Web Access Research Portal

Researcher: Lin, J (Dr John Lin)

Fields of Research

Neurosciences
Medical Molecular Engineering of Nucleic Acids and Proteins
Cellular Nervous System
Biomolecular Modelling and Design
Central Nervous System
Sensory Systems
Medical and Health Sciences
Engineering
Biochemistry and Cell Biology
Receptors and Membrane Biology
Signal Transduction
Nanobiotechnology
Proteins and Peptides

Research Objectives

Expanding Knowledge in the Biological Sciences
Nervous System and Disorders
Expanding Knowledge in Technology
Expanding Knowledge in the Medical and Health Sciences
Health
Expanding Knowledge in Psychology and Cognitive Sciences
Expanding Knowledge in the Chemical Sciences

Career Best Publications

Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics; Biophysical Journal
Engineering a memory with LTD and LTP; Nature
Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship; Nature Methods: techniques for life scientists and chemists
Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI); Neuron
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation; Nature Neuroscience

Research Publications

A far-red fluorescent protein evolved from a cyanobacterial phycobiliprotein; Nature Methods: techniques for life scientists and chemists
A userís guide to channelrhodopsin variants: features, limitations and future developments
An Optimized Triple Modality Reporter for Quantitative In Vivo Tumor Imaging and Therapy Evaluation; PL o S One
Broad spectral excitation of opsin for enhanced stimulation of cells; Optics Letters
Characterization of Engineered Channelrhodopsin Variants with Improved Properties and Kinetics; Biophysical Journal
Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex; Journal of Neuroscience
Engineering a memory with LTD and LTP; Nature
Optically monitoring voltage in neurons by photoinduced electron transfer through molecular wires; National Academy of Sciences of The United States of America. Proceedings
Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship; Nature Methods: techniques for life scientists and chemists
Optogenetic excitation of neurons with channelrhodopsins: Light instrumentation, expression systems, and channelrhodopsin variants; Optogenetics: tools for controlling and monitoring neuronal activity
Optogenetic Inhibition of Synaptic Release with Chromophore-Assisted Light Inactivation (CALI); Neuron
ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation; Nature Neuroscience
Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina; EMBO molecular medicine
The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins; Trends in biochemical sciences

Research Projects

Detection and manipulation of neuronal activities with a synthetic optogenetic activity-reporting transcription system; National Health & Medical Research Council (NHMRC)
Novel tools for manipulating neuronal activity for behavioural studies; Australian Research Council (ARC)
Optogenetic mapping of synaptic activity and control of intracellular signaling; National Institutes of Health (NIH)
Structure guided design of photoselectable channelrhodopsins; National Institutes of Health (NIH)

Research Candidate Supervision