Web Access Research Portal

Researcher: Sinclair, D (Dr Duncan Sinclair)

Fields of Research

Cellular nervous system
Central nervous system
Preventative health care
Medical parasitology
Mental health services
Neurosciences
Psychology of ageing
Sensory systems
Aged health care
Psychiatry (incl. psychotherapy)
Health services and systems
Epidemiology
Occupational and workplace health and safety

Research Objectives

Clinical health
Treatment of human diseases and conditions
Health related to ageing
Specific population health (excl. Indigenous health)
Expanding knowledge in the agricultural, food and veterinary sciences

Career Best Publications

Change in modifiable dementia risk factors during COVID-19 lockdown: the experience of over 50s in Tasmania, Australia; Alzheimer's & Dementia: Translational Research & Clinical Interventions
Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development; Molecular Psychiatry
Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness; Scientific reports
GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome; eNeuro
Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain; Psychopharmacology
Sensory processing in autism spectrum disorders and Fragile X syndrome - from the clinic to animal models; Neuroscience and Biobehavioral Reviews

Research Publications

1143. The changing postsynaptic protein landscape in the developing brain; Society of Biological Psychiatry Annual Meeting 2015
663.13 - Effects of GABA-B agonist baclofen on neural oscillations and behaviour in the FMRP1 knockout mouse model of Fragile X syndrome; Neuroscience 2016
81. Changes in molecular stress signaling chaperone FKBP5 in the aging human brain; Australian Dementia Forum 2018
Abnormal glucocorticoid receptor mRNA and protein isoform expression in the prefrontal cortex in psychiatric illness; Neuropsychopharmacology
Are stress hormones protective in Alzheimer's disease? Using cultured cells to understand hormonal stress responses in the ageing human brain; “Back to Basics Workshop” – Understanding the Molecular basis of Alzheimer’s disease
Brain antibodies in the cortex and blood of people with schizophrenia and controls; Translational psychiatry
Cannabidiol (CBD) reduces anxiety-related behavior in mice via an FMRP-independent mechanism; Pharmacology Biochemistry and Behavior
Cellular and molecular stress responsiveness across the human lifespan; 49th Winter Conference on Brain Research
Change in modifiable dementia risk factors during COVID-19 lockdown: the experience of over 50s in Tasmania, Australia; Alzheimer's & Dementia: Translational Research & Clinical Interventions
Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development; Molecular Psychiatry
Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness; Scientific reports
Dysregulations of synaptic vesicle trafficking in Schizophrenia; Current Psychiatry Reports
Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus; Journal of Neurodevelopmental Disorders
FKBP5 messenger RNA increases after adolescence in human dorsolateral prefrontal cortex; Biological Psychiatry
GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome; eNeuro
Glucocorticoid receptor 1B and 1C mRNA transcript alterations in schizophrenia and bipolar disorder, and their possible regulation by GR gene variants; PloS one
Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder; BMC psychiatry
GluN2B-Containing NMDA receptors in interneurons modulate auditory-evoked high frequency neural oscillations in adulthood; Australasian Neuroscience Society Annual Scientific Meeting 2016
How are older Tasmanians experiencing the pandemic?
Impacts of sex on postsynaptic NMDA receptor signaling in the cortex; 49th Winter Conference on Brain Research
Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain; Psychopharmacology
Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder; Translational Psychiatry
Microarray analyses of mouse responses to infection by Neospora caninum identifies disease associated cellular pathways in the host response; Molecular and Biochemical Parasitology
Microarrays and stage conversion in Toxoplasma gondii; Trends in Parasitology
Molecular evidence for decreased synaptic efficacy in the postmortem olfactory bulb of individuals with schizophrenia; Schizophrenia Research
Molecular stress signalling in human psychiatric illness and cortical development: the glucocorticoid receptor and its chaperones
Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice; Schizophrenia Bulletin
P60. Abnormalities of FKBP5 and BAG1 within the glucocorticoid receptor stress signalling pathway in schizophrenia and bipolar disorder; 45th Annual Winter Conference on Brain Research
P64. Changes in molecular stress response pathways in normal adolescence and schizophrenia— Implications for the developmental onset of psychiatric illness; 44th Annual Winter Conference on Brain Research
Program#/Poster#: 213.20/C21- Dynamic developmental changes and gender differences in the abundance of postsynaptic NMDA signaling proteins in the mouse frontal cortex; Neuroscience 2014
Program#/Poster#: 259.19/CC10 - Glucocorticoid receptor mRNA transcript variants 1B and 1C are decreased in schizophrenia and bipolar disorder, and are differentially regulated by SNPs overrepresented in schizophrenia; Neuroscience 2011
Rethinking schizophrenia in the context of normal neurodevelopment; Frontiers in cellular neuroscience
Sensory processing in autism spectrum disorders and Fragile X syndrome - from the clinic to animal models; Neuroscience and Biobehavioral Reviews
Transcriptional changes in the stress pathway are related to symptoms in schizophrenia and to mood in schizoaffective disorder; Schizophrenia Research
Transcriptome analysis of male-female differences in prefrontal cortical development; Molecular Psychiatry
Translational potential of olfactory mucosa for the study of neuropsychiatric illness; Translational psychiatry
Using cultured human neuronal cells to understand hormonal stress responses in Alzheimer’s disease; Australian Dementia Forum 2019
W29. GABA-B agonist baclofen normalizes auditory-evoked neural oscillations and some cognitive deficits in the FMR1 knockout mouse model of Fragile X Syndrome; 50th Winter Conference on Brain Research

Research Projects

Developing isogenic iPSC lines to understand the role of stress hormones in Alzheimer s disease; University of Tasmania (UTAS)
How does stress impact pathological processes in Alzheimer's disease?; Dementia Australia Research Foundation Ltd (DARF)
Investigating NMDA receptor hypofunction as a point of convergence for genetic and environmental risk factors in schizophrenia; National Health & Medical Research Council (NHMRC)
Investigating stress related therapeutic targets for Alzheimers disease in human neuronal cells; Dementia Australia Research Foundation Ltd (DARF)
The ISLAND Resilience Initiative: tailored education to improve bushfire-related health outcomes for older Tasmanians; Department of Police, Fire and Emergency Management [TAS] (DPFEM)

Research Candidate Supervision