Indonesia; BMC Medical Education
Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions; Blood
Pathway analysis of fucoidan activity using a yeast gene deletion library screen; Marine drugs
Reciprocal intercultural peer e-learning in global health: Experiences and perceptions of Australian and Indonesian third-year medical students; 7th International Conference on Public health among the Greater Mekong Sub-Regional Countries
Spontaneous mutations in bacteria: chance or necessity?; Genetica
The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation; Journal of Clinical Investigation
Transcriptional networks in S. cerevisiae linked to an accumulation of base excision repair intermediates; PLoS One

Research Projects

A human paraoxonase 2-based therapy for cystic fibrosis A; Australian Cystic Fibrosis Research Trust (ACFRT)
Cystic Fibrosis: Investigating the acute stage of infection by Pseudomonas aeruginosa; Royal Hobart Hospital Research Foundation (RHHRF)
Molecular profiling of the post radiotherapy chromatin landscape in prostate cancer cells; Cancer Council of Tasmania (CCT)
Non-conventional antimicrobial testing of emerging pathogens; Royal Hobart Hospital Research Foundation (RHHRF)
Prevalence and virulence of an emerging bacterial pathogen of Tasmanian cystic fibrosis patients; Royal Hobart Hospital Research Foundation (RHHRF)
Testing a new therapy against lung infections for people with cystic fibrosis; Clifford Craig Foundation (CCFoundation)
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota

Research Candidate Supervision

Cross Kingdom Signaling During P.auruginosa Infection of the CF Lung Results in a Decreased Capacity of the Host to Clear the Infection
Studies on Stress Response Pathways in Cellular Models of Cystic Fibrosis
The microbial ecology of transmission sites of Tasmanian devil facial tumour disease