Web Access Research Portal

Researcher: Negishi, K (Dr Kazuaki Negishi)

Fields of Research

Cardiology (incl. cardiovascular diseases)
Ecosystem function
Occupational and workplace health and safety
Cancer cell biology
Infant and child health
Central nervous system
Nutrigenomics and personalised nutrition
Community child health
Aboriginal and Torres Strait Islander public health and wellbeing
Medical biochemistry - amino acids and metabolites

Research Objectives

Clinical health
Public health (excl. specific population health)
Occupational health
Neonatal and child health
Diagnosis of human diseases and conditions
Treatment of human diseases and conditions
Prevention of human diseases and conditions
Atmospheric processes and dynamics
Behaviour and health

Career Best Publications

Research Publications

A risk score with additional four independent factors to predict the incidence and recovery from Metabolic Syndrome: development and validation in large Japanese cohorts; PLoS One
Abstract 16275: Out-of-Hospital Cardiac Arrest and Short-Term Exposure to Air Pollutants: A Case-Crossover Study; Circulation
Abstract 16338: A Case-Crossover Study of Short Term Effects of Air Pollutants on Stroke in Gunma, Japan; Circulation
Abstract 16370: Short Term Effects of Photochemical Oxidant on Heart Failure: A Case-Crossover Study; Circulation
Accuracy of blinded clinician interpretation of single-lead smartphone electrocardiograms and a proposed clinical workflow; American Heart Journal
Accuracy of left ventricular volumes and ejection fraction measurements by contemporary three-dimensional echocardiography with semi- and fully automated software: systematic review and meta-analysis of 1,881 subjects; Journal of the American Society of Echocardiography
Afterload dependence of right ventricular myocardial strain; Journal of the American Society of Echocardiography
Air pollution and telomere length: a systematic review of 12,058 subjects; Cardiovascular Diagnosis and Therapy
Aortic systolic pressure derived with different calibration methods: associations to brachial systolic pressure in the general population; Blood Pressure Monitoring
Appropriate test selection for single-photon emission computed tomography imaging: Association with clinical risk, posttest management, and outcomes; American Heart Journal
Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals; Heart
Association between circulating ketone bodies and worse outcomes in hemodialysis patients; Journal of the American Heart Association
Association between electrocardiographic and echocardiographic markers of stage B heart failure and cardiovascular outcome; ESC Heart Failure
Association between fibroblast growth factor 23 and left ventricular hypertrophy in maintenance hemodialysis patients. Comparison with B-type natriuretic peptide and cardiac troponin T; Circulation Journal
Association of ambient particulate matter with heart failure incidence and all-cause readmissions in Tasmania: an observational study; BMJ Open
Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus; Cardiovascular Diabetology
Association of left ventricular strain with 30-Day mortality and readmission in patients with heart failure; Journal of the American Society of Echocardiography
Association of reduced apical untwisting with incident HF in asymptomatic patients with HF risk factors; JACC: Cardiovascular Imaging
Association of survival time with transthoracic echocardiography in stable patients with heart failure: Is routine follow-up ever appropriate?; International Journal of Cardiology
Association of the active and passive components of left atrial deformation with left ventricular function; Journal of the American Society of Echocardiography
Association of waist circumference with impaired six-minute walk in type 2 diabetes mellitus is independent of cardiac function; Journal of Diabetes and Its Complications
Associations between respiratory and vascular function in early childhood; Respirology
Back to the Future: Mitral annular plane systolic excursion on cardiac magnetic resonance; JACC: Cardiovascular Imaging
CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting; Physiological Reports
Clinical prediction of incident heart failure risk: a systematic review and meta-analysis; Open Heart
Cognitive domains and postdischarge outcomes in hospitalized patients with heart failure; Circulation: Heart Failure
Cognitive impairment as a determinant of response to management plans after heart failure admission; European Journal of Heart Failure
Community Screening for Nonischemic Cardiomyopathy in Asymptomatic Subjects ≥65 Years With Stage B Heart Failure; The American Journal of Cardiology
Comparison of accurate measurement of left ventricular mass in patients with hypertrophied hearts by real-time three-dimensional echocardiography versus magnetic resonance imaging; The American Journal of Cardiology
Comparison of different interdialytic intervals among hemodialysis patients on their echocardiogram-based cardiovascular parameters; American Heart Journal
Comparison of two-dimensional strain analysis using vendor-independent and vendor-specific software in adult and pediatric patients; JRSM Cardiovascular Disease
Detection of Obstructive Coronary Artery Disease Using Peak Systolic Global Longitudinal Strain Derived by Two-Dimensional Speckle-Tracking: A Systematic Review and Meta-Analysis; Journal of the American Society of Echocardiography
Detection of prolonged regional myocardial systolic dysfunction after exercise-induced myocardial ischemia by strain echocardiography with high frame rate tissue Doppler echocardiography; Journal of Echocardiography
Diagnosis of nonischemic stage B heart failure in type 2 diabetes mellitus: optimal parameters for prediction of heart failure; JACC: Cardiovascular Imaging
Direct comparison of severity grading assessed by two-dimensional, three-dimensional, and doppler echocardiography for predicting prognosis in asymptomatic aortic stenosis; Journal of the American Society of Echocardiography
Dyssynchrony, contraction efficiency and regional function with apical and non-apical RV pacing; Heart
Early life exposure to coal mine fire and tobacco smoke affect subclinical vascular function; Archives of Disease in Childhood
Echocardiographic evaluation of cardiac function after cancer chemotherapy; Journal of Echocardiography
Echocardiographic feature of diabetic cardiomyopathy: where are we now?; Cardiovascular Diagnosis and Therapy
Echocardiographic predictors of reverse remodeling after cardiac resynchronization therapy and subsequent events; Circulation: Cardiovascular Imaging
