Web Access Research Portal

Researcher: Zosky, GR (Associate Professor Graeme Zosky)

Fields of Research

Respiratory Diseases
Health and Community Services
Comparative Physiology
Ecosystem Function
Environmental and Occupational Health and Safety
Aboriginal and Torres Strait Islander Health
Cancer Genetics
Neurology and Neuromuscular Diseases
Endocrinology
Foetal Development and Medicine
Central Nervous System
Pharmacology and Pharmaceutical Sciences
Medical Bacteriology
Medical Biotechnology
Systems Physiology
Paediatrics
Medical and Health Sciences
Environmental Monitoring
Animal Physiology - Biophysics
Epigenetics (incl. Genome Methylation and Epigenomics)
Medical Biochemistry: Amino Acids and Metabolites
Motor Control
Autonomic Nervous System

Research Objectives

Respiratory System and Diseases (incl. Asthma)
Environmental Health
Aboriginal and Torres Strait Islander Health - Determinants of Health
Expanding Knowledge in the Biological Sciences
Child Health
Nervous System and Disorders
Diabetes
Expanding Knowledge in the Medical and Health Sciences
Expanding Knowledge in Technology
Digestive System Disorders
Occupational Health
Health
Infectious Diseases
Endocrine Organs and Diseases (excl. Diabetes)
Reproductive System and Disorders
Inherited Diseases (incl. Gene Therapy)
Mental Health
Clinical Health (Organs, Diseases and Abnormal Conditions)
Nutrition
Urban and Industrial Air Quality

Career Best Publications

Early life arsenic exposure and acute and long-term responses to influenza A infection in mice; Environmental Health Perspectives
In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice; Environmental Health Perspectives
Linking lung function and inflammatory responses in ventilator-induced lung injury; American Journal of Physiology: Lung Cellular and Molecular Physiology
Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation; Clinical and Experimental Allergy
Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection; Journal of Applied Physiology
Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells; The Journal of Experimental Medicine
The bimodal quasi-static and dynamic elastance of the murine lung; Journal of Applied Physiology
Vitamin D deficiency causes deficits in lung function and alters lung structure; American Journal of Respiratory and Critical Care Medicine

