Web Access Research Portal

Researcher: Karupiah, G (Associate Professor Guna Karupiah)

Fields of Research

Medical Virology
Humoural Immunology and Immunochemistry
Cellular Immunology
Medical Bacteriology
Innate Immunity
Transplantation Immunology
Tumour Immunology

Research Objectives

Infectious Diseases
Immune System and Allergy
Respiratory System and Diseases (incl. Asthma)
Expanding Knowledge in the Medical and Health Sciences
Cancer and Related Disorders

Career Best Publications

Research Publications

A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection; PLoS pathogens
A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus; PLoS pathogens
Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells; Journal of Immunology
Deficiency in Th2 Cytokine Responses Exacerbate Orthopoxvirus Infection; PloS one
Evidence for Persistence of Ectromelia Virus in Inbred Mice, Recrudescence Following Immunosuppression and Transmission to Na´ve Mice; PLoS pathogens
Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria; Journal of Immunology
LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins; Immunology and Cell Biology
Loss of actin-based motility impairs ectromelia virus release in vitro but is not critical to spread in vivo; Viruses
Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo; Journal of Virology (Online)
Propagation and Purification of Ectromelia Virus; Current Protocols in Microbiology
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells; Nature Immunology
The orchestrated functions of innate leukocytes and T cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge; Journal of Virology
Vaccine-Induced Protection against Orthopoxvirus Infection Is Mediated through the Combined Functions of CD4 T Cell-Dependent Antibody and CD8 T Cell Responses; Journal of Virology
Viral Replicative Capacity, Antigen Availability via Hematogenous Spread, and High TFH:TFR Ratios Drive Induction of Potent Neutralizing Antibody Responses; Journal of Virology

Research Projects

Novel combination therapy for effective virus control and amelioration of influenza pneumonia; The MPST Foundation Ltd (MPST)

Research Candidate Supervision