Web Access Research Portal

Researcher: O'Toole, RF (Dr Ronan O'Toole)

Fields of Research

Medical Bacteriology
Bacteriology
Respiratory Diseases
Marine and Estuarine Ecology (incl. Marine Ichthyology)
Clinical Sciences
Public Health and Health Services
Cancer Genetics
Health and Community Services
Infectious Diseases

Research Objectives

Infectious Diseases
Human Pharmaceutical Treatments (e.g. Antibiotics)
Respiratory System and Diseases (incl. Asthma)
Antarctic and Sub-Antarctic Flora, Fauna and Biodiversity
Fresh, Ground and Surface Water Flora, Fauna and Biodiversity
Health Inequalities
Indigenous Health
Marine Flora, Fauna and Biodiversity
Diagnostic Methods
Expanding Knowledge in the Medical and Health Sciences

Career Best Publications

A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis; Journal of Bacteriology
An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke; The International Journal of Chronic Obstructive Pulmonary Disease
Chemotactic motility is required for invasion of the host by the fish pathogen Vibrio anguillarum; Molecular Microbiology
Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues; Tuberculosis
Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in New Zealand; Genome Announcements
Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors; Tuberculosis
Experimental Models Used to Study Human Tuberculosis; Advances in Applied Microbiology
Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria; Antimicrobial Agents and Chemotherapy
Phylogenetic lineages of tuberculosis isolates in New Zealand and their association with patient demographics; International Journal of Tuberculosis and Lung Disease
Relating annual migration from high tuberculosis burden country of origin to changes in foreign-born tuberculosis notification rates in low-medium incidence European countries; Tuberculosis
RpoN of the fish pathogen Vibrio (Listonella) anguillarum is essential for flagellum production and virulence by the water-borne but not intraperitoneal route of inoculation; Microbiology
Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery; Journal of Antimicrobial Chemotherapy
The chemotactic response of Vibrio anguillarum to fish intestinal mucus is mediated by a combination of multiple mucus components; Journal of Bacteriology
Tuberculosis incidence in the Irish Traveller population in Ireland from 2002 to 2013; Epidemiology and Infection
Visualisation of Zebrafish infection by GFP-labelled Vibrio anguillarum; Microbial Pathogenesis