Research Publications

In utero cigarette smoke exposure impairs somatic and lung growth in BALB/c mice; The European Respiratory Journal
In vitro assessment of the toxicity of bushfire emissions: A review; The Science of The Total Environment: An International Journal for Scientific Research Into The Environment and Its Relationship With Man
A cross-sectional survey of environmental health in remote Aboriginal communities in Western Australia; International Journal of Environmental Health Research
A method for measuring the ECG and ventilation rate in bats; Journal of the Royal Society of Western Australia
A Mouse Model of Asthma; Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2014 Annual Scientific Meetings
A pathogenic role for the integrin CD103 in experimental allergic airways disease; Physiological Reports
Absence of airway tone in BALB/c mice; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2008
Absence of cholinergic airway tone in normal BALB/c mice; Respiration Physiology and Neurobiology
Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus; Journal of Immunology
Acute diesel exhaust particle exposure increases viral titre and inflammation associated with existing influenza infection, but does not exacerbate deficits in lung function; Influenza and Other Respiratory Viruses
Acute Diesel Exhaust Particle Exposure Increases Viral Titre Associated With Influenza But Does Not Exacerbate Inflammation Or Deficits In Baseline Lung Function; American Thoracic Society 2011 International Conference
Acute diesel exhaust particle exposure increases viral titre associated with influenza but does not exacerbate inflammation or deficits in lung function; TSANZ ASM 2011
Acute exposure to diesel exhaust particles elicits dose-dependent pulmonary inflammatory and impairment of lung function in naive BALB/C mice; TSANZ ASM 2011
Acute Influenza A infection induces bronchial hyper-responsiveness in mice; Respiration Physiology and Neurobiology
Aging of the normal lung; Comparative Biology of the Normal Lung
Airway hyperresponsiveness in mouse models of asthma is associated with activated T cells in the airways; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2008
Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways; American Journal of Physiology: Lung Cellular and Molecular Physiology
Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa; Journal of Immunology
Animal models of asthma; Clinical and Experimental Allergy
Are mice good physiological models of asthma; TSANZ 2006 Annual Scientific Meeting
Arsenic exposure via drinking water adversely affects lung health; TSANZ/ANZSRS (NZ) 2012 Annual Scientific Meeting
Arsenic Is A Developmental Toxicant To The Lung; American Thoracic Society 2012 International Conference
Assessment of airway response distribution and paradoxical airway dilation in mice during methacholine challenge; Journal of Applied Physiology
Both sex and type of virus influence lung inflammatory responses in BALB/C mice; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2009
Cardiac autonomic innervation of the western pygmy possum (Cercatetus concinnus) and golden bandicoot (Isoodon auratus); Journal of Comparative Physiology Part B: Biochemical, Systemic, and Environmental Physiology
Characterisation of allergen induced airway hyperresponsiveness (AHR) in a murine model of allergic sensitisation; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2004
Characterizing the respiratory inflammatory response to geogenic dusts; TSANZ/ANZSRS (NZ) 2012 Annual Scientific Meeting
Coal workers’ pneumoconiosis: an Australian perspective; Medical Journal of Australia
Deep inspiration prior to bronchoconstrictor challenge has beneficial and detrimental effects on lung mechanics in mice; TSANZ ASM 2011
Disassembly of epithelial tight junctions in well-differentiated air-liquid interface (ALI) cultures following human rhinovirus infection results in airway epithelial permeability changes; TSANZ ASM Gold Coast 2015
Dose but not sex determines inflammatory responses to acute diesel exhaust particle exposure in mice; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting 2010
Down Under in the Coal Mines; American Journal of Respiratory and Critical Care Medicine
Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery; The Journal of Allergy and Clinical Immunology
Early life arsenic exposure and acute and long-term responses to influenza A infection in mice; Environmental Health Perspectives
Early Life Exposure To Arsenic And Influenza Has Additive Effects On Lung Function Impairment; American Thoracic Society 2010 International Conference
Early life exposure to arsenic and influenza has additive effects on lung impairment; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting 2010
Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability; Experimental Lung Research
Effect Of In Utero Exposure To Ceiling Particles On Post-Natal Lung Function And Immune Cell Populations; C105. Disorders of respiratory physiology and sleep in children
Effect of In Utero Exposure to Ceiling Particles on Post-Natal Lung Function and Immune Cell Populations; Respirology
Effect Of In Utero Exposure To Ceiling Particles on the Early Post-Natal Immune Cell Populations; Respirology
Emerging Early Life Environmental Exposures and Lung Development; Journal of Environmental Immunology and Toxicology
Emerging issues in the Pacific Basin; Reviews on Environmental Health
Environmental health challenges in remote Aboriginal Australian communities: clean air, clean water and safe housing; Australian Indigenous Health Bulletin
Exacerbation Of A Respiratory Viral Infection By Low Doses Of Geogenic Dust; B106 Occupational and Environmental Determinants of Lung Function
Exacerbation of influenza infection by low doses of geogenic dust; The Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2013
Exposure to iron laden geogenic dust exacerbates the response to influenza infection; Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2014 Annual Scientific Meetings
Factors influencing the assessment of lung function in mice with influenza-induced lung disease; Influenza and Other Respiratory Viruses
Female mice exposed to influenza A have greater inflammation and lung responsiveness compared to male mice; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2009
Genotypically defined β-lactamase-negative ampicillin-resistant isolates of non-typable Haemophilus influenzae are associated with increased invasion of bronchial epithelial cells in vitro; Journal of Medical Microbiology
Geogenic PM10 exposure exacerbates responses to influenza infection; Science of the Total Environment
High tidal volume ventilation in infant mice; Respiration Physiology and Neurobiology
House dust mite induced lung inflammation does not alter circulating vitamin D levels; PLoS One
Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice; Respiratory Research
Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways disease; American Journal of Physiology
Identification of vitamin D sensitive pathways during lung development; Respiratory Research
Identifying The Key Drivers Of The Lung Response To Inhaled Geogenic Dusts; The Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2013
Identifying The Key Drivers Of The Lung Response To Inhaled Geogenic Dusts; The Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2013
Identifying The Key Drivers Of The Lung Response To Inhaled Geogenic Dusts; D17 Impact of Diesel and Other Particles Mini Symposium
Imaging lung tissue oscillations using high-speed X-ray velocimetry; Journal of Synchrotron Radiation
Impact of Age of Infection and Sex on the Physiological Consequences of Influenza A Infection; American Thoracic Society 2009 International Conference
Impact of supplemental oxygen in mechanically ventilated adult and infant mice; Respiration Physiology and Neurobiology
In utero arsenic exposure via drinking water alters genes related to lung growth and mucociliary function; TSANZ 2011 Annual Scientific Meetings
In utero cigarette smoke exposure results in impaired growth and impaired lung function in neonatal BALB/C mice; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting 2010
In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice; Environmental Health Perspectives
In Utero Exposure to Arsenic Via Drinking Water Alters Post−Natal Lung Function; merican Thoracic Society 2009 International Conference
In Utero Exposure to Arsenic Via Drinking Water Alters Post−Natal Lung Function; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2009
In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice; BMC Pharmacology and Toxicology