Echocardiographic risk assessment to guide screening for atrial fibrillation; Journal of the American Society of Echocardiography
Echocardiographic screening for non-ischaemic stage B heart failure in the community; European Journal of Heart Failure
Echocardiography and Cardio-Oncology; Heart, Lung and Circulation
Echocardiography updates: from cardiac functional assessments to guiding procedures; Cardiovascular Diagnosis and Therapy
Echocardiography-based pressure-volume loop assessment in the evaluation for the effects of indoxyl sulfate on cardiovascular function; Journal of Echocardiography
Effect of Experience and Training on the Concordance and Precision of Strain Measurements; JACC: Cardiovascular Imaging
Effect of gravitational gradients on cardiac filling and performance; Journal of the American Society of Echocardiography
Effect of right ventricular pacing on right ventricular mechanics and tricuspid regurgitation in patients with high-grade atrioventricular block and sinus rhythm (from the Protection of Left Ventricular Function During Right Ventricular Pacing Study); American Journal of Cardiology
Effect of Sex Differences on the Association between Stroke Risk and Left Atrial Anatomy or Mechanics in Patients with Atrial Fibrillation; Circulation: Cardiovascular Imaging
Effects of post-discharge management on rates of early re-admission and death after hospitalisation for heart failure; Medical Journal of Australia
Estimation of myocardial ischemia by diastolic strain analysis in exercise stress echocardiography: comparison with exercise thallium-201 single photon emission computed tomography; Journal of Cardiology
Evolution of myocardial dysfunction in asymptomatic patients at risk of heart failure; JACC: Cardiovascular Imaging
Feasibility and normal ranges of arterial intima-media thickness and stiffness in 2-year-old children: a pilot study; Pediatric Cardiology
Functional and anatomic responses of the left atrium to change in estimated left ventricular filling pressure; Journal of the American Society of Echocardiography
Gender differences in age-related changes in left and right ventricular geometries and functions: Echocardiography of a healthy subject group; Circulation Journal
Global left atrial strain in the prediction of sinus rhythm maintenance after catheter ablation for atrial fibrillation; Journal of the American Society of Echocardiography
Grading diastolic function by echocardiography: hemodynamic validation of existing guidelines; Cardiovascular Ultrasound
Imaging-guided cardioprotective treatment in a community elderly population of stage B heart failure; JACC: Cardiovascular Imaging
Impact of repeat myocardial revascularization on outcome in patients with silent ischemia after previous revascularization; Journal of the American College of Cardiology
Importance of calibration method in central blood pressure for cardiac structural abnormalities; American Journal of Hypertension
Improvement in strain concordance between two major vendors after the Strain Standardization Initiative; Journal of the American Society of Echocardiography
Incremental diagnostic value of la strain with leg lifts in heart failure with preserved ejection fraction; JACC: Cardiovascular Imaging
Incremental diagnostic value of left atrial strain over left atrial volume: An analogy of glucose level and glycosylated hemoglobin?; JACC: Cardiovascular Imaging
Incremental predictive value of left atrial parameters over clinical risk scores for subsequent atrial fibrillation: : Function beyond size; JACC: Cardiovascular Imaging
Incremental prognostic value of global longitudinal strain and 18F-fludeoxyglucose positron emission tomography in patients with systemic sarcoidosis; American Journal of Cardiology
Incremental prognostic value of ventricular-arterial coupling over ejection fraction in patients with maintenance hemodialysis; Journal of the American Society of Echocardiography
Incremental value of left atrial structural and functional characteristics for prediction of atrial fibrillation in patients receiving cardiac pacing; Circulation: Cardiovascular Imaging
Independent and incremental prognostic value of novel cardiac biomarkers in chronic hemodialysis patients; American Heart Journal
Independent and incremental value of deformation indices for prediction of trastuzumab-induced cardiotoxicity; Journal of the American Society of Echocardiography
Infective endocarditis complicated by mycotic aneurysm of a coronary artery with a perforated mitral valvular aneurysm; Journal of the American Society of Echocardiography
Influence of risk on reduction of readmission and death by disease management programs in heart failure; Journal of Cardiac Failure
Intervendor variability of two-dimensional strain using vendor-specific and vendor-independent software; Journal of the American Society of Echocardiography
Is Speckle-Tracking Echocardiography a Panacea? Experience Is Still Required; American Society of Echocardiography. Journal
Left atrial booster pump function is an independent predictor of subsequent life-threatening ventricular arrhythmias in non-ischaemic cardiomyopathy; European Heart Journal Cardiovascular Imaging
Left atrial mechanical dispersion assessed by strain echocardiography as an independent predictor of new-onset atrial fibrillation: a case-control study; Journal of the American Society of Echocardiography
Left atrial strain provides incremental value for embolism risk stratification over CHA2DS2-VASc score and indicates prognostic impact in patients with atrial fibrillation; Journal of the American Society of Echocardiography
Left atrial strain: a multi-modality, multi-vendor comparison study; European Heart Journal - Cardiovascular Imaging
Left Ventricular Systolic Function; ASE’s Comprehensive Echocardiography, 2nd Edition
Long-term exposure to ambient air pollution is associated with coronary artery calcification among asymptomatic adults; European Heart Journal Cardiovascular Imaging
Mechanics and prognostic value of left and right ventricular dysfunction in patients with systemic sclerosis; European Heart Journal Cardiovascular Imaging
Meta-Analysis of Association Between Mediastinal Radiotherapy and Long-Term Heart Failure; The American Journal of Cardiology
Meta-analysis of risks for short-term readmission in patients with heart failure; American Journal of Cardiology
Mild cognitive impairment predicts death and readmission within 30 days of discharge for heart failure; International Journal of Cardiology
MRI-derived myocardial strain measures in normal subjects; JACC: Cardiovascular Imaging
Multiple papillary fibroelastomas of the aortic valve detected by real time three-dimensional transesophageal echocardiographic images; Journal of Cardiology Cases
