Web Access Research Portal

Researcher: Flies, AS (Dr Andy Flies)

Fields of Research

Animal immunology
Cellular immunology
Veterinary immunology
Tumour immunology
Immunology
Medical biotechnology diagnostics (incl. biosensors)
Infectious diseases
Animal cell and molecular biology
Veterinary epidemiology
Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)
Rural clinical health
Ecology
Biological oceanography
Cancer genetics
Host-parasite interactions
Infectious agents
Health psychology
Transplantation immunology
Behavioural ecology
Conservation and biodiversity
Innate immunity
Cancer therapy (excl. chemotherapy and radiation therapy)
Genomics

Research Objectives

Clinical health
Terrestrial biodiversity
Expanding knowledge in the biological sciences
Expanding knowledge in the health sciences
Expanding knowledge in the agricultural, food and veterinary sciences
Expanding knowledge in the biomedical and clinical sciences
Veterinary diagnostics
Public health (excl. specific population health)
Health status (incl. wellbeing)
Other health
Efficacy of medications
Control of pests, diseases and exotic species in terrestrial environments
Treatment of human diseases and conditions
Veterinary biological preventatives
Fisheries - aquaculture
Disease distribution and transmission (incl. surveillance and response)

Career Best Publications

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers; Science Advances
An oral bait vaccination approach for the Tasmanian devil facial tumor diseases; Expert Review of Vaccines
Comparative analysis of immune checkpoint molecules and their potential role in the transmissible Tasmanian Devil facial tumor disease; Frontiers in Immunology
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in 3 transmissible cancers; Journal of Cancer Research and Clinical Oncology
PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment; Frontiers in Immunology
Rewilding immunology; Science
Socioecological predictors of immune defences in wild spotted hyenas; Functional Ecology
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences

Research Publications

A novel system to map protein interactions reveals evolutionarily conserved immune evasion pathways on transmissible cancers; Science Advances
An oral bait vaccination approach for the Tasmanian devil facial tumor diseases; Expert Review of Vaccines
Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world; Conservation Physiology
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells; Blood
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells; Journal of Immunology
B7-H3 promotes pathogenesis of autoimmune disease and inflammation by regulating the activity of different T cell subsets; PLoS One
B7-H4–deficient mice display augmented neutrophil-mediated innate immunity; Blood
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype; Blood
Characterization of Toll-like receptors 1-10 in spotted hyenas; Veterinary Research Communications: An International Journal Publishing Topical Reviews and Research Articles on All Aspects of The Veterinary Sciences
Comparative analysis of immune checkpoint molecules and their potential role in the transmissible Tasmanian Devil facial tumor disease; Frontiers in Immunology
Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
Cytokines: Signalling improved immunotherapy?; Current Oncology Reports
Deadly disease can 'hide' from a Tasmanian devil's immune system
Development of a hyena immunology toolbox; Veterinary Immunology and Immunopathology: An International Journal of Comparative Immunology
Editorial: Wild Immunology - The answers are out there; Frontiers in Immunology
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis; Journal of Clinical Investigation
Extreme competence: keystone hosts of infections; Trends in Ecology and Evolution
Generation and testing of Fluorescent Adaptable Simple Theranostic (FAST) Proteins; Bio-protocol
Generation and Testing of Fluorescent Adaptable Simple Theranostic (FAST) Proteins; Bio-protocol
Inducible IFN-γ expression for MHC-I upregulation in devil facial tumor cells; Frontiers in Immunology
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy; Blood
Markedly elevated antibody responses in wild versus captive spotted hyenas show that environmental and ecological factors are important modulators of immunity; PLoS One
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in 3 transmissible cancers; Journal of Cancer Research and Clinical Oncology
Papillomavirus-associated Cutaneous Papillomas in a Population of Wild Spotted Hyenas (Crocuta crocuta); Journal of Wildlife Diseases
PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment; Frontiers in Immunology
Post release immune responses of Tasmanian devils vaccinated with an experimental devil facial tumour disease vaccine; Wildlife Research
Regional comparison of mosquito bloodmeals in South Australia: implications for Ross River virus ecology; Journal of Medical Entomology
Rewilding immunology; Science
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells; Blood
RTA in a COVID-19 Environment
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease; Blood
Socioecological predictors of immune defences in wild spotted hyenas; Functional Ecology
Spotted hyenas rarely die from disease: we set out to discover why
Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells; Developmental and Comparative Immunology
Two decades of the impact of Tasmanian Devil Facial Tumour Disease (DFTD); Integrative and Comparative Biology
Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii); Cellular and Molecular Life Sciences
We developed tools to study cancer in Tasmanian devils. They could help fight disease in humans

Research Projects

A live-attenuated vaccine (DFT-Off) to promote long-term anti-DFTD immunity; University of Tasmania Foundation Inc (UTF)
Cancer Shapeshifters Deciphering the contribution of tumour plasticity to DFT vaccine failure and tumour emergence; University of Tasmania Foundation Inc (UTF)
CRISPR screen to identify key genes driving DFTD; University of Tasmania Foundation Inc (UTF)
Development of a devil facial tumour bait-vaccine for landscape-level distribution; University of Tasmania (UTAS)
Development of a devil facial tumour disease vaccine; University of Tasmania Foundation Inc (UTF)
Development of a field diagnostic test for DFT1/2; University of Tasmania Foundation Inc (UTF)
Evaluation of the role natural killer (NK) cells in protection against DFTD; University of Tasmania Foundation Inc (UTF)
Identification of devil facial tumour-associated antigens for vaccine development; University of Tasmania Foundation Inc (UTF)
Identification of host-tumour interactions driving immune evasion and survival of devil facial tumor disease; University of Tasmania (UTAS)
Immunisation to protect against transmissible cancers in Tasmanian devils; Australian Research Council (ARC)
Improving the DFTD vaccine by targeting key immune signalling molecules; University of Tasmania Foundation Inc (UTF)
Investigation into an overlooked pathway towards anti-cancer immunity. Inhibitory motifs in the extracellular domains of immune checkpoint molecules; University of Tasmania Foundation Inc (UTF)
Investigation of cancer immunotherapy for the Tasmanian devil facial tumor disease; Morris Animal Foundation (MANF)
Rapid antibody development for improved cancer immunotherapy diagnostics; Royal Hobart Hospital Research Foundation (RHHRF)
Select Foundation Senior Research Fellowship - Immunology; The Select Foundation (SelF)
Tipping the Balance from Tolerance to Immunity for the Devil Facial Tumour; Australian Research Council (ARC)
Advice to the AAD (PMU) re RTA in a COVID19 Environment
Cancer Research to Help Tasmanian Devils
ICG - GREYSCAN PTY LTD
Translating human cancer immunotherapy techniques for use in pets and Tasmanian devils

Research Candidate Supervision