Web Access Research Portal

Researcher: Eapen, MS (Dr Mathew Eapen)

Fields of Research

Respiratory diseases
Cardiology (incl. cardiovascular diseases)
Pharmaceutical sciences
Bioprocessing, bioproduction and bioproducts
Genetic immunology
Medical bacteriology
Cellular interactions (incl. adhesion, matrix, cell wall)

Research Objectives

Clinical health
Diagnosis of human diseases and conditions
Treatment of human diseases and conditions
Public health (excl. specific population health)
Human pharmaceutical treatments
Prevention of human diseases and conditions

Career Best Publications

Research Publications

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD); Scientific reports
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma; Respirology
Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease; The European Respiratory Journal
Airway inflammation and inhaled corticosteroids in COPD; The European Respiratory Journal
Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox
Altered Calcium in Ciliary Dysfunction: Potential Role of Endoplasmic Reticulum Stress and Ciliophagy; American Journal of Respiratory Cell and Molecular Biology
Angiotensin-converting enzyme 2 (ACE2), transmembrane peptidase serine 2 (TMPRSS2), and furin expression increases in the lungs of patients with idiopathic pulmonary fibrosis (IPF) and lymphangioleiomyomatosis (LAM): implications for SARS-CoV-2 (COVID-19) infections; Journal of Clinical Medicine
Anti-inflammatory activity of fucoidan extracts in vitro; Marine Drugs
Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease; Clinical Science
Arterial remodelling in smokers and in patients with small airway disease and COPD: implications for lung physiology and early origins of pulmonary hypertension; ERJ Open Research
Asthma, COPD and SARS-CoV-2 infection (COVID-19): potential mechanistic insights; The European Respiratory Journal
Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities; Drugs
Clinical features and mechanistic insights into drug repurposing for combating COVID-19; International Journal of Biochemistry and Cell Biology
Cochrane review update leaves big questions unanswered regarding vaping: implications for medical practitioners; The European Respiratory Journal
Containment strategies for COVID-19 in India: lessons from the second wave; Expert Review of Anti-infective Therapy
COVID-19 and vaping: risk for increased susceptibility to SARS-CoV-2 infection?; The European Respiratory Journal
Current understanding of corticosteroid therapy in chronic obstructive pulmonary disease (COPD): an overview; International Journal of Medical and Biological Frontiers
Diagnostic approaches in COVID-19: clinical updates; Expert Review of Respiratory Medicine
Differential airway remodeling changes were observed in patients with asthma COPD overlap compared to patients with asthma and COPD alone; American Journal of Physiology
Dysfunctional immunity and microbial adhesion molecules in smoking-induced pneumonia; American Journal of Respiratory and Critical Care Medicine
Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections; American Journal of Physiology
Electronic cigarette aerosol is cytotoxic and increases ACE2 expression on human airway epithelial cells: Implications for SARS-CoV-2 (COVID-19); Journal of Clinical Medicine
Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease; Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease
Endothelial to mesenchymal transition (EndMT) and vascular remodeling in pulmonary hypertension and idiopathic pulmonary fibrosis; Expert Review of Respiratory Medicine
Endothelial to mesenchymal transition: a precursor to post-COVID-19 interstitial pulmonary fibrosis and vascular obliteration?; The European Respiratory Journal
Epithelial-mesenchymal transition, a spectrum of states: role in lung development, homeostasis, and disease; Developmental Dynamics
Epithelial–mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics; International Journal of Chronic Obstructive Pulmonary Disease
Epithelial–Mesenchymal Transition: A Necessary New Therapeutic Target in Chronic Obstructive Pulmonary Disease?; American Journal of Respiratory and Critical Care Medicine
Fucoidan as an inhibitor of pro-inflammatory cytokines: potential candidate for treating inflammatory-related conditions; Experimental Biology 2022
Ground-breaking Australian study is a ‘paradigm shift’ in understanding lung scarring this Rare Diseases Day
Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies; Laboratory Investigation
Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma; Molecular and Clinical Oncology
Impact of deleterious mutations on structure, function and stability of serum/glucocorticoid regulated kinase 1: A gene to diseases correlation; Frontiers in Molecular Biosciences
Impact of maternal air pollution exposure on children's lung health: An Indian perspective; Toxics
Implications of the second wave of COVID-19 in India; The Lancet Respiratory Medicine
