Web Access Research Portal

Researcher: Liu, G (Dr Guei-Sheung Liu)

Fields of Research

Gene and Molecular Therapy
Ophthalmology
Cellular Nervous System
Cancer Genetics
Cell Development, Proliferation and Death
Gene Expression (incl. Microarray and other genome-wide approaches)
Central Nervous System
Molecular Targets
Otorhinolaryngology
Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
Genomics
Cancer Cell Biology
Biochemistry and Cell Biology
Genetics
Animal Immunology

Research Objectives

Inherited Diseases (incl. Gene Therapy)
Hearing, Vision, Speech and Their Disorders
Diabetes
Neurodegenerative Disorders Related to Ageing
Expanding Knowledge in the Medical and Health Sciences
Cancer and Related Disorders
Urogenital System and Disorders
Expanding Knowledge in the Biological Sciences
Cardiovascular System and Diseases
Nervous System and Disorders
Flora, Fauna and Biodiversity at Regional or Larger Scales

Career Best Publications

Research Publications

AAV-mediated CRISPR/Cas gene editing of retinal cells in vivo; Investigative Ophthalmology & Visual Science
AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization; Angiogenesis
Acrylic acid surface-modified contact lens for the culture of limbal stem cells; Tissue Engineering. Part A
Annexin peptide Ac2-26 suppresses TNFα-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells; PLoS One
Autophagic cell death participates in POMC-induced melanoma suppression; Cell Death Discovery
Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart; Stem Cell
Defining the structural characteristics of annexin V binding to a mimetic apoptotic membrane; European Biophysics Journal
Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells; Breast Cancer Research and Treatment
Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead Box O1 mediated upregulation of antioxidant enzymes; Stem Cells and Development
Downregulation of hepatoma-derived growth factor contributes to retarded lung metastasis via inhibition of epithelial-mesenchymal transition by systemic POMC gene delivery in melanoma; Molecular Cancer Therapeutics
Enhancement of neurite outgrowth in neuron cancer stem cells on 3-D collagen scaffolds; Biochemical and Biophysical Research Communications
Expression of the proangiogenic protein hepatoma-derived growth factor in neovessels in an arterial venous loop-based tissue engineering chamber; Biomedical Engineering: Applications, Basis and Communications
Gene delivery by subconjunctival injection of adenovirus in rats: A study of local distribution, transgene duration and safety; PLoS One
Gene delivery of calreticulin anti-angiogenic domain attenuates the development of choroidal neovascularization in rats; Human Gene Therapy
Gene therapy for diabetic retinopathy: are we ready to make the leap from bench to bedside?; Pharmacology and Therapeutics
Gene therapy for visual loss: Opportunities and concerns; Progress in Retinal and Eye Research
Gene therapy with endogenous inhibitors of angiogenesis for neovascular age-related macular degeneration: Beyond anti-VEGF therapy; Journal of Ophthalmology
Glial cell line-derived neurotrophic factor gene transfer exerts protective effect on axons in sciatic nerve following constriction-induced peripheral nerve injury; Human Gene Therapy
Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt pathway; Biochemical and Biophysical Research Communications
Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis; Experimental Biology and Medicine
Inhibition of experimental choroidal neovascularization by a novel peptide derived from calreticulin anti-angiogenic domain; International Journal of Molecular Sciences
Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy; PLoS One
Involvement of Nox2 NADPH oxidase in retinal neovascularization; Investigative Ophthalmology and Visual Science
Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina; Retinal Gene Therapy: Methods and Protocols
Microphthalmia-associated transcription factor modulates expression of NADPH oxidase type 4: a negative regulator of melanogenesis; Free Radical Biology and Medicine
Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells; Cell Death Discovery
NADPH oxidase 2 plays a role in experimental corneal neovascularization; Clinical Science
NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses; Redox Biology
Nanocarriers for treatment of ocular neovascularization in the back of the eye: new vehicles for ophthalmic drug delivery; Nanomedicine
Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro; Biochemical and Biophysical Research Communications
Ocular drug delivery: role of degradable polymeric nanocarriers for ophthalmic application; International Journal of Molecular Sciences
Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit; International Journal of Ophthalmology
Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine; Journal of Tissue Engineering and Regenerative Medicine
Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization; International Journal of Nanomedicine
Pro-opiomelanocortin gene delivery suppresses the growth of established Lewis lung carcinoma through a melanocortin-1 receptor-independent pathway; Journal of Gene Medicine
Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation; Free Radical Biology and Medicine
Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis; Antioxidants and Redox Signaling
Public attitudes toward gene therapy in China; Molecular Therapy - Methods & Clinical Development
Redox mechanisms in pathological angiogenesis in the retina: roles for NADPH oxidase; Current Pharmaceutical Design
Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response; Cells
Redox mechanisms of the beneficial effects of heme oxygenase in hypertension; Journal of Hypertension
Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression; Cell Death & Disease
Systemic pro-opiomelanocortin expression induces melanogenic differentiation and inhibits tumor angiogenesis in established mouse melanoma; Human Gene Therapy
Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications; PLoS One
Transforming growth factor β1-induced NADPH Oxidase-4 expression and fibrotic response in conjunctival fibroblasts; Investigative Ophthalmology & Visual Science
Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo; Journal of Cellular and Molecular Medicine
Transplantation of engineered cardiac muscle flaps in syngeneic rats; Tissue Engineering: Part A
Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas; Journal of Neuro-Oncology
Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma; PLoS One

Research Projects

CRISPR screen to identify key genes driving DFTD; University of Tasmania Foundation Inc (UTF)
Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies; University of Tasmania Foundation Inc (UTF)
Targeting dysregulated miRNAs and transforming growth factor-B-activated kinase 1 (TAK1) to stop the growth of leaky blood vessels in diabetic eyes; University of Tasmania (UTAS)

Research Candidate Supervision