Web Access Research Portal

Researcher: Sinclair, D (Dr Duncan Sinclair)

Fields of Research

Cellular nervous system
Central nervous system
Preventative health care
Medical parasitology
Mental health services
Sensory systems
Aged health care
Health services and systems
Occupational and workplace health and safety

Research Objectives

Clinical health
Health related to ageing
Expanding knowledge in the agricultural, food and veterinary sciences
Specific population health (excl. Indigenous health)

Career Best Publications

Research Publications

Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness; Neuropsychopharmacology
Brain antibodies in the cortex and blood of people with schizophrenia and controls; Translational psychiatry
Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism; Pharmacology Biochemistry and Behavior
Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development; Molecular Psychiatry
Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness; Scientific reports
Dysregulations of synaptic vesicle trafficking in Schizophrenia; Current Psychiatry Reports
Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus; Journal of Neurodevelopmental Disorders
GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome; eNeuro
Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants; PloS one
Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder; BMC psychiatry
Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain; Psychopharmacology
Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder; Translational Psychiatry
Microarray analyses of mouse responses to infection by Neospora caninum identifies disease associated cellular pathways in the host response; Molecular and Biochemical Parasitology
Microarrays and stage conversion in Toxoplasma gondii; Trends in Parasitology
Molecular evidence for decreased synaptic efficacy in the postmortem olfactory bulb of individuals with schizophrenia; Schizophrenia Research
Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice; Schizophrenia Bulletin
Rethinking schizophrenia in the context of normal neurodevelopment; Frontiers in cellular neuroscience
Sensory processing in autism spectrum disorders and Fragile X syndrome - from the clinic to animal models; Neuroscience and Biobehavioral Reviews
Transcriptional changes in the stress pathway are related to symptoms in schizophrenia and to mood in schizoaffective disorder; Schizophrenia Research
Transcriptome analysis of male-female differences in prefrontal cortical development; Molecular Psychiatry
Translational potential of olfactory mucosa for the study of neuropsychiatric illness; Translational psychiatry

Research Projects

Developing isogenic iPSC lines to understand the role of stress hormones in Alzheimer s disease; University of Tasmania (UTAS)
How does stress impact pathological processes in Alzheimer's disease?; Dementia Australia Research Foundation Ltd (DARF)
Investigating NMDA receptor hypofunction as a point of convergence for genetic and environmental risk factors in schizophrenia; National Health & Medical Research Council (NHMRC)
Investigating stress related therapeutic targets for Alzheimers disease in human neuronal cells; Dementia Australia Research Foundation Ltd (DARF)

Research Candidate Supervision