Normal ranges of left atrial strain by speckle-tracking echocardiography: A systematic review and meta-analysis; Journal of the American Society of Echocardiography
Normal values of echocardiographic parameters in relation to age in a healthy Japanese population - The JAMP study; Circulation Journal
Normal values of real-time 3-dimensional echocardiographic parameters in a healthy Japanese population: The JAMP-3D study; Circulation Journal
Pathophysiological effects of different risk factors for heart failure; Open Heart
Patient risk factors for bioprosthetic aortic valve degeneration: a systematic review and meta-analysis; Heart, Lung and Circulation
Pericardiectomy is associated with improvement in longitudinal displacement of left ventricular free wall due to increased counterclockwise septal-to-lateral rotational displacement; Journal of the American Society of Echocardiography
Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease; International Journal of Cardiovascular Imaging
Practical guidance in echocardiographic assessment of global longitudinal strain; JACC: Cardiovascular Imaging
Prediction of cardiovascular outcomes by imaging coronary atherosclerosis; Cardiovascular Diagnosis and Therapy
Prediction of heart failure in patients with type 2 diabetes mellitus - A systematic review and meta-analysis; Diabetes Research and Clinical Practice
Predictive Score for 30-Day Readmission or Death in Heart Failure; JAMA Cardiology
Prednisone and azathioprine in patients with inflammatory cardiomyopathy: systematic review and meta-analysis; ESC Heart Failure
Prognostic Implications of LV Strain Risk Score in Asymptomatic Patients With Hypertensive Heart Disease; JACC: Cardiovascular Imaging
Prognostic value of energy loss coefficient for predicting asymptomatic aortic stenosis outcomes: direct comparison with aortic valve area; Journal of the American Society of Echocardiography
Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: Comparison with 2D echocardiography; JACC: Cardiovascular Imaging
Prognostic value of right ventricular ejection fraction assessed by transthoracic 3D echocardiography; Circulation: Cardiovascular Imaging
Prolonged vortex formation during the ejection period in the left ventricle with low ejection fraction: a study by vector flow mapping; Journal of Medical Ultrasonics
Rapid progression of nodular calcification documented by intra-coronary imaging devices and histology; European Heart Journal Cardiovascular Imaging
Rationale and design of the strain surveillance of chemotherapy for improving cardiovascular outcomes: the SUCCOUR Trial; JACC: Cardiovascular Imaging
Relation Between Echocardiogram-Based Cardiac Parameters and Outcome in Heart Failure With Preserved and Reduced Ejection Fraction; American Journal of Cardiology
Relation between echocardiographically estimated and invasively measured filling pressures in constrictive pericarditis; The American Journal of Cardiology
Relation of functional status to risk of development of atrial fibrillation; American Journal of Cardiology
Relation of heart-rate recovery to new onset heart failure and atrial fibrillation in patients with diabetes mellitus and preserved ejection fraction; The American Journal of Cardiology
Relationships of high cardiac output with ventricular morphology, myocardial energetics, and energy costs in hemodialysis patients with preserved ejection fraction; International Journal of Cardiovascular Imaging
Reliability of updated left ventricular diastolic function recommendations in predicting elevated left ventricular filling pressure and prognosis; American Heart Journal
Research to Practice: assessment of left ventricular global longitudinal strain for surveillance of cancer chemotherapeutic-related cardiac dysfunction; JACC: Cardiovascular Imaging
Role of temporal resolution in selection of the appropriate strain technique for evaluation of subclinical myocardial dysfunction; Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
Roles of nonclinical and clinical data in prediction of 30-day rehospitalization or death among heart failure patients; Journal of Cardiac Failure
Serum syndecan-4 is a novel biomarker for patients with chronic heart failure; Journal of Cardiology
Sex differences in left ventricular afterload and diastolic function are independent from the aortic size; PLoS One
Short-term exposure to ambient fine particulate matter and out-of-hospital cardiac arrest: a nationwide case-crossover study in Japan; The Lancet Planetary Health
Single versus standard multiview assessment of global longitudinal strain for the diagnosis of cardiotoxicity during cancer therapy; JACC: Cardiovascular Imaging
Temporal changes in appropriateness of cardiac imaging; Journal of the American College of Cardiology
The effects of temperature and air pollution on heart failure incidence and readmissions: is beta-blocker protective?; European Heart Journal
The importance of calibration method in determining the association between central blood pressure with left ventricular and left atrial strain; International Journal of Cardiovascular Imaging
The seabed-like appearance of atherosclerotic plaques: three-dimensional transesophageal echocardiographic images of the aortic arch causing cholesterol crystal emboli; Journal of the American Society of Echocardiography
Threshold of ambient particulate matter level for increasing heart failure incidence may be lower than national standard; European Heart Journal
Two-dimensional strain is more precise than conventional measures of left ventricular systolic function in pediatric patients; Pediatric Cardiology
Use of atrial strain to predict atrial fibrillation after cerebral ischemia; JACC: Cardiovascular Imaging
Use of speckle strain to assess left ventricular responses to cardiotoxic chemotherapy and cardioprotection; European Heart Journal Cardiovascular Imaging
Validation of global longitudinal strain and strain rate as reliable markers of right ventricular dysfunction: comparison with cardiac magnetic resonance and outcome; Journal of Cardiovascular Ultrasound
Validation of predictive score of 30-day hospital readmission or death in patients with heart failure; American Journal of Cardiology
Variations in subclinical left ventricular dysfunction, functional capacity, and clinical outcomes in different heart failure aetiologies; ESC Heart Failure
What is the evidence status of Appropriate Use Criteria (AUC)? Insight from a matching exercise with the guidelines for echocardiography; Internal Medicine Journal
What is the primary source of discordance in strain measurement between vendors: imaging or analysis?; Ultrasound in Medicine and Biology