In utero vitamin D deficiency alters the expression of MMPs in foetal lung; Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2015 Annual Scientific Meetings
Independent Effects Of Airway Smooth Muscle Remodelling And Allergic Inflammation On Airway Responsiveness; American Thoracic Society 2015 International Conference
Independent effects of airway smooth muscle remodelling and allergic inflammation on airway responsiveness; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2015
Influenza infection facilitates allergen-specific responses in pre-sensitized mice; TSANZ ASM Gold Coast 2015
Intrinsic Differences Of Epithelial Tight Junctions In Asthmatic Airway Epithelium And Barrier Compromisation Following Human Rhinoviral Insult; American Thoracic Society 2015 International Conference
Lack of long-term effects of respiratory syncytial virus infection on airway function in mice; Respiration Physiology and Neurobiology
Linking lung function and inflammatory responses in ventilator-induced lung injury; American Journal of Physiology: Lung Cellular and Molecular Physiology
Local Lung Function And Airway Size Response During Methacholine Challenge And Salbutamol Treatment Measured Using High-Resolution Dynamic CT And Functional Lung Imaging; Lung Imaging: State of play on structure and function
Lung development; Photochemical & Photobiological Sciences
Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice; Respiration Physiology and Neurobiology
Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse; Behavioural Brain Research: An International Journal
Maternal Vitamin D Deficiency Does Not Cause Airway Hyperresponsiveness And Increased Airway Smooth Muscle In Young Mice; Chronic Lung Diesease Throughout Life: From priming in utuero to the aging lung
Maternal vitamin D deficiency is associated with impaired lung function and asthma in children; Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2014 Annual Scientific Meetings
Measuring severe lung disease in mice - a cautionary tale; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2008
Mouse models of asthma: what physiological evidence are they based on?; Allergy and Clinical Immunology International
Neonatal antigen and viral exposure alters airway and parenchymal responsiveness in adult mice; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2008
No role for neutrophil elastase in influenza-induced cellular recruitment, cytokine production or airway hyperresponsiveness in mice; Respiration Physiology and Neurobiology
No role for neutrophil serine proteases in influenza-induced hyperresponsiveness; The Thoracic Society of Australia & New Zealand Annual Scientific Meeting 2010
Novel Analysis of 4DCT Imaging Quantifies Progressive Increases in Anatomic Dead Space During Mechanical Ventilation in Mice; Journal of Applied Physiology
Optical coherence tomographybased contactindentation for diaphragm mechanics in a mouse model of transforming growth factor alpha induced lung disease; Scientific reports
Ovalbumin-sensitized mice are good models for airway hyperresponsiveness but not acute physiological responses to allergen inhalation; Clinical and Experimental Allergy
Persistence of airway hyperresponsiveness in mice infected with influenza as infants; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2008
Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following Influenza A Virus infection; PLoS One
Physiological and immunological responses to allergen in three strains of mouse; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2007
Physiological and immunological responses to allergen in three strains of mouse; Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2007
Physiological and inflammatory responses in an anthropomorphically relevant model of acute diesel exhaust particle exposure are sex and dose-dependent; Inhalation Toxicology
Plethysmographic estimation of thoracic gas volume in apneic mice; Journal of Applied Physiology
Protective mechanical ventilation does not exacerbate lung function impairment or lung inflammation following influenza A infection; Journal of Applied Physiology
Quantification of heterogeneity in lung disease with image-based pulmonary function testing; Scientific Reports
Reply: Seasonality and total 25-hydroxyviatmin D levels as sources of potential misclassification of vitamin D deficiency; Annals of the American Thoracic Society
Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cells; The Journal of Experimental Medicine
Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease; PLoS One
Rhinovirus exacerbates house-dust-mite induced lung disease in adult mice; PLoS One
Self-Reported Geogenic Dust Exposure Is Associated With Increased Severity Of Infectious Diseases In Aboriginal Children; Respirology
Sensitizing and Th2 adjuvant activity of cysteine protease allergens; International Archives of Allergy and Immunology
Sexual dimorphism in lung function responses to acute influenza A infection; Influenza and Other Respiratory Viruses
Stepwise Changes In Lung Function And Growth With Age In Mice; American Thoracic Society 2011 International Conference
Suppression of the asthmatic phenotype by ultraviolet B-induced, antigen-specific regulatory cells; Clinical and Experimental Allergy
The bimodal quasi-static and dynamic elastance of the murine lung; Journal of Applied Physiology
The cardiac innervation of a marsupial heterotherm, the fat-tailed dunnart (Sminthopsis crassicaudata); Journal of Comparative Physiology. B: Biochemical, Systemic, and Environmental Physiology
The concentration of iron in real-world geogenic PM10 is associated with increased inflammation and deficits in lung function in mice; PLoS One
The Effects of In Utero Vitamin D Deficiency on Airway Smooth Muscle Mass and Lung Function; American Journal of Respiratory Cell and Molecular Biology
The importance of research: towards improved outcomes for asthmatics; Asthma Foundation of W.A. Research Awards Keynote Presentation (2013)
The mechanism of deep inspiration-induced bronchoprotection: evidence from a mouse model; The European Respiratory Journal
The parasympathetic nervous system and its influence on heart rate in torpid western pygmy possums, Cercatetus concinnus (Marsupialia: Burramyidae); Zoology: Analysis of Complex Systems
The parasympathetic nervous system: its role during torpor in the fat-tailed dunnart (Sminthopsis crassicaudata); Journal of Comparative Physiology. B: Biochemical, Systemic, and Environmental Physiology
The pattern of methacholine responsiveness in mice is dependent on antigen challenge dose; Respiratory Research
Tracheal smooth muscle responses in a murine model of respiratory syncytial virus; TSANZ 2005 Annual Scientific Meeting
Transforming growth factor alpha increases extracellular matrix within a transgenic mouse model of airway disease; TSANZ ASM Gold Coast 2015
UV inhibits allergic airways disease in mice by reducing effector CD4 T cells; Clinical and Experimental Allergy
Variability and consistency in lung inflammatory responses to particles with a geogenic origin; Respirology
Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide; Scientific reports
Vitamin D Deficiency Alters Lung Function But Does Not Have An Effect On Airway Smooth Muscle Mass; American Thoracic Society 2012 International Conference
Vitamin D deficiency and the lung: disease initiator or disease modifier?; Nutrients
Vitamin D deficiency at 16 to 20 weeks' gestation is associated with impaired lung function and asthma at 6 years of age; Annals of the American Thoracic Society
Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-b expression in the lungs of female BALB/c mice; Physiological Reports
Vitamin D deficiency causes deficits in lung function and alters lung structure; TSANZ 2011 Annual Scientific Meetings
Vitamin D deficiency causes deficits in lung function and alters lung structure; American Journal of Respiratory and Critical Care Medicine
Vitamin D deficiency causes deficits in lung function but does not alter airway smooth muscle mass; TSANZ/ANZSRS (NZ) 2012 Annual Scientific Meeting
Vitamin D Deficiency Has Protective Effects In A Mouse Model Of Chronic House Dust Mite Exposure; B34 Airway Hyperresponsiveness: Underlying Mechanisms and Clinical Implications
Vitamin D deficiency in BALB/c mouse pregnancy increases placental transfer of glucocorticoids; Endocrinology
Vitamin D deficiency protects against the effects of chronic house dust mite exposure; The Thoracic Society of Australia and New Zealand Annual Scientific Meeting 2013
Vitamin D in fetal development: findings from a birth cohort study; Pediatrics
Whole life arsenic exposure via drinking water results in impaired lung function and airway hyperresponsiveness; TSANZ 2011 Annual Scientific Meetings

