Web Access Research Portal

Researcher: Liu, J (Dr Johnson Liu)

Fields of Research

Clinical pharmacology and therapeutics
Veterinary pharmacology
Pharmacology and pharmaceutical sciences
Basic pharmacology
Pharmaceutical sciences
Molecular targets
Oncology and carcinogenesis
Toxicology (incl. clinical toxicology)

Research Objectives

Clinical health
Other health
Specific population health (excl. Indigenous health)
Expanding knowledge in the health sciences
Public health (excl. specific population health)

Career Best Publications

Research Publications

ABC transporter inhibitors in reversing multidrug resistance to chemotherapy; Current Drug Targets
Antitumour action of 5,6-dimethylxanthenone-4-acetic acid in rats bearing chemically induced primary mammary tumours; Cancer Chemotherapy and Pharmacology
Application of liquid chromatography-mass spectrometry to monitoring plasma cyclophosphamide levels in phase 1 trial cancer patients; Clinical and Experimental Pharmacology and Physiology
Association of PSMA4 polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population; Clinical and Translational Oncology
Comparative protein binding, stability and degradation of Satraplatin, JM118 and Cisplatin in human plasma in vitro; Clinical and Experimental Pharmacology and Physiology
Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons; Biochemical Pharmacology
Differential expression of ATP7A, ATP7B and CTR1 in adult rat dorsal root ganglion tissue; Molecular pain
Evaluation of effects of copper histidine on copper transporter 1-mediated accumulation of platinum and oxaliplatin-induced neurotoxicity in vitro and in vivo; Clinical and Experimental Pharmacology and Physiology
In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake; Journal of Inorganic Biochemistry
Membrane transporters as determinants of the pharmacology of platinum anticancer drugs; Current Cancer Drug Targets
Neuronal expression of copper transporter 1 in rat dorsal root ganglia: association with platinum neurotoxicity; Cancer Chemotherapy and Pharmacology
Nucleolar enlargement, nuclear eccentricity and altered cell body immunostaining characteristics of large-sized sensory neurons following treatment of rats with paclitaxel; NeuroToxicology
Oxaliplatin causes selective atrophy of a subpopulation of dorsal root ganglion neurons without inducing cell loss; Cancer Chemotherapy and Pharmacology
Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons; Journal of Pharmacology and Experimental Therapeutics
Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue; Molecular Pain
Paclitaxel induces nucleolar enlargement in dorsal root ganglion neurons in vivo reducing oxaliplatin toxicity; British Journal of Cancer
Pharmacokinetics of Florfenicol in Healthy Pigs and in Pigs Experimentally Infected with Actinobacillus pleuropneumoniae; Antimicrobial Agents and Chemotherapy
Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing; Journal of Veterinary Pharmacology and Therapeutics
Platinum-specific detection and quantification of oxaliplatin and Pt(R,R-diaminocyclohexane)Cl2 in the blood plasma of colorectal cancer patients; Journal of Analytical Atomic Spectrometry
Polymorphisms in C-reactive protein and Glypican-5 are associated with lung cancer risk and Gartrokine-1 influences Cisplatin-based chemotherapy response in a Chinese Han population; Disease Markers
Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population; European Journal of Cancer Prevention
Role of platinum DNA damage-induced transcriptional inhibition in chemotherapy-induced neuronal atrophy and peripheral neurotoxicity; Journal of Neurochemistry
Specific determination of intact cisplatin and monohydrated cisplatin in human plasma and culture medium ultrafiltrates using HPLC on-line with inductively coupled plasma mass spectrometry; Journal of Chromatography B
Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae; European Journal of Drug Metabolism and Pharmacokinetics

Research Projects

Bi-functional opioids as a novel cancer treatment; Cancer Council of Tasmania (CCT)
Profiling and functional studies of drug transporters in colorectal cancer: a pilot study in Tasmanian patients.; Royal Hobart Hospital Research Foundation (RHHRF)
Targeting drug transporters in colorectal cancer; Cancer Council of Tasmania (CCT)

Research Candidate Supervision

Copper Transporter 1 as a Cellular determinant of the Sensitivity of Colorectal Cancer to Oxaliplatin Chemotherapy