Web Access Research Portal

Researcher: Karupiah, G (Associate Professor Guna Karupiah)

Fields of Research

Innate immunity
Cellular immunology
Medical virology
Humoural immunology and immunochemistry
Cellular interactions (incl. adhesion, matrix, cell wall)
Medical biotechnology diagnostics (incl. biosensors)
Cell metabolism
Medical bacteriology
Molecular evolution
Transplantation immunology
Respiratory diseases
Tumour immunology
Veterinary diagnosis and diagnostics
Conservation and biodiversity
Wildlife and habitat management

Research Objectives

Prevention of human diseases and conditions
Clinical health
Treatment of human diseases and conditions
Efficacy of medications
Expanding knowledge in the health sciences
Control of pests, diseases and exotic species in terrestrial environments
Diagnosis of human diseases and conditions
Human pain management

Career Best Publications

Research Publications

A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection; PLoS pathogens
A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus; PLoS pathogens
Acute effects of parainfluenza virus on epithelial electrolyte transport; Journal of Biological Chemistry
Alternate mechanisms of initial pattern recognition drive differential immune responses to related poxviruses; Cell Host and Microbe
Analysis of the Th1/Th2 paradigm in transplantation: interferon-gamma deficiency converts Th1-type proislet allograft rejection to a Th2-type xenograft-like response; Cell Transplantation
Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?; Immunology and Cell Biology
Antiviral protection following immunization correlates with humoral but not cell-mediated immunity; Immunology and Cell Biology
Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells; Journal of Immunology
CD8+ T cells have an essential role in pulmonary clearance of nontypeable Haemophilus influenzae following mucosal immunization; Infection and Immunity
Cell-to-cell spread of vaccinia virus is promoted by TGF-β-independent Smad4 signalling; Cellular Microbiology Online
Chemokines and chemokine receptors in infectious diseases
Correlates of protective immunity in poxvirus infection: where does antibody stand?
Cow dung biomass smoke exposure increases adherence of respiratory pathogen nontypeable Haemophilus infuenzae to human bronchial epithelial cells; Exposure and Health
Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses; Journal of Immunology
Cytokines and immunity to viral infections; Immunological Reviews
Deficiency in Th2 Cytokine Responses Exacerbate Orthopoxvirus Infection; PloS one
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity; Nature Immunology
Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection; Journal of Virology
Draft genome sequence of an isolate of nontypeable Haemophilus influenzae from an acute exacerbation of chronic obstructive pulmonary disease in Tasmania; Microbiology Resource Announcements
Effects of vaccinia virus-expressed interleukin 2 on the immune system of sublethally irradiated mice; Microbial Pathogenesis
Elevated natural killer cell responses in mice infected with recombinant vaccinia virus encoding murine IL-2; Journal of Immunology
Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice; Journal of General Virology
Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus; National Academy of Sciences of The United States of America. Proceedings
Evidence for Persistence of Ectromelia Virus in Inbred Mice, Recrudescence Following Immunosuppression and Transmission to Naïve Mice; PLoS pathogens
Expression of adenovirus E3/19K protein does not alter mouse MHC class I-restricted responses to vaccinia virus; Virology
Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo; Immunological Reviews
Expression of the interferon-inducible chemokines MuMig and Crg-2 following vaccinia virus infection in vivo; Immunology and Cell Biology
Gamma Interferon in Antiviral Defense; Chapman & Hall
Gamma Interferon-Induced Nitric Oxide in Antiviral Defense and Immunopathology; Gamma Interferon in Antiviral Defense
Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication; Journal of Virology
Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest nonredundant roles in vivo; Journal of Immunology
Genetic resistance to smallpox: lessons from mousepox; Decoding the Genomic Control of Immune Reactions
Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria; Journal of Immunology
Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection; Journal of Virology
Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines; The Journal of Experimental Medicine
IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection; Journal of Immunology
Immunobiology of infection with recombinant vaccinia virus encoding murine IL-2. Mechanisms of rapid viral clearance in immunocompetent mice; Journal of Immunology
Immunopathogenesis of infectious disease: injury and death from friendly fire; Immunology and Cell Biology
Immunopathogenesis of poxvirus infections: forecasting the impending storm
Importance of interferons in recovery from mousepox; Journal of Virology
Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia; National Academy of Sciences of The United States of America. Proceedings
Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2; Journal of Immunology
Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase; Science
Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites; The Journal of Experimental Medicine
Interferon function is not required for recovery from a secondary poxvirus infection; Proceedings of the National Academy of Sciences
Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection; The Journal of Experimental Medicine
Interferon-inducible chemokines and immunity to poxvirus infections
LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins; Immunology and Cell Biology
Loss of actin-based motility impairs ectromelia virus release in vitro but is not critical to spread in vivo; Viruses
Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo; Journal of Virology (Online)
Modification and improvement of the haemadsorption immunosorbent technique (HIT) for the detection of dengue IgM antibodies; The Malaysian Journal of Pathology
Modulation of chemokines by poxvirus infections
Murine Cytomegalovirus Infection-Induced Polyclonal B Cell Activation Is Independent of CD41 T Cells and CD40; Virology
NADPH oxidase, Nramp1 and nitric oxide synthase 2 in the host antimicrobial response
Obligatory requirement for antibody in recovery from a primary poxvirus infection; Journal of Virology
Overview of Host Defense Mechanisms with Special Reference to Viral Infections; Gamma Interferon in Antiviral Defense
Polarized type 1 cytokine response and cell-mediated immunity determine genetic resistance to mousepox; Proceedings of the National Academy of Sciences
Poxvirus CD8+ T-Cell determinants and cross-reactivity in BALB/c mice; Journal of Virology
Poxvirus-encoded gamma interferon binding protein dampens the host immune response to infection; Journal of Virology
Poxvirus-encoded TNF receptor homolog dampens inflammation and protects from uncontrolled lung pathology during respiratory infection; National Academy of Sciences of The United States of America. Proceedings
Propagation and Purification of Ectromelia Virus; Current Protocols in Microbiology
Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function; Journal of Virology
Rapid Interferon g–dependent Clearance of Influenza A Virus and Protection from Consolidating Pneumonitis in Nitric Oxide Synthase 2–deficient Mice; The Journal of Experimental Medicine
Recombinant vaccine vector-induced protection of athymic, nude mice from influenza A virus infection. Analysis of protective mechanisms; Scandinavian Journal of Immunology
T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control; National Academy of Sciences of The United States of America. Proceedings
Targeting tumour necrosis factor to ameliorate viral pneumonia
Techniques for studying murine natural killer cells in defense against viral infection; Methods in Molecular Biology
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells; Nature Immunology
The Interferon-Inducible Chemokines MuMig and Crg-2 Exhibit Antiviral Activity In Vivo; Journal of Virology
The orchestrated functions of innate leukocytes and T cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge; Journal of Virology
TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection; Proceedings of the National Academy of Sciences of the United States of America
Transcription of the interferon gamma (IFN-gamma )-inducible chemokine Mig in IFN-gamma-deficient mice; Journal of Biological Chemistry
Type 1 and type 2 cytokines in antiviral defense
Unexpected effects of pathogens on epithelial Na+ channels; Journal of Korean Medical Science
Vaccine-Induced Protection against Orthopoxvirus Infection Is Mediated through the Combined Functions of CD4 T Cell-Dependent Antibody and CD8 T Cell Responses; Journal of Virology
Vaccinia virus-mediated damage of murine ovaries and protection by virus-expressed interleukin-2; Immunology and Cell Biology
Vaccinia-Directed Cytokine Gene Expression and Infection; Immunology of Virus Diseases
Viral replicative capacity, antigen availability via hematogenous spread, and high TFH:TFR ratios drive induction of potent neutralizing antibody responses; Journal of Virology
Whole-genome analyses reveal gene content differences between nontypeable Haemophilus influenzae isolates from chronic obstructive pulmonary disease compared to other clinical phenotypes; Microbial Genomics