Research Publications

A two-component regulator of universal stress protein expression and adaptation to oxygen starvation in Mycobacterium smegmatis; Journal of Bacteriology
Absolutely, positively searching for new anti-tubercular drugs; Webster Centre Symposium 2009
An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke; The International Journal of Chronic Obstructive Pulmonary Disease
An antagonist of the platelet-activating factor receptor inhibits streptococcus pneumoniae and non-typeable haemophilus influenzae infection of human bronchial epithelial cells exposed to cigarette smoke; Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting
Augmenting public health TB surveillance with genotyping: the Irish mycobacteria reference laboratory (IMRL) experience; Royal Academy of Medicine in Ireland Winter Scientific Meeting
Bacterial Lung Disease and COPD; Journal of Pulmonary & Respiratory Medicine
Chemotactic motility is required for invasion of the host by the fish pathogen Vibrio anguillarum; Molecular Microbiology
Cloning, mutagenesis and virulence analyses of a flagellin gene of Vibrio anguillarum
Cluster Analysis of Mycobacterium tuberculosis Using Whole Genome Sequencing (Wgs): The Irish Mycobacteria Reference Laboratory (Imrl) Experience; ASM Microbe 2016
Comparative bioactivation of the novel anti-tuberculosis agent PA-824 in Mycobacteria and a subcellular fraction of human liver; British Journal of Pharmacology
Comparison of the microalgal community within fast ice at two sites along the Ross Sea coast, Antarctica; Antarctic Science
Contrasting signal transduction mechanisms in bacterial and eukaryotic gene transcription
Convergence in the Epidemiology and Pathogenesis of COPD and Pneumonia; COPD: journal of chronic obstructive pulmonary disease
Design, synthesis and analysis of anti-tuberculosis peptides
Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen; Journal of Microbiology
Development and application of unstable GFP variants to kinetic studies of mycobacterial gene expression; Journal of Microbiological Methods
Development of a Mycobacterium smegmatis transposon mutant array for characterising the mechanism of action of tuberculosis drugs: Findings with isoniazid and its structural analogues; Tuberculosis
Differential carriage of virulence-associated loci in the New Zealand Rangipo outbreak strain of Mycobacterium tuberculosis; Infectious Diseases
Discovering new drugs to fight tuberculosis
Does upregulated host cell receptor expression provide a link betweenbacterial adhesion andchronic respiratory disease?; Journal of Translational Medicine
Draft genome sequence of a drug-susceptible New Zealand isolate of Mycobacterium tuberculosis Lineage 3; Genome announcements
Draft genome sequence of a multidrug-resistant New Zealand isolate of Mycobacterium tuberculosis Lineage 3; Genome Announcements
Draft Genome Sequence of a New Zealand Rangipo Strain of Mycobacterium tuberculosis; Genome Announcements
Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in Ireland; Genome Announcements
Draft Genome Sequence of the First Isolate of Extensively Drug-Resistant Mycobacterium tuberculosis in New Zealand; Genome Announcements
Establishment of the absolute configuration of the bioactive marine alkaloid eudistomin X by stereospecific synthesis; Tetrahedron Letters: International Journal for The Rapid Publication of Preliminary Communications in Organic Chemistry
Evaluation of online webtools for the prediction of drug resistance and genotyping in Mycobacterium tuberculosis Complex in Ireland, a low prevalence country, from a User's perspective; 37th Annual Congress of the European Society of Mycobacteriology
Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors; Tuberculosis
Evidence of Non-sporadic Distribution of Campylobacteriosis Cases in New Zealand
Experimental Models Used to Study Human Tuberculosis; Advances in Applied Microbiology
Experts attack TB from all sides
Expression of zebrafish cxcl8 (interleukin-8) and its receptors during development and in response to immune stimulation; Developmental and Comparative Immunology: Ontogeny - Phylogeny - Aging
Flagellin A is essential for the virulence of Vibrio anguillarum; Journal of Bacteriology
High single-cell metabolic activity in Antarctic sea ice bacteria; Aquatic Microbial Ecology
Identification and bioactivity of 3-epi-xestoaminol C isolated from the New Zealand brown alga Xiphophora chondrophylla; Journal of Natural Products
Investigation of the physiological relationship between the cyanide-insensitive oxidase and cyanide production in Pseudomonas aeruginosa; Microbiology
Limitations of the Mycobacterium tuberculosis reference genome H37Rv in the detection of virulence-related loci; Genomics
Mapping the origin and spread of Mycobacterium tuberculosis complex in the Tasmanian population using whole-genome sequence and epidemiological data analyses; Australian Society for Microbiology Annual Scientific Meeting 2017
Mapping the origin and spread of Mycobacterium tuberculosis complex in the Tasmanian population using whole-genome sequence and epidemiological data analyses; Applied Bioinformatics & Public Health Microbiology
Microbial community structure at Champagne Pool, Waiotapu, New Zealand
Modifying culture conditions in chemical library screening identifies alternative inhibitors of mycobacteria; Antimicrobial Agents and Chemotherapy
Molecular Characterisation of the first Extensively Drug Resistant (XDR) Mycobacterium tuberculosis isolated in Ireland; 35th Congress of the European Society of Mycobacteriology
Molecular epidemiology of human tuberculosis in New Zealand and potential insights for disease control; The New Zealand Medical Journal
Native New Zealand plants with inhibitory activity towards Mycobacterium tuberculosis; BMC Alternative Medicine
Navigating tuberculosis drug discovery with target-based screening; Expert Opinion on Drug Discovery
Next-generation sequencing for the characterisation of bacterial respiratory pathogens; Annual Meeting of the Mycobacteria Special Interest Group
NZ plant may cure superTB
Phylogenetic analyses of bacteria in sea ice at Cape Hallett, Antarctica; New Zealand Journal of Marine and Freshwater Research
Phylogenetic lineages of tuberculosis isolates associate with specific patient demographics in New Zealand; The ACID FAST CLUB Summer Meeting
Phylogenetic lineages of tuberculosis isolates in New Zealand and their association with patient demographics; International Journal of Tuberculosis and Lung Disease
Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target; Expert Review of Respiratory Medicine
Relating annual migration from high tuberculosis burden country of origin to changes in foreign-born tuberculosis notification rates in low-medium incidence European countries; Tuberculosis
Relating microbial community and physicochemical parameters of a hot spring: Champagne pool, wai-o-tapu, New Zealand; Geomicrobiology Journal: An International Journal of Geomicrobiology and Microbial Biogeochemistry
Role of motility in adherence to and invasion of a fish cell line by Vibrio anguillarum; Journal of Bacteriology
RpoN of the fish pathogen Vibrio (Listonella) anguillarum is essential for flagellum production and virulence by the water-borne but not intraperitoneal route of inoculation; Microbiology
Subcuticular Bacteria Associated with Two Common New Zealand Echinoderms: Characterization Using 16S rRNA Sequence Analysis and Fluorescence in situ Hybridization; Biological Bulletin
Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery; Journal of Antimicrobial Chemotherapy
TB levels three times higher in Travellers
TB meets COPD: An emerging global co-morbidity in human lung disease; Tuberculosis
TbNZ Meeting: a new barometer for tuberculosis research in New Zealand
Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease; Microbiology
Tetracycline-inducible gene regulation in mycobacteria; Nucleic Acids Research
The chemotactic response of Vibrio anguillarum to fish intestinal mucus is mediated by a combination of multiple mucus components; Journal of Bacteriology
The origin of cyanobacteria in Antarctic sea ice: Marine or freshwater?; Environmental Microbiology Reports
Translating Mycobacterium tuberculosis research into new interventions for human tuberculosis control; The Australian Society for Microbiology
Travellers have more TB and measles but an action plan could help
Tuberculosis incidence in the Irish Traveller population in Ireland from 2002 to 2013; Epidemiology and Infection
Universal stress proteins and Mycobacterium tuberculosis
Visualisation of Zebrafish infection by GFP-labelled Vibrio anguillarum; Microbial Pathogenesis
WGS analysis of TB isolates from Tasmania; Annual Meeting of the Mycobacteria Special Interest Group of the Australian Society for Microbiology
Whole genome sequence analysis of an outbreak strain of Mycobacterium tuberculosis; Keystone Symposia on Molecular and Cellular Biology: New Developments in Our Basic Understanding of Tuberculosis (A5
Whole Genome Sequencing Analysis; Annual Workshop of the Mycobacteria Special Interest Group of the Australian Society for Microbiology
Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis; Tuberculosis

Research Projects

Tracking the origin and spread of hospital-acquired infections using whole-genome sequencing; Royal Hobart Hospital Research Foundation (RHHRF)
Supporting respiratory research
The effect of currently used COPD pharmacological agents on Platelet Activating Factor re-ceptor (PAFr) expression in human epithelial cell culture systems from smokers and COPD
ISCA India Programme
Microbial biodiversity in sea ice
Pushing the boundaries of target-based tuberculosis drug discovery with inhibitors of the essential cell division gene, parA.
Pushing the boundaries of target-based tuberculosis drug discovery with inhibitors of the essential cell division gene, parA.

Research Candidate Supervision