Increased myofibroblasts in the small airways, and relationship to remodelling and functional changes in smokers and COPD patients: potential role of epithelial-mesenchymal transition; ERJ Open Research
Inhaled corticosteroids attenuate epithelial mesenchymal transition (EMT): implications for COPD and lung cancer prophylaxis; European Respiratory Journal
Investigations into the physical and chemical stability of concentrated co-trimoxazole intravenous infusions; European Journal of Hospital Pharmacy
IQOS exposure impairs human airway cell homeostasis: Direct comparison with traditional cigarette and e-cigarette; ERJ Open Research
Mechanistic insights into the role of serum-glucocorticoid kinase 1 in diabetic nephropathy: A systematic review; International Journal of Biological Macromolecules
microRNAs are key regulators in chronic lung disease: exploring the vital link between disease progression and lung cancer
Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD
New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways; Clinical Science
Novel insights into chronic obstructive pulmonary disease (COPD): an overview; EMJ Respiratory
Opposing effects of low molecular weight heparins on the release of inflammatory cytokines from peripheral blood mononuclear cells of asthmatics; PLoS One
Pathogenesis, clinical features of asthma COPD overlap (ACO), and therapeutic modalities; American Journal of Physiology
Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target; Expert Review of Respiratory Medicine
Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease; Chest
Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD; Respirology
Renin-Angiotensin-Aldosterone System Inhibitors in Covid-19; New England Journal of Medicine
Respiratory research Holy Grail: EndMT as a therapeutic target in lung fibrosis
Role of corticosteroids in chronic obstructive pulmonary disease (COPD); Corticosteroids and Steroid Therapy: New Research
SARS-CoV-2 (COVID-19) adhesion site protein upregulation in small airways, type 2 pneumocytes, and alveolar macrophages of smokers and COPD - possible implications for interstitial fibrosis; International Journal of Chronic Obstructive Pulmonary Disease
sE-cadherin and sVE-cadherin indicate active epithelial/endothelial to mesenchymal transition (EMT and EndoMT) in smokers and COPD: implications for new biomarkers and therapeutics; Biomarkers
Smoking upregulates angiotensin-converting enzyme-2 receptor: A potential adhesion site for Novel Coronavirus SARS-CoV-2; Journal of Clinical Medicine
The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases; Journal of Thoracic Disease
The ER Stress/UPR axis in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis; Life
The ill effects of IQOS on airway cells: Let’s not get burned all over again; American Journal of Respiratory Cell and Molecular Biology
The rise of electronic nicotine delivery systems and the emergence of electronic-cigarette-driven disease; American Journal of Physiology: Lung Cellular and Molecular Physiology
Therapeutic targets in lung tissue remodelling and fibrosis; Pharmacology and Therapeutics
Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets; Clinical science
Update on the Pathogenesis of COPD; New England Journal of Medicine
Vascular remodelling in idiopathic pulmonary fibrosis patients and its detrimental effect on lung physiology: potential role of endothelial-to-mesenchymal transition; ERJ Open Research
Ventilatory efficiency slope as a predictor of suitability for surgery in chronic obstructive pulmonary disease patients with lung cancer; The Annals of Translational Medicine
Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide; Scientific Reports
WNT/β-catenin pathway: A novel therapeutic target for attenuating airway remodelling and EMT in COPD; EBioMedicine

Research Projects

Are newly introduced electronic smoking devices safe for smoking cessation and implications for SARS-CoV-2 infection (COVID-19); Clifford Craig Foundation (CCFoundation)
Epithelial mesenchymal transition (EMT) in the lungs and airways in Idiopathic Pulmonary Fibrosis (IPF); Clifford Craig Foundation (CCFoundation)
Establishment of a Tasmanian lung cancer registry: a north and north-west collaborative initiative.; Clifford Craig Foundation (CCFoundation)
Evaluation of new therapeutic targets in idiopathic pulmonary fibrosis (IPF): insights from Australian IPF registry tissue analysis; Clifford Craig Foundation (CCFoundation)
Prevalence of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) in north-west Tasmanian population: understanding and translation to early therapy; Clifford Craig Foundation (CCFoundation)
The effect of current and investigational COPD pharmacological agents on the airway Epithelial-Mesenchymal Transition (EMT) process in smokers and COPD; Clifford Craig Foundation (CCFoundation)
To evaluate the role of endothelial to mesenchymal transition in the pathogenesis of idiopathic pulmonary fibrosis and pulmonary hypertension. ; Clifford Craig Foundation (CCFoundation)

Research Candidate Supervision