Research Projects

Novel combination therapy for effective virus control and amelioration of influenza pneumonia; The MPST Foundation Ltd (MPST)
A novel strategy to regulate host antiviral immune response and inflammation through mTNF
Antiviral targeting of motility
CD8+ T cell responses in mouse models of smallpox vaccination and challenge
Control of influenza A virus infection by gamma interferon-inducible mediators
Critical role of TNF in host-virus interactions and outcome of infection: Involvement of reverse signalling through mTNF
Critical soluble effector molecules causing immune damage in a model of West Nile virus encephalitis
Immunity to viral infections
Immunity to viral infections
Immunity to viral infections
Models of human viral disease: Role of nitric oxide and chemokines in the pathogenesis of lethal pneumonia and encephalitis as a basis for interventive drug development
Pathophysiological significance of reverse signalling through membrane TNF
Regulation of leukocyte migration and interaction by the homing receptor EBI2
Role of nitric oxide in influenza A virus-induced pneumonia
Role of plasmacytoid dendritic cells and neutrophils in the generation of antiviral immunity
Systems Approach to Immunity and Inflammation
Systems Approach to Immunity and Inflammation
Understanding the key attributes of CD8 T cell receptor transfer as an antiviral strategy and harnessing the process to combat persistent viral infections

Research Candidate Supervision