Web Access Research Portal

Researcher: Bissember, AC (Dr Alex Bissember)

Fields of Research

Organic Chemical Synthesis
Natural Products Chemistry
Transition Metal Chemistry
Biologically Active Molecules
Organometallic Chemistry
Medical Bacteriology
Design Innovation
Science, Technology and Engineering Curriculum and Pedagogy
Synthesis of Materials
Physical Chemistry of Materials
Polymerisation Mechanisms

Research Objectives

Expanding Knowledge in the Chemical Sciences
Environmentally Sustainable Manufacturing
Human Pharmaceutical Treatments (e.g. Antibiotics)
Syllabus and Curriculum Development
Organic Industrial Chemicals (excl. Resins, Rubber and Plastics)
Expanding Knowledge in the Biological Sciences

Career Best Publications

Research Publications

α-Cyanocarbanion complexes and their application in synthesis; Journal of Organometallic Chemistry
4-iodo-6-methoxyquinoline; Organic Preparations and Procedures International
ent-Labdane Diterpenoids from Dodonaea viscosa; Journal of Natural Products
A mild, palladium-catalyzed method for the dehydrohalogenation of alkyl bromides: Synthetic and mechanistic studies; Journal of the American Chemical Society
A versatile approach to Ullmann C-N couplings at room temperature: New families of nucleophiles and electrophiles for photoinduced, copper-catalyzed processes; Journal of the American Chemical Society
Applications of visible light photoredox catalysis to the synthesis of natural products and related compounds; Natural Product Reports
Arbutin derivatives isolated from ancient proteaceae: potential phytochemical markers present in Bellendena, Cenarrhenes, and Persoonia Genera; Journal of Natural Products
Base-promoted reactions of dichlorocarbene adducts of cyclic enamines: A new route to annulated pyrroles; Organic Letters
Brønsted acid cocatalysis in copper(I)-photocatalyzed α-amino C−H bond functionalization; ACS Catalysis
Brønsted acid-mediated annulations of pyrroles featuring N-tethered α,β-unsaturated ketones and esters: total syntheses of (±)-tashiromine and (±)-indolizidine 209I; Tetrahedron
Brønsted acid-mediated radical processes in organic synthesis; Australian Journal of Chemistry
Chapter 7: Seven-Membered Rings; Progress in Heterocyclic Chemistry
Complete stereocontrol in the synthesis of harmonine and novel analogues facilitated by a Grubbs Z-selective cross-metathesis catalysis; Australian Journal of Chemistry
Counterion-induced asymmetric control in ring-opening of azetidiniums: facile access to chiral amines; Angewandte Chemie International Edition
Extraction of carboxylic acid-containing diterpenoids form Dodonaea viscosa via pressurised hot water extraction; Fitoterapia
Extraction of Eugenol from Cloves Using an Unmodified Household Espresso Machine: An Alternative to Traditional Steam-Distillation; Journal of Chemical Education
Green chemistry is key to reducing waste and improving sustainablity
Growing and bio-fabricating SCOBY: a project developed in an extended cross-disciplinary research team; 1st Annual Design Research Conference (ADR18)
Identifying the potential of pulsed LED irradiation in synthesis: copper-photocatalysed C-F functionalisation; Chemical Communications
Investigating the viability of a competency-based, qualitative laboratory assessment model in first-year undergraduate chemistry; Chemistry Education Research and Practice
Methods for the synthesis of annulated pyrroles via cyclisation strategies; Organic and Biomolecular Chemistry
Methyl cyanoformate (Mander's reagent); Synlett
Microwave-assisted trans-halogenation reactions of various chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines, isoquinolines, and pyridines leading to the corresponding iodinated heterocycles; The Journal of Organic Chemistry
New method for the rapid extraction of natural products: efficient isolation of shikimic acid from star anise; Organic Letters
Nuances in fundamental Suzuki−Miyaura cross-couplings employing [Pd(PPh3)4]: poor reactivity of aryl Iodides at lower temperatures; Organometallics
Oranges, lemons and limonene: addressing surprisingly persistent and enduring myths
Photoinduced, copper-catalyzed alkylation of amides with unactivated secondary alkyl halides at room temperature; Journal of the American Chemical Society
Phytochemical profile of the rare, ancient clone Lomatia tasmanica and comparison to other endemic Tasmanian species L. tinctoria and L. polymorpha; Phytochemistry
Polygodial: a viable natural product scaffold for the rapid synthesis of novel polycyclic pyrrole and pyrrolidine derivatives; Tetrahedron
Practical Isolation of Asperuloside from Coprosma quadrifida via Rapid Pressurised Hot Water Extraction; Australian Journal of Chemistry
Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis; Organic and Biomolecular Chemistry
Preparation of some angularly substituted and highly functionalized quinolizidines as building blocks for the synthesis of various alkaloids and related scaffolds of medicinal interest; Tetrahedron
Pressurized hot water extraction as a viable bioprospecting tool: isolation of coumarin natural products from previously unexamined Correa (Rutaceae) species; ChemistrySelect
Progress in the development of Platelet-Activating Factor Receptor (PAFr) antagonists and applications in the treatment of inflammatory diseases; ChemMedChem
Recent applications of [Cu(dap)2]Cl in visible light-mediated photoredox catalysis; Australian Journal of Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Seven-Membered Rings; Progress in Heterocyclic Chemistry
Siliquapyranone: a tannic acid Tetrahydropyran-2-one isolated from the leaves of carob (Ceratonia siliqua) by pressurised hot water extraction; Australian Journal of Chemistry
Synthesis of 2,3-dihydro-4(1H)-quinolones and the corresponding 4(1H)-quinolones via low-temperature fries rearrangement of N-arylazetidin-2-ones; Australian Journal of Chemistry
The Au(I)-catalyzed intramolecular hydroarylation of terminal alkynes under mild conditions: Application to the synthesis of 2H-chromenes, coumarins, benzofurans, and dihydroquinolines; The Journal of Organic Chemistry
The oxidation of pyrrole; Chemistry - An Asian Journal
Transition-metal-catalyzed alkylations of amines with alkyl halides: Photoinduced, copper-catalyzed couplings of carbazoles; Angewandte Chemie: International Edition
Visible light dye-photosensitised oxidation of pyrroles using a simple LED photoreactor; Organic and Biomolecular Chemistry

Research Projects

Artificial Photosynthesis: Using Light to Sustainably Prepare Valuable Chemical Compounds; Collier Charitable Fund (CCFund)
Development of new viable and inexpensive visible light copper photocatalysts; United Nations Educational, Scientific & Cultural Organization (UNESCO)
Development of novel transition metal-catalyzed processes: Cascade and photochemical reactions; University of Tasmania (UTAS)
Extraction and analysis of Plant Material
Isolation and synthesis of potential new therapeutic agents from Hemp (Cannabis sativa) and their biological evaluation
Synthesis of Opiate Derivatives

Research Candidate Supervision

Chemical survey of Tasmanian land plants by Hot Pressurised Water Extraction (HPWE) targeting new molecular scaffolds for chemical modification for medicinal chemistry applications
Oxidation of Pyrroles- Applications to the Sythesis of Biologically Active Molecules
Synthesis of New Derivatives Targeting Mitochondrial Disease