Web Access Research Portal

Researcher: Liu, G (Associate Professor Guei-Sheung Liu)

Fields of Research

Gene and molecular therapy
Cancer genetics
Molecular targets
Animal immunology
Gene expression (incl. microarray and other genome-wide approaches)
Cellular nervous system
Cancer cell biology
Regenerative medicine (incl. stem cells)
Medical biotechnology diagnostics (incl. biosensors)
Cell development, proliferation and death
Veterinary immunology
Central nervous system
Biological network analysis
Vision science
Biochemistry and cell biology
Infectious diseases
Infectious agents
Conservation and biodiversity
Solid tumours
Aboriginal and Torres Strait Islander public health and wellbeing

Research Objectives

Clinical health
Treatment of human diseases and conditions
Expanding knowledge in the biomedical and clinical sciences
Expanding knowledge in the biological sciences
Expanding knowledge in the health sciences
Diagnosis of human diseases and conditions
Veterinary biological preventatives
Terrestrial biodiversity
Expanding knowledge in the environmental sciences
Veterinary diagnostics
Expanding knowledge in the agricultural, food and veterinary sciences
Disease distribution and transmission (incl. surveillance and response)
Control of pests, diseases and exotic species in terrestrial environments
Efficacy of medications

Career Best Publications

Research Publications

A drug-tunable Flt23k gene therapy for controlled intervention in retinal neovascularization; Angiogenesis
A human adenovirus encoding IFN-γ can transduce Tasmanian devil facial tumour cells and upregulate MHC-I; Journal of General Virology
AAV-mediated CRISPR/Cas gene editing of retinal cells in vivo; Investigative Ophthalmology & Visual Science
AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization; Angiogenesis
Acrylic acid surface-modified contact lens for the culture of limbal stem cells; Tissue Engineering. Part A
An oral bait vaccination approach for the Tasmanian devil facial tumor diseases; Expert Review of Vaccines
Annexin peptide Ac2-26 suppresses TNFα-induced inflammatory responses via inhibition of Rac1-dependent NADPH oxidase in human endothelial cells; PLoS One
Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue; Journal of Materials Chemistry B
Approach for in vivo delivery of CRISPR/Cas system: a recent update and future prospect; Cellular and Molecular Life Sciences
Approaches for the sensitive detection of rare base and prime editing events; Methods
Autophagic cell death participates in POMC-induced melanoma suppression; Cell Death Discovery
Bulk gene expression deconvolution reveals infiltration of M2 macrophages in retinal neovascularization; Investigative Ophthalmology & Visual Science
Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart; Stem Cell
Comparison of CRISPR/Cas endonucleases for in vivo retinal gene editing; Frontiers in Cellular Neuroscience
Defining the structural characteristics of annexin V binding to a mimetic apoptotic membrane; European Biophysics Journal
Development of kaempferol-loaded gelatin nanoparticles for the treatment of corneal neovascularization in mice; Pharmaceutics
Differential effects of superoxide dismutase and superoxide dismutase/catalase mimetics on human breast cancer cells; Breast Cancer Research and Treatment
Differentiation of human adipose-derived stem cells into fat involves reactive oxygen species and Forkhead Box O1 mediated upregulation of antioxidant enzymes; Stem Cells and Development
Downregulation of hepatoma-derived growth factor contributes to retarded lung metastasis via inhibition of epithelial-mesenchymal transition by systemic POMC gene delivery in melanoma; Molecular Cancer Therapeutics
Editorial: Advances in cell and gene therapy in treating neural diseases; Frontiers in Cellular Neuroscience
Editorial: The current CRISPR methods; Methods
Enhancement of neurite outgrowth in neuron cancer stem cells on 3-D collagen scaffolds; Biochemical and Biophysical Research Communications
Expression of the proangiogenic protein hepatoma-derived growth factor in neovessels in an arterial venous loop-based tissue engineering chamber; Biomedical Engineering: Applications, Basis and Communications
Gene delivery by subconjunctival injection of adenovirus in rats: A study of local distribution, transgene duration and safety; PLoS One
Gene delivery of calreticulin anti-angiogenic domain attenuates the development of choroidal neovascularization in rats; Human Gene Therapy
Gene therapy for diabetic retinopathy: are we ready to make the leap from bench to bedside?; Pharmacology and Therapeutics
Gene therapy for visual loss: opportunities and concerns; Progress in Retinal and Eye Research
Gene therapy intervention in neovascular eye disease: a recent update; Molecular Therapy
Gene therapy with endogenous inhibitors of angiogenesis for neovascular age-related macular degeneration: Beyond anti-VEGF therapy; Journal of Ophthalmology
Glial cell line-derived neurotrophic factor gene transfer exerts protective effect on axons in sciatic nerve following constriction-induced peripheral nerve injury; Human Gene Therapy
Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol 3-kinase/Akt pathway; Biochemical and Biophysical Research Communications
Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis; Experimental Biology and Medicine
Inhibition of experimental choroidal neovascularization by a novel peptide derived from calreticulin anti-angiogenic domain; International Journal of Molecular Sciences
Intraocular Pressure Induced Retinal Changes Identified Using Synchrotron Infrared Microscopy; PLoS One
