Web Access Research Portal

Researcher: Patchett, AL (Dr Amanda Patchett)

Fields of Research

Animal immunology
Animal cell and molecular biology
Cellular immunology
Veterinary immunology
Tumour immunology
Proteomics and intermolecular interactions (excl. medical proteomics)
Humoural immunology and immunochemistry
Veterinary diagnosis and diagnostics
Infectious diseases
Infectious agents
Conservation and biodiversity
Host-parasite interactions
Cancer therapy (excl. chemotherapy and radiation therapy)
Wildlife and habitat management
Gene expression (incl. microarray and other genome-wide approaches)

Research Objectives

Clinical health
Terrestrial biodiversity
Control of pests, diseases and exotic species in terrestrial environments
Expanding knowledge in the biological sciences
Expanding knowledge in the health sciences
Veterinary biological preventatives
Veterinary diagnostics
Expanding knowledge in the biomedical and clinical sciences
Treatment of human diseases and conditions
Expanding knowledge in the agricultural, food and veterinary sciences
Disease distribution and transmission (incl. surveillance and response)
Other health
Environmentally sustainable commercial services and tourism

Career Best Publications

Research Publications

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers; Science Advances
Abstract B040: Imiquimod initiates tumor specific overload of the ER stress response in Tasmanian devil facial cancer cells; Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: translating science into survival
An oral bait vaccination approach for the Tasmanian devil facial tumor diseases; Expert Review of Vaccines
Analysis of toll-like receptor responses in the endangered Tasmanian devil; International Congress of Immunology
Application of metabolomics and proteomics for biomarker discovery and development of therapies for the transmissible cancer, Tasmanian Devil Facial Tumour Disease; 22nd Annual Lorne Proteomics Symposium 2017
Curse of the Devil: Devil Facial Tumour Disease; Australasian Cytometry Society 38th Annual Scientific Meeting
Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
Generation and Testing of Fluorescent Adaptable Simple Theranostic (FAST) Proteins; Bio-protocol
Generation and testing of Fluorescent Adaptable Simple Theranostic (FAST) Proteins; Bio-protocol
Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease; PLoS ONE
Immunization strategies producing a humoral IgG immune response against devil facial tumor disease in the majority of Tasmanian devils destined for wild release; Frontiers in Immunology
Mesenchymal plasticity of devil facial tumour cells during in vivo vaccine and immunotherapy trials; Immunology and Cell Biology
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in 3 transmissible cancers; Journal of Cancer Research and Clinical Oncology
OPINION: We canít risk nature taking its course against this most iconic Tasmanian animal
Rewilding immunology; Science
Targeting transmissible cancers in animals
The immunomodulatory small molecule imiquimod induces apoptosis in devil facial tumour cell lines; PL o S One
The toll-like receptor ligands Hiltonol® (polyICLC) and imiquimod effectively activate antigen-specific immune responses in Tasmanian devils (Sarcophilus harrisii); Developmental and Comparative Immunology
Toll-like receptor signaling is functional in immune cells of the endangered Tasmanian devil; Developmental and Comparative Immunology
Transcriptome and proteome profiling reveals stress-induced expression signatures of imiquimod-treated Tasmanian devil facial tumor disease (DFTD) cells; OncoTarget
Two of†a†kind: transmissible Schwann cell cancers in†the†endangered Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
We developed tools to study cancer in Tasmanian devils. They could help fight disease in humans

Research Projects

Can the DFTD tumour microenvironment influence vaccine responses in the Tasmanian devil?; University of Tasmania Foundation Inc (UTF)
Cancer Shapeshifters Deciphering the contribution of tumour plasticity to DFT vaccine failure and tumour emergence; University of Tasmania Foundation Inc (UTF)
Developing DFTD vaccination approaches to favour cell mediated anti-tumour immunity; University of Tasmania Foundation Inc (UTF)
Development of a devil facial tumour bait-vaccine for landscape-level distribution; University of Tasmania (UTAS)
Development of a devil facial tumour disease vaccine; University of Tasmania Foundation Inc (UTF)
Development of a field diagnostic test for DFT1/2; University of Tasmania Foundation Inc (UTF)
Development of an early diagnostic liquid biopsy for DFT2; University of Tasmania Foundation Inc (UTF)
Identification of host-tumour interactions driving immune evasion and survival of devil facial tumor disease; University of Tasmania (UTAS)

Research Candidate Supervision