Research Projects

Energy transitions, air pollution and health in Australia; National Health & Medical Research Council (NHMRC)
Finding the right ventilator settings in patients with respiratory failure; Royal Hobart Hospital Research Foundation (RHHRF)
Hazelwood coal mine fire emissions: Are there risks for infant brain development?; University of Tasmania (UTAS)
Investigating the burden of childhood fever on Tasmanian families and the Royal Hobart Hospitals Emergency Department.; Royal Hobart Hospital Research Foundation (RHHRF)
Iron laden particulate matter enhances bacterial growth in the lung; Australian Respiratory Council (AusRespC)
Preclinical Development of Neuropeptide Y for the Treatment of Motor Neuron Disease; The Cure for MND Foundation (CMF)
Regional mechanisms of ventilator induced lung injury: insights from dynamic lung imaging; National Health & Medical Research Council (NHMRC)
The impact of iron oxide particles on lung health; Thoracic Society of Australia & New Zealand/ Allen & Hanbury (TSANZ)
The UTAS Smoke Lab: A request for CAR to fund essential equipment for an Australian facility for inter-disciplinary air quality research; National Health & Medical Research Council (NHMRC)
Vitamin D, lung growth and chronic lung disease; National Health & Medical Research Council (NHMRC)
Anti-inflammatory efficacy of Marinovas Fucoidan & interactions with microbiota
Childhood lung disease
Supporting respiratory research
Airway smooth muscle and asthma
Does abnormal epithelial function facilitate aero-allergen sensitization
Early life arsenic exposure alters lung development and inflammatory responses to virus and cigarette smoke
From the synchrotron to the clinic: translation of a novel functional imaging technology

Research Candidate Supervision