Involvement of Nox2 NADPH oxidase in retinal neovascularization; Investigative Ophthalmology and Visual Science
Methods for in vitro CRISPR/CasRx-mediated RNA editing; Frontiers in Cell and Developmental Biology
Methods for assessing scaffold vascularization in vivo; Skin Tissue Engineering: Methods and Protocols, Methods in Molecular Biology
Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina; Retinal Gene Therapy: Methods and Protocols
Microphthalmia-associated transcription factor modulates expression of NADPH oxidase type 4: a negative regulator of melanogenesis; Free Radical Biology and Medicine
Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells; Cell Death Discovery
NADPH oxidase 2 plays a role in experimental corneal neovascularization; Clinical Science
NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses; Redox Biology
Nanocarriers for treatment of ocular neovascularization in the back of the eye: new vehicles for ophthalmic drug delivery; Nanomedicine
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in 3 transmissible cancers; Journal of Cancer Research and Clinical Oncology
Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro; Biochemical and Biophysical Research Communications
Ocular drug delivery: role of degradable polymeric nanocarriers for ophthalmic application; International Journal of Molecular Sciences
Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit; International Journal of Ophthalmology
Pharmacological priming of adipose-derived stem cells for paracrine VEGF production with deferoxamine; Journal of Tissue Engineering and Regenerative Medicine
Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization; International Journal of Nanomedicine
Pro-opiomelanocortin gene delivery suppresses the growth of established Lewis lung carcinoma through a melanocortin-1 receptor-independent pathway; Journal of Gene Medicine
Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation; Free Radical Biology and Medicine
Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis; Antioxidants and Redox Signaling
Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina; Scientific Reports
Public attitudes toward gene therapy in China; Molecular Therapy - Methods & Clinical Development
Rapid and efficient cataract gene evaluation in F0 zebrafish using CRISPR-Cas9 ribonucleoprotein complexes; Methods: A Companion to Methods in Enzymology
Redox mechanisms in pathological angiogenesis in the retina: roles for NADPH oxidase; Current Pharmaceutical Design
Redox mechanisms in regulation of adipocyte differentiation: beyond a general stress response; Cells
Redox mechanisms of the beneficial effects of heme oxygenase in hypertension; Journal of Hypertension
Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant; Molecular Vision
Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression; Cell Death & Disease
Systemic pro-opiomelanocortin expression induces melanogenic differentiation and inhibits tumor angiogenesis in established mouse melanoma; Human Gene Therapy
TAK1 signaling is a potential therapeutic target for pathological angiogenesis; Angiogenesis
Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model; Acta Biomaterialia
Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications; PLoS One
Topical application of hyaluronic acid-RGD peptide-coated gelatin/epigallocatechin-3 gallate (EGCG) nanoparticles inhibits corneal neovascularization via inhibition of VEGF production; Pharmaceutics
Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization; Theranostics
Transforming growth factor β1-induced NADPH Oxidase-4 expression and fibrotic response in conjunctival fibroblasts; Investigative Ophthalmology & Visual Science
Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo; Journal of Cellular and Molecular Medicine
Transplantation of 3D adipose‑derived stem cell/hepatocyte spheroids alleviates chronic hepatic damage in a rat model of thioacetamide‑induced liver cirrhosis; Scientific Reports
Transplantation of engineered cardiac muscle flaps in syngeneic rats; Tissue Engineering: Part A
Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas; Journal of Neuro-Oncology
Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma; PLoS One
Updates on gene therapy for diabetic retinopathy; Current Diabetes Reports
Utility of self-destructing CRISPR/Cas constructs for targeted gene editing in the retina; Human Gene Therapy

Research Projects

CRISPR screen to identify key genes driving DFTD; University of Tasmania Foundation Inc (UTF)
Developing CRISPR/Cas Library Screens for identifying Novel Cancer Therapies; University of Tasmania Foundation Inc (UTF)
Development of a devil facial tumour disease vaccine; University of Tasmania Foundation Inc (UTF)
Gaining new insights into metastatic bone tumours; Royal Hobart Hospital Research Foundation (RHHRF)
Guei-Sheung Liu - gene therapy blocking VGEF; CSIRO-Commonwealth Scientific & Industrial Research Organisation (CSIRO)
Losing the needle: Using eye drop-based switchable gene therapy as a non-invasive controlled intervention in neovascular blindness; National Health & Medical Research Council (NHMRC)
Switchable Gene Therapy for Controlled Intervention in Neovascular Blindness; Ophthalmic Research Institute of Australia (ORIA)
Targeting dysregulated miRNAs and transforming growth factor-B-activated kinase 1 (TAK1) to stop the growth of leaky blood vessels in diabetic eyes; University of Tasmania (UTAS)
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Research Candidate Supervision