Web Access Research Portal

Researcher: Liu, G (Dr Guei-Sheung Liu)

Fields of Research

Gene and Molecular Therapy
Ophthalmology
Cellular Nervous System
Cancer Genetics
Genomics
Central Nervous System
Cancer Cell Biology
Animal Immunology

Research Objectives

Inherited Diseases (incl. Gene Therapy)
Hearing, Vision, Speech and Their Disorders
Neurodegenerative Disorders Related to Ageing
Flora, Fauna and Biodiversity at Regional or Larger Scales
Expanding Knowledge in the Medical and Health Sciences
Diabetes

Career Best Publications

Research Publications

Acrylic acid surface-modified contact lens for the culture of limbal stem cells; Tissue Engineering. Part A
Annexin peptide Ac2-26 suppresses TNFα-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells; PLoS One
Defining the structural characteristics of annexin V binding to a mimetic apoptotic membrane; European Biophysics Journal
Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells; Breast Cancer Research and Treatment
Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead Box O1 mediated upregulation of antioxidant enzymes; Stem Cells and Development
Downregulation of hepatoma-derived growth factor contributes to retarded lung metastasis via inhibition of epithelial-mesenchymal transition by systemic POMC gene delivery in melanoma; Molecular Cancer Therapeutics
Enhancement of neurite outgrowth in neuron cancer stem cells by growth on 3-D collagen scaffolds; Biochemical and Biophysical Research Communications
Expression of the proangiogenic protein hepatoma-derived growth factor in neovessels in an arterial venous loop-based tissue engineering chamber; Biomedical Engineering: Applications, Basis and Communications
Gene delivery by subconjunctival injection of adenovirus in rats: A study of local distribution, transgene duration and safety; PLoS One
Gene therapy with endogenous inhibitors of angiogenesis for neovascular age-related macular degeneration: Beyond anti-VEGF therapy; Journal of Ophthalmology
Glial cell line-derived neurotrophic factor gene transfer exerts protective effect on axons in sciatic nerve following constriction-induced peripheral nerve injury; Human Gene Therapy
Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt pathway; Biochemical and Biophysical Research Communications
Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis; Experimental Biology and Medicine
Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy; PLoS One
Involvement of Nox2 NADPH oxidase in retinal neovascularization; Investigative Ophthalmology and Visual Science
Microphthalmia-associated transcription factor modulates expression of NADPH oxidase type 4: a negative regulator of melanogenesis; Free Radical Biology and Medicine
NADPH oxidase 2 plays a role in experimental corneal neovascularization; Clinical Science
NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses; Redox Biology
Nanocarriers for treatment of ocular neovascularization in the back of the eye: new vehicles for ophthalmic drug delivery; Nanomedicine
Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro; Biochemical and Biophysical Research Communications
Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit; International Journal of Ophthalmology
Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine; Journal of Tissue Engineering and Regenerative Medicine
Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization; International Journal of Nanomedicine
Pro-opiomelanocortin gene delivery suppresses the growth of established Lewis lung carcinoma through a melanocortin-1 receptor-independent pathway; Journal of Gene Medicine
Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation; Free Radical Biology and Medicine
Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis; Antioxidants and Redox Signaling
Redox mechanisms in pathological angiogenesis in the retina: roles for NADPH oxidase; Current Pharmaceutical Design
Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response; Cells
Redox mechanisms of the beneficial effects of heme oxygenase in hypertension; Journal of Hypertension
Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression; Cell Death & Disease
Systemic pro-opiomelanocortin expression induces melanogenic differentiation and inhibits tumor angiogenesis in established mouse melanoma; Human Gene Therapy
Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications; PLoS One
Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo; Journal of Cellular and Molecular Medicine
Transplantation of engineered cardiac muscle flaps in syngeneic rats; Tissue Engineering: Part A
Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas; Journal of Neuro-Oncology
Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma; PLoS One

Research Projects

CRISPR screen to identify key genes driving DFTD; University of Tasmania Foundation Inc (UTF)

Research Candidate Supervision