Web Access Research Portal

Researcher: Azimi, I (Dr Iman Azimi)

Fields of Research

Cancer cell biology
Molecular targets
Pharmacology and pharmaceutical sciences
Basic pharmacology
Signal transduction
Biochemistry and cell biology
Cancer therapy (excl. chemotherapy and radiation therapy)
Pharmaceutical sciences
Separation science
Cellular nervous system
Medical genetics (excl. cancer genetics)
Cell neurochemistry
Clinical sciences
Cardiology (incl. cardiovascular diseases)
Tumour immunology
Oncology and carcinogenesis
Haematological tumours
Radiation therapy
Metabolic medicine
Cell physiology
Sport and exercise nutrition
Metal organic frameworks
Cancer genetics
Gene expression (incl. microarray and other genome-wide approaches)

Research Objectives

Clinical health
Expanding knowledge in the biological sciences
Other health
Expanding knowledge in the health sciences
Expanding knowledge in the biomedical and clinical sciences
Expanding knowledge in the chemical sciences
Treatment of human diseases and conditions
Health related to ageing
Health policy evaluation
Human pharmaceutical products
Diagnosis of human diseases and conditions

Career Best Publications

Research Publications

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions; ACS Pharmacology and Translational Sciences
A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial-mesenchymal transition; Biochemical and biophysical research communications
Activation of the ion channel induces epithelial to mesenchymal transition in breast cancer cells; International Journal of Molecular Sciences
Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells; Molecular oncology
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay; Bioorganic & Medicinal Chemistry
Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells; Oncology Letters
Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells; Bmc Cell Biology
Ca2+mediates extracellular vesicle biogenesis through alternate pathways in malignancy; Journal of Extracellular Vesicles
Calcium influx pathways in breast cancer: opportunities for pharmacological intervention; British Journal of Pharmacology
Calcium signaling in brain cancers: roles and therapeutic targeting; Cancers
Comparative in vitro toxicology of novel cytoprotective short-chain naphthoquinones; Pharmaceuticals
Control of mature protein function by allosteric disulfide bonds; Antioxidants and Redox Signaling
Development of a high-throughput agar colony formation assay to identify drug candidates against medulloblastoma; Pharmaceuticals
Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli; Laboratory Investigation
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels; Cell Calcium
Disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin; Journal of Biological Chemistry
EMT signaling: potential contribution of CRISPR/Cas gene editing
Endogenous anti-cancer candidates in GPCR, ER stress, and EMT; Biomedicines
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a fluorescence imaging plate reader assay; Bioorganic and Medicinal Chemistry
Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells; Scientific reports
Immune checkpoints in targeted-immunotherapy of pancreatic cancer: new hope for clinical development
Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent; Oncogene
Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells; The international journal of biochemistry & cell biology
Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells; Oncogene
ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses; Cancers
Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: consequences on calcium signalling, cell migration and proliferation; Cellular and Molecular Life Sciences
Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells; Endocrine-related cancer
Reduced monomeric CD4 is the preferred receptor for HIV; Journal of Biological Chemistry
Stepwise Degradable Nanocarriers Enabled Cascade Delivery for Synergistic Cancer Therapy; Advanced Functional Materials
The interplay between HIF-1 and calcium signalling in cancer; International Journal of Biochemistry and Cell Biology
TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells; Journal of Cell Science

Research Projects

A novel tool to enhance Orai1 ; CSIRO-Commonwealth Scientific & Industrial Research Organisation (CSIRO)
Characterisation and targeting of Lin28 for the control of paediatric medulloblastoma; Brain Foundation (BrainF)
Identifying shared mechanisms in response to radiotherapy; Cancer Council of Tasmania (CCT)
Repurposing of FDA approved drugs against medulloblastoma; Cancer Council of Tasmania (CCT)
Targeting Lin28 for the control of the most aggressive subgroups of medulloblastoma; University of Tasmania (UTAS)
Identification of novel therapeutic targets for paediatric medulloblastoma
Novotech consultancy

Research Candidate Supervision