Research Projects

American College of Cardiology 63rd Annual Meeting, Washington DC, USA; University of Tasmania (UTAS)
Clinical application of cardiovascular imaging for detection of subclinical cardiovascular dysfunction and establishing treatment; Heart Foundation (HF)
Early detection of cardiovascular risk using comprehensive evaluation of endothelial function in occupations exposed to inhaled particulates; University of Tasmania (UTAS)
Effect of ambient air quality on cardiovascular disease and telomere length; Avant Insurance Ltd (AVANT)
Effectiveness of imaging pathways for CVD epidemics of the elderly; National Health & Medical Research Council (NHMRC)
Select Foundation Fellowship - Dr Kazuaki Negishi ; The Select Foundation (SelF)
Tasmanian Study of Echocardiographic Detection of Left Ventricular Dysfunction; University of Tasmania (UTAS)
Use of Advanced Cardiac Imaging in Radiation-Related Cardiotoxicity.; Heart Foundation (HF)

Research Candidate Supervision

An evaluation of cost-effectiveness analysis of cardio-prophylaxis
Appropriate use criteria in cardiovascular imaging
Early Detection of Myocardial Dysfunction
Impact of Speckle-tracking Strain Echocardiography for Early Diagnosis of Anthracycline-Mediated Cardiotoxicity