Web Access Research Portal

Researcher: Azimi, I (Dr Iman Azimi)

Fields of Research

Cancer Cell Biology
Signal Transduction
Molecular Targets
Biochemistry and Cell Biology
Pharmacology and Pharmaceutical Sciences
Medical Genetics (excl. Cancer Genetics)
Basic Pharmacology
Cell Neurochemistry
Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
Pharmaceutical Sciences
Synthesis of Materials
Nanobiotechnology
Cell Physiology

Research Objectives

Cancer and Related Disorders
Expanding Knowledge in the Biological Sciences
Expanding Knowledge in the Chemical Sciences

Career Best Publications

Research Publications

A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial-mesenchymal transition; Biochemical and biophysical research communications
Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells; Molecular oncology
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay; Bioorganic & Medicinal Chemistry
Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells; Oncology Letters
Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells; Bmc Cell Biology
Calcium influx pathways in breast cancer: opportunities for pharmacological intervention; British Journal of Pharmacology
Calcium signaling in brain cancers: roles and therapeutic targeting; Cancers
Control of mature protein function by allosteric disulfide bonds; Antioxidants and Redox Signaling
Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli; Laboratory Investigation
Disulfide bond that constrains the HIV-1 gp120 V3 domain is cleaved by thioredoxin; Journal of Biological Chemistry
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a fluorescence imaging plate reader assay; Bioorganic and Medicinal Chemistry
Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells; Scientific reports
Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent; Oncogene
Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells; The international journal of biochemistry & cell biology
Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells; Oncogene
ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses; Cancers
Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: consequences on calcium signalling, cell migration and proliferation; Cellular and Molecular Life Sciences
Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells; Endocrine-related cancer
Reduced monomeric CD4 is the preferred receptor for HIV; Journal of Biological Chemistry
Stepwise Degradable Nanocarriers Enabled Cascade Delivery for Synergistic Cancer Therapy; Advanced Functional Materials
The interplay between HIF-1 and calcium signalling in cancer; International Journal of Biochemistry and Cell Biology
TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells; Journal of Cell Science

Research Projects

Characterisation and targeting of Lin28 for the control of paediatric medulloblastoma; Brain Foundation (BrainF)

Research Candidate Supervision